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chr16:87,284,177-90,172,696

Best TWAS P=6.2e-31 · Best GWAS P=2.78e-50 conditioned to 2.24e-26

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Heart Left Ventricle	PIEZO1	0.16	0.00	enet	22	0.01	6.7e-02	-2.53	11.6	6.2e-31	0.43	0.06	0.25	TRUE
2	CommonMind	Brain Pre-frontal Cortex	GALNS	0.14	0.00	bslmm	423	0.04	1.2e-05	-0.37	8.6	5.9e-18	0.04	0.04	0.03	TRUE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTU2	0.10	0.04	blup	66	0.08	1.4e-09	4.44	7.5	7.6e-14	-0.02	0.96	0.02	TRUE
9	GTEx	Cells Transformed fibroblasts	RP5-1142A6.9	0.08	0.07	lasso	4	0.06	2.6e-05	-7.10	7.1	9.1e-13	0.08	0.88	0.04	TRUE
16	GTEx	Testis	BANP	0.26	0.19	lasso	5	0.16	8.9e-08	6.36	6.3	2.2e-10	0.03	0.98	0.00	TRUE
3	GTEx	Adipose Subcutaneous	DEF8	0.11	0.02	enet	16	0.06	1.3e-05	3.63	6.0	1.5e-09	-0.06	0.13	0.46	TRUE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC7A5	0.05	0.05	lasso	2	0.05	5.1e-10	5.96	6.0	2.5e-09	-0.04	0.37	0.63	TRUE
12	GTEx	Heart Left Ventricle	CTU2	0.21	0.04	lasso	5	0.04	2.1e-03	-6.81	10.2	1.3e-24	0.11	0.08	0.06	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CTU2	0.10	0.07	lasso	5	0.08	4.0e-10	-7.21	8.1	4.8e-16	0.06	1.00	0.00	FALSE
10	GTEx	Cells Transformed fibroblasts	RP5-1142A6.7	0.08	0.01	lasso	5	0.00	1.4e-01	-7.19	7.2	4.5e-13	0.10	0.18	0.10	FALSE
15	GTEx	Stomach	RNF166	0.21	0.00	enet	25	0.09	5.1e-05	-2.14	-7.0	2.9e-12	-0.37	0.07	0.17	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTU2	0.03	0.00	blup	66	0.02	1.3e-04	-3.21	6.6	5.4e-11	-0.05	0.19	0.04	FALSE
8	GTEx	Cells Transformed fibroblasts	PIEZO1	0.11	0.11	lasso	2	0.11	1.0e-08	-7.10	6.4	1.3e-10	0.09	0.97	0.01	FALSE
18	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CTU2	0.06	0.03	blup	67	0.03	1.3e-03	-0.11	6.2	6.2e-10	-0.07	0.05	0.04	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BANP	0.03	0.02	blup	104	0.02	6.1e-03	6.38	-6.1	1.1e-09	-0.09	0.01	0.78	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BANP	0.02	0.03	enet	3	0.02	2.6e-03	5.70	-5.8	6.5e-09	-0.07	0.06	0.79	FALSE
5	GTEx	Artery Aorta	CDK10	0.33	0.07	enet	27	0.18	2.7e-10	4.65	-5.4	6.6e-08	0.11	0.06	0.92	FALSE
7	GTEx	Breast Mammary Tissue	RPL13	0.09	0.05	enet	7	0.04	5.3e-03	-4.88	5.4	7.9e-08	0.00	0.04	0.86	FALSE
17	METSIM	Adipose	RP11-368I7.4	0.04	0.03	enet	12	0.02	2.2e-04	4.70	5.3	9.3e-08	-0.07	0.07	0.87	FALSE
4	GTEx	Adipose Visceral Omentum	CDK10	0.43	0.19	lasso	6	0.32	3.6e-17	4.70	-5.3	1.0e-07	0.07	0.06	0.93	FALSE
14	GTEx	Skin Sun Exposed Lower leg	VPS9D1	0.24	0.13	lasso	6	0.15	3.4e-12	4.36	5.3	1.0e-07	-0.05	0.19	0.75	FALSE
6	GTEx	Brain Cerebellum	TRAPPC2L	0.20	0.12	enet	13	0.11	4.3e-04	-2.51	5.3	1.1e-07	0.13	0.11	0.05	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CBFA2T3	0.04	0.04	lasso	3	0.03	1.2e-04	5.23	-5.3	1.2e-07	-0.07	0.65	0.03	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	BANP	0.13	0.07	enet	12	0.09	1.2e-03	6.19	-5.3	1.3e-07	-0.06	0.01	0.92	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CBFA2T3	0.08	0.06	blup	61	0.08	4.2e-04	5.54	-5.2	2.3e-07	-0.04	0.06	0.05	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf7	0.04	0.00	blup	44	0.02	1.6e-03	4.36	5.2	2.5e-07	-0.07	0.00	0.49	FALSE
13	GTEx	Lung	RNF166	0.15	0.01	enet	8	0.02	1.9e-02	1.43	5.1	2.7e-07	0.11	0.11	0.03	FALSE