Best TWAS P=3.76e-15 · Best GWAS P=3.81e-23 conditioned to 4.14e-21
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | QPCT | 0.19 | 0.04 | lasso | 10 | 0.07 | 5.7e-06 | 2.0 | 5.1 | 2.9e-07 | -0.02 | 0.96 | 0.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | GPATCH11 | 0.11 | 0.08 | lasso | 2 | 0.05 | 2.0e-04 | -6.1 | 6.6 | 3.2e-11 | -0.05 | 0.45 | 0.26 | FALSE |
| 3 | GTEx | Esophagus Muscularis | STRN | 0.19 | 0.03 | lasso | 5 | 0.01 | 4.0e-02 | 7.4 | 7.9 | 3.8e-15 | -0.02 | 0.01 | 0.98 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CEBPZ | 0.14 | 0.07 | bslmm | 479 | 0.09 | 1.7e-11 | 5.0 | 6.0 | 2.7e-09 | -0.09 | 1.00 | 0.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CDC42EP3 | 0.07 | 0.01 | enet | 13 | 0.04 | 1.0e-05 | -3.0 | -5.3 | 8.9e-08 | -0.07 | 0.74 | 0.01 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC75 | 0.02 | 0.01 | blup | 32 | 0.01 | 3.3e-03 | -6.1 | 6.1 | 1.4e-09 | -0.05 | 0.01 | 0.66 | TRUE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC75 | 0.12 | -0.01 | blup | 32 | 0.06 | 5.3e-03 | 7.3 | 5.6 | 2.7e-08 | -0.07 | 0.01 | 0.16 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | QPCT | 0.08 | 0.02 | blup | 65 | 0.05 | 2.0e-06 | 4.9 | 5.3 | 9.7e-08 | -0.08 | 0.02 | 0.92 | FALSE |