Best TWAS P=1.53e-11 · Best GWAS P=8.33e-17 conditioned to 6.94e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | RP11-672L10.6 | 0.12 | 0.08 | lasso | 5 | 0.08 | 4.4e-06 | 6.5 | -6.7 | 1.5e-11 | -0.87 | 0.08 | 0.92 | TRUE |
| 2 | GTEx | Esophagus Muscularis | YES1 | 0.13 | 0.10 | lasso | 2 | 0.07 | 4.0e-05 | 5.8 | 5.6 | 1.8e-08 | 0.68 | 0.19 | 0.49 | FALSE |
| 3 | GTEx | Thyroid | RP11-672L10.6 | 0.12 | 0.04 | lasso | 5 | 0.06 | 1.3e-05 | 7.8 | -6.7 | 2.5e-11 | -0.78 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | YES1 | 0.07 | 0.03 | blup | 104 | 0.05 | 1.0e-03 | 7.8 | -5.2 | 2.1e-07 | -0.71 | 0.01 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | YES1 | 0.08 | 0.04 | lasso | 5 | 0.08 | 5.1e-08 | -3.1 | 5.8 | 7.4e-09 | 0.54 | 0.60 | 0.28 | TRUE |