Hub : Genes

FAR2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0820 0.0260 1.5e-05 0.054 0.046 0.052 0.054 0.051 3.2e-07 2.3e-06 5.6e-07 3.6e-07 8.0e-07
2 GTEx Adipose Subcutaneous 0.0640 0.0280 8.1e-03 0.051 NA 0.024 NA 0.034 4.9e-05 NA 4.2e-03 NA 8.6e-04
3 GTEx Adipose Visceral Omentum 0.1660 0.0680 3.6e-03 0.006 NA -0.003 NA 0.003 1.4e-01 NA 5.5e-01 NA 2.2e-01
4 GTEx Lung 0.1832 0.0462 8.5e-07 0.106 NA 0.092 NA 0.102 1.7e-08 NA 1.5e-07 NA 3.2e-08
5 METSIM Adipose 0.0450 0.0175 7.9e-04 0.025 0.021 0.027 0.026 0.026 1.1e-04 2.9e-04 6.2e-05 8.0e-05 8.2e-05
6 TCGA Brain Lower Grade Glioma 0.0971 0.0416 1.5e-03 0.034 0.016 0.012 NA 0.028 8.2e-05 5.2e-03 1.5e-02 NA 3.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 2.0 3.1 7.2 1.9 1.5 1.0 -1.5 2.7 1.5
Bipolar Disorder or Schizophrenia 0.9 2.2 6.3 2.3 0.3 -0.6 -2.5 0.7 0.6
Depressed Affect (Nagel 2018) 0.4 0.9 2.6 0.0 1.0 -0.9 -1.6 -0.2 -1.1
Depression (Nagel 2018) 0.4 0.6 3.0 -0.2 0.1 -0.5 -1.7 -0.5 -0.1
Intelligence (Savage-Jansen 2018) 1.3 4.0 13.8 1.7 1.1 1.3 -0.1 3.7 -2.0
Neuroticism (Nagel 2018) 0.6 1.4 7.3 -0.2 0.8 -0.1 -2.7 0.7 -0.3
Schizophrenia (2018) 0.9 1.8 4.2 1.4 -0.9 -1.4 -2.0 -1.2 -0.5
Schizophrenia vs Biploar Disorder 1.2 1.6 5.0 -0.6 -1.4 -0.5 0.7 -2.2 1.2
Worry (Nagel 2018) 0.7 1.4 6.0 0.5 0.8 -1.2 -2.4 -0.2 0.5
Alzheimer’s Disease (in mother) 0.4 0.5 1.1 0.3 -0.3 0.9 -0.2 1.1 -0.8
Alzheimer’s Disease (in father) 0.8 0.8 1.9 -1.1 1.4 -0.0 -0.4 0.6 1.3
Alzheimer’s Disease (including proxy) 0.5 0.7 1.9 -0.6 1.0 0.9 0.2 1.4 0.3
Crohns Disease (2017) 0.2 0.5 2.0 -0.1 -0.1 0.0 0.4 1.4 -0.9
Irritable Bowel Disease (IBD) 0.4 0.9 1.5 -1.2 0.8 0.8 0.4 1.2 -1.1
Ulcerative Colitis (UC) 0.9 1.6 6.3 -2.5 1.3 1.1 0.3 0.4 -0.7
Major Depression (MDD) 0.6 0.8 1.5 1.2 -1.1 0.4 0.8 1.1 0.3
Reaction Time 0.8 1.5 4.3 -0.3 1.0 1.5 -2.1 0.9 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.7 3.1 0.4 -0.1 0.1 0.8 1.8 -0.5
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.2 0.5 -0.3 -0.1 -0.3 0.7 0.2 -0.7
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.6 2.4 4.9 0.4 1.3 2.2 -1.5 2.2 -0.6
Bipolar Disorder (2011) 1.0 1.0 2.0 1.4 0.4 -1.0 -0.9 -0.5 1.3
Body Mass Index (BMI) (2010) 0.9 1.2 2.8 1.7 -1.4 -0.6 -0.9 -0.9 -0.8
Coronary Artery Disease (CAD) 1.1 1.3 3.9 0.5 -1.1 -1.3 0.6 -2.0 -0.5
Crohns Disease (2012) 0.2 0.3 0.9 -0.1 -0.9 -0.5 -0.3 -0.1 0.9
Mean Putamen Volume 0.8 0.9 1.8 1.4 -1.3 -1.1 0.4 -0.8 0.3
Fasting Glucose 0.5 0.6 2.2 0.4 -0.7 -0.3 -1.5 -0.5 -0.3
HbA1C 0.4 0.4 1.2 1.1 0.1 0.9 -0.8 -0.1 -0.0
HDL Cholesterol 0.6 1.0 2.8 -0.6 1.7 0.6 0.9 0.7 1.0
LDL Cholesterol 0.3 0.5 2.1 1.4 0.1 -0.5 -0.2 -0.7 -0.6
Lupus 0.3 0.5 1.2 -1.1 -0.6 1.0 -0.1 -0.5 0.1
Neuroticism (2016) 0.8 1.1 2.4 -0.8 1.3 0.4 -1.6 0.9 0.8
Primary Biliary Cirrhosis 0.9 1.3 3.9 -1.3 -0.4 -1.2 -0.4 -0.5 2.0
Rheumatoid Arthritis 0.4 0.5 1.7 1.0 0.4 1.3 -0.1 0.2 -0.6
Schizophrenia (2014) 0.8 1.8 3.1 1.7 -1.2 -1.1 -1.8 -1.1 1.0
Triglycerides 0.9 1.5 4.4 0.7 -1.6 -1.1 0.0 -2.1 -0.4
Type 2 Diabetes (T2D) (2012) 0.8 0.9 3.0 -1.2 -0.6 -0.4 -0.1 -0.7 1.7
Ulcerative Colitis 0.8 1.2 4.6 -2.2 0.2 0.6 -0.7 -0.3 1.1
Blood Eosinophil Count 0.1 0.5 1.1 -1.1 0.8 -0.2 0.8 -0.3 -0.7
Blood Platelet Count 9.9 114.6 501.8 9.4 -3.7 -6.0 -22.4 -6.9 0.6
Blood Red Count 0.1 1.0 1.9 -1.2 -1.0 -0.9 -0.7 -1.4 0.6
Blood White Count 0.3 2.2 4.4 -2.1 0.4 -1.0 1.9 -1.7 -1.1
Heel T-Score 1.1 8.7 19.6 1.9 3.6 2.2 -2.9 4.4 1.7
BMI 0.2 1.3 3.8 -1.9 1.5 -0.6 1.1 0.4 0.5
Height 1.2 23.5 67.4 -3.1 4.1 5.5 -1.5 8.2 -3.9
Waist Hip Ratio (WHR) 0.4 1.7 8.7 -0.7 0.6 -0.6 0.1 0.3 -3.0
Systolic Blood Pressure 0.3 1.5 3.7 1.4 0.3 -1.9 1.5 -0.6 -0.7
Smoking Status 0.4 1.0 1.4 -0.8 1.2 -1.1 -0.3 1.2 -1.0
Allergy or Eczema 0.6 1.6 4.2 0.2 2.0 0.5 -1.0 1.2 1.6
Cardiovascular Disease 0.1 0.4 0.9 0.3 0.9 -0.4 1.0 -0.3 -0.8
Hypothyroidism (self reported) 0.7 1.6 3.1 1.5 1.1 0.1 -1.2 1.8 -1.1
Respiratory disease 1.1 2.5 6.9 0.2 1.0 -2.6 0.2 -2.5 -0.8
Type 2 Diabetes (T2D) (2018) 0.7 1.4 3.1 -1.8 -0.8 -0.5 1.7 -1.2 -0.4
Lung FEV1/FVC ratio 0.2 0.8 2.3 -1.5 -0.0 1.5 0.3 0.7 0.1
Lung FVC 0.6 3.3 8.6 2.9 0.1 1.5 -2.3 1.8 0.2
Neuroticism 0.2 0.4 1.9 -0.0 0.3 0.0 -1.4 0.5 -0.1
Chronotype (morning person) 0.6 1.5 3.4 1.8 0.7 1.7 -0.1 1.2 0.7
Hair Pigment 0.2 6.0 19.4 -3.3 -1.0 0.8 4.4 -1.8 -1.1
Tanning 0.1 0.8 2.1 1.4 -0.1 1.4 -0.7 0.3 0.1
Hand grip strength (left) 1.1 2.8 7.9 1.3 -2.8 -1.6 -0.1 -1.9 -1.0
Number of treatments/medications taken 0.1 0.3 0.9 -0.0 0.3 0.9 -0.2 0.8 0.1
Average weekly spirits intake 0.8 1.0 2.0 0.0 1.3 0.1 -1.4 1.3 -0.9
Sensitivity / hurt feelings 0.4 0.7 1.7 1.0 -0.3 0.1 -1.3 1.1 -0.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.7 -0.6 -0.3 0.4 -0.0 -1.3 0.0
Hearing difficulty/problems: Yes 0.9 1.4 3.3 0.7 0.1 -1.8 1.7 -1.3 0.4
Relative age of first facial hair 1.6 3.3 11.5 3.4 0.7 -2.4 -0.8 -0.8 -0.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 -0.2 -0.2 -0.6 -0.9 0.8 0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.4 1.0 -0.1 0.5 -1.2 1.1 -0.1
Ever had hysterectomy (womb removed) 1.3 1.5 4.8 0.1 -0.2 -2.2 -0.4 -1.9 0.7
Systolic blood pressure, automated reading 0.3 1.0 2.7 0.3 0.3 -1.5 1.6 -0.8 0.5
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.3 0.0 0.7 -2.1 0.1 -1.4 -0.9
Angina 0.9 1.2 4.0 -0.3 -0.5 -0.5 1.6 -2.0 0.2
Medication for hormone replacement therapy 0.8 0.9 2.8 0.2 -1.7 -0.6 -0.0 -1.6 0.3
Vitamin and mineral supplements 1.1 1.5 2.6 0.9 -0.8 -1.6 0.0 -1.6 -1.6
Supplements: Zinc 0.7 0.7 3.3 -0.2 -0.2 1.0 0.3 -0.3 1.8
Medication: Co-codamol 1.3 1.5 4.2 1.9 -0.4 -0.1 -2.0 0.9 -0.6
Medication: Metformin 0.1 0.1 0.3 -0.3 0.4 -0.1 0.3 -0.3 -0.6
Diabetes (father) 0.2 0.3 0.6 0.7 -0.4 -0.3 0.5 0.2 -0.8
Diabetes (mother) 1.1 1.4 3.0 0.4 0.8 -1.7 0.9 0.8 -1.7
Severe depression (siblings) 0.4 0.5 1.5 0.0 -0.3 -0.2 1.2 -0.5 -0.9
Pack years adult smoking proportion 0.8 1.2 2.4 -0.8 0.0 -1.3 1.5 -1.2 1.1
Impedance of leg (right) 0.3 1.4 3.5 -0.4 -1.2 1.9 1.0 -1.3 0.8
Leg fat-free mass (left) 0.5 2.7 9.3 -1.0 1.5 -0.2 -0.7 3.0 -1.9
Trunk fat percentage 0.3 1.1 1.8 -1.3 1.4 -0.6 0.9 0.3 -1.2
Hand grip strength (right) 1.1 3.0 7.7 1.2 -2.8 -1.4 0.3 -2.5 -0.7
Townsend deprivation index at recruitment 0.8 1.2 4.1 1.0 0.6 -0.1 1.1 0.6 -2.0
Current tobacco smoking 0.5 0.8 2.2 -0.1 0.4 -0.6 -1.5 1.5 -0.1
Average weekly fortified wine intake 0.7 0.8 1.8 0.9 -0.2 1.3 -0.8 1.1 -0.6
Maternal smoking around birth 0.5 0.7 1.3 0.3 0.8 -1.1 -0.0 -1.0 0.9
Fed-up feelings 0.3 0.6 2.7 -1.6 -0.3 -0.3 -0.6 -0.3 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.5 -0.3 -0.9 -0.8 -0.9 -1.2 -0.6
Relative age voice broke 0.3 0.5 1.4 0.8 -1.2 -0.2 0.7 -0.0 -0.4
Taking other prescription medications 0.6 0.9 1.7 0.8 0.8 0.5 -1.3 1.1 -0.9
Age when periods started (menarche) 0.8 1.8 5.6 0.7 -1.8 -1.0 -0.0 -2.4 -0.9
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 3.3 -0.1 -0.5 -1.5 0.3 -1.6 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 3.0 0.9 0.9 0.5 -1.3 1.7 1.3
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 4.3 0.6 -0.8 -2.1 -0.6 -1.1 -0.8
Qualifications: CSEs or equivalent 1.0 1.4 4.1 -2.0 -0.3 -0.9 -0.1 -1.2 1.3
Serious illness, injury or assault to yourself 0.9 1.1 3.6 -0.9 1.3 -0.6 -0.3 -0.1 -1.9
High blood pressure 0.1 0.2 0.6 0.2 0.8 -0.6 -0.2 -0.1 -0.1
Hayfever, allergic rhinitis or eczema 0.9 1.9 5.2 -0.4 2.3 1.0 -0.2 1.1 1.9
Multivitamins +/- minerals 0.7 0.9 2.1 -0.6 -0.4 1.3 0.3 1.2 1.4
Stomach or abdominal pain in last month 0.4 0.5 1.4 -1.2 0.7 0.5 -0.0 -0.7 0.8
Supplements: Glucosamine 0.2 0.3 0.9 0.1 0.0 -1.0 -0.3 -0.4 0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.7 1.3 -0.5 -0.6 -0.1 -0.1 0.8
Medication: Atenolol 0.6 0.7 1.4 0.3 -1.2 -0.9 0.8 -0.6 0.9
Medication: Levothyroxine sodium 0.6 1.1 3.4 0.1 1.1 -1.8 -0.7 1.0 -0.6
Sitting height 0.8 5.6 17.6 -0.7 1.4 2.1 -2.8 4.2 -1.2
Chronic bronchitis/emphysema (father) 1.9 2.2 4.6 1.4 1.1 0.2 -1.9 2.1 -1.3
High blood pressure (mother) 0.1 0.2 0.3 0.3 -0.2 0.6 -0.5 0.2 -0.5
Body mass index (BMI) 0.3 1.4 2.7 -1.3 1.3 -1.6 1.0 -0.0 -1.1
Impedance of leg (left) 0.2 1.1 2.6 0.0 -1.2 1.3 0.6 -1.6 0.6
Leg predicted mass (left) 0.5 2.7 9.2 -1.1 1.5 -0.2 -0.6 3.0 -1.8
Trunk fat mass 0.4 1.7 3.3 -1.5 1.7 -0.3 0.5 1.2 -1.8
Waist circumference 0.7 2.7 7.2 -1.7 1.8 -1.1 0.1 1.3 -2.7
Number of incorrect matches in round 0.6 1.1 4.4 2.1 -0.1 0.5 -0.5 -0.7 -1.0
Past tobacco smoking 0.4 0.7 2.2 0.7 -0.2 1.5 -0.9 -0.9 -0.1
Alcohol usually taken with meals 0.6 1.0 2.2 0.3 -1.1 0.7 0.9 1.1 -1.5
Nervous feelings 0.6 1.1 4.3 1.2 -0.2 0.9 -2.1 -0.4 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 3.1 -0.4 0.5 -0.1 -0.9 -1.8 0.6
Hearing difficulty/problems with background noise 1.4 2.3 5.4 2.3 -1.2 -2.3 0.4 -1.1 -0.8
Hair/balding pattern: Pattern 2 1.2 1.5 5.1 -2.3 -1.2 -0.4 1.0 -1.1 0.1
Had menopause 0.4 0.5 2.3 0.4 -0.2 0.6 -1.5 0.2 -0.5
Had other major operations 1.3 1.6 3.1 -1.2 0.6 1.2 -1.1 1.8 -1.5
Forced vital capacity (FVC) 0.7 2.7 5.5 0.7 1.1 1.5 -2.3 2.4 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 4.0 0.5 0.5 -0.0 -1.5 2.0 1.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.3 -1.5 -1.0 -0.3 0.5 0.3 -0.1
Qualifications: None of the above 0.6 1.2 4.8 1.1 -0.1 0.9 -2.2 0.0 0.5
Financial difficulties in last 2 years 0.8 1.1 3.4 -0.9 -0.5 -1.9 0.2 -0.5 1.2
Mouth/teeth dental problems 1.7 2.6 6.5 -0.7 1.4 2.3 2.5 1.4 -0.1
Heart attack 0.8 1.0 2.2 -0.8 0.7 -0.7 1.5 -0.2 -1.4
Allergy 0.3 0.7 2.3 -0.5 -1.5 -0.1 0.9 0.3 -0.9
Pain all over the body in last month 1.2 1.2 4.2 0.2 0.5 1.3 -0.8 0.8 -2.0
Diabetes (self-reported) 0.9 1.4 2.5 -1.5 -0.4 -1.4 1.6 -1.1 -0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.6 -0.4 1.2 0.1 1.3 -0.1 -0.6
Medication: Ramipril 0.7 0.9 2.5 -0.2 0.6 1.6 0.8 1.0 -0.9
Medication: Simvastatin 0.5 0.8 1.4 -0.5 0.1 -1.2 1.2 -1.2 -0.3
Fluid intelligence score 0.7 1.5 4.0 -0.1 0.8 -0.9 1.0 2.0 -1.5
Illnesses of siblings 0.7 1.0 2.9 -0.1 0.8 -1.4 -0.3 -0.7 1.7
Neuroticism score 0.3 0.6 2.5 -0.8 0.5 -0.5 -1.6 0.3 -0.0
Weight 0.6 3.1 5.3 -1.9 2.1 -0.2 -0.0 2.3 -2.2
Impedance of arm (right) 0.1 0.6 1.4 0.5 0.6 1.2 -0.9 -0.2 0.7
Arm fat percentage (right) 0.3 1.3 2.7 -1.1 1.4 -1.6 1.0 -0.2 -1.1
Trunk fat-free mass 0.6 3.4 12.1 -1.2 0.9 0.7 -0.7 3.5 -2.3
Hip circumference 0.4 1.8 3.6 -1.2 1.7 -0.7 -0.5 1.5 -1.9
Time employed in main current job 2.0 2.3 4.2 -1.5 1.9 1.8 2.1 0.0 -0.5
Alcohol intake versus 10 years previously 0.2 0.3 0.8 -0.2 0.7 0.6 -0.9 -0.0 0.2
Father’s age at death 0.2 0.2 0.5 0.6 -0.5 0.7 0.3 0.2 -0.2
Worrier / anxious feelings 0.3 0.6 2.4 -0.4 1.0 1.6 -0.2 0.1 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.8 -0.1 0.5 -0.7 -0.1 0.1 -1.4
Falls in the last year 0.4 0.6 1.4 1.0 1.2 0.1 -0.6 -0.1 -0.7
Hair/balding pattern: Pattern 3 2.2 3.2 11.1 3.3 1.8 -1.2 -1.5 1.1 0.1
Number of live births 2.5 3.5 8.8 1.9 0.9 0.9 -3.0 2.6 -0.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 5.5 0.7 1.0 1.4 -2.3 1.9 -1.1
Pulse rate 0.3 0.6 1.7 -1.1 1.3 0.0 0.6 0.4 -0.1
Happiness 0.9 1.1 3.9 -0.0 -0.4 -1.2 0.6 -2.0 -0.7
Noisy workplace 2.2 2.7 5.8 1.9 -1.6 -1.4 -2.4 -1.5 0.5
Qualifications: A levels/AS levels or equivalent 0.5 1.0 3.8 1.1 0.0 -0.0 -0.9 1.9 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 8.3 0.3 -0.3 -2.9 -1.1 -0.5 0.1
Mouth/teeth dental problems: Dentures 1.3 2.2 9.8 0.8 0.3 -1.1 -3.1 0.7 0.9
Asthma 1.0 1.9 5.3 1.6 0.4 -1.5 -1.0 -2.3 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.6 -1.6 0.7 -0.4 1.4 -1.3 -0.3
Medication: Cholesterol lowering 0.4 0.6 1.8 0.8 -0.3 -1.4 -0.4 -0.7 0.3
Depression (self-reported) 0.5 0.6 1.6 -1.3 -0.6 -0.4 0.4 -0.5 1.1
Medication: Lansoprazole 0.7 0.9 3.1 -1.0 1.8 -0.3 -0.2 -0.8 0.2
Prospective memory result 0.3 0.4 2.1 0.0 -0.1 1.5 0.1 0.2 0.1
Lung cancer (father) 2.0 2.4 7.5 1.3 -1.8 -0.5 1.3 0.2 -2.7
Illnesses of mother 1.0 1.2 5.3 -0.6 -0.7 0.6 0.4 -1.0 2.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 7.7 1.1 1.3 1.7 -2.8 2.0 -1.1
Pulse wave Arterial Stiffness index 2.0 2.4 6.2 -1.4 1.6 0.8 -0.1 2.5 1.8
Impedance of arm (left) 0.2 1.0 4.0 0.1 0.7 2.0 -0.8 0.1 0.9
Arm fat mass (right) 0.4 1.7 2.7 -1.4 1.6 -1.5 0.6 0.7 -1.6
Trunk predicted mass 0.6 3.5 12.6 -1.0 0.9 0.7 -0.9 3.5 -2.3
Standing height 0.9 9.0 27.2 -1.4 1.9 3.1 -1.9 5.2 -2.8
Length of working week for main job 1.0 1.2 3.2 -1.0 0.9 0.8 0.7 -1.8 0.9
Exposure to tobacco smoke at home 0.5 0.6 1.6 -0.9 0.1 -0.6 -0.2 -0.7 1.3
Breastfed as a baby 2.2 2.7 9.7 0.7 -3.1 -1.4 0.8 -1.9 -0.3
Tense / ‘highly strung’ 0.4 0.7 3.2 -0.8 0.4 -0.5 -1.8 -0.1 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 3.5 1.1 1.4 -1.9 -1.5 0.0 -1.4
Hair/balding pattern: Pattern 4 4.2 10.1 43.5 6.6 0.5 -0.6 -3.7 -1.3 1.1
Birth weight of first child 0.4 0.7 2.2 -1.0 -0.2 1.5 0.4 -0.0 -0.9
Peak expiratory flow (PEF) 0.3 0.8 2.1 1.4 0.3 -0.3 -1.4 0.1 -0.7
Pulse wave reflection index 1.9 2.3 8.0 -0.7 0.9 0.6 -0.5 2.0 2.8
Ever highly irritable/argumentative for 2 days 0.8 0.9 4.0 -1.0 -2.0 -0.0 -0.2 -0.6 -0.4
Loud music exposure frequency 0.8 0.9 2.4 -0.3 -1.0 -1.5 -0.8 -1.0 -0.2
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.0 -0.8 -0.5 -1.4 1.3 -0.3 1.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.7 -0.6 -0.6 -1.2 -0.1 -1.3 -0.5
Blood clot in the leg (DVT) 0.6 0.8 2.6 0.7 -0.9 -0.6 -0.4 -1.6 -0.6
Medication: Paracetamol 0.2 0.3 1.0 0.2 -0.0 -0.3 -1.0 -0.6 -0.2
Headache pain in last month 0.6 1.0 3.0 -0.7 0.3 -1.2 -0.8 -1.7 0.4
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.2 -0.5 -0.5 -0.3 1.4 -0.9 -1.5
Glaucoma (self-reported) 1.6 1.9 4.7 1.1 1.6 1.7 -0.6 0.3 -2.2
Gout (self-reported) 0.9 1.2 2.9 0.8 -1.7 0.7 -0.8 -0.2 1.7
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.1 0.9 1.3 -1.1 -1.8 1.8 -0.9
Medication: Amlodipine 0.4 0.5 1.2 0.8 1.1 0.3 -0.0 -0.4 1.0
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.5 0.3 0.7 0.4 -0.1 -0.5 0.7
Birth weight 0.3 0.6 2.8 -0.6 0.4 0.1 0.6 -0.1 -1.7
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.7 -0.5 0.2 -1.3 0.9 -1.2 -0.3
High blood pressure (siblings) 0.4 0.6 1.5 0.4 -1.1 1.2 -0.8 -0.4 -0.2
Forced vital capacity (FVC), Best measure 1.3 4.7 9.6 1.3 1.7 2.4 -3.1 2.7 -1.1
Body fat percentage 0.3 1.1 1.8 -1.3 1.3 -0.8 1.1 0.0 -1.1
Leg fat percentage (right) 0.3 1.0 2.8 -1.3 0.6 -0.6 1.7 -0.3 -0.6
Arm fat-free mass (right) 0.5 2.5 7.2 -1.1 0.7 0.0 -0.5 2.7 -2.5
Exposure to tobacco smoke outside home 0.5 0.6 1.4 -1.2 0.9 -0.8 0.4 0.1 -0.9
Comparative body size at age 10 0.7 2.0 5.7 0.6 1.5 -0.1 -2.4 2.0 0.2
Number of full brothers 0.8 1.1 2.5 0.9 -1.6 -0.9 0.3 -1.4 0.5
Worry too long after embarrassment 0.8 1.4 4.1 0.2 0.1 1.5 -2.0 1.3 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.8 0.0 -0.6 -0.9 -1.5 -1.7 -0.3
Wheeze or whistling in the chest in last year 1.3 2.3 6.4 1.1 0.1 -2.1 -1.4 -2.5 -0.2
Number of children fathered 2.2 2.5 6.2 -2.2 -0.1 1.3 2.5 -0.2 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.1 -1.0 0.7 1.0 0.4 -0.2 0.3
Age at first live birth 0.4 0.6 2.7 -0.6 0.1 1.6 0.0 0.7 0.5
Pulse wave peak to peak time 1.9 2.2 5.1 1.2 -1.6 -0.9 0.0 -2.2 -1.8
Health satisfaction 0.6 0.7 3.3 -1.8 0.5 0.8 -0.0 -0.3 0.0
Shortness of breath walking on level ground 2.7 3.2 8.2 -2.9 2.0 1.6 -0.2 2.1 -0.0
Qualifications: College or University degree 0.4 1.1 2.1 1.4 -0.8 1.1 -1.4 0.3 -0.9
Eye problems/disorders: None of the above 0.8 0.9 3.9 -0.6 -1.0 0.0 0.6 -0.2 2.0
Mouth/teeth dental problems: Loose teeth 0.2 0.3 1.2 0.1 0.1 -0.1 -0.0 -0.6 -1.1
Emphysema/chronic bronchitis 0.9 1.0 1.9 -0.6 0.6 -1.2 0.3 -1.4 -1.3
Medication for pain relief, constipation, heartburn 0.8 1.4 4.6 0.3 0.7 0.7 -1.6 2.2 -0.7
Neck or shoulder pain in last month 0.3 0.4 1.5 -0.3 -0.7 -1.2 -0.2 -0.4 0.3
Medication: Blood pressure 0.9 1.5 4.9 0.1 0.2 1.1 -0.9 1.4 2.2
Angina (self-reported) 1.0 1.3 4.5 -0.3 -0.5 -0.9 1.5 -2.1 -0.1
Migraine (self-reported) 0.3 0.4 1.1 -1.1 0.2 1.0 -0.1 -0.1 0.6
Medication: Ibuprofen 1.3 1.5 4.6 -2.1 0.9 -0.4 1.5 -1.0 -0.5
Medication: Allopurinol 0.5 0.7 2.3 1.1 -1.5 0.5 0.2 -0.4 0.6
Medication: Omeprazole 0.7 0.9 2.0 1.4 1.4 0.5 0.7 0.4 0.6
Medication: Seretide 50 evohaler 0.5 0.6 1.5 0.4 1.2 0.9 -1.0 0.0 0.1
Mean time to correctly identify matches 1.5 2.9 5.6 0.3 1.7 2.0 -2.4 1.8 -1.2
Heart disease (mother) 0.7 0.8 3.1 1.1 0.6 -0.1 -0.2 0.5 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.3 -0.1 -0.8 -1.1 0.7 -0.9 1.0
Whole body fat mass 0.3 1.4 2.3 -1.5 1.5 -0.6 0.6 1.0 -1.5
Leg fat mass (right) 0.3 1.2 1.9 -1.4 1.1 -0.9 0.9 0.6 -1.3
Arm predicted mass (right) 0.5 2.6 7.1 -1.2 0.9 -0.1 -0.7 2.7 -2.4
Pulse rate, automated reading 0.3 0.9 2.3 -0.7 -0.0 -1.1 -0.9 0.7 1.5
Alcohol intake frequency. 0.4 1.0 2.1 -0.9 -0.4 -0.1 -1.4 -1.2 1.3
Comparative height size at age 10 1.0 5.3 17.2 -0.7 2.2 2.6 -1.4 4.2 -1.1
Number of full sisters 0.5 0.7 2.0 0.3 0.3 -0.6 -1.2 1.4 0.0
Suffer from ‘nerves’ 0.3 0.5 1.8 -0.3 0.7 0.0 -1.3 -0.0 0.7
Overall health rating 0.6 1.2 2.9 -1.6 1.7 0.8 0.6 0.7 0.5
Chest pain or discomfort 1.0 1.4 5.7 -0.9 0.3 -0.5 -0.1 -2.4 -1.3
Had major operations 0.8 1.0 2.4 0.1 -0.5 -1.6 -1.6 0.5 -0.7
Age at last live birth 0.1 0.2 0.4 -0.4 -0.3 -0.1 -0.6 0.5 0.6
Family relationship satisfaction 0.3 0.4 1.1 -1.0 0.2 -0.2 -0.5 -0.5 -0.7
Leg pain on walking 1.0 1.2 5.5 -0.6 -0.9 -0.7 -2.3 -0.4 0.5
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 3.0 0.4 0.9 -1.6 0.3 1.0 -1.7
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 -0.6 0.2 0.3 -0.5 0.6 0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 2.4 0.2 -0.6 1.6 -1.0 0.2 0.3
Medication: Aspirin 2.3 3.0 4.7 -0.1 -0.7 -2.0 2.2 -2.1 2.1
Supplements: Vitamin C 0.4 0.5 1.8 -0.5 0.9 1.3 0.0 0.5 0.3
Knee pain experienced in last month 0.8 1.2 2.6 0.3 -1.6 -1.6 -1.4 -0.1 -0.3
Hypertension (Self-reported) 0.0 0.1 0.4 0.3 0.6 -0.5 -0.1 -0.0 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.1 -0.7 -0.3 0.3 0.8 -0.6 1.1
Illnesses of father: Heart disease 0.1 0.2 0.5 0.5 -0.1 0.7 -0.1 -0.3 0.5
Illnesses of siblings: Diabetes 0.4 0.5 1.5 -0.6 0.5 0.4 0.4 0.8 -1.2
Smoking status: Previous 0.4 0.5 1.5 -0.3 -0.5 -1.2 1.1 0.4 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.6 4.8 -1.8 -0.2 2.2 0.5 0.9 -0.4
Whole body fat-free mass 0.6 3.2 11.4 -1.0 1.2 0.1 -0.8 3.4 -2.2
Leg fat-free mass (right) 0.5 2.8 8.6 -0.8 1.4 -0.5 -1.0 2.9 -2.0
Arm fat percentage (left) 0.3 1.2 2.2 -1.4 1.5 -1.1 0.9 -0.0 -0.8
Average weekly red wine intake 0.4 0.6 2.4 0.8 -0.5 0.6 -0.2 1.5 -0.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.6 -0.8 0.6 -0.3 0.5 -1.3 0.6
Mood swings 0.4 0.7 2.0 -0.1 0.7 -0.4 -1.2 0.1 -1.4
Loneliness, isolation 0.5 0.7 2.2 0.9 -0.2 -1.5 -0.5 -0.8 -0.6
Long-standing illness, disability or infirmity 0.5 0.8 2.9 0.4 0.7 -1.7 -0.4 1.1 0.1
Ever had bowel cancer screening 1.9 2.2 10.5 3.2 0.7 0.8 -0.8 0.8 -0.4
Diabetes diagnosed by doctor 0.8 1.3 1.8 -1.2 -0.9 -1.2 1.3 -0.8 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 6.1 1.1 -0.5 -0.3 -2.5 -0.2 0.1
Friendships satisfaction 0.8 0.9 3.7 0.5 0.6 0.1 -1.1 0.1 -1.9
Qualifications: nursing, teaching 0.8 1.2 2.8 -1.7 -1.3 -0.4 1.0 -1.3 0.1
Commuting to job workplace: Walk 0.8 0.8 2.7 0.3 -0.8 -0.5 0.6 -1.6 -1.0
Eye problems/disorders: Cataract 0.8 1.0 3.1 -1.8 0.2 1.1 0.1 0.3 -1.2
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 4.2 2.1 -1.2 -0.9 -1.8 -1.4 -0.1
Medication for cholesterol 0.4 0.6 2.3 0.2 0.5 0.3 -1.0 1.5 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 12.0 0.7 -3.5 -0.1 0.9 -1.5 -0.7
Back pain experienced in last month 0.7 1.0 3.1 -1.8 1.3 0.4 -0.4 1.1 0.2
Mineral and other dietary supplements 1.1 1.4 2.8 -1.5 0.7 -0.1 1.6 -0.9 -1.7
Breast cancer (self-reported) 0.7 0.8 1.9 -1.4 0.5 0.7 0.9 -1.1 0.2
Asthma (self-reported) 1.1 2.1 5.1 1.6 0.5 -1.8 -1.2 -2.3 -0.3
Osteoporosis (self-reported) 0.4 0.6 1.5 -0.2 0.7 1.2 -1.0 0.5 -0.3
Osteoarthritis (self-reported) 0.5 0.7 2.1 1.4 0.1 -0.3 -0.4 0.8 -1.1
Medication: Aspirin 2.9 3.8 7.1 -0.1 -1.2 -2.3 2.2 -2.7 2.1
Medication: Gliclazide 1.1 1.3 3.7 -0.6 1.5 -0.4 1.1 0.0 -1.9
Illnesses of father: None of the above (group 1) 0.9 1.1 1.9 -0.8 -0.5 -1.2 1.3 -1.4 0.7
Smoking status: Current 0.8 1.3 4.0 -0.3 1.2 -0.3 -1.4 2.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.5 5.2 13.5 1.1 2.7 2.0 -2.0 3.7 -1.0
Whole body water mass 0.6 3.2 10.5 -1.0 1.2 -0.0 -0.9 3.2 -2.3
Leg predicted mass (right) 0.5 2.7 8.6 -0.9 1.4 -0.5 -0.9 2.9 -2.0
Arm fat mass (left) 0.4 1.6 2.7 -1.5 1.5 -1.4 0.5 0.7 -1.6
Number of self-reported non-cancer illnesses 0.3 0.4 1.0 -0.0 -0.1 -1.0 -0.4 -1.0 0.7
Average weekly champagne plus white wine intake 0.3 0.4 0.9 0.7 -1.0 0.4 -0.4 -0.5 -0.3
Miserableness 0.9 1.5 3.5 1.5 0.2 -1.0 -1.9 1.0 -1.1
Guilty feelings 0.5 0.8 2.3 -0.8 -0.8 0.3 -1.5 -1.0 -0.2
Wears glasses or contact lenses 0.5 0.5 2.6 0.4 0.2 0.0 0.1 0.6 -1.6
Ever taken oral contraceptive pill 1.0 1.1 3.6 -0.8 0.4 0.7 1.9 0.9 0.9
Hearing aid user 1.0 1.2 5.6 0.4 0.0 -2.4 0.4 -0.3 -1.0
Mother’s age at death 1.2 1.5 7.1 0.2 0.5 1.1 -0.0 2.7 -0.5
Financial situation satisfaction 1.2 1.5 6.0 -1.0 -0.4 0.4 -1.1 -0.6 2.4
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.9 1.0 0.3 0.4 0.8 -0.8 -0.6
Commuting to job workplace: Public transport 1.4 1.7 5.9 2.4 -0.7 -1.0 -0.7 0.3 -1.6
Eye problems/disorders: Glaucoma 0.8 1.0 2.6 1.1 0.6 1.1 -0.2 -0.7 -1.6
Medication: Blood pressure 0.3 0.6 1.9 -0.1 0.1 -1.4 0.1 -0.8 -1.1
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.1 0.5 -0.4 -0.1 -0.5 1.1 -0.1
Supplements: Fish oil (including cod liver oil) 0.7 0.8 3.0 0.9 -0.3 0.4 -0.7 0.8 1.7
High cholesterol (Self-reported) 1.0 1.8 4.6 -0.0 -1.4 -1.1 2.1 -1.8 0.2
Medication: Bendroflumethiazide 0.4 0.7 2.0 -0.7 0.9 0.5 -0.6 1.4 0.3
Medication: Paracetamol 0.3 0.5 1.8 -0.1 -0.1 -0.9 -0.5 -1.3 -0.6
Medication: Lisinopril 1.6 2.0 7.5 -1.1 -1.3 0.6 -0.7 1.0 2.7
Medication: Atorvastatin 0.4 0.5 1.1 0.7 -0.7 -1.0 0.7 -0.6 0.5
Illnesses of father: High blood pressure 0.2 0.2 0.5 0.5 -0.6 -0.7 0.1 -0.4 0.1
Alcohol drinker status: Never 1.0 1.2 3.4 1.5 -1.8 -0.4 -0.7 -0.4 -1.0
Ever smoked 0.6 1.0 1.5 -1.2 0.7 -1.1 1.1 1.2 -0.0
Basal metabolic rate 0.6 3.1 9.6 -1.3 1.4 -0.2 -0.5 3.1 -2.2
Leg fat percentage (left) 0.2 0.8 1.8 -1.1 0.8 -0.8 1.3 -0.4 -0.7
Arm fat-free mass (left) 0.5 2.5 6.0 -1.4 0.8 -0.7 -0.3 2.4 -2.4
Number of operations (self-reported) 1.0 1.4 3.3 1.0 -0.7 -1.4 -1.8 0.3 -1.3
Average weekly beer plus cider intake 0.9 1.3 4.7 0.3 -1.1 -1.2 -0.2 -2.2 -0.1
Irritability 0.3 0.5 2.9 -1.7 -0.1 -0.3 -0.3 0.3 -0.0
Risk taking 1.0 1.5 4.0 2.0 -0.7 -1.4 -1.3 0.4 -0.9
Ever had prostate specific antigen (PSA) test 1.8 2.1 3.8 1.9 -0.5 1.4 -1.7 1.9 -0.4
Fractured/broken bones in last 5 years 0.8 1.0 3.1 -1.8 -0.3 -1.2 0.3 -1.1 -0.3
Age started oral contraceptive pill 1.0 1.3 3.5 1.0 1.2 1.9 0.2 1.3 -0.4
Diastolic blood pressure, automated reading 0.5 1.6 5.6 -0.5 2.4 -1.1 0.2 1.4 0.6
Ever depressed for a whole week 0.3 0.4 1.1 -0.2 -0.5 -1.0 0.2 0.1 -1.0
Unable to work because of sickness or disability 1.2 1.6 2.9 -1.1 -1.7 1.5 0.5 -1.5 0.5
Commuting to job workplace: Cycle 1.0 1.3 3.1 -1.6 0.8 -0.6 -1.8 0.9 -0.1
Myopia 1.0 1.4 5.1 0.4 1.7 0.4 0.3 2.3 -0.2
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.9 0.1 -0.9 0.4 -0.1 -0.2 -0.1
Cholesterol lowering medication 1.5 2.2 8.4 -1.1 -0.5 -0.3 2.9 -1.6 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.8 1.3 1.3 -0.1 1.3 -0.5 -0.2
Pain experienced in last month 0.3 0.4 1.6 0.7 -0.1 0.4 0.4 0.2 1.3
Supplements: Calcium 0.5 0.5 1.2 -0.4 0.4 1.0 -1.1 0.6 0.6
Basal cell carcinoma (self-reported) 1.8 2.1 5.8 1.4 -2.4 1.6 0.9 0.8 -0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.9 -0.7 0.6 -0.6 1.4 -0.3 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 2.1 0.7 -1.0 -0.1 -0.4 -1.4 -0.6
Heart disease (siblings) 1.6 2.0 5.5 -0.2 0.1 2.1 0.4 2.4 -1.3
Alcohol drinker status: Previous 0.8 0.9 3.6 -0.1 -0.9 -1.9 -0.1 -1.1 0.2
Pack years of smoking 0.8 1.2 3.5 -0.5 -0.0 -1.3 1.9 -1.0 1.0
Impedance of whole body 0.1 0.7 3.2 0.3 -0.2 1.8 -0.4 -0.6 0.7
Leg fat mass (left) 0.3 1.2 2.0 -1.3 1.4 -0.9 0.8 0.6 -1.4
Arm predicted mass (left) 0.5 2.6 6.1 -1.6 0.7 -0.4 -0.3 2.5 -2.4