Best TWAS P=1.34e-15 · Best GWAS P=5.3e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | DNM1L | 0.13 | 0.02 | lasso | 6 | 0.07 | 9.3e-06 | 7.9 | -5.3 | 1.4e-07 | -0.78 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | FGD4 | 0.11 | 0.00 | enet | 9 | 0.02 | 1.3e-02 | 4.7 | -5.3 | 1.2e-07 | -0.44 | 0.14 | 0.06 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | RP11-278C7.1 | 0.08 | 0.06 | lasso | 5 | 0.05 | 5.9e-05 | 7.9 | -7.7 | 1.5e-14 | -0.98 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Testis | DNM1L | 0.13 | 0.14 | lasso | 11 | 0.12 | 5.1e-06 | 8.0 | -8.0 | 1.3e-15 | -1.00 | 0.03 | 0.97 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RP11-278C7.1 | 0.05 | 0.05 | lasso | 6 | 0.04 | 1.9e-06 | 8.0 | -7.3 | 2.4e-13 | -0.96 | 0.04 | 0.96 | FALSE |
| 6 | YFS | Blood | DNM1L | 0.06 | 0.06 | lasso | 6 | 0.06 | 6.8e-20 | 4.1 | 5.7 | 1.5e-08 | 0.83 | 0.83 | 0.17 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | DNM1L | 0.10 | 0.01 | blup | 83 | 0.05 | 1.1e-02 | 4.5 | -7.6 | 2.3e-14 | -0.94 | 0.02 | 0.64 | FALSE |