Best TWAS P=2.16e-111 · Best GWAS P=1.31e-157 conditioned to 6.73e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAR2 | 0.08 | 0.05 | bslmm | 659 | 0.05 | 3.6e-07 | -5.29 | 9.4 | 7.8e-21 | -0.21 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | FAR2 | 0.17 | 0.01 | lasso | 5 | 0.00 | 2.2e-01 | 0.28 | -6.0 | 1.9e-09 | 0.30 | 0.16 | 0.15 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | ERGIC2 | 0.12 | 0.03 | enet | 23 | 0.05 | 1.4e-04 | -0.30 | -5.9 | 4.4e-09 | 0.22 | 0.94 | 0.00 | FALSE |
| 4 | GTEx | Lung | FAR2 | 0.18 | 0.11 | lasso | 8 | 0.10 | 3.2e-08 | -22.65 | -22.4 | 2.2e-111 | 0.79 | 0.50 | 0.50 | TRUE |
| 5 | GTEx | Vagina | RP11-996F15.2 | 0.44 | 0.31 | enet | 23 | 0.27 | 5.9e-07 | -0.26 | -5.5 | 4.0e-08 | 0.19 | 0.82 | 0.02 | FALSE |
| 6 | METSIM | Adipose | FAR2 | 0.05 | 0.02 | enet | 10 | 0.03 | 6.2e-05 | -8.04 | -6.9 | 4.3e-12 | 0.32 | 0.98 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERGIC2 | 0.03 | 0.00 | blup | 62 | 0.02 | 2.6e-04 | -21.87 | -11.6 | 3.7e-31 | 0.45 | 0.01 | 0.82 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERGIC2 | 0.06 | 0.02 | enet | 9 | 0.04 | 4.8e-05 | -7.46 | 11.1 | 9.0e-29 | -0.45 | 0.14 | 0.02 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ERGIC2 | 0.05 | 0.02 | lasso | 4 | 0.05 | 3.3e-06 | 5.23 | -8.5 | 1.9e-17 | 0.29 | 0.19 | 0.13 | FALSE |