Hub : Genes

GINS2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.2110	0.0780	7.7e-03	0.012	NA	0.002	NA	-0.001	8.9e-02	NA	2.5e-01	NA	3.7e-01
2	GTEx	Thyroid	0.2780	0.0550	6.3e-07	0.117	NA	0.096	NA	0.125	3.0e-09	NA	8.5e-08	NA	8.9e-10
3	YFS	Blood	0.0685	0.0132	3.0e-13	0.063	0.043	0.072	0.064	0.072	9.0e-20	6.6e-14	1.3e-22	5e-20	1.5e-22
4	TCGA	Breast Invasive Carcinoma	0.0221	0.0124	1.9e-04	0.025	0.016	0.017	NA	0.020	5.3e-06	2.6e-04	1.9e-04	NA	4.7e-05
5	TCGA	Lung Squamous Cell Carcinoma	0.0759	0.0420	6.6e-04	0.014	0.015	0.018	NA	0.020	9.6e-03	6.3e-03	3.8e-03	NA	2.1e-03
6	TCGA	Prostate Adenocarcinoma	0.0456	0.0221	1.2e-05	0.056	0.045	0.032	NA	0.046	1.4e-06	1.5e-05	2.5e-04	NA	1.4e-05
7	TCGA	Thyroid Carcinoma	0.1410	0.0570	6.5e-11	0.097	0.119	0.132	NA	0.120	1.2e-09	1.3e-11	7.7e-13	NA	9.5e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.7	3.5	-1.9	-0.2	-0.6	0.1	0.5	-0.0	-0.9
Bipolar Disorder or Schizophrenia	0.8	2.0	3.5	-0.7	1.9	0.9	1.5	-1.4	1.8	1.1
Depressed Affect (Nagel 2018)	6.1	12.8	17.1	-4.0	-3.5	-3.4	-3.3	3.1	-3.6	-4.1
Depression (Nagel 2018)	2.7	4.0	6.1	-1.1	-1.8	-2.5	-2.1	1.4	-2.2	-2.5
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	-1.1	-0.3	-0.3	-0.8	-0.5	-0.8	-0.4
Neuroticism (Nagel 2018)	4.4	10.4	13.9	-3.7	-3.2	-3.1	-3.0	2.5	-3.2	-3.7
Schizophrenia (2018)	1.9	4.0	6.8	0.6	2.6	1.7	1.9	-2.2	2.3	2.2
Schizophrenia vs Biploar Disorder	2.8	3.7	5.5	2.1	2.1	1.9	1.7	-1.6	1.8	2.3
Worry (Nagel 2018)	1.4	3.0	5.6	-2.4	-1.9	-1.4	-1.6	0.7	-1.7	-2.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.5	-0.6	-0.3	-0.0	-0.1	-0.2	-0.3
Alzheimer’s Disease (in father)	3.1	3.4	4.4	1.5	1.9	1.7	1.9	-1.8	1.9	2.1
Alzheimer’s Disease (including proxy)	0.8	1.2	1.9	0.7	0.9	0.9	1.1	-1.1	1.3	1.4
Crohns Disease (2017)	0.8	1.7	2.8	-1.2	-1.2	-1.1	-1.5	1.5	-1.7	-0.6
Irritable Bowel Disease (IBD)	1.6	3.7	5.6	-2.4	-1.7	-1.8	-2.2	1.6	-2.1	-1.6
Ulcerative Colitis (UC)	1.1	2.1	3.0	-1.7	-1.2	-1.5	-1.7	0.6	-1.5	-1.6
Major Depression (MDD)	0.1	0.1	0.2	0.0	-0.1	0.0	-0.2	0.0	-0.4	0.5
Reaction Time	2.2	4.1	5.6	1.3	2.4	2.3	2.3	-1.6	2.2	1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.1	-0.9	-1.0	-0.3	-0.8	0.3	-1.0	-0.8
Breast Cancer	0.6	1.3	2.2	1.2	1.5	1.1	1.1	-1.0	1.1	0.9
Ovarian Cancer	1.6	2.1	2.9	1.5	1.5	1.7	1.5	-1.1	1.3	1.3
Prostate Cancer	1.9	2.6	4.9	1.6	2.2	1.7	1.5	-0.8	1.6	1.6
Age at First Birth	0.6	0.8	3.0	-0.2	-1.7	-0.5	-1.0	-0.2	-1.1	-0.5
Bipolar Disorder (2011)	0.4	0.4	1.8	0.0	0.0	0.0	-0.6	0.7	-0.4	-1.3
Body Mass Index (BMI) (2010)	0.9	1.3	1.9	1.0	1.0	0.9	1.3	-1.4	0.9	1.3
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.3	-0.5	-0.4	-0.7	0.5	-0.9	-0.1
Crohns Disease (2012)	0.6	1.0	1.7	-1.0	-0.7	-0.9	-1.3	1.1	-1.3	-0.6
Mean Putamen Volume	0.1	0.1	0.2	-0.3	-0.3	-0.1	-0.3	0.1	-0.3	-0.4
Fasting Glucose	1.4	1.7	3.4	0.3	-1.4	-1.3	-1.7	0.9	-1.8	-1.2
HbA1C	3.6	4.0	5.4	2.3	2.0	2.2	2.3	-0.7	2.1	2.0
HDL Cholesterol	2.1	3.6	4.6	1.2	2.0	1.8	1.7	-2.1	2.1	2.0
LDL Cholesterol	1.4	2.3	3.8	-1.5	-1.4	-1.4	-1.1	1.9	-1.1	-2.0
Lupus	3.7	5.5	8.6	-2.9	-2.0	-2.9	-2.5	1.9	-2.1	-1.9
Neuroticism (2016)	0.5	0.7	1.0	-0.7	-0.8	-0.7	-1.0	0.5	-0.8	-1.0
Primary Biliary Cirrhosis	0.6	0.8	3.5	-1.9	-0.5	-0.6	-0.6	-0.4	-0.5	-0.8
Rheumatoid Arthritis	0.2	0.2	0.5	0.7	0.7	-0.0	0.6	0.3	0.4	0.3
Schizophrenia (2014)	2.2	4.9	8.1	0.6	2.8	2.1	2.3	-2.3	2.5	2.2
Triglycerides	0.7	1.1	2.1	0.1	-1.1	-1.2	-0.8	1.4	-1.5	-0.7
Type 2 Diabetes (T2D) (2012)	4.8	5.5	8.0	-1.4	-2.2	-2.5	-2.4	2.8	-2.1	-2.7
Ulcerative Colitis	1.5	2.1	3.6	-1.9	-1.1	-1.4	-1.6	1.3	-1.5	-1.2
Blood Eosinophil Count	0.2	1.8	11.0	3.3	0.4	1.0	-0.0	0.1	0.5	-0.0
Blood Platelet Count	7.3	85.0	99.6	6.6	10.0	9.3	9.3	-9.0	9.9	10.0
Blood Red Count	0.1	0.8	1.6	-0.4	-1.1	-0.9	-1.1	-0.5	-1.3	-0.7
Blood White Count	1.7	12.3	18.4	-1.3	-3.9	-3.7	-4.1	3.0	-4.3	-3.3
Heel T-Score	0.2	1.6	4.2	2.1	1.4	1.0	0.9	-1.1	0.7	1.2
BMI	0.1	0.3	0.7	0.8	0.1	0.5	0.4	-0.4	0.7	0.8
Height	0.0	0.3	0.6	0.2	-0.8	-0.7	-0.6	0.4	-0.4	-0.7
Waist Hip Ratio (WHR)	2.2	9.8	13.9	-2.4	-3.7	-3.3	-3.3	2.0	-3.7	-3.1
Systolic Blood Pressure	0.1	0.6	2.4	0.5	0.9	0.2	0.6	-1.6	0.1	0.3
Smoking Status	0.1	0.2	0.5	-0.2	-0.5	-0.5	-0.5	0.2	-0.7	-0.2
Allergy or Eczema	0.0	0.1	0.3	0.2	-0.3	0.1	0.3	-0.6	0.2	-0.3
Cardiovascular Disease	0.1	0.4	1.0	-0.8	-0.1	-0.7	-0.2	-0.4	-0.4	-1.0
Hypothyroidism (self reported)	0.6	1.5	3.3	0.8	1.1	1.3	0.7	-1.5	0.9	1.8
Respiratory disease	0.2	0.4	1.4	0.7	-0.3	-0.5	-0.5	1.2	-0.2	-0.1
Type 2 Diabetes (T2D) (2018)	2.6	4.8	6.0	-2.0	-2.1	-2.4	-2.3	1.9	-2.4	-2.1
Lung FEV1/FVC ratio	0.2	0.9	2.0	-0.5	-1.1	-0.8	-1.1	0.4	-1.1	-1.4
Lung FVC	0.2	1.1	1.9	-0.4	-1.3	-0.7	-0.9	1.3	-1.4	-0.9
Neuroticism	3.4	8.2	11.5	-3.4	-2.6	-2.8	-2.8	1.8	-3.0	-3.4
Chronotype (morning person)	0.7	1.6	3.1	-1.2	-1.4	-1.0	-1.6	1.1	-1.8	-0.4
Hair Pigment	0.2	6.0	8.0	1.3	2.3	2.5	2.8	-2.3	2.8	2.7
Tanning	0.0	0.5	1.4	0.1	1.2	0.7	0.7	-0.3	0.8	0.8
Hand grip strength (left)	0.8	2.0	2.7	-1.6	-1.2	-1.4	-1.7	1.3	-1.4	-1.3
Number of treatments/medications taken	0.5	0.8	1.5	-1.2	-0.7	-0.8	-0.7	0.7	-1.0	-1.0
Average weekly spirits intake	0.1	0.2	0.2	0.4	0.5	0.3	0.4	0.2	0.5	0.3
Sensitivity / hurt feelings	0.9	1.5	3.1	-1.8	-0.9	-1.7	-0.7	0.7	-1.0	-1.3
Frequency of depressed mood in last 2 weeks	3.3	4.7	6.4	-1.8	-2.2	-2.5	-2.2	1.6	-2.4	-2.3
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.4	0.3	-0.5	-0.0	0.4	-0.2	-0.6
Relative age of first facial hair	2.5	5.2	9.6	-3.1	-1.3	-2.1	-2.1	2.6	-1.7	-2.6
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	-0.0	-0.2	0.3	-0.2	0.0	-0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.4	1.8	0.4	0.4	0.6	0.2	0.4	1.2
Ever had hysterectomy (womb removed)	1.2	1.4	2.4	1.2	1.1	0.9	0.9	-1.4	0.9	1.6
Systolic blood pressure, automated reading	0.1	0.4	0.9	-0.0	-0.2	-1.0	-0.6	-0.8	-0.8	-0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	-0.6	-0.7	-0.4	-0.5	1.1	-0.1	-0.6
Angina	0.5	0.7	1.2	0.5	-1.0	-0.9	-0.8	0.7	-1.1	-0.4
Medication for hormone replacement therapy	1.4	1.6	3.1	1.8	1.3	1.3	1.3	-0.2	1.0	1.4
Vitamin and mineral supplements	3.3	4.4	7.4	2.3	1.9	2.1	2.2	-1.1	2.7	2.1
Supplements: Zinc	0.6	0.6	1.2	-0.9	-0.3	-1.1	-0.6	0.9	-0.8	-0.8
Medication: Co-codamol	0.1	0.1	0.2	0.1	0.2	0.0	-0.2	-0.5	-0.4	-0.1
Medication: Metformin	0.5	0.7	0.8	-0.4	-0.8	-0.9	-0.8	0.9	-0.9	-0.9
Diabetes (father)	0.0	0.1	0.1	0.2	-0.3	-0.1	-0.2	0.3	0.1	-0.4
Diabetes (mother)	0.1	0.1	0.3	-0.4	0.0	-0.1	0.3	-0.5	-0.1	-0.2
Severe depression (siblings)	0.8	0.9	1.4	-0.3	-1.0	-0.5	-0.9	1.2	-1.0	-1.2
Pack years adult smoking proportion	0.3	0.4	0.8	-0.3	-0.7	-0.6	-0.9	0.7	-0.9	0.0
Impedance of leg (right)	0.1	0.3	0.5	-0.5	0.4	0.4	0.7	-0.6	0.5	0.6
Leg fat-free mass (left)	0.0	0.0	0.2	0.1	0.1	-0.0	0.2	-0.0	0.5	-0.1
Trunk fat percentage	0.5	2.2	4.2	1.7	0.7	1.0	0.9	-2.1	1.3	2.0
Hand grip strength (right)	1.9	5.2	8.0	-2.8	-1.9	-2.2	-2.1	2.3	-2.0	-2.4
Townsend deprivation index at recruitment	0.3	0.4	1.0	0.7	0.7	0.3	0.6	-0.1	0.5	1.0
Current tobacco smoking	0.1	0.1	0.7	0.3	-0.3	-0.0	-0.2	0.8	-0.2	-0.1
Average weekly fortified wine intake	0.2	0.2	0.6	-0.7	-0.3	-0.4	-0.2	-0.8	-0.2	-0.4
Maternal smoking around birth	1.6	2.3	2.6	-1.5	-1.6	-1.5	-1.5	1.2	-1.6	-1.6
Fed-up feelings	7.1	12.8	17.1	-4.1	-3.4	-3.6	-3.2	3.4	-3.5	-3.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.6	-1.0	-1.0	-1.6	-1.6	0.4	-1.6	-1.9
Relative age voice broke	0.1	0.1	0.4	-0.6	0.1	0.3	-0.2	-0.2	-0.0	0.2
Taking other prescription medications	0.1	0.1	0.4	-0.3	-0.1	-0.1	-0.3	0.3	-0.7	-0.2
Age when periods started (menarche)	0.5	1.1	2.6	-0.4	-1.1	-1.2	-0.6	1.6	-0.6	-1.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	-0.3	0.0	-0.1	0.2	-0.0	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	2.7	1.7	1.7	1.2	1.3	-1.6	1.4	1.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	-1.0	-1.0	-0.5	-0.5	1.2	-0.2	-1.0
Qualifications: CSEs or equivalent	1.5	2.0	3.6	-1.4	-1.1	-1.5	-1.3	1.9	-1.1	-1.3
Serious illness, injury or assault to yourself	0.2	0.2	0.3	-0.4	-0.6	-0.6	-0.3	0.2	-0.5	-0.5
High blood pressure	0.3	0.9	2.8	1.0	0.9	0.5	0.9	-1.7	0.6	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.1	-0.4	-0.3	-0.6
Multivitamins +/- minerals	3.0	3.8	5.2	-2.3	-1.4	-2.1	-1.9	1.1	-2.3	-2.1
Stomach or abdominal pain in last month	2.1	2.6	3.3	-1.6	-1.4	-1.8	-1.6	1.3	-1.8	-1.8
Supplements: Glucosamine	0.0	0.1	0.2	0.1	0.1	0.4	0.4	0.2	0.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.6	-0.4	-0.3	-0.3	-0.5	-0.2	-0.2
Medication: Atenolol	3.1	3.9	5.2	-1.8	-1.8	-2.3	-1.8	2.0	-2.0	-2.1
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.4	0.0	-0.1	-0.4	-0.6	-0.6	0.2
Sitting height	0.0	0.1	0.4	0.6	0.4	0.2	0.3	0.1	0.5	-0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.9	-0.7	-0.4	-0.3	-0.0	1.4	0.2	-0.8
High blood pressure (mother)	0.2	0.3	0.7	0.1	-0.3	-0.6	-0.8	-0.3	-0.8	-0.6
Body mass index (BMI)	0.3	1.5	3.4	1.9	0.9	0.9	0.8	-1.2	1.0	1.5
Impedance of leg (left)	0.0	0.1	0.5	-0.2	0.0	0.2	0.2	-0.7	0.1	0.4
Leg predicted mass (left)	0.0	0.0	0.2	0.1	0.2	-0.0	0.2	-0.0	0.5	-0.0
Trunk fat mass	0.3	1.5	3.0	1.5	0.6	0.8	0.7	-1.7	1.1	1.5
Waist circumference	0.1	0.2	0.9	1.0	-0.4	-0.2	-0.2	-0.3	-0.2	0.2
Number of incorrect matches in round	0.1	0.1	0.3	-0.4	0.5	0.0	0.5	-0.3	0.2	-0.2
Past tobacco smoking	0.1	0.2	0.7	0.5	0.1	0.6	0.1	-0.9	0.3	0.1
Alcohol usually taken with meals	2.5	4.0	6.4	-2.5	-1.8	-2.2	-1.7	1.3	-1.9	-2.2
Nervous feelings	0.6	1.1	5.0	-2.2	-0.7	-0.7	-0.5	0.4	-0.4	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	2.0	-0.2	0.3	0.1	-0.0	-1.4	-0.1	-0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.1	-0.4	-0.8	-0.5	0.6	-0.5	-0.9
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	-0.0	-0.4	-0.2	-0.5	0.9	-0.3	-0.1
Had menopause	0.7	0.9	1.4	0.9	0.8	0.8	1.1	-0.9	1.0	1.2
Had other major operations	0.7	0.9	1.6	0.7	0.7	1.0	0.9	-1.3	1.0	1.0
Forced vital capacity (FVC)	0.3	1.1	2.5	-1.6	-0.8	-0.6	-0.6	1.3	-0.6	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	0.6	1.1	0.6	0.9	-0.3	0.8	0.5
Ever unenthusiastic/disinterested for a whole week	3.6	4.4	6.4	-1.6	-1.6	-2.4	-2.3	1.7	-2.3	-2.5
Qualifications: None of the above	0.2	0.5	1.2	0.9	-0.1	-0.4	-0.8	-0.2	-1.1	-0.4
Financial difficulties in last 2 years	0.3	0.5	1.0	-0.7	-0.5	-1.0	-0.7	-0.6	-0.6	-0.5
Mouth/teeth dental problems	0.1	0.2	0.5	-0.7	0.1	0.6	0.1	-0.5	0.3	-0.0
Heart attack	1.9	2.5	4.3	-0.1	-1.8	-1.5	-2.1	1.8	-2.0	-0.7
Allergy	0.0	0.1	0.2	-0.4	0.2	0.4	0.2	0.2	0.2	0.3
Pain all over the body in last month	0.2	0.3	0.5	0.2	0.7	0.4	0.6	0.2	0.7	0.5
Diabetes (self-reported)	0.2	0.2	0.5	-0.2	-0.4	-0.6	-0.6	0.2	-0.7	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.4	-0.3	-0.3	-0.3	-0.1	-0.7	-0.5
Medication: Ramipril	0.2	0.3	0.6	0.3	-0.8	-0.2	-0.5	0.8	-0.4	-0.3
Medication: Simvastatin	1.2	1.8	3.5	-0.8	-1.2	-1.7	-1.4	0.5	-1.9	-1.3
Fluid intelligence score	0.0	0.1	0.2	-0.5	-0.4	0.1	-0.3	0.1	-0.4	0.3
Illnesses of siblings	0.9	1.3	2.7	0.1	1.1	0.9	1.3	-0.7	1.7	1.5
Neuroticism score	3.0	6.3	10.2	-3.2	-2.2	-2.5	-2.3	1.2	-2.6	-2.9
Weight	0.2	0.9	2.0	1.4	0.6	0.6	0.6	-1.0	1.0	1.0
Impedance of arm (right)	0.3	1.6	3.0	0.2	0.8	1.1	1.3	-1.6	1.7	1.4
Arm fat percentage (right)	0.9	3.6	5.6	2.3	1.3	1.4	1.4	-2.2	1.8	2.4
Trunk fat-free mass	0.0	0.2	0.5	0.7	0.6	0.2	0.4	0.2	0.5	-0.1
Hip circumference	0.3	1.5	2.5	1.6	1.0	1.1	1.1	-0.7	1.4	1.3
Time employed in main current job	0.5	0.6	1.2	-0.2	-1.0	-0.6	-0.7	0.7	-1.1	-0.8
Alcohol intake versus 10 years previously	1.3	2.0	3.3	-0.9	-1.1	-0.9	-1.6	1.8	-1.7	-1.5
Father’s age at death	0.0	0.1	0.2	-0.4	0.1	-0.0	0.4	0.2	0.4	0.1
Worrier / anxious feelings	2.0	3.8	5.8	-2.2	-2.4	-1.9	-1.8	1.1	-1.8	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.9	-0.5	0.1	-1.0	-0.5	-0.4	-0.2	-0.3
Falls in the last year	0.3	0.4	1.9	1.4	-0.0	0.1	0.3	-0.8	-0.0	0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	-0.2	0.6	0.3	0.4	-0.9	0.5	0.4
Number of live births	1.8	2.5	5.0	2.2	1.7	1.5	1.3	-0.7	1.3	1.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	-1.4	-0.8	-0.7	-0.7	1.0	-0.7	-1.5
Pulse rate	0.2	0.3	1.0	-0.0	-0.7	0.0	-0.3	-1.0	-0.6	0.0
Happiness	3.2	3.8	5.3	-1.4	-1.8	-2.3	-2.2	2.1	-2.1	-1.6
Noisy workplace	0.1	0.1	0.2	0.3	-0.1	-0.2	-0.4	-0.4	-0.4	-0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.4	0.2	1.2	0.9	1.2	-1.1	1.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.7	-0.6	-0.5	-0.1	0.6	-0.1	0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	0.9	0.2	-0.4	0.4	0.7	0.4	0.1
Asthma	0.1	0.2	1.1	1.1	0.1	0.0	-0.1	0.5	0.1	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.7	0.5	0.2	-0.1	0.2	0.8	0.4	-0.1
Medication: Cholesterol lowering	0.8	1.2	2.7	-0.5	-1.0	-1.3	-1.4	0.5	-1.6	-0.9
Depression (self-reported)	0.5	0.6	1.1	-0.6	-0.5	-1.1	-0.6	-0.2	-0.8	-1.1
Medication: Lansoprazole	0.3	0.4	0.7	0.7	0.7	0.7	0.5	-0.5	0.1	0.9
Prospective memory result	0.1	0.1	0.6	0.8	-0.1	-0.1	-0.1	0.1	0.0	-0.1
Lung cancer (father)	1.1	1.3	4.3	2.1	1.2	0.7	1.1	-0.1	0.9	0.9
Illnesses of mother	1.4	1.7	3.1	1.0	1.2	1.3	1.8	-0.8	1.7	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	-0.1	0.1	0.3	0.3	-0.5	0.5	-0.1
Pulse wave Arterial Stiffness index	1.4	1.6	3.5	1.9	1.1	1.1	1.0	-1.3	0.8	1.4
Impedance of arm (left)	0.1	0.6	1.3	-0.5	0.2	0.5	0.6	-1.2	1.0	0.8
Arm fat mass (right)	0.5	2.0	3.7	1.9	1.0	1.0	1.0	-1.6	1.4	1.7
Trunk predicted mass	0.0	0.3	0.6	0.8	0.7	0.3	0.5	0.1	0.6	0.0
Standing height	0.0	0.2	0.6	-0.7	-0.2	-0.3	-0.0	0.2	0.4	-0.8
Length of working week for main job	0.2	0.2	0.4	0.1	-0.2	-0.2	-0.6	0.5	-0.5	-0.5
Exposure to tobacco smoke at home	1.2	1.3	3.8	-1.9	-0.8	-1.3	-0.8	1.2	-0.6	-0.7
Breastfed as a baby	2.0	2.5	7.3	2.7	1.0	1.6	0.9	-1.3	1.1	1.8
Tense / ‘highly strung’	0.3	0.5	1.9	-1.4	-0.2	-0.2	-0.5	-0.3	-0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	0.5	-0.3	-0.4	-0.6	-1.2	-0.7	-0.2
Hair/balding pattern: Pattern 4	0.9	2.2	4.7	-0.3	-1.2	-1.7	-1.5	0.3	-2.2	-1.9
Birth weight of first child	5.9	10.7	14.5	2.7	3.1	3.4	3.0	-3.8	3.4	3.4
Peak expiratory flow (PEF)	1.8	4.2	6.1	-1.5	-2.0	-2.5	-2.3	1.4	-2.3	-2.2
Pulse wave reflection index	0.7	0.9	2.0	0.7	1.4	0.3	0.9	-0.4	1.2	1.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.7	-1.0	-1.2	-1.1	-1.4	1.4	-1.5	-1.6
Loud music exposure frequency	2.2	2.4	3.9	-0.6	-2.0	-1.5	-1.9	1.1	-1.8	-1.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	0.3	0.7	0.8	1.1	-0.7	1.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	0.1	-0.3	-0.2	-0.5	0.2	-0.8	-0.2
Blood clot in the leg (DVT)	2.0	2.5	4.2	-0.9	-1.9	-1.9	-1.9	0.6	-2.1	-1.2
Medication: Paracetamol	0.8	1.4	2.3	0.4	1.0	1.2	1.3	-1.5	1.4	1.0
Headache pain in last month	0.0	0.1	0.3	-0.5	-0.0	-0.6	-0.2	0.1	0.1	-0.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.1	-0.0	0.3	0.3	0.3	0.3	0.0
Glaucoma (self-reported)	0.3	0.4	1.0	1.0	0.4	0.3	0.4	-0.8	0.2	0.8
Gout (self-reported)	0.3	0.4	0.8	-0.3	0.9	0.5	0.7	-0.0	0.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	-0.2	0.8	0.7	0.4	-1.1	0.4	1.2
Medication: Amlodipine	0.2	0.3	0.7	-0.1	0.2	0.2	0.4	-0.8	0.6	0.9
Medication: Ventolin 100micrograms inhaler	8.8	11.2	13.2	-3.0	-3.1	-3.6	-3.6	3.1	-3.6	-3.4
Birth weight	4.6	10.0	13.6	2.9	3.0	3.3	3.3	-3.7	3.1	2.8
Chronic bronchitis/emphysema (mother)	3.7	4.3	5.3	-1.7	-1.7	-2.2	-2.3	2.3	-2.1	-2.2
High blood pressure (siblings)	0.2	0.3	0.5	0.2	-0.5	-0.4	-0.6	0.3	-0.7	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.4	0.6	-0.3	0.6	0.7	0.8	-0.6	0.8	0.2
Body fat percentage	0.4	1.6	3.4	1.5	0.6	0.8	0.7	-1.8	1.0	1.7
Leg fat percentage (right)	0.2	0.7	2.3	0.8	0.6	0.5	0.6	-1.5	0.6	1.1
Arm fat-free mass (right)	0.0	0.2	0.3	0.3	-0.3	-0.3	-0.5	0.5	-0.4	-0.5
Exposure to tobacco smoke outside home	0.6	0.8	1.9	-0.3	-0.8	-1.1	-1.4	0.6	-1.1	-0.7
Comparative body size at age 10	1.1	3.1	4.7	0.9	1.7	1.7	2.2	-1.8	1.8	1.9
Number of full brothers	0.6	0.8	2.0	0.7	1.4	0.6	1.0	-1.1	0.7	-0.0
Worry too long after embarrassment	2.1	3.5	5.9	-1.4	-2.0	-2.1	-2.2	0.6	-2.4	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	3.4	-1.8	-0.6	-1.0	-1.0	-0.1	-0.8	-0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	0.8	0.6	0.5	0.3	-0.3	0.3	0.7
Number of children fathered	0.5	0.6	1.9	0.5	-0.3	-0.5	-0.8	-1.4	-0.8	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	0.1	0.6	0.8	0.9	-1.1	0.9	0.5
Age at first live birth	0.7	1.3	2.4	1.4	0.8	0.8	0.7	-1.5	1.1	1.5
Pulse wave peak to peak time	1.1	1.3	2.9	-1.7	-1.0	-0.9	-0.8	1.1	-0.6	-1.3
Health satisfaction	0.2	0.3	0.9	-0.6	-0.5	-0.4	-0.5	-0.1	-1.0	-0.6
Shortness of breath walking on level ground	0.2	0.3	1.4	1.2	0.2	0.2	0.3	0.3	0.2	0.2
Qualifications: College or University degree	0.9	2.9	5.2	1.1	1.7	1.6	1.5	-2.3	1.7	1.8
Eye problems/disorders: None of the above	0.4	0.5	0.7	0.2	0.9	0.7	0.7	-0.7	0.7	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	0.6	0.4	0.5	0.2	-1.1	0.2	0.7
Emphysema/chronic bronchitis	1.7	1.9	3.4	1.0	1.4	1.0	1.7	-1.4	1.9	1.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.0	-0.1	0.9	1.0	0.9	-0.7	1.0	0.6
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.0	0.1	-0.4	0.0	0.2	0.2	-0.6
Medication: Blood pressure	0.1	0.1	0.2	0.3	0.2	0.2	0.3	-0.4	0.3	0.5
Angina (self-reported)	0.5	0.7	1.3	0.3	-1.0	-0.9	-0.9	0.7	-1.1	-0.5
Migraine (self-reported)	2.4	2.9	5.3	1.9	1.7	1.6	1.6	-0.9	1.6	2.3
Medication: Ibuprofen	0.3	0.4	0.8	0.8	0.7	0.4	0.8	0.1	0.9	0.2
Medication: Allopurinol	0.3	0.4	0.9	-0.1	0.7	0.3	0.6	-0.6	0.9	0.8
Medication: Omeprazole	0.1	0.1	0.4	-0.2	-0.1	-0.6	-0.2	-0.2	0.0	-0.4
Medication: Seretide 50 evohaler	0.3	0.4	0.9	-0.0	0.4	0.9	1.0	-0.1	0.8	0.4
Mean time to correctly identify matches	3.6	6.9	9.1	2.3	2.8	3.0	2.9	-2.5	2.5	2.4
Heart disease (mother)	0.1	0.1	0.4	0.6	0.3	0.3	0.0	-0.5	-0.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.6	-0.4	-0.3	-0.2	0.2	-0.2	-0.5
Whole body fat mass	0.2	1.0	1.8	1.2	0.4	0.6	0.6	-1.4	0.9	1.3
Leg fat mass (right)	0.2	0.7	1.5	0.9	0.6	0.6	0.6	-1.2	0.8	1.1
Arm predicted mass (right)	0.0	0.1	0.3	0.3	-0.2	-0.2	-0.3	0.5	-0.3	-0.4
Pulse rate, automated reading	0.8	2.4	4.9	-0.2	-2.2	-1.3	-2.0	0.6	-2.2	-1.1
Alcohol intake frequency.	2.5	5.9	8.1	-1.8	-2.5	-2.4	-2.5	2.5	-2.4	-2.9
Comparative height size at age 10	0.1	0.6	1.6	0.7	0.6	0.7	0.9	-1.3	0.8	0.1
Number of full sisters	0.1	0.1	0.5	0.7	0.1	-0.1	-0.3	0.3	-0.3	-0.5
Suffer from ‘nerves’	0.3	0.4	1.6	-1.3	-0.4	-0.3	-0.4	-0.4	-0.4	-0.7
Overall health rating	0.1	0.3	0.7	-0.4	-0.5	-0.3	-0.7	0.2	-0.8	-0.3
Chest pain or discomfort	0.4	0.6	0.9	-0.7	-0.4	-0.8	-0.8	0.7	-0.8	-1.0
Had major operations	2.1	2.4	3.8	-1.0	-1.6	-1.5	-1.5	1.3	-1.9	-1.8
Age at last live birth	2.0	2.9	4.3	1.5	1.3	1.7	1.5	-2.0	1.6	2.1
Family relationship satisfaction	0.7	0.9	1.9	-1.4	-0.6	-1.2	-0.5	1.0	-0.7	-1.0
Leg pain on walking	0.3	0.4	1.0	0.5	0.4	0.6	0.7	-1.0	0.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	5.8	-1.4	-2.0	-1.9	-1.2	2.4	-1.2	-1.6
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.1	1.0	-0.5	-0.2	-0.5	1.0	-0.8	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.5	0.2	0.3	0.2	-0.0	1.2	0.1	0.0
Medication: Aspirin	3.8	5.0	9.4	-0.6	-2.6	-2.2	-2.7	1.7	-3.1	-1.9
Supplements: Vitamin C	1.4	1.7	2.7	-1.6	-1.2	-1.2	-1.2	1.6	-1.5	-0.6
Knee pain experienced in last month	0.4	0.6	1.8	1.4	0.0	0.3	0.1	-1.3	-0.4	0.1
Hypertension (Self-reported)	0.2	0.6	1.9	1.0	0.8	0.4	0.7	-1.4	0.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	0.1	0.8	0.4	0.4	-0.5	0.3	0.6
Illnesses of father: Heart disease	0.1	0.2	0.5	-0.4	-0.3	-0.2	-0.4	-0.0	-0.7	-0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.9	0.7	-0.3	-0.5	-0.2	0.3	-1.1	-1.4
Smoking status: Previous	0.1	0.2	0.5	-0.4	-0.1	-0.7	-0.3	0.7	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.3	0.2	-0.3	-0.3	-0.1	0.4	0.1	-0.5
Whole body fat-free mass	0.0	0.1	0.2	0.5	0.3	-0.0	0.1	0.2	0.3	-0.2
Leg fat-free mass (right)	0.0	0.0	0.1	0.3	0.0	-0.1	-0.0	0.0	0.3	-0.1
Arm fat percentage (left)	0.7	2.6	4.3	1.9	1.0	1.2	1.1	-2.0	1.5	2.1
Average weekly red wine intake	3.9	5.8	8.8	2.5	2.2	2.2	2.4	-1.9	2.6	3.0
Handedness (chirality/laterality): Left-handed	0.1	0.2	1.0	1.0	-0.1	0.4	0.2	0.0	0.1	0.0
Mood swings	0.8	1.4	3.0	-1.7	-0.9	-1.1	-1.3	0.0	-1.4	-1.1
Loneliness, isolation	7.6	10.5	12.5	-3.0	-3.3	-3.3	-3.5	2.8	-3.5	-3.2
Long-standing illness, disability or infirmity	0.3	0.4	0.7	-0.4	-0.5	-0.7	-0.6	0.7	-0.8	-0.7
Ever had bowel cancer screening	0.5	0.6	1.3	0.0	-1.0	-0.2	-0.7	0.9	-0.9	-1.1
Diabetes diagnosed by doctor	0.4	0.6	1.0	-0.6	-0.6	-1.0	-0.7	0.6	-0.9	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	-0.1	-0.7	-1.1	-0.8	0.0	-0.9	-0.0
Friendships satisfaction	0.9	1.2	2.0	0.2	1.0	1.0	1.2	-1.4	1.1	1.1
Qualifications: nursing, teaching	0.4	0.6	1.0	0.6	0.6	0.6	0.9	-0.6	0.9	1.0
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.5	0.4	-0.4	-0.1	0.4	-0.2	0.3
Eye problems/disorders: Cataract	0.3	0.4	0.7	0.6	-0.4	-0.5	-0.7	0.5	-0.9	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.7	-1.0	-0.9	-1.3	-0.6	0.7	-0.5	-0.7
Medication for cholesterol	0.2	0.2	0.6	-0.8	0.3	0.4	0.4	0.2	0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.2	-0.1	0.0	-0.4	-0.2	1.1	0.2	-0.5
Back pain experienced in last month	2.3	3.3	4.9	2.1	1.6	2.0	1.9	-0.5	2.2	1.9
Mineral and other dietary supplements	0.4	0.5	1.1	0.5	-0.9	-0.7	-1.1	0.9	-0.5	-0.5
Breast cancer (self-reported)	0.2	0.3	0.7	-0.8	-0.5	-0.5	-0.2	0.3	0.0	-0.8
Asthma (self-reported)	0.2	0.4	1.1	0.6	-0.4	-0.5	-0.6	1.1	-0.5	-0.1
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.3	0.5	0.6	0.7	0.0	0.5	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.5	0.5	0.2	0.4	-0.8	-0.1	0.3
Medication: Aspirin	3.6	4.7	9.1	-0.7	-2.4	-2.2	-2.6	1.7	-3.0	-1.8
Medication: Gliclazide	0.9	1.1	2.2	-0.9	-0.9	-1.1	-0.8	1.5	-1.0	-0.9
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.1	-0.3	-0.4	-0.5	0.6	-0.3	0.2
Smoking status: Current	0.0	0.0	0.2	0.2	-0.2	0.1	-0.0	0.5	-0.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.3	-0.3	-0.7	-0.2	-0.7	-0.0	-0.8	-1.1
Whole body water mass	0.0	0.1	0.3	0.5	0.4	0.0	0.2	0.2	0.3	-0.1
Leg predicted mass (right)	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.1	0.1	0.3	-0.2
Arm fat mass (left)	0.6	2.4	4.2	2.0	1.1	1.2	1.1	-1.7	1.5	1.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.7	-0.3	-0.5	-0.4	-0.1	-0.8	-0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.5	-0.1	0.7	0.6	0.7	-0.3	0.5	0.4
Miserableness	1.2	2.1	7.3	-2.7	-1.0	-1.0	-0.9	0.2	-1.2	-1.8
Guilty feelings	0.5	0.8	1.6	-1.3	-0.6	-0.9	-0.8	-0.7	-0.9	-1.0
Wears glasses or contact lenses	1.1	1.2	3.7	1.9	0.8	0.3	0.9	-1.3	0.3	1.2
Ever taken oral contraceptive pill	2.6	2.9	3.7	1.9	1.5	1.7	1.5	-1.9	1.5	1.8
Hearing aid user	0.6	0.6	2.2	-1.0	-0.7	-0.7	-0.3	1.5	-0.1	-0.2
Mother’s age at death	0.9	1.1	1.7	0.6	1.1	0.7	1.1	-1.1	1.3	1.3
Financial situation satisfaction	1.4	1.7	3.0	-1.7	-1.0	-1.3	-1.3	1.0	-1.2	-1.4
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.0	0.8	0.8	0.7	0.7	-1.4	0.7	1.1
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.7	-0.1	0.4	0.2	-0.6	0.5	0.2
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	0.9	0.5	0.4	0.5	-0.7	0.2	0.8
Medication: Blood pressure	0.2	0.3	1.3	1.0	0.1	-0.0	-0.0	-1.1	-0.3	-0.1
Pain type(s) experienced in last month: Hip pain	2.0	2.5	3.9	1.5	2.0	1.6	1.7	-1.5	1.5	1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.1	0.1	1.2	1.1	1.5	-1.2	1.0	1.1
High cholesterol (Self-reported)	0.6	1.0	2.6	0.1	-1.1	-1.0	-1.2	-0.3	-1.6	-0.7
Medication: Bendroflumethiazide	0.4	0.6	1.6	1.3	0.2	0.5	0.7	-1.1	0.6	0.7
Medication: Paracetamol	0.3	0.4	1.1	-0.4	0.4	0.6	0.8	-1.0	0.8	0.0
Medication: Lisinopril	0.1	0.2	0.9	-0.9	-0.1	-0.2	0.0	-0.5	0.1	-0.3
Medication: Atorvastatin	1.6	1.9	3.7	-0.5	-1.9	-1.2	-1.6	1.1	-1.8	-1.2
Illnesses of father: High blood pressure	0.6	0.8	1.9	-1.1	-0.8	-0.7	-0.5	0.1	-0.8	-1.4
Alcohol drinker status: Never	1.7	2.1	3.0	-1.5	-1.7	-1.4	-1.5	0.9	-1.3	-1.5
Ever smoked	0.2	0.3	0.7	0.5	0.7	0.2	0.5	0.3	0.5	0.8
Basal metabolic rate	0.0	0.2	0.5	0.7	0.5	0.2	0.4	-0.2	0.6	0.2
Leg fat percentage (left)	0.2	0.7	2.6	0.9	0.4	0.4	0.3	-1.6	0.4	0.9
Arm fat-free mass (left)	0.1	0.3	1.1	1.0	0.7	0.3	0.4	-0.2	0.5	0.2
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.5	0.7	0.8	-0.3	0.5	0.2
Average weekly beer plus cider intake	0.1	0.1	0.3	0.1	0.3	0.2	0.3	-0.4	0.4	0.5
Irritability	1.7	2.9	3.6	-1.9	-1.8	-1.7	-1.6	1.5	-1.7	-1.7
Risk taking	3.9	5.7	8.2	2.6	2.4	1.8	2.1	-2.5	2.3	2.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	-0.7	0.7	0.5	1.0	-0.5	1.1	0.5
Fractured/broken bones in last 5 years	1.0	1.3	3.4	-1.9	-1.0	-1.1	-0.8	1.5	-0.8	-0.5
Age started oral contraceptive pill	0.1	0.1	0.2	0.3	0.3	0.1	0.3	-0.4	0.2	0.0
Diastolic blood pressure, automated reading	0.2	0.7	1.7	0.1	-0.4	-1.1	-0.9	-1.3	-0.9	0.0
Ever depressed for a whole week	2.4	3.0	5.1	-1.3	-1.6	-2.3	-1.9	0.9	-1.8	-1.9
Unable to work because of sickness or disability	0.6	0.7	2.2	1.0	0.7	0.5	0.7	-1.5	0.5	0.6
Commuting to job workplace: Cycle	0.4	0.4	0.9	0.7	-0.9	-0.6	-0.8	-0.3	-0.7	-0.4
Myopia	2.0	2.9	4.7	-0.8	-2.0	-2.1	-2.0	1.2	-2.2	-1.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.0	-0.8	-0.4	0.1	-0.3	1.0	0.0	-0.0
Cholesterol lowering medication	1.3	1.9	3.3	-0.3	-1.6	-1.5	-1.4	0.9	-1.8	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.3	0.3	-0.1	-0.1	-0.6	0.1	0.3
Pain experienced in last month	1.0	1.7	2.3	-1.3	-1.1	-1.2	-1.3	1.0	-1.5	-1.5
Supplements: Calcium	0.2	0.2	1.2	-0.0	-0.1	0.5	0.2	-1.1	-0.1	-0.2
Basal cell carcinoma (self-reported)	2.9	3.4	4.6	-1.7	-1.8	-1.8	-2.1	2.0	-2.1	-1.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.4	-0.1	-1.5	-1.2	-1.8	1.6	-1.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	4.2	-1.2	-1.8	-2.0	-1.9	0.9	-2.0	-1.2
Heart disease (siblings)	2.8	3.4	6.7	-0.3	-1.8	-2.0	-2.5	1.0	-2.6	-1.6
Alcohol drinker status: Previous	0.1	0.1	0.3	0.0	0.3	0.5	0.5	0.1	0.3	-0.5
Pack years of smoking	0.5	0.7	1.5	-0.3	-0.9	-0.9	-1.1	0.6	-1.2	-0.2
Impedance of whole body	0.1	0.4	1.0	-0.5	0.1	0.4	0.5	-1.0	0.7	0.6
Leg fat mass (left)	0.2	0.8	1.9	1.0	0.6	0.7	0.6	-1.4	0.8	1.1
Arm predicted mass (left)	0.1	0.3	1.3	1.1	0.6	0.2	0.3	-0.3	0.4	0.2