TWAS hub - FGD6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.069	0.0260	2.6e-03	0.005	0.029	0.018	0.031	0.018	6.8e-02	0.00016	2.4e-03	0.00011	2.6e-03
2	GTEx	Artery Aorta	0.186	0.0470	1.0e-06	0.187	NA	0.182	NA	0.194	1.5e-10	NA	2.8e-10	NA	6.2e-11
3	GTEx	Artery Tibial	0.174	0.0469	1.7e-06	0.087	NA	0.087	NA	0.095	2.6e-07	NA	2.6e-07	NA	7.1e-08
4	GTEx	Cells Transformed fibroblasts	0.195	0.0420	8.0e-08	0.225	NA	0.200	NA	0.205	8.5e-17	NA	5.7e-15	NA	2.4e-15
5	GTEx	Heart Atrial Appendage	0.115	0.0480	1.0e-02	-0.006	NA	-0.006	NA	-0.006	7.8e-01	NA	7.9e-01	NA	8.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Lung FEV1/FVC ratio	10.0	50.7	100.0	-5.1	-10.0	-8.6	-7.3
Illnesses of father: Heart disease	9.1	12.6	18.9	3.4	4.1	4.3	4.0
Coronary Artery Disease (CAD)	6.2	7.4	13.0	1.1	3.6	3.3	3.5
Heart disease (mother)	4.5	5.4	10.0	0.4	2.9	2.9	3.2
Illnesses of father: None of the above (group 1)	4.4	5.4	10.4	-1.8	-3.2	-3.1	-1.9
Ovarian Cancer	4.1	5.5	12.8	0.6	-2.8	-2.6	-3.6
Illnesses of mother	3.3	4.1	10.0	-0.1	-2.9	-3.2	-1.5
Heart attack	3.2	4.1	8.1	-2.8	2.0	2.0	2.2
Breast cancer (self-reported)	3.2	3.8	8.3	-0.2	1.9	2.7	2.9
Father’s age at death	3.1	4.2	9.6	-3.1	-2.3	-1.5	-1.9
Heart attack/myocardial infarction (self-reported)	2.9	3.7	6.2	-2.5	1.9	1.8	2.4
Time employed in main current job	2.8	3.3	8.4	-1.2	2.0	2.9	1.5
Exposure to tobacco smoke at home	2.5	2.8	6.3	-1.3	1.3	2.1	2.5
Blood Platelet Count	2.4	28.0	64.3	-4.5	-5.8	-4.7	-8.0
Systolic blood pressure, automated reading	2.4	7.1	15.9	-0.6	4.0	3.6	2.4
Medication: Paracetamol	2.2	3.6	8.5	-1.5	-2.9	-1.8	-2.1
Age started oral contraceptive pill	2.2	2.7	4.9	1.1	2.2	1.7	2.2
Medication: Co-codamol	2.0	2.3	4.4	-0.9	-2.1	-1.9	-1.6
Pain all over the body in last month	2.0	2.2	5.8	0.4	-2.4	-2.1	-0.6
Angina (self-reported)	2.0	2.6	8.3	-0.3	1.4	1.7	2.9
Eye problems/disorders: Cataract	2.0	2.3	5.6	-0.0	2.0	2.4	1.5
Heart disease (siblings)	2.0	2.4	5.4	2.2	0.9	0.9	2.3
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.6	-1.4	1.3	2.2	1.2
Supplements: Glucosamine	1.7	2.2	3.6	1.7	1.8	1.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	6.6	-2.3	-2.6	-1.9	-1.7
Hearing aid user	1.7	1.9	3.5	1.6	1.6	0.9	1.9
Alcohol intake frequency.	1.6	3.7	7.3	-1.1	-2.7	-2.7	-1.6
Diabetes (father)	1.5	1.8	2.7	-1.5	-1.6	-1.2	-1.6
Medication: Ramipril	1.5	1.9	4.7	1.1	1.2	1.4	2.2
Fluid intelligence score	1.5	3.2	9.7	3.1	-1.2	-1.8	-1.2
Noisy workplace	1.5	1.8	4.0	-1.5	2.0	1.6	0.6
Eye problems/disorders: Glaucoma	1.5	1.7	4.4	0.1	-2.1	-1.7	-1.3
Ulcerative Colitis	1.4	2.1	5.5	-0.1	-1.4	-1.8	-2.3
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.4	1.3	-1.6	-1.8	-1.6
Angina	1.4	1.8	6.1	-0.3	1.0	1.3	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.8	0.7	-1.7	-2.2	-1.0
Hearing difficulty/problems with background noise	1.4	2.2	3.8	1.7	2.0	1.6	1.3
Number of full brothers	1.4	1.8	5.8	-0.0	-1.0	-1.4	-2.4
Long-standing illness, disability or infirmity	1.4	2.1	4.5	0.2	2.1	2.1	1.1
Fractured/broken bones in last 5 years	1.4	1.8	3.1	0.7	1.7	1.8	1.7
Alcohol drinker status: Previous	1.4	1.6	4.2	-0.8	-1.4	-1.0	-2.0
Systolic Blood Pressure	1.3	6.5	15.8	-0.7	4.0	3.3	2.3
Nervous feelings	1.3	2.4	8.6	2.9	1.2	0.5	1.3
Medication: Aspirin	1.3	1.7	5.5	-2.3	0.7	1.4	0.4
Risk taking	1.3	1.8	4.2	1.4	2.0	1.7	0.6
Cholesterol lowering medication	1.3	2.0	4.5	0.6	1.9	2.1	1.2
Depression (Nagel 2018)	1.2	1.8	5.4	0.3	-1.4	-2.3	-1.2
Medication: Atenolol	1.2	1.5	7.1	-2.7	-0.1	0.4	0.3
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.6	-1.5	-1.0	-1.6	-1.0
Ever had bowel cancer screening	1.2	1.3	3.0	0.2	1.7	1.4	1.3
Blood White Count	1.1	8.0	19.3	-1.1	-3.2	-3.0	-4.4
Current tobacco smoking	1.1	1.8	4.4	0.2	-2.1	-2.0	-0.9
Alcohol intake versus 10 years previously	1.1	1.7	3.5	-0.5	-1.9	-1.5	-1.6
Pulse wave reflection index	1.1	1.4	2.3	-1.4	1.5	1.4	0.7
Loud music exposure frequency	1.1	1.3	3.2	-0.1	1.6	1.8	0.7
Medication: Ibuprofen	1.1	1.3	4.8	2.2	0.3	0.7	1.1
Number of full sisters	1.1	1.3	3.5	-0.0	1.7	1.9	0.3
Medication: Aspirin	1.1	1.4	5.1	-2.3	0.5	1.4	0.2
Medication: Blood pressure	1.1	2.1	4.4	0.1	1.9	2.1	1.6
Alzheimer’s Disease (in mother)	1.0	1.1	3.0	-0.9	-1.7	-1.3	-0.6
Verbal and Numeric Reasoning (VNR)	1.0	2.3	11.2	3.3	0.5	-0.3	0.1
Pack years adult smoking proportion	1.0	1.5	4.2	-2.0	-1.5	-0.9	-0.4
Hair/balding pattern: Pattern 2	1.0	1.3	3.6	0.2	-1.1	-1.2	-1.9
Age at first live birth	1.0	1.7	6.4	2.5	0.6	0.6	1.3
Average weekly champagne plus white wine intake	1.0	1.3	2.6	0.5	-1.6	-1.5	-1.2
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.1	-0.2	1.4	1.3	1.5
Commuting to job workplace: Public transport	1.0	1.2	3.5	0.9	0.8	1.1	1.9
Illnesses of father: High blood pressure	1.0	1.3	2.8	-0.6	1.1	1.4	1.7
Pack years of smoking	1.0	1.5	3.9	-2.0	-1.5	-1.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.7	1.5	0.8	1.2	1.9
Diabetes (mother)	0.9	1.2	2.3	-1.2	1.0	1.5	1.1
Fed-up feelings	0.9	1.7	4.2	-0.5	-2.0	-1.9	-0.4
Number of live births	0.9	1.3	4.3	-2.1	0.3	0.0	-1.5
Pulse rate	0.9	1.5	3.2	1.2	-1.8	-1.7	-0.3
Hair/balding pattern: Pattern 4	0.9	2.2	5.6	-0.8	1.8	2.4	1.1
Qualifications: College or University degree	0.9	2.9	4.7	2.1	1.7	2.2	1.6
Medication for cholesterol	0.9	1.4	3.0	-0.2	-1.6	-1.7	-1.2
Smoking status: Current	0.9	1.3	3.4	0.2	-1.8	-1.7	-0.6
Waist Hip Ratio (WHR)	0.8	3.5	7.1	0.1	2.4	2.1	2.7
Allergy or Eczema	0.8	2.1	10.3	3.2	0.1	0.0	0.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.9	0.8	1.7	1.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	1.0	1.1	0.4	1.5
Length of working week for main job	0.8	0.9	1.8	0.7	1.3	1.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.1	1.5	1.4	1.4	-0.1
Headache pain in last month	0.8	1.4	4.4	-0.3	-1.0	-1.3	-2.1
High blood pressure (siblings)	0.8	1.1	4.2	-1.0	-0.2	-0.4	-2.0
Exposure to tobacco smoke outside home	0.8	1.1	4.4	-1.0	0.1	-0.2	-2.1
Migraine (self-reported)	0.8	1.0	2.1	0.8	-1.4	-1.5	-0.1
Suffer from ‘nerves’	0.8	1.3	2.7	1.4	1.0	0.9	1.6
Diabetes diagnosed by doctor	0.8	1.3	2.8	1.5	0.8	0.9	1.7
Medication: Paracetamol	0.8	1.2	3.9	-0.6	-2.0	-1.2	-0.6
Medication: Atorvastatin	0.8	1.0	3.1	-1.8	1.1	0.8	0.5
Number of operations (self-reported)	0.8	1.1	3.2	-0.6	-1.8	-1.4	-0.5
Irritability	0.8	1.3	3.1	-0.5	-1.8	-1.8	-0.3
Supplements: Calcium	0.8	0.9	3.2	-1.8	-0.8	-0.5	-0.6
Worry (Nagel 2018)	0.7	1.4	4.2	2.1	1.2	0.2	1.1
Alzheimer’s Disease (in father)	0.7	0.8	1.8	-0.5	-0.8	-1.3	-1.0
Cardiovascular Disease	0.7	2.2	4.3	-2.1	1.7	1.8	0.9
Townsend deprivation index at recruitment	0.7	1.0	4.5	-2.1	-0.2	-0.0	-0.5
Maternal smoking around birth	0.7	1.0	3.0	-1.2	-0.5	-0.5	-1.7
Serious illness, injury or assault to yourself	0.7	0.8	2.0	0.2	1.4	1.1	1.0
Multivitamins +/- minerals	0.7	0.9	2.7	0.8	-0.5	-0.8	-1.6
Medication: Levothyroxine sodium	0.7	1.2	3.1	-0.5	1.8	1.6	-0.4
Had menopause	0.7	0.8	3.4	-1.8	-0.7	0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.2	0.7	-1.5	-1.4	-0.9
Lung cancer (father)	0.7	0.9	2.6	-0.1	-1.3	-1.6	0.1
Tense / ‘highly strung’	0.7	1.2	5.5	2.3	0.4	-0.3	0.5
Number of children fathered	0.7	0.8	1.7	1.3	-0.7	-0.7	1.1
Osteoporosis (self-reported)	0.7	0.8	1.6	-1.0	-1.0	-1.3	-0.8
Miserableness	0.7	1.2	2.5	1.1	-1.4	-1.6	-0.5
Guilty feelings	0.7	1.0	1.7	1.3	-0.5	-1.3	-1.3
Mother’s age at death	0.7	0.9	3.3	-0.5	-1.8	-0.9	-0.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.9	-1.7	0.5	0.7	-0.6
Basal cell carcinoma (self-reported)	0.7	0.8	1.7	1.2	1.3	1.0	0.4
Intelligence (Savage-Jansen 2018)	0.6	2.0	8.8	3.0	0.6	-0.2	0.8
Neuroticism (2016)	0.6	0.8	2.5	0.6	1.6	1.0	0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	0.1	0.8	0.8	1.4
Severe depression (siblings)	0.6	0.7	2.2	-0.3	-0.5	-0.9	-1.5
Stomach or abdominal pain in last month	0.6	0.7	1.5	0.8	1.2	1.2	-0.1
High blood pressure (mother)	0.6	0.8	2.0	0.0	1.3	1.4	-0.6
Qualifications: None of the above	0.6	1.3	2.5	-1.6	-1.1	-1.3	-1.1
Diabetes (self-reported)	0.6	1.0	3.1	1.7	0.4	0.2	1.3
Birth weight of first child	0.6	1.1	4.1	-2.0	0.3	0.5	-1.1
Peak expiratory flow (PEF)	0.6	1.3	5.0	-2.2	-0.3	0.5	-1.1
Medication for pain relief, constipation, heartburn	0.6	1.0	3.3	0.4	1.8	1.0	0.6
Medication: Blood pressure	0.6	1.0	4.3	-2.1	-0.8	-0.4	-0.3
Age at last live birth	0.6	0.9	4.1	2.0	-0.2	-0.6	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	-0.1	1.0	1.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.1	1.0	1.0	0.9	0.8
Depressed Affect (Nagel 2018)	0.5	1.1	2.6	1.0	-1.4	-1.6	-0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	-0.6	-1.1	-1.3	-0.2
Ulcerative Colitis (UC)	0.5	1.0	4.1	-0.4	-0.6	-0.6	-2.0
Major Depression (MDD)	0.5	0.6	2.7	1.6	-0.3	-0.3	-0.3
Triglycerides	0.5	0.8	3.7	-1.9	-0.3	-0.1	0.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-1.2	-0.9	-0.8	-0.1
Vitamin and mineral supplements	0.5	0.7	2.0	-1.2	0.1	0.4	1.4
Trunk fat percentage	0.5	1.9	3.8	0.3	1.7	1.9	1.6
Relative age voice broke	0.5	0.7	2.2	-0.2	-1.5	-1.2	-0.2
Hayfever, allergic rhinitis or eczema	0.5	1.0	4.8	2.2	-0.2	-0.3	-0.6
Allergy	0.5	1.1	5.0	-2.2	0.1	0.4	0.7
Medication: Simvastatin	0.5	0.7	1.4	-0.1	1.0	1.2	1.2
Falls in the last year	0.5	0.6	1.7	-0.1	-0.4	-1.2	-1.3
Prospective memory result	0.5	0.7	1.1	-1.1	-0.9	-1.0	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.4	1.9	-0.6	-0.3	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.3	-0.2	-1.0	-1.1	-0.7
Blood clot in the leg (DVT)	0.5	0.7	1.4	1.2	0.9	0.7	0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.8	1.9	0.2	0.0	-0.1
Birth weight	0.5	1.1	3.1	0.2	-1.8	-1.5	-0.6
Shortness of breath walking on level ground	0.5	0.6	1.6	-1.3	0.6	0.4	-1.0
Pulse rate, automated reading	0.5	1.7	3.9	-0.2	-1.4	-1.6	-2.0
Qualifications: nursing, teaching	0.5	0.8	3.5	1.9	0.4	0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	1.2	-0.1	0.2	1.2
Back pain experienced in last month	0.5	0.7	2.0	1.4	1.1	0.7	-0.1
Medication: Bendroflumethiazide	0.5	0.8	1.9	-1.4	0.8	1.0	-0.5
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.9	0.9	1.2	0.4
Myopia	0.5	0.7	3.5	1.9	-0.1	-0.1	0.2
HbA1C	0.4	0.5	1.3	0.4	-0.4	-1.1	-0.9
Neuroticism	0.4	0.9	2.7	1.7	-0.2	-1.3	-0.2
Medication: Metformin	0.4	0.6	1.7	-0.2	0.6	1.0	1.3
Hand grip strength (right)	0.4	1.0	1.9	1.4	1.1	1.1	1.0
Average weekly fortified wine intake	0.4	0.5	1.3	-0.1	0.8	0.6	1.2
Taking other prescription medications	0.4	0.6	2.2	0.4	-0.2	-0.7	-1.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	-0.1	-1.2	-0.7	0.6
Number of incorrect matches in round	0.4	0.6	1.9	0.6	-1.0	-1.4	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.6	0.2	-0.5	-1.1	-1.6
Impedance of arm (right)	0.4	1.6	3.6	1.9	1.3	0.2	1.7
Medication: Cholesterol lowering	0.4	0.5	2.0	-0.7	-0.3	-0.4	1.4
Depression (self-reported)	0.4	0.5	2.0	1.4	-0.2	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.5	-1.2	-1.9	-0.8	-1.2
Impedance of arm (left)	0.4	1.7	3.3	1.6	1.5	0.5	1.8
Glaucoma (self-reported)	0.4	0.5	1.0	-0.3	-1.0	-0.7	-1.0
Gout (self-reported)	0.4	0.5	2.0	-0.3	-1.4	-0.6	0.1
Medication: Amlodipine	0.4	0.5	2.3	-1.5	0.0	0.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	2.0	1.4	0.6	0.6	-0.2
Health satisfaction	0.4	0.5	1.1	1.0	0.5	0.6	1.0
Family relationship satisfaction	0.4	0.5	1.2	1.1	-0.3	-0.6	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	0.0	0.5	0.2	-1.5
Knee pain experienced in last month	0.4	0.6	1.7	0.5	0.8	1.3	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	-0.8	-1.0	-0.7	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.2	1.5	-0.6	-0.9	0.3
Osteoarthritis (self-reported)	0.4	0.5	1.6	-0.3	-1.3	-0.9	-0.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.5	-0.5	1.2	1.2	-0.5
Ever taken oral contraceptive pill	0.4	0.4	0.9	-0.1	0.8	0.9	-0.8
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	1.6	-0.8	-1.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	1.4	0.6	0.0	0.1
Neuroticism (Nagel 2018)	0.3	0.8	2.7	1.6	-0.1	-1.1	0.3
Age at First Birth	0.3	0.4	1.9	1.4	0.5	0.2	-0.1
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.4	-0.6	-0.8	-0.9
Mean Putamen Volume	0.3	0.3	1.2	1.1	-0.2	-0.0	-0.7
LDL Cholesterol	0.3	0.5	2.3	-1.5	-0.0	-0.3	-0.1
Lupus	0.3	0.5	1.2	-0.8	0.8	1.1	0.3
Smoking Status	0.3	0.8	1.9	1.1	-1.4	-0.9	0.5
Average weekly spirits intake	0.3	0.4	1.7	1.3	-0.3	-0.3	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	-0.5	-0.5	0.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.1	-0.2	-0.2	-0.7	-1.8
High blood pressure	0.3	0.7	2.8	-1.7	0.2	0.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.4	-1.0	-0.7	-0.1
Trunk fat mass	0.3	1.2	2.6	0.4	1.2	1.6	1.4
Waist circumference	0.3	1.2	3.1	0.0	1.2	1.8	1.1
Forced vital capacity (FVC)	0.3	1.1	3.5	0.1	1.1	1.9	1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	0.9	0.3	-0.1	0.8
Worrier / anxious feelings	0.3	0.7	2.0	0.0	-0.7	-1.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.9	1.4	0.4	1.0	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.7	1.3	-0.6	-0.2	-0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	-0.1	1.3	1.2	-0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.3	-0.7	-0.9	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.5	0.7	0.9	0.7
Body fat percentage	0.3	1.1	2.4	0.3	1.4	1.5	1.1
Emphysema/chronic bronchitis	0.3	0.4	1.2	-0.1	-0.7	-1.1	-0.4
Comparative height size at age 10	0.3	1.6	4.5	0.8	-2.1	-1.7	-0.1
Had major operations	0.3	0.3	0.7	-0.6	-0.6	-0.9	-0.1
Hypertension (Self-reported)	0.3	0.8	3.4	-1.8	0.1	0.3	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.7	-1.3	-0.4	0.3	0.4
Mood swings	0.3	0.6	1.2	0.9	-1.1	-1.0	-0.4
Loneliness, isolation	0.3	0.4	1.1	1.0	0.8	0.3	-0.1
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.9	0.1	0.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	0.4	0.7	1.1	0.3
Alcohol drinker status: Never	0.3	0.3	1.0	-0.1	-0.7	-1.0	-0.3
Diastolic blood pressure, automated reading	0.3	0.9	3.0	-1.1	0.4	0.0	-1.7
Impedance of whole body	0.3	1.3	4.9	0.6	1.1	0.5	2.2
Schizophrenia (2018)	0.2	0.4	1.3	-0.6	0.2	-0.7	-1.1
Reaction Time	0.2	0.4	1.5	1.2	0.2	-0.5	0.4
HDL Cholesterol	0.2	0.3	1.6	1.3	0.0	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.4	0.5	0.5	0.6
Blood Eosinophil Count	0.2	1.8	4.8	-1.9	-0.7	-0.1	-2.2
BMI	0.2	1.1	2.7	-0.5	0.7	1.6	1.4
Chronotype (morning person)	0.2	0.4	0.8	-0.9	0.6	0.8	-0.6
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.9	0.1	-0.6	-0.7
Supplements: Zinc	0.2	0.2	0.6	-0.5	0.4	0.8	0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.6	-0.8	0.4	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	1.2	-0.4	-0.4	-0.0
Neuroticism score	0.2	0.4	0.9	1.0	-0.4	-0.9	-0.4
Arm fat percentage (right)	0.2	0.9	1.5	1.0	1.2	1.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.0	-1.4	-1.0	-0.1	-0.6
Happiness	0.2	0.2	0.5	0.2	-0.3	-0.6	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.4	-0.3	-0.0	-0.5	-1.2
Medication: Lansoprazole	0.2	0.2	0.5	-0.3	0.7	0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.9	0.0	0.1	0.9
Comparative body size at age 10	0.2	0.5	0.9	0.9	-0.9	-0.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	-0.1	0.2	0.2	1.0
Pulse wave peak to peak time	0.2	0.2	0.5	0.7	-0.3	-0.2	-0.5
Medication: Omeprazole	0.2	0.2	0.5	0.6	0.7	0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.8	-0.5	-0.5	-0.3
Whole body fat mass	0.2	0.8	2.0	0.2	0.9	1.4	1.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.1	1.0	-0.5	0.0	-0.4
Smoking status: Previous	0.2	0.3	0.8	0.5	0.6	0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	1.1	-0.1	0.4	0.9
Arm fat percentage (left)	0.2	1.0	1.9	1.0	1.3	1.4	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.9	-0.3	-0.2	-0.0	0.9
Friendships satisfaction	0.2	0.2	0.6	0.4	0.8	0.3	-0.4
Financial situation satisfaction	0.2	0.3	0.7	0.7	0.8	-0.3	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.7	-0.0	-0.1	-0.7
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.8	0.7	0.6	0.5
Medication: Lisinopril	0.2	0.2	0.4	-0.5	-0.2	-0.6	0.6
Average weekly beer plus cider intake	0.2	0.2	0.7	-0.5	0.4	0.3	-0.8
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.5	0.3	0.5	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.8	0.3	-0.2	-0.8
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	0.3	0.2	0.1	0.7
Crohns Disease (2017)	0.1	0.3	0.8	-0.3	-0.0	0.9	0.7
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	-0.6	-0.5	0.0	-1.0
Bipolar Disorder (2011)	0.1	0.1	0.5	0.7	-0.2	-0.1	0.4
Fasting Glucose	0.1	0.1	0.1	0.3	0.3	0.3	-0.3
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.2	0.6	0.6	-0.4
Schizophrenia (2014)	0.1	0.2	0.7	-0.5	0.8	-0.1	0.3
Blood Red Count	0.1	0.5	1.9	0.7	0.1	0.0	1.4
Heel T-Score	0.1	0.5	1.8	1.4	-0.0	-0.8	-0.6
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.3	0.4	0.3	-0.9
Respiratory disease	0.1	0.2	0.8	0.9	-0.1	-0.3	-0.5
Tanning	0.1	1.2	5.9	2.4	0.3	-0.1	-0.2
Hand grip strength (left)	0.1	0.4	1.5	1.2	0.4	0.1	0.4
Number of treatments/medications taken	0.1	0.2	0.4	-0.4	0.5	0.6	0.1
Relative age of first facial hair	0.1	0.1	0.6	0.8	0.3	0.2	0.2
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.5	-0.4	-0.0	-0.4
Impedance of leg (right)	0.1	0.6	2.7	-0.6	-0.2	-0.2	1.6
Leg fat-free mass (left)	0.1	0.3	0.8	0.9	0.3	0.8	0.5
Age when periods started (menarche)	0.1	0.2	0.4	-0.4	-0.6	-0.7	-0.6
Sitting height	0.1	0.8	2.7	-0.6	0.3	1.0	1.6
Body mass index (BMI)	0.1	0.4	1.4	-0.3	0.6	1.2	-0.2
Impedance of leg (left)	0.1	0.6	2.5	-0.7	-0.2	-0.3	1.6
Leg predicted mass (left)	0.1	0.4	0.7	0.8	0.3	0.8	0.6
Alcohol usually taken with meals	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.3
Had other major operations	0.1	0.1	0.2	0.2	0.2	0.4	0.2
Financial difficulties in last 2 years	0.1	0.1	0.3	0.5	0.5	0.0	-0.2
Mouth/teeth dental problems	0.1	0.2	0.7	-0.8	0.2	0.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	0.7	0.4	0.3	0.3
Illnesses of siblings	0.1	0.1	0.3	0.4	-0.4	-0.3	0.6
Weight	0.1	0.4	1.4	0.0	0.5	1.2	0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.7	-0.4	0.1	-0.3	0.8
Asthma	0.1	0.2	1.1	1.1	0.3	0.0	-0.0
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	-0.6	0.2	0.2	0.6
Arm fat mass (right)	0.1	0.4	1.3	0.5	0.7	1.1	0.5
Standing height	0.1	0.8	2.9	1.1	-0.2	0.3	1.7
Breastfed as a baby	0.1	0.1	0.3	0.2	0.3	0.3	0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	1.5	0.6	0.4	1.2	0.9
Worry too long after embarrassment	0.1	0.2	0.9	1.0	0.4	0.2	0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.4	0.4	0.7	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	-0.4	-0.5	-0.3
Medication: Allopurinol	0.1	0.2	0.5	0.3	-0.7	-0.4	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.5
Mean time to correctly identify matches	0.1	0.2	0.4	0.7	0.2	-0.3	0.6
Overall health rating	0.1	0.1	0.6	-0.1	0.8	0.3	-0.1
Chest pain or discomfort	0.1	0.2	0.4	-0.7	-0.6	-0.5	-0.1
Supplements: Vitamin C	0.1	0.2	0.4	-0.2	0.6	0.6	-0.2
Leg fat-free mass (right)	0.1	0.3	0.7	0.8	0.3	0.8	0.5
Average weekly red wine intake	0.1	0.2	0.6	0.3	0.8	0.5	-0.3
Asthma (self-reported)	0.1	0.3	1.2	1.1	0.2	-0.0	-0.1
Medication: Gliclazide	0.1	0.1	0.3	-0.5	0.2	0.0	-0.1
Leg predicted mass (right)	0.1	0.3	0.7	0.8	0.2	0.7	0.5
Arm fat mass (left)	0.1	0.5	1.5	0.5	0.8	1.2	0.5
Ever smoked	0.1	0.2	0.8	-0.2	-0.1	0.9	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.3	0.1	-0.3	-0.5	-0.5
Pain experienced in last month	0.1	0.2	0.3	-0.4	-0.5	-0.6	0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.1	-0.2	-0.3	0.3	0.1
Rheumatoid Arthritis	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.2
Height	0.0	0.5	2.2	0.3	-0.4	0.4	1.5
Lung FVC	0.0	0.2	0.8	0.5	0.2	0.9	-0.2
Hair Pigment	0.0	0.8	2.5	-0.0	1.1	0.5	-1.6
Hearing difficulty/problems: Yes	0.0	0.0	0.1	0.2	-0.0	0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	0.3	-0.1	-0.1	0.4
Past tobacco smoking	0.0	0.1	0.1	-0.3	0.2	-0.4	0.2
Trunk fat-free mass	0.0	0.2	0.7	0.0	-0.8	0.3	-0.2
Hip circumference	0.0	0.2	0.8	0.0	-0.0	0.9	0.3
Trunk predicted mass	0.0	0.2	0.9	0.1	-1.0	0.1	-0.2
Leg fat percentage (right)	0.0	0.1	0.3	-0.3	0.1	0.6	0.3
Arm fat-free mass (right)	0.0	0.2	0.4	-0.2	-0.5	0.6	0.4
Neck or shoulder pain in last month	0.0	0.1	0.1	0.1	-0.0	0.3	-0.4
Leg fat mass (right)	0.0	0.2	0.5	-0.0	0.1	0.7	0.6
Arm predicted mass (right)	0.0	0.1	0.4	0.0	-0.6	0.5	0.3
Leg pain on walking	0.0	0.0	0.1	-0.1	-0.3	-0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.1
Whole body fat-free mass	0.0	0.1	0.3	0.2	-0.4	0.5	0.2
Mineral and other dietary supplements	0.0	0.0	0.2	-0.0	-0.1	-0.4	0.2
Whole body water mass	0.0	0.1	0.3	0.4	-0.4	0.5	0.3
Wears glasses or contact lenses	0.0	0.0	0.1	-0.3	0.1	0.2	-0.2
Basal metabolic rate	0.0	0.1	0.4	0.3	-0.2	0.6	0.3
Leg fat percentage (left)	0.0	0.1	0.2	-0.5	0.0	0.4	0.3
Arm fat-free mass (left)	0.0	0.2	0.3	-0.3	-0.6	0.5	0.3
Ever depressed for a whole week	0.0	0.0	0.2	0.4	0.0	-0.0	-0.2
Leg fat mass (left)	0.0	0.1	0.4	-0.1	0.1	0.6	0.5
Arm predicted mass (left)	0.0	0.2	0.3	-0.3	-0.5	0.6	0.4

Hub : Genes

FGD6

Models

Trait associations