Best TWAS P=4.74e-28 · Best GWAS P=7.21e-52 conditioned to 5.04e-52
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | GINS2 | 0.21 | 0.01 | enet | 12 | 0.00 | 2.5e-01 | 7.4 | 6.6 | 3.8e-11 | -0.07 | 0.16 | 0.05 | FALSE |
| 2 | GTEx | Thyroid | GINS2 | 0.28 | 0.12 | lasso | 7 | 0.12 | 8.9e-10 | 10.0 | 10.0 | 1.9e-23 | -0.07 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Vagina | RNU1-103P | 0.44 | 0.07 | lasso | 6 | 0.09 | 4.6e-03 | 9.3 | 11.0 | 4.7e-28 | 0.00 | 0.08 | 0.15 | TRUE |
| 4 | YFS | Blood | GINS2 | 0.07 | 0.06 | enet | 18 | 0.07 | 1.3e-22 | 8.5 | 9.3 | 1.5e-20 | -0.03 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GINS2 | 0.02 | 0.03 | lasso | 3 | 0.02 | 4.7e-05 | 9.0 | 9.3 | 1.3e-20 | -0.05 | 0.15 | 0.80 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GINS2 | 0.08 | 0.01 | lasso | 5 | 0.02 | 2.1e-03 | 8.5 | -9.0 | 2.6e-19 | 0.08 | 0.14 | 0.29 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GINS2 | 0.05 | 0.06 | lasso | 2 | 0.05 | 1.4e-05 | 9.2 | 9.9 | 2.8e-23 | -0.02 | 0.12 | 0.87 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | GINS2 | 0.14 | 0.10 | enet | 8 | 0.13 | 7.7e-13 | 9.3 | 10.0 | 2.1e-23 | -0.03 | 0.62 | 0.38 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0182 | 0.03 | 0.00 | blup | 45 | 0.02 | 3.5e-03 | 9.0 | -10.2 | 1.9e-24 | 0.06 | 0.01 | 0.68 | FALSE |