TWAS
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Models
Genes
Traits
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Traits
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Blood Platelet Count
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chr12:94,772,262-96,309,958
Best TWAS P=1.03e-15 · Best GWAS P=8.14e-17 conditioned to 1
94.8M
95M
95.2M
95.4M
95.6M
95.8M
96M
96.2M
96.4M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Cells Transformed fibroblasts
FGD6
0.19
0.22
lasso
5
0.20
2.4e-15
8.2
-8.0
1.0e-15
-0.95
0.01
0.99
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
NDUFA12
0.02
0.01
blup
93
0.01
2.2e-02
3.0
6.0
2.3e-09
0.51
0.04
0.18
FALSE
1
GTEx
Artery Aorta
FGD6
0.19
0.19
lasso
6
0.19
6.2e-11
2.4
-5.8
8.3e-09
-0.56
0.66
0.34
FALSE
4
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
NDUFA12
0.08
0.00
blup
93
0.04
1.0e-03
-1.3
5.4
8.4e-08
0.40
0.01
0.28
FALSE