TWAS hub - FAR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0820	0.0260	1.5e-05	0.054	0.046	0.052	0.054	0.051	3.2e-07	2.3e-06	5.6e-07	3.6e-07	8.0e-07
2	GTEx	Adipose Subcutaneous	0.0640	0.0280	8.1e-03	0.051	NA	0.024	NA	0.034	4.9e-05	NA	4.2e-03	NA	8.6e-04
3	GTEx	Adipose Visceral Omentum	0.1660	0.0680	3.6e-03	0.006	NA	-0.003	NA	0.003	1.4e-01	NA	5.5e-01	NA	2.2e-01
4	GTEx	Lung	0.1832	0.0462	8.5e-07	0.106	NA	0.092	NA	0.102	1.7e-08	NA	1.5e-07	NA	3.2e-08
5	METSIM	Adipose	0.0450	0.0175	7.9e-04	0.025	0.021	0.027	0.026	0.026	1.1e-04	2.9e-04	6.2e-05	8.0e-05	8.2e-05
6	TCGA	Brain Lower Grade Glioma	0.0971	0.0416	1.5e-03	0.034	0.016	0.012	NA	0.028	8.2e-05	5.2e-03	1.5e-02	NA	3.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	9.9	114.6	501.8	9.4	-3.7	-6.0	-22.4	-6.9	0.6
Hair/balding pattern: Pattern 4	4.2	10.1	43.5	6.6	0.5	-0.6	-3.7	-1.3	1.1
Medication: Aspirin	2.9	3.8	7.1	-0.1	-1.2	-2.3	2.2	-2.7	2.1
Shortness of breath walking on level ground	2.7	3.2	8.2	-2.9	2.0	1.6	-0.2	2.1	-0.0
Number of live births	2.5	3.5	8.8	1.9	0.9	0.9	-3.0	2.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	13.5	1.1	2.7	2.0	-2.0	3.7	-1.0
Medication: Aspirin	2.3	3.0	4.7	-0.1	-0.7	-2.0	2.2	-2.1	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	12.0	0.7	-3.5	-0.1	0.9	-1.5	-0.7
Hair/balding pattern: Pattern 3	2.2	3.2	11.1	3.3	1.8	-1.2	-1.5	1.1	0.1
Noisy workplace	2.2	2.7	5.8	1.9	-1.6	-1.4	-2.4	-1.5	0.5
Breastfed as a baby	2.2	2.7	9.7	0.7	-3.1	-1.4	0.8	-1.9	-0.3
Number of children fathered	2.2	2.5	6.2	-2.2	-0.1	1.3	2.5	-0.2	1.4
Bipolar Disorder (2018)	2.0	3.1	7.2	1.9	1.5	1.0	-1.5	2.7	1.5
Time employed in main current job	2.0	2.3	4.2	-1.5	1.9	1.8	2.1	0.0	-0.5
Lung cancer (father)	2.0	2.4	7.5	1.3	-1.8	-0.5	1.3	0.2	-2.7
Pulse wave Arterial Stiffness index	2.0	2.4	6.2	-1.4	1.6	0.8	-0.1	2.5	1.8
Chronic bronchitis/emphysema (father)	1.9	2.2	4.6	1.4	1.1	0.2	-1.9	2.1	-1.3
Pulse wave reflection index	1.9	2.3	8.0	-0.7	0.9	0.6	-0.5	2.0	2.8
Pulse wave peak to peak time	1.9	2.2	5.1	1.2	-1.6	-0.9	0.0	-2.2	-1.8
Ever had bowel cancer screening	1.9	2.2	10.5	3.2	0.7	0.8	-0.8	0.8	-0.4
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.8	1.9	-0.5	1.4	-1.7	1.9	-0.4
Basal cell carcinoma (self-reported)	1.8	2.1	5.8	1.4	-2.4	1.6	0.9	0.8	-0.8
Mouth/teeth dental problems	1.7	2.6	6.5	-0.7	1.4	2.3	2.5	1.4	-0.1
Age at First Birth	1.6	2.4	4.9	0.4	1.3	2.2	-1.5	2.2	-0.6
Relative age of first facial hair	1.6	3.3	11.5	3.4	0.7	-2.4	-0.8	-0.8	-0.7
Glaucoma (self-reported)	1.6	1.9	4.7	1.1	1.6	1.7	-0.6	0.3	-2.2
Medication: Lisinopril	1.6	2.0	7.5	-1.1	-1.3	0.6	-0.7	1.0	2.7
Heart disease (siblings)	1.6	2.0	5.5	-0.2	0.1	2.1	0.4	2.4	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	8.3	0.3	-0.3	-2.9	-1.1	-0.5	0.1
Mean time to correctly identify matches	1.5	2.9	5.6	0.3	1.7	2.0	-2.4	1.8	-1.2
Cholesterol lowering medication	1.5	2.2	8.4	-1.1	-0.5	-0.3	2.9	-1.6	-0.9
Hearing difficulty/problems with background noise	1.4	2.3	5.4	2.3	-1.2	-2.3	0.4	-1.1	-0.8
Commuting to job workplace: Public transport	1.4	1.7	5.9	2.4	-0.7	-1.0	-0.7	0.3	-1.6
Intelligence (Savage-Jansen 2018)	1.3	4.0	13.8	1.7	1.1	1.3	-0.1	3.7	-2.0
Ever had hysterectomy (womb removed)	1.3	1.5	4.8	0.1	-0.2	-2.2	-0.4	-1.9	0.7
Medication: Co-codamol	1.3	1.5	4.2	1.9	-0.4	-0.1	-2.0	0.9	-0.6
Had other major operations	1.3	1.6	3.1	-1.2	0.6	1.2	-1.1	1.8	-1.5
Mouth/teeth dental problems: Dentures	1.3	2.2	9.8	0.8	0.3	-1.1	-3.1	0.7	0.9
Forced vital capacity (FVC), Best measure	1.3	4.7	9.6	1.3	1.7	2.4	-3.1	2.7	-1.1
Wheeze or whistling in the chest in last year	1.3	2.3	6.4	1.1	0.1	-2.1	-1.4	-2.5	-0.2
Medication: Ibuprofen	1.3	1.5	4.6	-2.1	0.9	-0.4	1.5	-1.0	-0.5
Schizophrenia vs Biploar Disorder	1.2	1.6	5.0	-0.6	-1.4	-0.5	0.7	-2.2	1.2
Height	1.2	23.5	67.4	-3.1	4.1	5.5	-1.5	8.2	-3.9
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.3	0.0	0.7	-2.1	0.1	-1.4	-0.9
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.3	-0.1	-0.5	-1.5	0.3	-1.6	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	4.3	0.6	-0.8	-2.1	-0.6	-1.1	-0.8
Hair/balding pattern: Pattern 2	1.2	1.5	5.1	-2.3	-1.2	-0.4	1.0	-1.1	0.1
Pain all over the body in last month	1.2	1.2	4.2	0.2	0.5	1.3	-0.8	0.8	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	3.5	1.1	1.4	-1.9	-1.5	0.0	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	6.1	1.1	-0.5	-0.3	-2.5	-0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	4.2	2.1	-1.2	-0.9	-1.8	-1.4	-0.1
Mother’s age at death	1.2	1.5	7.1	0.2	0.5	1.1	-0.0	2.7	-0.5
Financial situation satisfaction	1.2	1.5	6.0	-1.0	-0.4	0.4	-1.1	-0.6	2.4
Unable to work because of sickness or disability	1.2	1.6	2.9	-1.1	-1.7	1.5	0.5	-1.5	0.5
Coronary Artery Disease (CAD)	1.1	1.3	3.9	0.5	-1.1	-1.3	0.6	-2.0	-0.5
Heel T-Score	1.1	8.7	19.6	1.9	3.6	2.2	-2.9	4.4	1.7
Respiratory disease	1.1	2.5	6.9	0.2	1.0	-2.6	0.2	-2.5	-0.8
Hand grip strength (left)	1.1	2.8	7.9	1.3	-2.8	-1.6	-0.1	-1.9	-1.0
Vitamin and mineral supplements	1.1	1.5	2.6	0.9	-0.8	-1.6	0.0	-1.6	-1.6
Diabetes (mother)	1.1	1.4	3.0	0.4	0.8	-1.7	0.9	0.8	-1.7
Hand grip strength (right)	1.1	3.0	7.7	1.2	-2.8	-1.4	0.3	-2.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.0	0.4	0.9	-1.6	0.3	1.0	-1.7
Mineral and other dietary supplements	1.1	1.4	2.8	-1.5	0.7	-0.1	1.6	-0.9	-1.7
Asthma (self-reported)	1.1	2.1	5.1	1.6	0.5	-1.8	-1.2	-2.3	-0.3
Medication: Gliclazide	1.1	1.3	3.7	-0.6	1.5	-0.4	1.1	0.0	-1.9
Bipolar Disorder (2011)	1.0	1.0	2.0	1.4	0.4	-1.0	-0.9	-0.5	1.3
Qualifications: CSEs or equivalent	1.0	1.4	4.1	-2.0	-0.3	-0.9	-0.1	-1.2	1.3
Asthma	1.0	1.9	5.3	1.6	0.4	-1.5	-1.0	-2.3	-0.2
Illnesses of mother	1.0	1.2	5.3	-0.6	-0.7	0.6	0.4	-1.0	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	7.7	1.1	1.3	1.7	-2.8	2.0	-1.1
Length of working week for main job	1.0	1.2	3.2	-1.0	0.9	0.8	0.7	-1.8	0.9
Angina (self-reported)	1.0	1.3	4.5	-0.3	-0.5	-0.9	1.5	-2.1	-0.1
Comparative height size at age 10	1.0	5.3	17.2	-0.7	2.2	2.6	-1.4	4.2	-1.1
Chest pain or discomfort	1.0	1.4	5.7	-0.9	0.3	-0.5	-0.1	-2.4	-1.3
Leg pain on walking	1.0	1.2	5.5	-0.6	-0.9	-0.7	-2.3	-0.4	0.5
Ever taken oral contraceptive pill	1.0	1.1	3.6	-0.8	0.4	0.7	1.9	0.9	0.9
Hearing aid user	1.0	1.2	5.6	0.4	0.0	-2.4	0.4	-0.3	-1.0
High cholesterol (Self-reported)	1.0	1.8	4.6	-0.0	-1.4	-1.1	2.1	-1.8	0.2
Alcohol drinker status: Never	1.0	1.2	3.4	1.5	-1.8	-0.4	-0.7	-0.4	-1.0
Number of operations (self-reported)	1.0	1.4	3.3	1.0	-0.7	-1.4	-1.8	0.3	-1.3
Risk taking	1.0	1.5	4.0	2.0	-0.7	-1.4	-1.3	0.4	-0.9
Age started oral contraceptive pill	1.0	1.3	3.5	1.0	1.2	1.9	0.2	1.3	-0.4
Commuting to job workplace: Cycle	1.0	1.3	3.1	-1.6	0.8	-0.6	-1.8	0.9	-0.1
Myopia	1.0	1.4	5.1	0.4	1.7	0.4	0.3	2.3	-0.2
Bipolar Disorder or Schizophrenia	0.9	2.2	6.3	2.3	0.3	-0.6	-2.5	0.7	0.6
Schizophrenia (2018)	0.9	1.8	4.2	1.4	-0.9	-1.4	-2.0	-1.2	-0.5
Ulcerative Colitis (UC)	0.9	1.6	6.3	-2.5	1.3	1.1	0.3	0.4	-0.7
Body Mass Index (BMI) (2010)	0.9	1.2	2.8	1.7	-1.4	-0.6	-0.9	-0.9	-0.8
Primary Biliary Cirrhosis	0.9	1.3	3.9	-1.3	-0.4	-1.2	-0.4	-0.5	2.0
Triglycerides	0.9	1.5	4.4	0.7	-1.6	-1.1	0.0	-2.1	-0.4
Hearing difficulty/problems: Yes	0.9	1.4	3.3	0.7	0.1	-1.8	1.7	-1.3	0.4
Angina	0.9	1.2	4.0	-0.3	-0.5	-0.5	1.6	-2.0	0.2
Serious illness, injury or assault to yourself	0.9	1.1	3.6	-0.9	1.3	-0.6	-0.3	-0.1	-1.9
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.2	-0.4	2.3	1.0	-0.2	1.1	1.9
Diabetes (self-reported)	0.9	1.4	2.5	-1.5	-0.4	-1.4	1.6	-1.1	-0.2
Happiness	0.9	1.1	3.9	-0.0	-0.4	-1.2	0.6	-2.0	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.6	-1.6	0.7	-0.4	1.4	-1.3	-0.3
Standing height	0.9	9.0	27.2	-1.4	1.9	3.1	-1.9	5.2	-2.8
Gout (self-reported)	0.9	1.2	2.9	0.8	-1.7	0.7	-0.8	-0.2	1.7
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.1	0.9	1.3	-1.1	-1.8	1.8	-0.9
Emphysema/chronic bronchitis	0.9	1.0	1.9	-0.6	0.6	-1.2	0.3	-1.4	-1.3
Medication: Blood pressure	0.9	1.5	4.9	0.1	0.2	1.1	-0.9	1.4	2.2
Illnesses of father: None of the above (group 1)	0.9	1.1	1.9	-0.8	-0.5	-1.2	1.3	-1.4	0.7
Miserableness	0.9	1.5	3.5	1.5	0.2	-1.0	-1.9	1.0	-1.1
Average weekly beer plus cider intake	0.9	1.3	4.7	0.3	-1.1	-1.2	-0.2	-2.2	-0.1
Alzheimer’s Disease (in father)	0.8	0.8	1.9	-1.1	1.4	-0.0	-0.4	0.6	1.3
Reaction Time	0.8	1.5	4.3	-0.3	1.0	1.5	-2.1	0.9	-0.8
Mean Putamen Volume	0.8	0.9	1.8	1.4	-1.3	-1.1	0.4	-0.8	0.3
Neuroticism (2016)	0.8	1.1	2.4	-0.8	1.3	0.4	-1.6	0.9	0.8
Schizophrenia (2014)	0.8	1.8	3.1	1.7	-1.2	-1.1	-1.8	-1.1	1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.0	-1.2	-0.6	-0.4	-0.1	-0.7	1.7
Ulcerative Colitis	0.8	1.2	4.6	-2.2	0.2	0.6	-0.7	-0.3	1.1
Average weekly spirits intake	0.8	1.0	2.0	0.0	1.3	0.1	-1.4	1.3	-0.9
Medication for hormone replacement therapy	0.8	0.9	2.8	0.2	-1.7	-0.6	-0.0	-1.6	0.3
Pack years adult smoking proportion	0.8	1.2	2.4	-0.8	0.0	-1.3	1.5	-1.2	1.1
Townsend deprivation index at recruitment	0.8	1.2	4.1	1.0	0.6	-0.1	1.1	0.6	-2.0
Age when periods started (menarche)	0.8	1.8	5.6	0.7	-1.8	-1.0	-0.0	-2.4	-0.9
Sitting height	0.8	5.6	17.6	-0.7	1.4	2.1	-2.8	4.2	-1.2
Financial difficulties in last 2 years	0.8	1.1	3.4	-0.9	-0.5	-1.9	0.2	-0.5	1.2
Heart attack	0.8	1.0	2.2	-0.8	0.7	-0.7	1.5	-0.2	-1.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	4.0	-1.0	-2.0	-0.0	-0.2	-0.6	-0.4
Loud music exposure frequency	0.8	0.9	2.4	-0.3	-1.0	-1.5	-0.8	-1.0	-0.2
Number of full brothers	0.8	1.1	2.5	0.9	-1.6	-0.9	0.3	-1.4	0.5
Worry too long after embarrassment	0.8	1.4	4.1	0.2	0.1	1.5	-2.0	1.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.8	0.0	-0.6	-0.9	-1.5	-1.7	-0.3
Eye problems/disorders: None of the above	0.8	0.9	3.9	-0.6	-1.0	0.0	0.6	-0.2	2.0
Medication for pain relief, constipation, heartburn	0.8	1.4	4.6	0.3	0.7	0.7	-1.6	2.2	-0.7
Had major operations	0.8	1.0	2.4	0.1	-0.5	-1.6	-1.6	0.5	-0.7
Knee pain experienced in last month	0.8	1.2	2.6	0.3	-1.6	-1.6	-1.4	-0.1	-0.3
Diabetes diagnosed by doctor	0.8	1.3	1.8	-1.2	-0.9	-1.2	1.3	-0.8	-1.3
Friendships satisfaction	0.8	0.9	3.7	0.5	0.6	0.1	-1.1	0.1	-1.9
Qualifications: nursing, teaching	0.8	1.2	2.8	-1.7	-1.3	-0.4	1.0	-1.3	0.1
Commuting to job workplace: Walk	0.8	0.8	2.7	0.3	-0.8	-0.5	0.6	-1.6	-1.0
Eye problems/disorders: Cataract	0.8	1.0	3.1	-1.8	0.2	1.1	0.1	0.3	-1.2
Smoking status: Current	0.8	1.3	4.0	-0.3	1.2	-0.3	-1.4	2.0	-0.4
Eye problems/disorders: Glaucoma	0.8	1.0	2.6	1.1	0.6	1.1	-0.2	-0.7	-1.6
Fractured/broken bones in last 5 years	0.8	1.0	3.1	-1.8	-0.3	-1.2	0.3	-1.1	-0.3
Alcohol drinker status: Previous	0.8	0.9	3.6	-0.1	-0.9	-1.9	-0.1	-1.1	0.2
Pack years of smoking	0.8	1.2	3.5	-0.5	-0.0	-1.3	1.9	-1.0	1.0
Worry (Nagel 2018)	0.7	1.4	6.0	0.5	0.8	-1.2	-2.4	-0.2	0.5
Hypothyroidism (self reported)	0.7	1.6	3.1	1.5	1.1	0.1	-1.2	1.8	-1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.1	-1.8	-0.8	-0.5	1.7	-1.2	-0.4
Supplements: Zinc	0.7	0.7	3.3	-0.2	-0.2	1.0	0.3	-0.3	1.8
Average weekly fortified wine intake	0.7	0.8	1.8	0.9	-0.2	1.3	-0.8	1.1	-0.6
Multivitamins +/- minerals	0.7	0.9	2.1	-0.6	-0.4	1.3	0.3	1.2	1.4
Waist circumference	0.7	2.7	7.2	-1.7	1.8	-1.1	0.1	1.3	-2.7
Forced vital capacity (FVC)	0.7	2.7	5.5	0.7	1.1	1.5	-2.3	2.4	-1.0
Medication: Ramipril	0.7	0.9	2.5	-0.2	0.6	1.6	0.8	1.0	-0.9
Fluid intelligence score	0.7	1.5	4.0	-0.1	0.8	-0.9	1.0	2.0	-1.5
Illnesses of siblings	0.7	1.0	2.9	-0.1	0.8	-1.4	-0.3	-0.7	1.7
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.5	0.7	1.0	1.4	-2.3	1.9	-1.1
Medication: Lansoprazole	0.7	0.9	3.1	-1.0	1.8	-0.3	-0.2	-0.8	0.2
Comparative body size at age 10	0.7	2.0	5.7	0.6	1.5	-0.1	-2.4	2.0	0.2
Medication: Omeprazole	0.7	0.9	2.0	1.4	1.4	0.5	0.7	0.4	0.6
Heart disease (mother)	0.7	0.8	3.1	1.1	0.6	-0.1	-0.2	0.5	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	4.8	-1.8	-0.2	2.2	0.5	0.9	-0.4
Back pain experienced in last month	0.7	1.0	3.1	-1.8	1.3	0.4	-0.4	1.1	0.2
Breast cancer (self-reported)	0.7	0.8	1.9	-1.4	0.5	0.7	0.9	-1.1	0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.8	3.0	0.9	-0.3	0.4	-0.7	0.8	1.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	1.3	1.3	-0.1	1.3	-0.5	-0.2
Neuroticism (Nagel 2018)	0.6	1.4	7.3	-0.2	0.8	-0.1	-2.7	0.7	-0.3
Major Depression (MDD)	0.6	0.8	1.5	1.2	-1.1	0.4	0.8	1.1	0.3
HDL Cholesterol	0.6	1.0	2.8	-0.6	1.7	0.6	0.9	0.7	1.0
Allergy or Eczema	0.6	1.6	4.2	0.2	2.0	0.5	-1.0	1.2	1.6
Lung FVC	0.6	3.3	8.6	2.9	0.1	1.5	-2.3	1.8	0.2
Chronotype (morning person)	0.6	1.5	3.4	1.8	0.7	1.7	-0.1	1.2	0.7
Taking other prescription medications	0.6	0.9	1.7	0.8	0.8	0.5	-1.3	1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.0	0.9	0.9	0.5	-1.3	1.7	1.3
Medication: Atenolol	0.6	0.7	1.4	0.3	-1.2	-0.9	0.8	-0.6	0.9
Medication: Levothyroxine sodium	0.6	1.1	3.4	0.1	1.1	-1.8	-0.7	1.0	-0.6
Number of incorrect matches in round	0.6	1.1	4.4	2.1	-0.1	0.5	-0.5	-0.7	-1.0
Alcohol usually taken with meals	0.6	1.0	2.2	0.3	-1.1	0.7	0.9	1.1	-1.5
Nervous feelings	0.6	1.1	4.3	1.2	-0.2	0.9	-2.1	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.0	0.5	0.5	-0.0	-1.5	2.0	1.1
Qualifications: None of the above	0.6	1.2	4.8	1.1	-0.1	0.9	-2.2	0.0	0.5
Weight	0.6	3.1	5.3	-1.9	2.1	-0.2	-0.0	2.3	-2.2
Trunk fat-free mass	0.6	3.4	12.1	-1.2	0.9	0.7	-0.7	3.5	-2.3
Trunk predicted mass	0.6	3.5	12.6	-1.0	0.9	0.7	-0.9	3.5	-2.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-0.8	-0.5	-1.4	1.3	-0.3	1.1
Blood clot in the leg (DVT)	0.6	0.8	2.6	0.7	-0.9	-0.6	-0.4	-1.6	-0.6
Headache pain in last month	0.6	1.0	3.0	-0.7	0.3	-1.2	-0.8	-1.7	0.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	-0.5	0.2	-1.3	0.9	-1.2	-0.3
Health satisfaction	0.6	0.7	3.3	-1.8	0.5	0.8	-0.0	-0.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-0.1	-0.8	-1.1	0.7	-0.9	1.0
Overall health rating	0.6	1.2	2.9	-1.6	1.7	0.8	0.6	0.7	0.5
Whole body fat-free mass	0.6	3.2	11.4	-1.0	1.2	0.1	-0.8	3.4	-2.2
Whole body water mass	0.6	3.2	10.5	-1.0	1.2	-0.0	-0.9	3.2	-2.3
Ever smoked	0.6	1.0	1.5	-1.2	0.7	-1.1	1.1	1.2	-0.0
Basal metabolic rate	0.6	3.1	9.6	-1.3	1.4	-0.2	-0.5	3.1	-2.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	-0.7	0.6	-0.6	1.4	-0.3	-1.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.9	-0.6	1.0	0.9	0.2	1.4	0.3
Fasting Glucose	0.5	0.6	2.2	0.4	-0.7	-0.3	-1.5	-0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	1.0	-0.1	0.5	-1.2	1.1	-0.1
Leg fat-free mass (left)	0.5	2.7	9.3	-1.0	1.5	-0.2	-0.7	3.0	-1.9
Current tobacco smoking	0.5	0.8	2.2	-0.1	0.4	-0.6	-1.5	1.5	-0.1
Maternal smoking around birth	0.5	0.7	1.3	0.3	0.8	-1.1	-0.0	-1.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	-0.3	-0.9	-0.8	-0.9	-1.2	-0.6
Leg predicted mass (left)	0.5	2.7	9.2	-1.1	1.5	-0.2	-0.6	3.0	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.1	-0.4	0.5	-0.1	-0.9	-1.8	0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.3	-1.5	-1.0	-0.3	0.5	0.3	-0.1
Medication: Simvastatin	0.5	0.8	1.4	-0.5	0.1	-1.2	1.2	-1.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.8	1.1	0.0	-0.0	-0.9	1.9	-0.4
Depression (self-reported)	0.5	0.6	1.6	-1.3	-0.6	-0.4	0.4	-0.5	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.6	-0.9	0.1	-0.6	-0.2	-0.7	1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.7	-0.6	-0.6	-1.2	-0.1	-1.3	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.2	-0.5	-0.5	-0.3	1.4	-0.9	-1.5
Arm fat-free mass (right)	0.5	2.5	7.2	-1.1	0.7	0.0	-0.5	2.7	-2.5
Exposure to tobacco smoke outside home	0.5	0.6	1.4	-1.2	0.9	-0.8	0.4	0.1	-0.9
Medication: Allopurinol	0.5	0.7	2.3	1.1	-1.5	0.5	0.2	-0.4	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.5	0.4	1.2	0.9	-1.0	0.0	0.1
Arm predicted mass (right)	0.5	2.6	7.1	-1.2	0.9	-0.1	-0.7	2.7	-2.4
Number of full sisters	0.5	0.7	2.0	0.3	0.3	-0.6	-1.2	1.4	0.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.4	0.2	-0.6	1.6	-1.0	0.2	0.3
Leg fat-free mass (right)	0.5	2.8	8.6	-0.8	1.4	-0.5	-1.0	2.9	-2.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-0.8	0.6	-0.3	0.5	-1.3	0.6
Loneliness, isolation	0.5	0.7	2.2	0.9	-0.2	-1.5	-0.5	-0.8	-0.6
Long-standing illness, disability or infirmity	0.5	0.8	2.9	0.4	0.7	-1.7	-0.4	1.1	0.1
Osteoarthritis (self-reported)	0.5	0.7	2.1	1.4	0.1	-0.3	-0.4	0.8	-1.1
Leg predicted mass (right)	0.5	2.7	8.6	-0.9	1.4	-0.5	-0.9	2.9	-2.0
Guilty feelings	0.5	0.8	2.3	-0.8	-0.8	0.3	-1.5	-1.0	-0.2
Wears glasses or contact lenses	0.5	0.5	2.6	0.4	0.2	0.0	0.1	0.6	-1.6
Arm fat-free mass (left)	0.5	2.5	6.0	-1.4	0.8	-0.7	-0.3	2.4	-2.4
Diastolic blood pressure, automated reading	0.5	1.6	5.6	-0.5	2.4	-1.1	0.2	1.4	0.6
Supplements: Calcium	0.5	0.5	1.2	-0.4	0.4	1.0	-1.1	0.6	0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.1	0.7	-1.0	-0.1	-0.4	-1.4	-0.6
Arm predicted mass (left)	0.5	2.6	6.1	-1.6	0.7	-0.4	-0.3	2.5	-2.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	0.0	1.0	-0.9	-1.6	-0.2	-1.1
Depression (Nagel 2018)	0.4	0.6	3.0	-0.2	0.1	-0.5	-1.7	-0.5	-0.1
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	0.3	-0.3	0.9	-0.2	1.1	-0.8
Irritable Bowel Disease (IBD)	0.4	0.9	1.5	-1.2	0.8	0.8	0.4	1.2	-1.1
HbA1C	0.4	0.4	1.2	1.1	0.1	0.9	-0.8	-0.1	-0.0
Rheumatoid Arthritis	0.4	0.5	1.7	1.0	0.4	1.3	-0.1	0.2	-0.6
Waist Hip Ratio (WHR)	0.4	1.7	8.7	-0.7	0.6	-0.6	0.1	0.3	-3.0
Smoking Status	0.4	1.0	1.4	-0.8	1.2	-1.1	-0.3	1.2	-1.0
Sensitivity / hurt feelings	0.4	0.7	1.7	1.0	-0.3	0.1	-1.3	1.1	-0.2
Severe depression (siblings)	0.4	0.5	1.5	0.0	-0.3	-0.2	1.2	-0.5	-0.9
Stomach or abdominal pain in last month	0.4	0.5	1.4	-1.2	0.7	0.5	-0.0	-0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.7	1.3	-0.5	-0.6	-0.1	-0.1	0.8
Trunk fat mass	0.4	1.7	3.3	-1.5	1.7	-0.3	0.5	1.2	-1.8
Past tobacco smoking	0.4	0.7	2.2	0.7	-0.2	1.5	-0.9	-0.9	-0.1
Had menopause	0.4	0.5	2.3	0.4	-0.2	0.6	-1.5	0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	-0.4	1.2	0.1	1.3	-0.1	-0.6
Hip circumference	0.4	1.8	3.6	-1.2	1.7	-0.7	-0.5	1.5	-1.9
Falls in the last year	0.4	0.6	1.4	1.0	1.2	0.1	-0.6	-0.1	-0.7
Medication: Cholesterol lowering	0.4	0.6	1.8	0.8	-0.3	-1.4	-0.4	-0.7	0.3
Arm fat mass (right)	0.4	1.7	2.7	-1.4	1.6	-1.5	0.6	0.7	-1.6
Tense / ‘highly strung’	0.4	0.7	3.2	-0.8	0.4	-0.5	-1.8	-0.1	-0.1
Birth weight of first child	0.4	0.7	2.2	-1.0	-0.2	1.5	0.4	-0.0	-0.9
Medication: Amlodipine	0.4	0.5	1.2	0.8	1.1	0.3	-0.0	-0.4	1.0
High blood pressure (siblings)	0.4	0.6	1.5	0.4	-1.1	1.2	-0.8	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-1.0	0.7	1.0	0.4	-0.2	0.3
Age at first live birth	0.4	0.6	2.7	-0.6	0.1	1.6	0.0	0.7	0.5
Qualifications: College or University degree	0.4	1.1	2.1	1.4	-0.8	1.1	-1.4	0.3	-0.9
Alcohol intake frequency.	0.4	1.0	2.1	-0.9	-0.4	-0.1	-1.4	-1.2	1.3
Supplements: Vitamin C	0.4	0.5	1.8	-0.5	0.9	1.3	0.0	0.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	-0.7	-0.3	0.3	0.8	-0.6	1.1
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-0.6	0.5	0.4	0.4	0.8	-1.2
Smoking status: Previous	0.4	0.5	1.5	-0.3	-0.5	-1.2	1.1	0.4	0.0
Average weekly red wine intake	0.4	0.6	2.4	0.8	-0.5	0.6	-0.2	1.5	-0.2
Mood swings	0.4	0.7	2.0	-0.1	0.7	-0.4	-1.2	0.1	-1.4
Medication for cholesterol	0.4	0.6	2.3	0.2	0.5	0.3	-1.0	1.5	0.4
Osteoporosis (self-reported)	0.4	0.6	1.5	-0.2	0.7	1.2	-1.0	0.5	-0.3
Arm fat mass (left)	0.4	1.6	2.7	-1.5	1.5	-1.4	0.5	0.7	-1.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	1.0	0.3	0.4	0.8	-0.8	-0.6
Medication: Bendroflumethiazide	0.4	0.7	2.0	-0.7	0.9	0.5	-0.6	1.4	0.3
Medication: Atorvastatin	0.4	0.5	1.1	0.7	-0.7	-1.0	0.7	-0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.1	0.4	-0.1	0.1	0.8	1.8	-0.5
LDL Cholesterol	0.3	0.5	2.1	1.4	0.1	-0.5	-0.2	-0.7	-0.6
Lupus	0.3	0.5	1.2	-1.1	-0.6	1.0	-0.1	-0.5	0.1
Blood White Count	0.3	2.2	4.4	-2.1	0.4	-1.0	1.9	-1.7	-1.1
Systolic Blood Pressure	0.3	1.5	3.7	1.4	0.3	-1.9	1.5	-0.6	-0.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.7	-0.6	-0.3	0.4	-0.0	-1.3	0.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.2	-0.2	-0.6	-0.9	0.8	0.5
Systolic blood pressure, automated reading	0.3	1.0	2.7	0.3	0.3	-1.5	1.6	-0.8	0.5
Impedance of leg (right)	0.3	1.4	3.5	-0.4	-1.2	1.9	1.0	-1.3	0.8
Trunk fat percentage	0.3	1.1	1.8	-1.3	1.4	-0.6	0.9	0.3	-1.2
Fed-up feelings	0.3	0.6	2.7	-1.6	-0.3	-0.3	-0.6	-0.3	-0.5
Relative age voice broke	0.3	0.5	1.4	0.8	-1.2	-0.2	0.7	-0.0	-0.4
Body mass index (BMI)	0.3	1.4	2.7	-1.3	1.3	-1.6	1.0	-0.0	-1.1
Allergy	0.3	0.7	2.3	-0.5	-1.5	-0.1	0.9	0.3	-0.9
Neuroticism score	0.3	0.6	2.5	-0.8	0.5	-0.5	-1.6	0.3	-0.0
Arm fat percentage (right)	0.3	1.3	2.7	-1.1	1.4	-1.6	1.0	-0.2	-1.1
Worrier / anxious feelings	0.3	0.6	2.4	-0.4	1.0	1.6	-0.2	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.8	-0.1	0.5	-0.7	-0.1	0.1	-1.4
Pulse rate	0.3	0.6	1.7	-1.1	1.3	0.0	0.6	0.4	-0.1
Prospective memory result	0.3	0.4	2.1	0.0	-0.1	1.5	0.1	0.2	0.1
Peak expiratory flow (PEF)	0.3	0.8	2.1	1.4	0.3	-0.3	-1.4	0.1	-0.7
Birth weight	0.3	0.6	2.8	-0.6	0.4	0.1	0.6	-0.1	-1.7
Body fat percentage	0.3	1.1	1.8	-1.3	1.3	-0.8	1.1	0.0	-1.1
Leg fat percentage (right)	0.3	1.0	2.8	-1.3	0.6	-0.6	1.7	-0.3	-0.6
Neck or shoulder pain in last month	0.3	0.4	1.5	-0.3	-0.7	-1.2	-0.2	-0.4	0.3
Migraine (self-reported)	0.3	0.4	1.1	-1.1	0.2	1.0	-0.1	-0.1	0.6
Whole body fat mass	0.3	1.4	2.3	-1.5	1.5	-0.6	0.6	1.0	-1.5
Leg fat mass (right)	0.3	1.2	1.9	-1.4	1.1	-0.9	0.9	0.6	-1.3
Pulse rate, automated reading	0.3	0.9	2.3	-0.7	-0.0	-1.1	-0.9	0.7	1.5
Suffer from ‘nerves’	0.3	0.5	1.8	-0.3	0.7	0.0	-1.3	-0.0	0.7
Family relationship satisfaction	0.3	0.4	1.1	-1.0	0.2	-0.2	-0.5	-0.5	-0.7
Arm fat percentage (left)	0.3	1.2	2.2	-1.4	1.5	-1.1	0.9	-0.0	-0.8
Number of self-reported non-cancer illnesses	0.3	0.4	1.0	-0.0	-0.1	-1.0	-0.4	-1.0	0.7
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.7	-1.0	0.4	-0.4	-0.5	-0.3
Medication: Blood pressure	0.3	0.6	1.9	-0.1	0.1	-1.4	0.1	-0.8	-1.1
Medication: Paracetamol	0.3	0.5	1.8	-0.1	-0.1	-0.9	-0.5	-1.3	-0.6
Irritability	0.3	0.5	2.9	-1.7	-0.1	-0.3	-0.3	0.3	-0.0
Ever depressed for a whole week	0.3	0.4	1.1	-0.2	-0.5	-1.0	0.2	0.1	-1.0
Pain experienced in last month	0.3	0.4	1.6	0.7	-0.1	0.4	0.4	0.2	1.3
Leg fat mass (left)	0.3	1.2	2.0	-1.3	1.4	-0.9	0.8	0.6	-1.4
Crohns Disease (2017)	0.2	0.5	2.0	-0.1	-0.1	0.0	0.4	1.4	-0.9
Ovarian Cancer	0.2	0.2	0.5	-0.3	-0.1	-0.3	0.7	0.2	-0.7
Crohns Disease (2012)	0.2	0.3	0.9	-0.1	-0.9	-0.5	-0.3	-0.1	0.9
BMI	0.2	1.3	3.8	-1.9	1.5	-0.6	1.1	0.4	0.5
Lung FEV1/FVC ratio	0.2	0.8	2.3	-1.5	-0.0	1.5	0.3	0.7	0.1
Neuroticism	0.2	0.4	1.9	-0.0	0.3	0.0	-1.4	0.5	-0.1
Hair Pigment	0.2	6.0	19.4	-3.3	-1.0	0.8	4.4	-1.8	-1.1
Diabetes (father)	0.2	0.3	0.6	0.7	-0.4	-0.3	0.5	0.2	-0.8
Supplements: Glucosamine	0.2	0.3	0.9	0.1	0.0	-1.0	-0.3	-0.4	0.6
Impedance of leg (left)	0.2	1.1	2.6	0.0	-1.2	1.3	0.6	-1.6	0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.2	0.7	0.6	-0.9	-0.0	0.2
Father’s age at death	0.2	0.2	0.5	0.6	-0.5	0.7	0.3	0.2	-0.2
Impedance of arm (left)	0.2	1.0	4.0	0.1	0.7	2.0	-0.8	0.1	0.9
Medication: Paracetamol	0.2	0.3	1.0	0.2	-0.0	-0.3	-1.0	-0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.3	0.7	0.4	-0.1	-0.5	0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.2	0.1	0.1	-0.1	-0.0	-0.6	-1.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.6	0.2	0.3	-0.5	0.6	0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	0.5	-0.4	-0.1	-0.5	1.1	-0.1
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.5	-0.6	-0.7	0.1	-0.4	0.1
Leg fat percentage (left)	0.2	0.8	1.8	-1.1	0.8	-0.8	1.3	-0.4	-0.7
Blood Eosinophil Count	0.1	0.5	1.1	-1.1	0.8	-0.2	0.8	-0.3	-0.7
Blood Red Count	0.1	1.0	1.9	-1.2	-1.0	-0.9	-0.7	-1.4	0.6
Cardiovascular Disease	0.1	0.4	0.9	0.3	0.9	-0.4	1.0	-0.3	-0.8
Tanning	0.1	0.8	2.1	1.4	-0.1	1.4	-0.7	0.3	0.1
Number of treatments/medications taken	0.1	0.3	0.9	-0.0	0.3	0.9	-0.2	0.8	0.1
Medication: Metformin	0.1	0.1	0.3	-0.3	0.4	-0.1	0.3	-0.3	-0.6
High blood pressure	0.1	0.2	0.6	0.2	0.8	-0.6	-0.2	-0.1	-0.1
High blood pressure (mother)	0.1	0.2	0.3	0.3	-0.2	0.6	-0.5	0.2	-0.5
Impedance of arm (right)	0.1	0.6	1.4	0.5	0.6	1.2	-0.9	-0.2	0.7
Age at last live birth	0.1	0.2	0.4	-0.4	-0.3	-0.1	-0.6	0.5	0.6
Illnesses of father: Heart disease	0.1	0.2	0.5	0.5	-0.1	0.7	-0.1	-0.3	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.9	0.1	-0.9	0.4	-0.1	-0.2	-0.1
Impedance of whole body	0.1	0.7	3.2	0.3	-0.2	1.8	-0.4	-0.6	0.7
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hypertension (Self-reported)	0.0	0.1	0.4	0.3	0.6	-0.5	-0.1	-0.0	-0.1

Hub : Genes

FAR2

Models

Trait associations