Best TWAS P=1.44e-13 · Best GWAS P=1.86e-17 conditioned to 2.58e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | C18orf25 | 0.14 | 0.00 | enet | 30 | 0.03 | 5.8e-03 | 0.75 | -5.5 | 4.6e-08 | -0.45 | 0.02 | 0.82 | TRUE |
| 2 | GTEx | Spleen | EPG5 | 0.43 | 0.19 | enet | 19 | 0.19 | 1.5e-05 | 4.95 | 5.9 | 3.7e-09 | 0.27 | 0.48 | 0.03 | FALSE |
| 3 | GTEx | Spleen | PSTPIP2 | 0.28 | 0.02 | lasso | 5 | 0.07 | 8.1e-03 | 4.37 | 6.1 | 1.1e-09 | 0.54 | 0.13 | 0.19 | FALSE |
| 4 | GTEx | Whole Blood | ATP5A1 | 0.12 | 0.05 | enet | 34 | 0.02 | 9.1e-03 | -6.46 | 6.2 | 4.2e-10 | 0.57 | 0.77 | 0.12 | FALSE |
| 5 | METSIM | Adipose | ATP5A1 | 0.03 | 0.04 | lasso | 12 | 0.03 | 4.4e-05 | -6.47 | 6.7 | 2.5e-11 | 0.72 | 0.94 | 0.01 | FALSE |
| 6 | METSIM | Adipose | PSTPIP2 | 0.05 | 0.02 | bslmm | 574 | 0.03 | 3.2e-05 | 5.27 | -7.4 | 1.4e-13 | -0.53 | 0.65 | 0.12 | TRUE |
| 7 | YFS | Blood | ATP5A1 | 0.14 | 0.16 | lasso | 18 | 0.17 | 2.3e-54 | -6.46 | 6.6 | 5.1e-11 | 0.69 | 1.00 | 0.00 | FALSE |
| 8 | YFS | Blood | PSTPIP2 | 0.05 | 0.03 | bslmm | 567 | 0.04 | 5.8e-12 | 5.34 | 5.5 | 3.5e-08 | 0.33 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATP5A1 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.2e-04 | -6.46 | 6.5 | 1.0e-10 | 0.73 | 0.01 | 0.98 | FALSE |