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chr2:54,506,070-56,036,348

Best TWAS P=8.21e-17 · Best GWAS P=7.44e-14 conditioned to 0.982

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RTN4	0.09	0.06	blup	100	0.07	1.3e-08	-6.8	8.3	8.2e-17	-0.90	0.00	1.00	TRUE
19	GTEx	Muscle Skeletal	RTN4	0.09	0.04	enet	7	0.04	6.6e-05	-7.5	8.0	1.9e-15	-0.85	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Glioblastoma Multiforme	RTN4	0.13	0.10	enet	6	0.09	8.5e-04	-7.5	7.8	7.7e-15	-0.93	0.01	0.90	FALSE
5	GTEx	Brain Cerebellar Hemisphere	RTN4	0.29	0.09	enet	13	0.14	2.4e-04	-7.5	7.8	9.1e-15	-0.96	0.00	0.99	FALSE
26	GTEx	Spleen	RTN4	0.52	0.22	lasso	6	0.22	1.9e-06	-6.7	7.6	2.2e-14	-0.93	0.01	0.98	FALSE
30	GTEx	Whole Blood	RTN4	0.14	0.12	lasso	3	0.11	1.5e-10	-6.8	7.6	3.6e-14	-0.86	0.20	0.80	FALSE
7	GTEx	Brain Cortex	RTN4	0.24	0.28	enet	11	0.28	1.6e-08	-7.5	7.5	5.9e-14	-0.94	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	RTN4	0.24	0.13	enet	16	0.25	4.1e-24	-6.6	7.4	1.2e-13	-0.74	0.43	0.57	FALSE
22	GTEx	Pancreas	RTN4	0.37	0.17	enet	25	0.18	3.5e-08	-6.8	7.3	2.0e-13	-0.80	0.01	0.99	FALSE
2	GTEx	Artery Aorta	RTN4	0.19	0.21	enet	11	0.20	1.6e-11	-6.6	7.3	2.6e-13	-0.89	0.13	0.87	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	RTN4	0.06	0.07	lasso	5	0.06	3.5e-07	-7.5	7.2	6.8e-13	-0.98	0.00	1.00	FALSE
14	GTEx	Esophagus Mucosa	RTN4	0.36	0.27	enet	31	0.35	2.2e-24	-6.8	7.2	7.3e-13	-0.88	0.02	0.98	FALSE
21	GTEx	Ovary	RTN4	0.41	0.04	lasso	6	0.05	2.5e-02	-6.8	7.1	1.1e-12	-0.85	0.06	0.70	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	RTN4	0.40	0.47	lasso	6	0.49	3.5e-71	-6.8	7.1	1.1e-12	-0.87	0.26	0.74	FALSE
29	GTEx	Thyroid	RTN4	0.60	0.43	enet	38	0.63	1.5e-61	4.9	7.1	1.4e-12	-0.70	1.00	0.00	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RTN4	0.28	0.20	enet	26	0.19	2.5e-15	-6.8	7.1	1.5e-12	-0.86	0.09	0.91	FALSE
20	GTEx	Nerve Tibial	RTN4	0.50	0.45	lasso	9	0.48	4.2e-38	-6.6	7.1	1.7e-12	-0.91	0.26	0.74	FALSE
12	GTEx	Colon Sigmoid	RTN4	0.23	0.09	lasso	3	0.09	3.6e-04	-6.8	7.0	3.1e-12	-0.87	0.01	0.96	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RTN4	0.14	0.16	lasso	2	0.17	2.3e-18	-6.8	6.9	5.3e-12	-0.82	0.22	0.78	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	RTN4	0.06	0.07	blup	100	0.06	9.1e-13	-7.5	6.9	5.4e-12	-0.92	0.00	1.00	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	RTN4	0.28	0.24	lasso	8	0.22	1.2e-08	-6.8	6.9	5.5e-12	-0.83	0.10	0.90	FALSE
4	GTEx	Brain Caudate basal ganglia	RTN4	0.23	0.25	lasso	5	0.20	2.0e-06	-6.8	6.9	6.8e-12	-0.79	0.17	0.76	FALSE
18	GTEx	Lung	RTN4	0.22	0.08	enet	26	0.07	5.7e-06	-7.5	6.8	8.8e-12	-0.68	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RTN4	0.08	0.08	lasso	1	0.08	3.4e-05	-6.8	6.8	1.0e-11	-0.84	0.03	0.95	FALSE
23	GTEx	Prostate	RTN4	0.31	0.21	lasso	8	0.22	3.4e-06	-6.8	6.8	1.3e-11	-0.82	0.04	0.89	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	RTN4	0.32	0.25	enet	16	0.32	5.2e-18	-6.8	6.8	1.4e-11	-0.89	0.04	0.96	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RTN4	0.15	0.16	lasso	4	0.16	7.2e-07	-6.5	6.7	1.6e-11	-0.84	0.03	0.97	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	RTN4	0.03	0.05	lasso	3	0.03	9.2e-05	-6.8	6.7	2.2e-11	-0.84	0.04	0.95	FALSE
15	GTEx	Esophagus Muscularis	RTN4	0.36	0.24	enet	26	0.30	1.3e-18	-6.6	6.7	2.5e-11	-0.85	0.07	0.93	FALSE
1	GTEx	Adipose Subcutaneous	RTN4	0.42	0.22	enet	41	0.30	2.2e-24	-7.5	6.6	3.3e-11	-0.87	0.00	1.00	FALSE
17	GTEx	Liver	RTN4	0.22	0.11	lasso	5	0.16	3.0e-05	-6.8	6.6	4.1e-11	-0.81	0.07	0.87	FALSE
6	GTEx	Brain Cerebellum	RTN4	0.48	0.47	enet	14	0.48	7.0e-16	-6.8	6.6	5.2e-11	-0.91	0.09	0.91	FALSE
3	GTEx	Artery Tibial	RTN4	0.34	0.31	lasso	6	0.36	1.3e-29	-6.8	6.5	8.6e-11	-0.90	0.13	0.87	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	RTN4	0.07	0.08	blup	100	0.08	1.9e-09	-7.5	6.5	8.6e-11	-0.89	0.00	1.00	FALSE
11	GTEx	Cells Transformed fibroblasts	RTN4	0.44	0.27	enet	29	0.29	7.8e-22	-6.8	6.3	3.7e-10	-0.90	0.21	0.79	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RTN4	0.10	0.04	enet	12	0.03	2.3e-02	-6.5	6.2	4.2e-10	-0.67	0.03	0.72	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	RTN4	0.19	0.14	enet	7	0.20	6.0e-06	-6.5	6.0	1.7e-09	-0.87	0.04	0.91	FALSE
10	GTEx	Breast Mammary Tissue (Male)	RTN4	0.37	0.13	lasso	8	0.10	2.6e-03	-7.5	6.0	2.3e-09	-0.91	0.01	0.94	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RTN4	0.04	0.01	enet	3	0.01	1.5e-02	-7.5	5.9	4.3e-09	-0.89	0.00	0.97	FALSE
16	GTEx	Heart Atrial Appendage	RTN4	0.14	0.08	enet	23	0.05	2.9e-03	6.9	5.8	7.7e-09	-0.36	0.11	0.52	FALSE
28	GTEx	Testis	RTN4	0.26	0.11	lasso	4	0.17	7.4e-08	-6.8	5.6	1.8e-08	-0.84	0.23	0.77	FALSE
33	The Cancer Genome Atlas	Esophageal Carcinoma	RTN4	0.21	0.09	lasso	5	0.16	6.7e-06	4.1	5.5	3.3e-08	-0.64	0.06	0.52	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RTN4	0.11	0.05	lasso	6	0.06	9.5e-05	5.1	5.5	4.7e-08	-0.50	0.34	0.48	FALSE
27	GTEx	Stomach	RTN4	0.20	0.12	lasso	2	0.14	2.9e-07	-6.8	5.4	5.6e-08	-0.79	0.09	0.91	FALSE
8	GTEx	Brain Hippocampus	RTN4	0.27	0.10	lasso	8	0.19	3.7e-05	5.4	5.4	5.8e-08	-0.71	0.05	0.79	FALSE