TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
:
Blood Platelet Count
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chr18:69,836-1,512,239
Best TWAS P=1.53e-11 · Best GWAS P=8.33e-17 conditioned to 6.94e-05
0
0.2M
0.4M
0.6M
0.8M
1M
1.2M
1.4M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Mucosa
RP11-672L10.6
0.12
0.08
lasso
5
0.08
4.4e-06
6.5
-6.7
1.5e-11
-0.87
0.08
0.92
TRUE
5
The Cancer Genome Atlas
Thyroid Carcinoma
YES1
0.08
0.04
lasso
5
0.08
5.1e-08
-3.1
5.8
7.4e-09
0.54
0.60
0.28
TRUE
3
GTEx
Thyroid
RP11-672L10.6
0.12
0.04
lasso
5
0.06
1.3e-05
7.8
-6.7
2.5e-11
-0.78
0.02
0.98
FALSE
2
GTEx
Esophagus Muscularis
YES1
0.13
0.10
lasso
2
0.07
4.0e-05
5.8
5.6
1.8e-08
0.68
0.19
0.49
FALSE
4
The Cancer Genome Atlas
Colon Adenocarcinoma
YES1
0.07
0.03
blup
104
0.05
1.0e-03
7.8
-5.2
2.1e-07
-0.71
0.01
0.93
FALSE