Best TWAS P=9.68e-20 · Best GWAS P=4.13e-20 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CFDP1 | 0.08 | 0.04 | lasso | 4 | 0.04 | 1.6e-05 | -8.6 | -8.0 | 1.8e-15 | 0.93 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CFDP1 | 0.11 | 0.09 | lasso | 2 | 0.09 | 1.1e-07 | -5.5 | -5.5 | 4.2e-08 | 0.65 | 0.78 | 0.21 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | TMEM170A | 0.11 | 0.00 | lasso | 5 | 0.01 | 6.7e-02 | -6.1 | -6.0 | 1.4e-09 | 0.79 | 0.03 | 0.87 | FALSE |
| 4 | GTEx | Adrenal Gland | TMEM170A | 0.11 | 0.06 | enet | 4 | 0.04 | 1.7e-02 | -9.1 | 9.1 | 9.7e-20 | -0.98 | 0.02 | 0.92 | TRUE |
| 5 | GTEx | Artery Aorta | BCAR1 | 0.18 | 0.13 | lasso | 3 | 0.11 | 9.8e-07 | -9.1 | 8.9 | 6.4e-19 | -0.98 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Artery Tibial | BCAR1 | 0.07 | 0.06 | lasso | 1 | 0.04 | 2.4e-04 | -8.8 | 8.8 | 1.0e-18 | -0.99 | 0.03 | 0.96 | FALSE |
| 7 | GTEx | Brain Cerebellum | BCAR1 | 0.18 | 0.08 | enet | 12 | 0.09 | 1.1e-03 | -8.6 | -7.6 | 2.6e-14 | 0.77 | 0.05 | 0.79 | FALSE |
| 8 | GTEx | Brain Cerebellum | CFDP1 | 0.25 | -0.01 | lasso | 2 | 0.05 | 1.7e-02 | -9.1 | -8.5 | 1.4e-17 | 0.81 | 0.02 | 0.88 | FALSE |
| 9 | GTEx | Brain Cortex | CFDP1 | 0.18 | 0.07 | lasso | 3 | 0.08 | 3.4e-03 | -4.9 | -6.1 | 8.4e-10 | 0.77 | 0.04 | 0.76 | FALSE |
| 10 | GTEx | Cells EBV-transformed lymphocytes | TMEM170A | 0.13 | 0.07 | lasso | 3 | 0.02 | 6.2e-02 | -8.6 | -8.1 | 7.9e-16 | 0.78 | 0.04 | 0.76 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | CFDP1 | 0.17 | 0.20 | enet | 10 | 0.24 | 9.9e-18 | -8.6 | -8.3 | 1.1e-16 | 0.96 | 0.11 | 0.89 | FALSE |
| 12 | GTEx | Esophagus Gastroesophageal Junction | CFDP1 | 0.31 | 0.17 | lasso | 4 | 0.16 | 3.0e-06 | -4.9 | -5.2 | 1.9e-07 | 0.61 | 0.56 | 0.38 | FALSE |
| 13 | GTEx | Esophagus Mucosa | BCAR1 | 0.16 | 0.13 | lasso | 8 | 0.14 | 1.8e-09 | -9.1 | -8.9 | 7.1e-19 | 0.96 | 0.02 | 0.98 | FALSE |
| 14 | GTEx | Nerve Tibial | CFDP1 | 0.16 | 0.14 | lasso | 3 | 0.12 | 1.6e-08 | -5.5 | -6.9 | 7.1e-12 | 0.79 | 0.16 | 0.84 | FALSE |
| 15 | GTEx | Nerve Tibial | TMEM170A | 0.12 | 0.09 | enet | 7 | 0.11 | 4.1e-08 | -6.4 | -8.7 | 4.6e-18 | 0.87 | 0.12 | 0.88 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM170A | 0.09 | 0.02 | lasso | 3 | 0.05 | 1.1e-03 | -4.7 | 5.8 | 6.2e-09 | -0.63 | 0.06 | 0.86 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | TMEM170A | 0.13 | 0.08 | lasso | 5 | 0.06 | 1.2e-05 | -8.6 | 7.9 | 3.2e-15 | -0.76 | 0.04 | 0.96 | FALSE |
| 18 | GTEx | Thyroid | TMEM170A | 0.09 | 0.02 | lasso | 4 | 0.00 | 4.0e-01 | -6.1 | -6.4 | 2.0e-10 | 0.60 | 0.08 | 0.69 | FALSE |
| 19 | METSIM | Adipose | TMEM170A | 0.03 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | -8.6 | -6.9 | 7.1e-12 | 0.87 | 0.06 | 0.93 | FALSE |
| 20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CFDP1 | 0.04 | 0.03 | enet | 10 | 0.03 | 5.2e-07 | -5.5 | -5.9 | 3.5e-09 | 0.67 | 0.94 | 0.06 | FALSE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CFDP1 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.9e-03 | -8.4 | -8.3 | 1.4e-16 | 0.93 | 0.03 | 0.85 | FALSE |
| 22 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CFDP1 | 0.13 | 0.07 | enet | 10 | 0.10 | 2.1e-06 | -4.9 | -5.4 | 7.7e-08 | 0.56 | 0.38 | 0.34 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TMEM170A | 0.08 | 0.10 | blup | 36 | 0.13 | 9.1e-08 | -5.7 | -8.4 | 2.8e-17 | 0.90 | 0.02 | 0.98 | FALSE |
| 24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CFDP1 | 0.04 | 0.02 | lasso | 6 | 0.03 | 4.0e-04 | -5.0 | -7.3 | 2.6e-13 | 0.87 | 0.04 | 0.95 | FALSE |
| 25 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CFDP1 | 0.23 | 0.00 | blup | 70 | 0.02 | 4.2e-02 | -4.9 | -6.3 | 2.6e-10 | 0.65 | 0.03 | 0.20 | FALSE |
| 26 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CFDP1 | 0.10 | 0.00 | blup | 70 | 0.04 | 1.4e-02 | -8.4 | -8.1 | 4.8e-16 | 0.89 | 0.02 | 0.46 | FALSE |
| 27 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CHST6 | 0.20 | 0.08 | enet | 10 | 0.10 | 2.2e-04 | -9.1 | 6.9 | 5.4e-12 | -0.86 | 0.01 | 0.92 | FALSE |