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chr16:74,578,110-76,197,034

Best TWAS P=9.68e-20 · Best GWAS P=4.13e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adrenal Gland	TMEM170A	0.11	0.06	enet	4	0.04	1.7e-02	-9.1	9.1	9.7e-20	-0.98	0.02	0.92	TRUE
5	GTEx	Artery Aorta	BCAR1	0.18	0.13	lasso	3	0.11	9.8e-07	-9.1	8.9	6.4e-19	-0.98	0.02	0.98	FALSE
13	GTEx	Esophagus Mucosa	BCAR1	0.16	0.13	lasso	8	0.14	1.8e-09	-9.1	-8.9	7.1e-19	0.96	0.02	0.98	FALSE
6	GTEx	Artery Tibial	BCAR1	0.07	0.06	lasso	1	0.04	2.4e-04	-8.8	8.8	1.0e-18	-0.99	0.03	0.96	FALSE
15	GTEx	Nerve Tibial	TMEM170A	0.12	0.09	enet	7	0.11	4.1e-08	-6.4	-8.7	4.6e-18	0.87	0.12	0.88	FALSE
8	GTEx	Brain Cerebellum	CFDP1	0.25	-0.01	lasso	2	0.05	1.7e-02	-9.1	-8.5	1.4e-17	0.81	0.02	0.88	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM170A	0.08	0.10	blup	36	0.13	9.1e-08	-5.7	-8.4	2.8e-17	0.90	0.02	0.98	FALSE
11	GTEx	Cells Transformed fibroblasts	CFDP1	0.17	0.20	enet	10	0.24	9.9e-18	-8.6	-8.3	1.1e-16	0.96	0.11	0.89	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CFDP1	0.02	0.02	lasso	4	0.02	1.9e-03	-8.4	-8.3	1.4e-16	0.93	0.03	0.85	FALSE
26	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CFDP1	0.10	0.00	blup	70	0.04	1.4e-02	-8.4	-8.1	4.8e-16	0.89	0.02	0.46	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	TMEM170A	0.13	0.07	lasso	3	0.02	6.2e-02	-8.6	-8.1	7.9e-16	0.78	0.04	0.76	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CFDP1	0.08	0.04	lasso	4	0.04	1.6e-05	-8.6	-8.0	1.8e-15	0.93	0.03	0.97	FALSE
17	GTEx	Skin Sun Exposed Lower leg	TMEM170A	0.13	0.08	lasso	5	0.06	1.2e-05	-8.6	7.9	3.2e-15	-0.76	0.04	0.96	FALSE
7	GTEx	Brain Cerebellum	BCAR1	0.18	0.08	enet	12	0.09	1.1e-03	-8.6	-7.6	2.6e-14	0.77	0.05	0.79	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	CFDP1	0.04	0.02	lasso	6	0.03	4.0e-04	-5.0	-7.3	2.6e-13	0.87	0.04	0.95	FALSE
27	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CHST6	0.20	0.08	enet	10	0.10	2.2e-04	-9.1	6.9	5.4e-12	-0.86	0.01	0.92	FALSE
14	GTEx	Nerve Tibial	CFDP1	0.16	0.14	lasso	3	0.12	1.6e-08	-5.5	-6.9	7.1e-12	0.79	0.16	0.84	FALSE
19	METSIM	Adipose	TMEM170A	0.03	0.01	lasso	3	0.02	1.5e-03	-8.6	-6.9	7.1e-12	0.87	0.06	0.93	FALSE
18	GTEx	Thyroid	TMEM170A	0.09	0.02	lasso	4	0.00	4.0e-01	-6.1	-6.4	2.0e-10	0.60	0.08	0.69	FALSE
25	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CFDP1	0.23	0.00	blup	70	0.02	4.2e-02	-4.9	-6.3	2.6e-10	0.65	0.03	0.20	FALSE
9	GTEx	Brain Cortex	CFDP1	0.18	0.07	lasso	3	0.08	3.4e-03	-4.9	-6.1	8.4e-10	0.77	0.04	0.76	FALSE
3	GTEx	Adipose Subcutaneous	TMEM170A	0.11	0.00	lasso	5	0.01	6.7e-02	-6.1	-6.0	1.4e-09	0.79	0.03	0.87	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	CFDP1	0.04	0.03	enet	10	0.03	5.2e-07	-5.5	-5.9	3.5e-09	0.67	0.94	0.06	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	TMEM170A	0.09	0.02	lasso	3	0.05	1.1e-03	-4.7	5.8	6.2e-09	-0.63	0.06	0.86	FALSE
2	GTEx	Adipose Subcutaneous	CFDP1	0.11	0.09	lasso	2	0.09	1.1e-07	-5.5	-5.5	4.2e-08	0.65	0.78	0.21	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CFDP1	0.13	0.07	enet	10	0.10	2.1e-06	-4.9	-5.4	7.7e-08	0.56	0.38	0.34	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	CFDP1	0.31	0.17	lasso	4	0.16	3.0e-06	-4.9	-5.2	1.9e-07	0.61	0.56	0.38	FALSE