[Hub]/) : Traits : Blood Platelet Count :

chr2:42,296,221-44,690,514

Best TWAS P=3.85e-58 · Best GWAS P=1.52e-66 conditioned to 4.35e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial PLEKHH2 0.49 0.17 enet 48 0.29 2.6e-23 -0.489 -6.4 2.1e-10 0.42 1.00 0.00 FALSE
2 GTEx Nerve Tibial ZFP36L2 0.06 0.00 lasso 8 0.01 3.5e-02 -16.029 13.6 7.9e-42 -0.80 0.09 0.66 TRUE
3 GTEx Stomach AC010883.5 0.16 0.07 lasso 6 0.07 2.4e-04 7.238 -5.8 7.1e-09 0.15 0.32 0.06 TRUE
4 GTEx Testis HAAO 0.30 0.08 lasso 6 0.12 5.0e-06 -1.701 5.5 3.7e-08 -0.07 0.76 0.02 FALSE
5 GTEx Thyroid AC010883.5 0.11 0.09 lasso 2 0.08 1.5e-06 -16.159 -16.1 3.9e-58 0.81 0.89 0.08 TRUE
6 GTEx Vagina ZFP36L2 0.32 0.08 enet 27 0.14 4.7e-04 -11.857 7.3 2.1e-13 -0.40 0.08 0.06 FALSE
7 METSIM Adipose AC016735.2 0.05 0.00 bslmm 466 0.01 3.0e-03 0.051 -10.8 2.7e-27 0.38 0.06 0.09 FALSE
8 The Cancer Genome Atlas Lung Adenocarcinoma ZFP36L2 0.03 0.01 blup 38 0.01 1.1e-02 -6.265 13.0 8.7e-39 -0.67 0.02 0.55 FALSE
9 The Cancer Genome Atlas Prostate Adenocarcinoma PLEKHH2 0.09 0.01 blup 127 0.05 1.1e-05 0.958 5.9 3.7e-09 -0.31 0.05 0.17 FALSE