Best TWAS P=6.49e-30 · Best GWAS P=1.23e-28 conditioned to 0.02
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Colon Transverse | UBE2N | 0.16 | 0.00 | lasso | 4 | 0.01 | 1.0e-01 | 1.63 | -6.8 | 7.8e-12 | -0.70 | 0.02 | 0.78 | FALSE |
2 | GTEx | Muscle Skeletal | MRPL42 | 0.07 | 0.02 | lasso | 3 | 0.04 | 1.5e-04 | 8.71 | 7.0 | 3.0e-12 | 0.37 | 0.69 | 0.02 | FALSE |
3 | GTEx | Testis | MRPL42 | 0.35 | 0.17 | lasso | 3 | 0.24 | 3.3e-11 | 10.87 | 11.2 | 5.1e-29 | 0.87 | 0.00 | 1.00 | FALSE |
4 | YFS | Blood | MRPL42 | 0.06 | 0.03 | lasso | 6 | 0.04 | 1.7e-14 | 11.10 | 10.1 | 3.7e-24 | 0.87 | 0.00 | 1.00 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MRPL42 | 0.05 | 0.03 | blup | 49 | 0.04 | 3.9e-08 | 10.78 | -8.6 | 7.8e-18 | -0.76 | 0.01 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MRPL42 | 0.16 | 0.06 | lasso | 4 | 0.10 | 5.2e-11 | 10.87 | -7.1 | 1.2e-12 | -0.79 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MRPL42 | 0.13 | 0.01 | blup | 49 | 0.02 | 1.4e-02 | 0.26 | -6.0 | 2.1e-09 | -0.71 | 0.01 | 0.78 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MRPL42 | 0.09 | 0.04 | enet | 10 | 0.06 | 5.9e-07 | 0.26 | -5.4 | 8.6e-08 | -0.51 | 0.11 | 0.54 | FALSE |
9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MRPL42 | 0.05 | 0.02 | blup | 49 | 0.03 | 5.1e-04 | -4.69 | -8.3 | 6.9e-17 | -0.53 | 0.06 | 0.24 | FALSE |
10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MRPL42 | 0.11 | 0.06 | lasso | 2 | 0.09 | 7.1e-07 | 5.41 | -8.7 | 3.7e-18 | -0.74 | 0.04 | 0.95 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MRPL42 | 0.07 | 0.03 | blup | 49 | 0.03 | 1.4e-04 | 11.10 | -11.4 | 6.5e-30 | -0.87 | 0.00 | 1.00 | TRUE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MRPL42 | 0.12 | 0.01 | blup | 49 | 0.04 | 4.0e-04 | 11.10 | -9.6 | 8.5e-22 | -0.71 | 0.00 | 0.79 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPL42 | 0.09 | 0.00 | enet | 8 | 0.03 | 9.4e-04 | 10.78 | -7.0 | 3.8e-12 | -0.68 | 0.00 | 0.88 | FALSE |