Best TWAS P=3.85e-58 · Best GWAS P=1.52e-66 conditioned to 4.35e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PLEKHH2 | 0.49 | 0.17 | enet | 48 | 0.29 | 2.6e-23 | -0.489 | -6.4 | 2.1e-10 | 0.42 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Nerve Tibial | ZFP36L2 | 0.06 | 0.00 | lasso | 8 | 0.01 | 3.5e-02 | -16.029 | 13.6 | 7.9e-42 | -0.80 | 0.09 | 0.66 | TRUE |
| 3 | GTEx | Stomach | AC010883.5 | 0.16 | 0.07 | lasso | 6 | 0.07 | 2.4e-04 | 7.238 | -5.8 | 7.1e-09 | 0.15 | 0.32 | 0.06 | TRUE |
| 4 | GTEx | Testis | HAAO | 0.30 | 0.08 | lasso | 6 | 0.12 | 5.0e-06 | -1.701 | 5.5 | 3.7e-08 | -0.07 | 0.76 | 0.02 | FALSE |
| 5 | GTEx | Thyroid | AC010883.5 | 0.11 | 0.09 | lasso | 2 | 0.08 | 1.5e-06 | -16.159 | -16.1 | 3.9e-58 | 0.81 | 0.89 | 0.08 | TRUE |
| 6 | GTEx | Vagina | ZFP36L2 | 0.32 | 0.08 | enet | 27 | 0.14 | 4.7e-04 | -11.857 | 7.3 | 2.1e-13 | -0.40 | 0.08 | 0.06 | FALSE |
| 7 | METSIM | Adipose | AC016735.2 | 0.05 | 0.00 | bslmm | 466 | 0.01 | 3.0e-03 | 0.051 | -10.8 | 2.7e-27 | 0.38 | 0.06 | 0.09 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZFP36L2 | 0.03 | 0.01 | blup | 38 | 0.01 | 1.1e-02 | -6.265 | 13.0 | 8.7e-39 | -0.67 | 0.02 | 0.55 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLEKHH2 | 0.09 | 0.01 | blup | 127 | 0.05 | 1.1e-05 | 0.958 | 5.9 | 3.7e-09 | -0.31 | 0.05 | 0.17 | FALSE |