TWAS hub - UBE2N

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1630	0.0700	0.0083	0.002	NA	-0.003	NA	0.010	2.4e-01	NA	0.50000	NA	1.0e-01
2	GTEx	Skin Sun Exposed Lower leg	0.0930	0.0340	0.0023	0.074	NA	0.012	NA	0.057	1.0e-06	NA	0.03000	NA	1.6e-05
3	YFS	Blood	0.0217	0.0090	0.0032	0.002	0.005	0.004	0.006	0.003	6.1e-02	0.00600	0.01300	0.0036	3.8e-02
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0509	0.0312	0.0028	0.001	0.028	0.028	NA	0.008	2.7e-01	0.00034	0.00036	NA	3.9e-02
5	TCGA	Liver Hepatocellular Carcinoma	0.1440	0.0750	0.0069	0.008	0.021	0.007	NA	0.014	1.3e-01	0.03300	0.15000	NA	6.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Ever used hormone-replacement therapy (HRT)	4.7	6.0	13.0	-3.6	-0.5	-1.3	-2.9	-2.6
Sitting height	4.1	29.2	79.9	2.1	7.0	8.9	-2.5	-2.7
Had menopause	3.9	4.9	6.6	2.5	-1.7	-1.6	2.6	2.5
Age started oral contraceptive pill	3.4	4.3	7.6	2.8	-1.0	0.3	2.4	2.6
Ever had bowel cancer screening	3.3	3.9	8.9	0.8	-2.0	-1.5	2.0	3.0
Rheumatoid Arthritis	3.2	4.4	8.4	-2.4	-0.4	-2.3	-1.6	-2.9
Hair/balding pattern: Pattern 4	3.2	7.9	10.2	3.0	-1.5	3.2	3.2	2.7
Forced vital capacity (FVC), Best measure	2.8	10.1	19.2	-0.4	4.2	4.4	-3.2	-1.8
Forced expiratory volume in 1-second (FEV1)	2.6	8.6	17.1	-0.5	3.6	4.1	-3.0	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	16.9	-0.1	4.1	4.0	-2.4	-1.5
Medication: Seretide 50 evohaler	2.6	3.0	9.5	-2.1	-3.1	0.3	0.7	-0.7
Forced vital capacity (FVC)	2.5	9.8	19.5	-0.7	3.5	4.4	-3.5	-2.1
Mouth/teeth dental problems: Loose teeth	2.4	2.8	5.1	1.5	-1.4	-0.1	2.2	2.3
Eye problems/disorders: Cataract	2.4	2.7	7.1	0.5	-1.9	1.4	2.7	0.9
Height	2.2	41.6	91.7	4.7	9.4	9.6	-2.2	-0.9
Ever taken oral contraceptive pill	2.2	2.4	3.9	-2.0	0.9	0.6	-1.8	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	15.4	1.3	1.8	3.9	-0.4	-1.2
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.6	2.1	-0.7	-0.1	1.6	2.1
Blood Platelet Count	2.0	23.0	46.8	-6.8	-5.1	-4.5	-3.9	-2.6
Medication for hormone replacement therapy	2.0	2.2	2.9	-1.1	1.1	1.7	-1.7	-1.7
Pulse rate	2.0	3.5	8.5	-0.3	2.5	-0.0	-2.9	-1.6
Standing height	2.0	19.6	47.7	2.8	5.7	6.9	-2.1	-2.4
Schizophrenia (2014)	1.9	4.2	9.4	2.5	0.8	0.4	2.1	3.1
Ulcerative Colitis	1.9	2.8	4.5	2.1	0.6	1.8	1.9	1.5
Trunk predicted mass	1.9	10.7	34.5	1.5	3.3	5.9	-0.1	-2.4
Trunk fat-free mass	1.8	10.6	33.5	1.6	3.4	5.8	-0.1	-2.3
Whole body fat-free mass	1.8	10.1	29.3	1.4	3.5	5.4	-0.4	-2.5
Arm fat-free mass (left)	1.8	8.9	27.7	1.0	2.9	5.3	-0.1	-2.7
LDL Cholesterol	1.7	2.8	5.0	-1.3	-0.1	-2.1	-2.2	-1.7
Medication: Co-codamol	1.7	2.0	5.5	-1.9	-2.4	-0.4	-0.0	-0.9
Number of incorrect matches in round	1.7	2.8	10.3	-0.3	0.4	-3.2	-1.6	-1.1
Health satisfaction	1.7	2.1	5.3	-0.2	-0.0	1.9	-1.4	-2.3
Medication for pain relief, constipation, heartburn	1.7	2.9	7.5	2.2	-0.2	0.7	2.7	1.3
Whole body water mass	1.7	9.9	29.2	1.4	3.4	5.4	-0.4	-2.6
Wears glasses or contact lenses	1.7	2.0	6.4	-0.0	-1.5	-2.5	0.5	1.1
Basal metabolic rate	1.7	9.5	27.4	1.4	3.2	5.2	-0.4	-2.7
Commuting to job workplace: Cycle	1.7	2.1	3.5	-1.2	1.1	-1.6	-1.9	-1.2
Basal cell carcinoma (self-reported)	1.7	2.0	5.7	-0.4	2.4	-0.9	-1.6	-0.9
Arm predicted mass (left)	1.7	8.8	25.8	1.0	3.0	5.1	-0.0	-2.8
Smoking Status	1.6	3.7	11.8	-1.7	0.1	-0.5	-1.9	-3.4
Sensitivity / hurt feelings	1.6	2.8	7.4	1.8	-2.7	-0.3	1.1	1.3
Townsend deprivation index at recruitment	1.6	2.3	4.9	-2.2	-0.7	-0.7	-0.8	-2.2
Arm fat-free mass (right)	1.6	8.2	23.8	1.3	3.0	4.9	-0.0	-2.6
HbA1C	1.5	1.6	5.3	2.3	0.7	0.9	1.1	-0.5
Allergy or Eczema	1.5	3.8	7.4	2.7	1.2	0.7	1.7	2.6
Age when periods started (menarche)	1.5	3.5	8.6	2.1	0.6	-2.9	0.5	2.0
Nervous feelings	1.5	2.9	11.1	0.4	-3.3	-1.7	-0.2	-0.2
Alcohol intake versus 10 years previously	1.5	2.2	8.8	-0.0	-0.4	1.3	-0.8	-3.0
Illnesses of mother	1.5	1.8	4.5	-1.1	-2.1	0.9	1.0	-1.2
Eye problems/disorders: None of the above	1.5	1.7	2.7	-0.9	0.6	-1.4	-1.7	-1.6
Loneliness, isolation	1.5	2.1	5.5	-0.8	-2.3	0.5	-0.5	-2.0
Respiratory disease	1.4	3.1	10.3	1.5	0.3	-0.7	1.4	3.2
Vitamin and mineral supplements	1.4	1.9	4.3	-0.3	-1.6	-2.1	1.2	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	12.6	0.8	0.9	3.6	0.9	0.9
Peak expiratory flow (PEF)	1.4	3.4	7.3	-1.0	2.2	0.4	-2.7	-1.8
Arm predicted mass (right)	1.4	7.3	21.0	1.0	2.8	4.6	-0.1	-2.5
Comparative height size at age 10	1.4	7.5	13.8	-0.4	3.7	3.0	-2.2	-3.0
Leg fat-free mass (right)	1.4	7.3	17.8	1.1	3.2	4.2	-1.0	-2.6
Long-standing illness, disability or infirmity	1.4	2.2	4.6	1.0	-2.1	1.9	0.9	-0.8
Smoking status: Current	1.4	2.3	7.9	-0.9	0.8	-0.6	-1.2	-2.8
Leg predicted mass (right)	1.4	7.6	18.3	1.0	3.3	4.3	-1.0	-2.6
Medication: Lisinopril	1.4	1.8	5.0	-1.4	-2.2	-1.0	0.2	1.0
Triglycerides	1.3	2.1	7.4	-0.8	-0.1	-0.4	-1.5	-2.7
Diabetes (father)	1.3	1.6	5.2	-2.3	1.0	0.6	-0.8	-0.9
Current tobacco smoking	1.3	2.1	6.4	-0.9	1.2	-0.5	-1.3	-2.5
High blood pressure (mother)	1.3	1.8	4.5	1.5	1.0	-0.8	-0.7	2.1
Leg predicted mass (left)	1.3	6.6	16.2	1.3	3.2	4.0	-0.6	-2.2
Medication: Allopurinol	1.3	1.8	4.2	-2.0	-0.2	-0.5	-1.7	-1.3
HDL Cholesterol	1.2	2.0	5.1	-2.3	0.5	-1.7	-1.1	0.8
Waist Hip Ratio (WHR)	1.2	5.2	11.1	-2.5	-2.3	-0.6	-1.7	-3.3
Lung FVC	1.2	5.9	16.2	-2.2	1.7	1.0	-4.0	-2.1
Supplements: Zinc	1.2	1.3	2.7	1.3	1.4	1.6	-0.4	0.2
Leg fat-free mass (left)	1.2	6.6	16.5	1.3	3.1	4.1	-0.6	-2.2
Financial difficulties in last 2 years	1.2	1.6	6.7	-0.9	0.4	2.6	-0.1	-0.3
Number of live births	1.2	1.7	3.4	1.0	-0.7	-1.8	0.5	1.8
Pulse wave reflection index	1.2	1.5	4.7	0.6	-1.5	-0.2	2.2	0.4
Ever highly irritable/argumentative for 2 days	1.2	1.4	4.2	0.2	0.9	1.2	-0.7	-2.0
Hearing aid user	1.2	1.3	4.6	2.1	-0.3	1.1	0.7	0.5
Pain experienced in last month	1.2	2.0	4.4	0.8	-0.6	-0.8	2.1	2.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.1	1.2	-0.4	0.5	1.8	1.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	5.0	0.5	-2.2	0.2	0.5	-0.7
Past tobacco smoking	1.1	2.1	4.1	1.6	0.1	1.0	1.6	2.0
Weight	1.1	5.2	13.1	1.2	2.1	3.6	-0.1	-2.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.3	-1.0	-1.5	0.5	-1.5	-1.8
High blood pressure (siblings)	1.1	1.6	7.3	0.2	-0.1	-0.3	0.8	2.7
Back pain experienced in last month	1.1	1.7	4.7	-0.3	0.7	1.4	-1.1	-2.2
Osteoarthritis (self-reported)	1.1	1.4	4.3	-0.8	-2.1	-0.1	0.5	-1.4
Ever smoked	1.1	1.9	4.5	-1.5	0.7	-0.5	-1.4	-2.1
Irritability	1.1	1.9	8.3	-0.4	-2.9	-0.7	-0.7	0.0
Risk taking	1.1	1.6	2.0	-1.4	1.0	1.4	-1.3	-1.2
Ovarian Cancer	1.0	1.3	5.5	-0.1	0.7	2.4	0.2	-0.7
Age at First Birth	1.0	1.5	3.1	0.9	0.4	-1.8	1.1	1.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.2	2.0	1.5	0.7	0.8	1.9
Shortness of breath walking on level ground	1.0	1.2	2.0	-0.0	0.8	1.4	-1.3	-1.2
Pulse rate, automated reading	1.0	3.3	8.9	-2.5	0.4	-0.5	-3.0	-0.9
Overall health rating	1.0	2.2	6.2	-0.4	-2.5	1.4	1.1	-1.2
Age at last live birth	1.0	1.4	2.8	1.7	1.3	1.1	0.4	1.0
Illnesses of father: Heart disease	1.0	1.3	5.0	-0.9	-0.6	-0.3	-0.6	-2.2
Number of self-reported non-cancer illnesses	1.0	1.7	5.6	-0.6	-2.4	-0.6	1.1	1.0
Mother’s age at death	1.0	1.2	4.4	2.1	1.1	0.4	0.6	0.1
Unable to work because of sickness or disability	1.0	1.2	3.1	-1.1	-0.8	0.7	-0.8	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.0	-1.4	0.2	-0.8	-1.7	-0.5
Bipolar Disorder or Schizophrenia	0.9	2.3	7.1	1.3	0.3	0.4	1.6	2.7
Alzheimer’s Disease (including proxy)	0.9	1.4	5.6	0.8	2.4	-0.5	-0.5	-0.0
Major Depression (MDD)	0.9	1.1	4.5	-0.6	-0.2	-0.0	0.7	2.1
Hypothyroidism (self reported)	0.9	2.0	7.2	0.3	0.9	2.7	0.3	-1.3
Chronotype (morning person)	0.9	2.0	3.8	-0.3	1.2	1.1	-1.9	-2.0
Qualifications: CSEs or equivalent	0.9	1.1	2.3	-1.2	0.8	0.4	-1.5	-1.1
Worrier / anxious feelings	0.9	1.8	3.9	1.0	-1.7	-0.5	0.9	2.0
Birth weight	0.9	2.0	6.5	2.5	1.2	0.7	0.6	1.0
Comparative body size at age 10	0.9	2.5	4.7	1.0	0.5	-1.8	1.8	2.2
Number of full sisters	0.9	1.1	2.7	0.6	-1.6	0.9	1.2	0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.9	2.0	0.1	-0.5	1.0	0.1
Illnesses of father: High blood pressure	0.9	1.1	2.7	1.0	-0.5	0.3	1.2	1.6
Bipolar Disorder (2018)	0.8	1.3	3.3	0.6	0.3	0.8	1.4	1.8
Type 2 Diabetes (T2D) (2012)	0.8	1.0	3.7	-0.1	-0.2	1.9	0.3	-1.0
Severe depression (siblings)	0.8	0.9	2.5	0.3	-1.2	-0.1	0.7	1.6
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	0.6	-1.2	-0.2	1.3	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.4	0.9	1.3	2.3	0.3	1.1
Medication: Ramipril	0.8	1.1	2.8	-0.7	-0.2	-0.6	-1.3	-1.7
Asthma	0.8	1.6	5.2	1.0	-0.7	0.4	1.1	2.3
Loud music exposure frequency	0.8	0.9	2.3	-0.3	-0.3	0.8	-1.5	-1.1
Gout (self-reported)	0.8	1.1	2.4	-1.5	-0.8	-0.9	-0.8	-1.0
Medication: Amlodipine	0.8	1.1	2.3	1.0	-0.8	0.6	1.2	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.3	0.4	-1.8	0.5	1.0	-0.6
Average weekly red wine intake	0.8	1.1	2.2	-0.9	0.7	1.2	-1.5	-0.9
Financial situation satisfaction	0.8	0.9	2.2	-0.5	1.3	1.5	-0.5	-0.5
Medication: Bendroflumethiazide	0.8	1.2	1.7	0.4	-1.3	-1.2	0.9	1.3
Alcohol drinker status: Never	0.8	0.9	2.1	0.8	-0.5	1.2	0.4	-1.4
Neuroticism (Nagel 2018)	0.7	1.7	3.3	1.8	-1.7	0.3	0.6	1.4
Schizophrenia vs Biploar Disorder	0.7	0.9	1.9	1.0	0.3	0.0	1.4	1.1
Blood Red Count	0.7	7.0	17.7	4.2	1.6	1.0	3.0	2.2
Heel T-Score	0.7	5.6	21.8	2.0	1.1	4.7	0.5	0.8
Average weekly spirits intake	0.7	0.9	1.6	-0.9	-1.3	0.5	-1.1	-0.8
Average weekly fortified wine intake	0.7	0.8	2.0	0.4	1.4	-0.5	-0.3	1.2
Serious illness, injury or assault to yourself	0.7	0.8	1.3	-1.0	-1.2	0.7	-1.0	-0.5
Multivitamins +/- minerals	0.7	0.9	2.6	0.0	1.2	1.6	-0.4	0.4
Hair/balding pattern: Pattern 2	0.7	0.9	2.5	-0.4	0.8	1.0	0.4	-1.6
Had other major operations	0.7	0.8	2.7	-0.2	0.1	0.9	-0.8	-1.6
Medication: Simvastatin	0.7	1.1	3.7	-0.3	-1.9	0.5	1.2	0.2
Illnesses of siblings	0.7	1.0	3.1	-0.5	-0.7	1.1	-0.2	-1.8
Neuroticism score	0.7	1.6	6.0	0.2	-2.5	-0.9	-0.8	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	3.6	0.1	0.0	-0.5	0.6	1.9
Tense / ‘highly strung’	0.7	1.2	1.7	-1.2	-0.9	-1.3	-1.3	-0.3
Glaucoma (self-reported)	0.7	0.8	2.3	0.8	0.5	0.4	0.7	1.5
Number of full brothers	0.7	0.9	1.9	1.1	0.2	0.8	0.7	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	0.9	1.0	-0.2	0.3	1.4
Pulse wave peak to peak time	0.7	0.8	1.1	-1.1	1.0	1.0	-1.0	-0.4
Medication: Blood pressure	0.7	1.3	2.8	-1.7	-0.8	-1.6	-0.8	-0.1
Medication: Ibuprofen	0.7	0.8	1.8	-0.1	0.8	1.3	-0.6	-1.1
Medication: Omeprazole	0.7	0.9	2.8	-0.6	0.6	-0.9	-1.7	0.0
Mean time to correctly identify matches	0.7	1.3	4.2	0.5	-1.3	0.6	2.0	0.1
Heart disease (mother)	0.7	0.9	2.0	0.2	0.9	-1.2	-0.2	1.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.3	-0.8	1.0	-0.3	-1.5	-1.3
Asthma (self-reported)	0.7	1.4	4.8	0.8	-0.5	-0.1	1.1	2.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.2	0.6	-0.5	1.8	0.2	-0.2
Schizophrenia (2018)	0.6	1.2	3.8	1.2	0.1	-0.1	0.9	1.9
Mean Putamen Volume	0.6	0.7	1.9	0.0	-1.4	-0.9	0.8	0.2
Neuroticism (2016)	0.6	0.8	2.4	0.1	-0.4	-1.2	0.0	1.6
Primary Biliary Cirrhosis	0.6	0.8	2.1	-1.3	0.1	1.4	0.5	-0.5
Cardiovascular Disease	0.6	1.9	5.6	-1.6	-2.4	-0.9	-0.4	0.7
Hand grip strength (left)	0.6	1.7	5.1	0.9	2.3	0.9	-0.9	-0.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.6	-1.2	-0.7	-0.5	-0.9
Waist circumference	0.6	2.0	8.0	-0.5	-0.1	1.4	0.3	-2.8
Heart attack	0.6	0.8	2.4	0.4	-1.6	-0.8	-0.5	-0.7
Hair/balding pattern: Pattern 3	0.6	1.0	1.6	1.1	1.3	-1.1	0.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	-0.1	0.8	1.0	-0.5	-1.4
Medication: Lansoprazole	0.6	0.7	1.3	-1.0	-0.9	-1.1	-0.2	0.1
Birth weight of first child	0.6	1.2	2.7	1.7	1.5	-0.9	0.1	0.4
Suffer from ‘nerves’	0.6	1.0	3.4	-0.4	-0.4	-1.8	-0.2	1.1
Smoking status: Previous	0.6	0.9	1.7	-1.3	-0.4	-1.1	-1.0	-0.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	1.4	0.9	0.5	0.2	-0.6
Mood swings	0.6	1.0	4.2	-0.5	-2.0	0.4	-0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.2	-1.1	-1.5	-0.7	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.7	-0.3	1.3	-0.3	-1.3	0.3
Average weekly beer plus cider intake	0.6	0.8	1.7	-1.0	-0.9	-1.3	0.5	0.5
Fractured/broken bones in last 5 years	0.6	0.8	1.6	-1.0	-0.2	-1.3	-0.4	-1.2
Depression (Nagel 2018)	0.5	0.7	1.3	1.1	-0.2	1.1	0.7	0.8
Worry (Nagel 2018)	0.5	1.1	3.0	0.6	-1.7	-0.9	0.1	1.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	-0.5	1.2	-0.9	-0.8	-0.3
Ulcerative Colitis (UC)	0.5	1.0	1.8	1.3	0.9	1.4	0.6	0.0
Reaction Time	0.5	1.0	1.6	-0.1	-1.3	1.1	1.1	-0.9
Lupus	0.5	0.7	2.3	-0.2	-1.0	1.5	0.4	0.4
Blood Eosinophil Count	0.5	3.6	11.8	1.6	-0.7	3.4	1.8	0.3
Number of treatments/medications taken	0.5	0.9	2.0	-1.4	-0.4	1.4	-0.3	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	0.3	-1.2	0.6	-0.3	-1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	0.7	-1.0	1.1	-0.3	-0.8
Hand grip strength (right)	0.5	1.4	5.1	0.7	2.3	0.5	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	0.8	-0.9	-0.9	-0.7	-0.5	0.6
Trunk fat mass	0.5	2.2	5.8	0.7	1.4	1.7	-0.3	-2.4
Alcohol usually taken with meals	0.5	0.9	2.4	0.8	0.9	1.5	-0.2	0.7
Allergy	0.5	1.2	3.2	-1.5	-0.8	0.0	-0.3	-1.8
Hip circumference	0.5	2.2	5.7	0.9	1.5	2.4	0.4	-1.5
Father’s age at death	0.5	0.6	2.9	0.2	1.7	0.2	0.0	0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.4	1.6	0.3	1.0	0.8	0.3
Wheeze or whistling in the chest in last year	0.5	0.8	1.5	0.7	-1.2	-0.1	1.1	0.9
Neck or shoulder pain in last month	0.5	0.8	1.5	0.5	-1.0	0.8	1.2	-0.6
Migraine (self-reported)	0.5	0.6	1.3	-0.5	1.1	0.1	-0.2	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.5	-1.3	0.7	0.9	0.2
Had major operations	0.5	0.6	2.2	-0.5	-0.5	-1.5	-0.3	0.2
Family relationship satisfaction	0.5	0.6	2.4	-0.3	0.6	1.5	0.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	-0.5	0.8	-1.1	-0.5	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	-0.2	1.1	-0.5	-0.4	-1.1
Friendships satisfaction	0.5	0.6	2.4	0.0	-0.6	1.5	0.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.4	-0.3	0.1	1.5	-0.4	0.7
Average weekly champagne plus white wine intake	0.5	0.7	2.2	-0.3	0.5	1.0	1.5	0.2
Guilty feelings	0.5	0.8	2.2	1.0	-1.5	0.1	-0.7	0.5
Commuting to job workplace: Public transport	0.5	0.6	1.3	-1.0	-0.1	0.4	-1.1	-0.8
Medication: Blood pressure	0.5	0.9	2.5	0.0	-0.8	-1.6	0.6	0.9
Medication: Paracetamol	0.5	0.7	1.9	-0.2	-1.2	0.2	0.2	1.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.7	0.6	1.6	1.6	-0.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	0.6	-1.4	-0.4	-0.5	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	1.1	-1.2	1.0	0.4	0.6
Coronary Artery Disease (CAD)	0.4	0.5	2.1	0.2	0.4	-1.5	-0.1	0.4
Crohns Disease (2012)	0.4	0.6	1.2	-1.0	-1.0	0.2	1.1	-0.0
Lung FEV1/FVC ratio	0.4	2.1	6.7	1.1	-0.7	0.4	2.6	1.5
Neuroticism	0.4	0.9	2.3	1.5	-1.1	-0.2	-0.4	0.9
High blood pressure	0.4	1.2	3.0	-0.6	-1.3	-1.7	0.3	0.8
Medication: Atenolol	0.4	0.6	1.9	0.3	-0.8	-1.4	0.3	0.4
Medication: Levothyroxine sodium	0.4	0.6	2.0	0.2	0.7	1.4	0.3	-0.6
Prospective memory result	0.4	0.5	1.1	0.5	-1.1	0.3	1.0	0.3
Lung cancer (father)	0.4	0.5	0.9	0.6	0.9	-0.9	-0.5	-0.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.4	1.2	-0.3	-0.5	0.7	0.1
Impedance of arm (left)	0.4	1.7	4.2	-0.1	0.1	-2.1	-2.0	0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.0	-1.4	0.7	-0.1	-0.3	0.2
Worry too long after embarrassment	0.4	0.6	1.2	1.1	-0.8	0.4	0.3	1.1
Age at first live birth	0.4	0.7	1.5	1.2	0.7	1.1	0.3	-0.1
Qualifications: College or University degree	0.4	1.2	3.6	1.4	0.1	0.4	1.9	0.4
Whole body fat mass	0.4	1.5	4.5	0.6	0.8	1.5	0.2	-2.1
Alcohol intake frequency.	0.4	0.9	2.4	0.4	-0.8	1.0	0.3	-1.5
Hypertension (Self-reported)	0.4	1.1	2.4	-0.6	-1.3	-1.5	0.4	0.9
Illnesses of siblings: Diabetes	0.4	0.6	2.1	0.7	1.4	-0.1	-0.5	0.0
Qualifications: nursing, teaching	0.4	0.7	1.5	1.2	0.7	-0.5	0.7	0.8
Medication: Gliclazide	0.4	0.4	1.2	-0.0	-0.4	0.6	1.1	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.5	1.1	0.8	-0.4	-0.4
Cholesterol lowering medication	0.4	0.5	1.4	-0.4	-1.2	0.3	-0.2	-0.9
Alzheimer’s Disease (in father)	0.3	0.3	1.0	0.3	0.5	-1.0	-0.1	0.2
Crohns Disease (2017)	0.3	0.7	2.3	-0.4	-1.5	0.4	0.8	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.0	0.9	-0.3	-0.2	1.4	0.6
Bipolar Disorder (2011)	0.3	0.3	1.0	0.0	0.0	0.0	-1.0	0.6
Body Mass Index (BMI) (2010)	0.3	0.5	1.4	0.5	-0.2	0.8	1.2	0.2
Systolic Blood Pressure	0.3	1.5	5.0	-2.2	-0.7	-1.3	-0.4	0.5
Systolic blood pressure, automated reading	0.3	1.0	3.0	0.0	-0.5	-1.7	0.7	1.0
Medication: Metformin	0.3	0.4	0.6	-0.5	-0.7	-0.7	-0.4	-0.7
Fed-up feelings	0.3	0.6	2.4	-0.0	-1.5	0.3	-0.6	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.8	-0.4	-0.9	-0.6	-0.3	-0.5
Relative age voice broke	0.3	0.5	0.8	-0.5	-0.9	-0.9	-0.0	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.3	-0.8	0.3	-0.6	-1.1
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.6	-0.7	0.3	-0.5	-1.0
Pain all over the body in last month	0.3	0.4	1.3	-0.6	-0.3	-1.1	-0.3	0.1
Time employed in main current job	0.3	0.3	0.8	0.9	0.4	-0.3	0.0	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	-0.7	-1.3	0.1	-0.3	-1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.8	-0.4	-0.0	-1.3	0.1	0.8
Arm fat mass (right)	0.3	1.4	4.3	0.5	0.5	1.5	0.1	-2.1
Length of working week for main job	0.3	0.4	1.0	1.0	-0.1	-0.8	0.4	-0.3
Exposure to tobacco smoke at home	0.3	0.4	1.4	0.5	0.3	-1.2	-0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	0.5	-1.3	0.2	0.8	-0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.9	0.7	0.3	-0.6	-0.4
Medication: Paracetamol	0.3	0.5	1.2	-0.4	-0.6	-0.8	-0.5	1.1
Headache pain in last month	0.3	0.6	2.0	0.7	0.2	1.4	0.4	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.7	-0.1	0.9	1.3	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	-1.2	0.3	-0.2	-0.5	-0.2
Leg fat percentage (right)	0.3	0.9	3.0	0.4	-1.0	0.2	1.7	-0.7
Emphysema/chronic bronchitis	0.3	0.3	0.8	0.6	0.9	0.7	-0.1	0.2
Leg fat mass (right)	0.3	1.2	2.8	0.6	0.1	1.4	1.0	-1.7
Chest pain or discomfort	0.3	0.4	0.7	0.6	-0.1	0.8	0.7	0.6
Supplements: Vitamin C	0.3	0.4	1.0	0.4	1.0	0.1	-0.6	-0.7
Knee pain experienced in last month	0.3	0.4	1.4	0.2	-0.2	-0.4	-0.8	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	0.1	0.9	-0.3	-0.0	1.1
Commuting to job workplace: Walk	0.3	0.4	1.3	-1.1	0.3	-0.5	0.1	0.3
Breast cancer (self-reported)	0.3	0.3	1.0	-1.0	-0.8	-0.1	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.4	-0.8	1.2	0.2	-0.6	0.4
Arm fat mass (left)	0.3	1.3	3.8	0.5	0.9	1.3	0.0	-1.9
Eye problems/disorders: Glaucoma	0.3	0.4	1.4	0.2	0.5	1.2	-0.3	0.1
Number of operations (self-reported)	0.3	0.4	1.8	0.5	-1.3	0.3	0.4	-0.2
Diastolic blood pressure, automated reading	0.3	0.9	3.4	-0.3	-0.2	-1.8	0.2	1.0
Ever depressed for a whole week	0.3	0.4	1.1	-0.3	-0.5	1.1	-0.6	-0.1
Supplements: Calcium	0.3	0.3	0.4	-0.6	0.6	0.6	-0.3	-0.6
Heart disease (siblings)	0.3	0.4	1.4	-0.1	0.4	-1.2	-0.5	0.3
Leg fat mass (left)	0.3	1.3	3.1	0.6	0.1	1.4	1.0	-1.8
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	0.7	-0.2	1.1	0.8	0.3
Fasting Glucose	0.2	0.3	0.5	-0.5	-0.7	0.7	0.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.4	-0.6	-0.3	-0.9	-0.6
Relative age of first facial hair	0.2	0.3	1.0	-0.2	0.5	-0.5	-1.0	0.2
Diabetes (mother)	0.2	0.3	0.7	0.1	0.8	0.8	-0.2	0.1
Trunk fat percentage	0.2	0.9	3.9	0.2	0.6	0.2	-0.3	-2.0
Maternal smoking around birth	0.2	0.2	0.4	-0.3	-0.6	0.3	0.6	-0.5
Taking other prescription medications	0.2	0.4	0.9	0.1	-0.9	0.9	-0.0	-0.3
Supplements: Glucosamine	0.2	0.3	0.5	0.7	0.7	0.5	0.1	0.4
Body mass index (BMI)	0.2	0.8	2.6	0.1	-0.4	0.5	1.0	-1.6
Diabetes (self-reported)	0.2	0.3	0.7	0.2	-0.9	0.9	0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	0.5	-0.1	0.9	0.2	-0.1
Impedance of arm (right)	0.2	1.2	2.7	-0.2	-0.4	-1.6	-1.6	0.5
Falls in the last year	0.2	0.3	0.6	0.6	-0.4	0.2	0.3	-0.8
Noisy workplace	0.2	0.2	0.4	0.5	-0.1	-0.7	0.6	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.1	-0.0	-1.0	-0.5	0.3
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.3	0.6	0.7	-0.3	0.5
Body fat percentage	0.2	0.6	2.9	0.2	0.0	-0.1	0.2	-1.7
Number of children fathered	0.2	0.2	0.7	-0.1	0.5	0.3	0.0	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.6	0.1	0.8	0.2	0.4
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.4	-0.7	0.4	0.3	-0.8
Medication for cholesterol	0.2	0.4	0.7	0.8	0.2	0.4	0.8	0.6
Mineral and other dietary supplements	0.2	0.2	0.8	0.0	-0.1	-0.9	0.3	-0.4
Medication: Aspirin	0.2	0.3	0.7	0.9	0.0	0.8	0.2	0.1
Medication: Atorvastatin	0.2	0.2	0.6	0.8	-0.2	-0.5	-0.1	0.4
Leg fat percentage (left)	0.2	0.9	2.5	0.2	-0.9	0.2	1.6	-1.0
Myopia	0.2	0.3	0.7	0.2	-0.8	0.4	-0.1	-0.8
Pack years of smoking	0.2	0.3	1.1	0.3	0.0	-1.0	-0.0	0.4
Impedance of whole body	0.2	1.1	3.1	-0.3	0.0	-1.8	-1.5	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.1	-0.2	-0.0	-0.0	1.0	0.4
Blood White Count	0.1	0.5	1.7	0.1	-1.3	0.4	-0.1	-0.7
BMI	0.1	0.4	1.3	0.4	-0.2	-0.0	0.8	-1.1
Hearing difficulty/problems: Yes	0.1	0.2	1.0	0.3	-1.0	-0.0	-0.2	-0.1
Angina	0.1	0.2	0.5	-0.1	-0.7	-0.2	-0.5	-0.1
Pack years adult smoking proportion	0.1	0.2	0.9	0.2	-0.0	-0.9	-0.2	0.2
Impedance of leg (right)	0.1	0.5	1.5	-0.4	-0.9	-1.2	-0.4	-0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.4	-0.5	-0.1	-0.3	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.3	-0.4	-0.1	-0.4	-0.0
Impedance of leg (left)	0.1	0.7	0.9	-0.8	-0.9	-1.0	-0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.6	0.2	0.1	-0.1	-0.8	-0.2
Qualifications: None of the above	0.1	0.3	0.7	0.4	-0.8	0.8	0.1	0.2
Mouth/teeth dental problems	0.1	0.2	1.0	0.1	0.2	1.0	0.3	0.0
Fluid intelligence score	0.1	0.2	0.6	0.2	0.2	-0.6	0.8	0.3
Arm fat percentage (right)	0.1	0.4	1.6	0.3	-0.3	-0.0	0.5	-1.2
Happiness	0.1	0.1	0.2	-0.2	-0.1	0.1	0.5	0.4
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.5	-0.1	-0.7	-0.3	-0.2
Depression (self-reported)	0.1	0.1	0.3	0.3	-0.1	-0.2	0.6	-0.3
Breastfed as a baby	0.1	0.2	0.4	-0.1	-0.6	0.1	0.1	-0.6
Exposure to tobacco smoke outside home	0.1	0.2	0.7	-0.3	0.2	-0.1	-0.2	-0.9
Angina (self-reported)	0.1	0.1	0.4	0.1	-0.6	-0.2	-0.4	0.1
Leg pain on walking	0.1	0.2	0.3	-0.5	0.1	0.1	-0.6	-0.5
Medication: Aspirin	0.1	0.1	0.2	0.1	0.2	0.5	-0.5	-0.3
Arm fat percentage (left)	0.1	0.3	1.3	0.3	-0.1	-0.4	0.4	-1.1
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.4	0.2
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.2	-0.4	-0.6	0.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.1	0.3	0.6	-0.5	0.2
Alcohol drinker status: Previous	0.1	0.1	0.4	0.3	0.0	-0.1	-0.4	-0.6
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.0	2.5	0.6	0.9	-1.1	-1.6	-0.4
Tanning	0.0	0.1	0.1	-0.4	0.2	0.3	-0.0	0.1
Miserableness	0.0	0.1	0.1	-0.3	-0.1	0.1	0.3	0.2

Hub : Genes

UBE2N

Models

Trait associations