Hub : Genes

PSTPIP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.2750	0.0900	2.6e-03	0.019	NA	0.041	NA	0.068	1.1e-01	NA	3.2e-02	NA	8.1e-03
2	METSIM	Adipose	0.0476	0.0200	2.4e-03	0.017	0.021	0.022	0.029	0.025	1.0e-03	3.9e-04	2.6e-04	3.2e-05	1.0e-04
3	NTR	Blood	0.0216	0.0102	1.4e-02	0.000	0.004	-0.001	0.004	-0.001	5.2e-01	2.0e-02	7.5e-01	1.1e-02	8.4e-01
4	YFS	Blood	0.0474	0.0120	9.3e-10	0.028	0.033	0.036	0.036	0.035	1.2e-09	4.1e-11	7.4e-12	5.8e-12	1.2e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.4	0.8	-0.9	-0.2	-0.9	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	-0.0	0.4	-1.2	-0.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.5	0.6	-0.5	-0.2
Depression (Nagel 2018)	0.6	0.9	1.9	1.1	-0.7	-0.3	1.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.8	0.5	-0.1	-0.9
Neuroticism (Nagel 2018)	0.1	0.2	0.6	0.8	0.3	-0.2	-0.5
Schizophrenia (2018)	0.2	0.4	0.9	0.7	0.6	-0.9	-0.3
Schizophrenia vs Biploar Disorder	1.1	1.5	5.1	0.7	0.3	2.3	-0.3
Worry (Nagel 2018)	0.1	0.2	0.3	0.4	0.4	0.6	-0.5
Alzheimer’s Disease (in mother)	4.4	5.2	8.8	2.1	-2.3	1.6	3.0
Alzheimer’s Disease (in father)	1.1	1.2	2.7	1.6	-0.8	-1.0	0.7
Alzheimer’s Disease (including proxy)	4.5	6.5	11.6	2.7	-2.6	0.4	3.4
Crohns Disease (2017)	0.2	0.3	0.9	0.3	1.0	-0.4	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	0.5	0.7	0.7	-0.6	-0.4
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.7	0.2	-0.4	-0.1
Major Depression (MDD)	0.7	0.8	1.6	-0.6	1.3	-0.3	-1.1
Reaction Time	1.6	3.0	5.3	2.3	-2.0	-1.1	1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.8	2.7	-1.4	1.6	-0.4	-1.6
Breast Cancer	0.1	0.3	0.9	0.6	0.9	-0.2	0.0
Ovarian Cancer	0.0	0.0	0.1	0.1	-0.0	-0.2	0.3
Prostate Cancer	0.4	0.5	1.2	-1.1	1.0	0.2	-0.2
Age at First Birth	0.0	0.0	0.1	0.2	-0.2	0.3	0.1
Bipolar Disorder (2011)	0.6	0.6	1.8	0.7	-0.1	-1.3	-0.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.4	-0.3	0.6	-1.2	0.5
Coronary Artery Disease (CAD)	0.6	0.7	1.8	0.6	-0.6	1.4	-0.2
Crohns Disease (2012)	0.3	0.5	1.1	0.5	0.3	-0.8	-1.0
Mean Putamen Volume	0.6	0.6	1.2	0.0	0.6	-1.1	-1.0
Fasting Glucose	0.6	0.7	1.4	-1.2	0.7	-0.8	-0.4
HbA1C	2.0	2.3	4.1	-1.8	2.0	-0.7	-1.1
HDL Cholesterol	0.2	0.3	0.8	0.9	-0.6	-0.2	0.2
LDL Cholesterol	0.1	0.2	0.5	-0.1	-0.2	0.7	0.5
Lupus	0.3	0.4	1.7	-0.2	0.2	1.3	-0.1
Neuroticism (2016)	0.6	0.9	2.0	-0.1	1.2	-0.3	-1.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.3
Rheumatoid Arthritis	0.6	0.8	2.6	-0.0	1.6	0.5	-0.6
Schizophrenia (2014)	0.0	0.1	0.2	0.5	0.2	-0.1	0.1
Triglycerides	0.0	0.0	0.1	-0.3	-0.1	0.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	1.1	-0.2	1.0	-0.8
Ulcerative Colitis	0.4	0.6	1.0	0.8	-0.1	0.9	-1.0
Blood Eosinophil Count	1.6	12.6	18.6	4.3	-4.2	1.9	3.2
Blood Platelet Count	2.6	30.6	54.6	6.1	-7.4	0.7	5.5
Blood Red Count	0.8	8.0	21.1	-1.2	2.6	-4.6	1.7
Blood White Count	1.2	9.1	14.3	2.7	-3.5	3.8	1.6
Heel T-Score	0.0	0.1	0.2	0.3	-0.4	0.3	0.4
BMI	0.1	0.8	1.2	-0.8	-0.3	1.1	1.1
Height	0.1	1.2	4.8	-0.3	0.3	2.2	-0.2
Waist Hip Ratio (WHR)	0.3	1.3	3.2	0.5	-1.8	0.9	1.0
Systolic Blood Pressure	0.4	1.8	5.3	0.7	-0.8	2.3	1.0
Smoking Status	1.8	4.3	7.0	2.6	-2.6	0.2	1.9
Allergy or Eczema	0.4	1.0	1.7	1.3	-0.8	-0.3	1.3
Cardiovascular Disease	0.2	0.6	1.1	1.0	-0.6	1.0	-0.0
Hypothyroidism (self reported)	0.3	0.8	1.1	0.9	-0.8	1.1	0.7
Respiratory disease	0.2	0.5	1.1	-0.5	1.0	0.8	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.1	-0.4	-0.1	0.8
Lung FEV1/FVC ratio	0.1	0.7	1.5	0.8	-0.8	1.2	0.3
Lung FVC	0.3	1.3	2.9	0.1	1.7	-1.5	-0.5
Neuroticism	0.2	0.4	0.5	0.7	0.7	-0.4	-0.7
Chronotype (morning person)	2.2	5.1	10.9	-2.2	2.1	-0.6	-3.3
Hair Pigment	0.0	0.8	1.9	0.6	-0.8	-0.4	-1.4
Tanning	0.1	0.7	2.1	0.6	-0.4	0.2	1.4
Hand grip strength (left)	3.0	7.9	17.1	-4.1	2.9	-0.3	-2.5
Number of treatments/medications taken	0.8	1.4	2.4	0.8	-1.5	0.7	1.4
Average weekly spirits intake	0.7	0.8	1.9	-1.0	0.2	1.4	-0.7
Sensitivity / hurt feelings	0.1	0.2	0.7	0.8	-0.4	0.1	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.1	0.3	-0.7	0.8
Hearing difficulty/problems: Yes	0.9	1.3	3.2	0.9	-0.7	-1.0	1.8
Relative age of first facial hair	0.2	0.5	1.2	-1.1	0.6	0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	6.7	2.6	-1.1	-0.3	1.3
Ever used hormone-replacement therapy (HRT)	1.8	2.3	5.0	-2.2	1.2	1.1	-1.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	0.1	-0.0	1.2	-0.6
Systolic blood pressure, automated reading	0.4	1.1	3.3	0.4	-0.8	1.8	0.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.0	0.0	-0.5	0.8	1.7
Angina	1.3	1.7	2.5	-1.6	1.3	-0.9	-1.4
Medication for hormone replacement therapy	0.2	0.3	0.4	-0.6	0.4	0.6	-0.2
Vitamin and mineral supplements	0.8	1.1	2.0	-1.4	1.3	-0.8	-0.5
Supplements: Zinc	2.3	2.5	3.5	1.9	-0.9	-1.6	1.9
Medication: Co-codamol	1.1	1.3	2.0	-1.4	1.4	0.3	-1.1
Medication: Metformin	1.5	2.1	4.4	-0.1	-2.1	0.1	2.0
Diabetes (father)	0.5	0.7	2.3	0.2	-0.4	1.5	-0.4
Diabetes (mother)	1.4	1.8	3.9	2.0	-1.4	0.1	1.2
Severe depression (siblings)	2.6	2.9	6.1	-0.4	2.2	0.6	-2.5
Pack years adult smoking proportion	0.1	0.2	0.4	-0.2	-0.4	-0.2	-0.7
Impedance of leg (right)	0.1	0.7	1.4	-0.0	-1.1	-1.2	0.6
Leg fat-free mass (left)	0.2	1.3	4.9	-0.5	0.2	2.2	-0.3
Trunk fat percentage	0.7	2.7	5.3	0.6	-2.3	0.8	2.1
Hand grip strength (right)	3.2	8.6	13.9	-3.5	3.7	-0.2	-2.9
Townsend deprivation index at recruitment	0.3	0.4	1.4	1.2	-0.2	0.0	0.6
Current tobacco smoking	0.3	0.4	1.2	0.6	-1.1	0.2	-0.4
Average weekly fortified wine intake	1.0	1.2	3.5	-0.2	1.1	0.0	-1.9
Maternal smoking around birth	0.2	0.3	0.9	-0.5	-0.1	0.9	0.2
Fed-up feelings	0.5	0.9	2.0	-0.6	1.4	-0.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.7	1.6	-1.0	-0.4	1.6
Relative age voice broke	0.2	0.3	0.6	-0.8	-0.5	-0.6	0.3
Taking other prescription medications	1.4	2.1	3.5	1.2	-1.1	1.9	1.5
Age when periods started (menarche)	1.1	2.5	4.9	-1.3	2.2	-0.7	-1.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	-0.3	0.2	-0.9	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.1	-0.2	-0.7	0.5	1.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	-0.9	0.9	1.2	0.6
Qualifications: CSEs or equivalent	0.3	0.4	0.5	0.5	-0.7	-0.7	-0.5
Serious illness, injury or assault to yourself	1.0	1.2	1.8	-1.4	0.9	-1.1	-1.0
High blood pressure	0.2	0.4	0.9	0.4	-1.0	0.5	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	-0.0	-0.1	-0.9	0.4
Multivitamins +/- minerals	0.4	0.5	0.7	0.7	-0.8	0.8	0.1
Stomach or abdominal pain in last month	1.4	1.7	3.6	1.6	-1.9	0.7	0.2
Supplements: Glucosamine	0.6	0.8	1.7	1.3	-0.2	-0.4	1.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	5.3	0.3	-0.4	-2.3	1.1
Medication: Atenolol	0.2	0.3	1.0	-0.1	-1.0	0.3	-0.2
Medication: Levothyroxine sodium	0.7	1.2	3.1	1.1	-0.4	0.4	1.8
Sitting height	0.3	2.0	4.9	-1.1	1.2	2.2	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-1.1	0.5	-0.2	-0.4
High blood pressure (mother)	0.3	0.4	1.3	0.2	-1.1	0.1	-0.5
Body mass index (BMI)	0.1	0.5	1.0	0.1	-0.9	0.5	1.0
Impedance of leg (left)	0.1	0.4	0.7	-0.1	-0.9	-0.8	0.6
Leg predicted mass (left)	0.2	1.3	4.9	-0.5	0.2	2.2	-0.3
Trunk fat mass	0.4	1.8	2.8	0.3	-1.7	1.4	1.5
Waist circumference	0.4	1.5	2.4	-0.1	-1.5	1.1	1.6
Number of incorrect matches in round	1.0	1.7	4.3	1.1	-0.7	-2.1	-0.9
Past tobacco smoking	1.7	3.1	5.3	-1.7	2.1	0.0	-2.3
Alcohol usually taken with meals	1.4	2.2	3.4	-1.2	1.4	1.8	-1.5
Nervous feelings	0.1	0.1	0.2	0.5	0.2	0.4	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	1.0	-0.0	-0.5	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.5	-0.0	0.6	-0.7	0.5
Hair/balding pattern: Pattern 2	0.9	1.1	2.5	-1.6	0.2	-1.3	-0.1
Had menopause	0.5	0.6	1.3	-1.1	-0.3	-0.5	0.8
Had other major operations	0.4	0.5	1.6	1.3	-0.7	-0.3	0.1
Forced vital capacity (FVC)	0.5	1.9	4.2	-1.0	2.0	-0.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	0.0	-0.7	-0.3	1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.4	0.4	-0.4	-0.1
Qualifications: None of the above	0.1	0.1	0.3	0.4	0.3	0.0	-0.6
Financial difficulties in last 2 years	0.2	0.3	0.4	0.6	-0.1	-0.6	0.6
Mouth/teeth dental problems	0.4	0.7	2.3	-0.4	-0.4	0.0	1.5
Heart attack	0.1	0.1	0.4	-0.2	0.7	0.3	-0.2
Allergy	0.3	0.6	2.4	0.1	-0.1	1.6	-0.0
Pain all over the body in last month	0.1	0.1	0.3	0.2	0.0	0.1	0.5
Diabetes (self-reported)	2.2	3.4	6.0	1.4	-2.4	0.3	2.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.7	-1.2	0.5	-0.9	-1.6
Medication: Ramipril	0.3	0.4	0.7	0.8	-0.5	0.4	0.7
Medication: Simvastatin	0.4	0.6	1.0	-0.4	0.9	1.0	-0.6
Fluid intelligence score	0.5	1.0	2.4	-0.5	1.6	0.4	-1.1
Illnesses of siblings	2.4	3.4	6.8	-2.6	1.9	0.8	-1.6
Neuroticism score	0.2	0.4	0.5	0.6	0.7	-0.6	-0.6
Weight	0.2	0.9	2.8	-0.6	-0.5	1.7	0.6
Impedance of arm (right)	0.4	1.7	4.3	1.3	-2.1	-0.9	0.6
Arm fat percentage (right)	0.5	2.1	4.0	1.2	-2.0	0.2	1.7
Trunk fat-free mass	0.3	1.7	3.8	-1.2	1.1	1.9	-0.6
Hip circumference	0.1	0.5	1.3	-0.8	-0.2	1.2	0.3
Time employed in main current job	1.0	1.1	1.4	0.9	-1.0	-1.2	1.2
Alcohol intake versus 10 years previously	0.3	0.5	0.7	0.9	-0.8	-0.7	-0.2
Father’s age at death	1.5	2.0	4.6	-0.6	1.7	2.1	-0.0
Worrier / anxious feelings	1.4	2.6	4.3	-1.2	2.0	-0.6	-2.1
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	4.9	2.2	-1.6	-0.5	1.1
Falls in the last year	4.1	5.6	11.8	1.9	-2.6	0.6	3.4
Hair/balding pattern: Pattern 3	1.2	1.8	3.7	1.9	-1.4	-0.2	1.3
Number of live births	0.6	0.8	1.4	-1.2	1.1	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.6	-1.0	1.9	0.3	-1.7
Pulse rate	1.9	3.2	12.0	-0.5	-0.6	3.5	0.3
Happiness	0.6	0.7	2.0	-0.1	0.6	1.4	0.7
Noisy workplace	0.2	0.2	0.8	0.3	-0.3	0.9	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	-0.2	0.8	0.3	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	-0.0	0.0	-0.2	0.8
Mouth/teeth dental problems: Dentures	0.5	0.9	2.9	-0.2	0.3	-1.7	-0.8
Asthma	0.2	0.4	0.9	-0.9	0.6	0.3	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.3	-0.6	0.6	0.5	-0.5
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1
Depression (self-reported)	1.9	2.2	3.7	1.9	-1.5	-1.1	1.3
Medication: Lansoprazole	1.5	1.7	3.4	1.3	-1.8	-1.0	0.9
Prospective memory result	0.4	0.5	0.9	-0.1	-0.6	-0.9	0.8
Lung cancer (father)	0.9	1.0	2.3	-0.6	0.8	1.5	-0.9
Illnesses of mother	2.4	2.9	6.3	-1.4	2.5	0.4	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.2	-0.2	1.0	0.3	-1.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.4	-0.9	1.0	-0.0
Impedance of arm (left)	0.2	1.1	2.8	1.0	-1.7	-0.7	0.4
Arm fat mass (right)	0.2	0.9	1.4	0.4	-1.2	0.9	1.1
Trunk predicted mass	0.3	1.6	3.8	-1.2	1.0	1.9	-0.6
Standing height	0.3	2.6	6.2	-1.6	0.7	2.5	-0.9
Length of working week for main job	0.1	0.1	0.2	0.1	-0.0	0.3	0.5
Exposure to tobacco smoke at home	1.0	1.1	3.4	0.5	-0.7	1.8	0.6
Breastfed as a baby	0.5	0.6	1.1	1.0	-0.9	-0.4	0.7
Tense / ‘highly strung’	0.1	0.2	0.8	-0.1	0.1	0.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	1.0	0.0	0.4	0.7
Hair/balding pattern: Pattern 4	1.4	3.3	7.7	-1.1	2.1	-0.0	-2.8
Birth weight of first child	0.7	1.3	4.0	-0.6	-0.6	2.0	-0.7
Peak expiratory flow (PEF)	0.7	1.6	2.5	-0.5	1.3	1.6	-1.4
Pulse wave reflection index	0.4	0.5	0.9	-1.0	0.7	-0.4	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.9	0.1	-0.2	-0.1
Loud music exposure frequency	1.4	1.6	2.4	-0.8	1.3	1.2	-1.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	4.5	0.5	-1.1	2.1	0.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.7	-0.7	1.6	-0.2	-1.6
Blood clot in the leg (DVT)	0.4	0.6	1.3	0.1	0.0	-1.2	-0.9
Medication: Paracetamol	0.7	1.1	2.4	0.6	-0.8	-1.0	1.6
Headache pain in last month	0.0	0.1	0.2	-0.2	0.3	-0.5	-0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.2	-0.4	0.5	-1.1	-0.0
Glaucoma (self-reported)	0.1	0.1	0.3	-0.0	-0.6	-0.1	0.0
Gout (self-reported)	1.3	1.8	3.5	1.9	-1.5	0.5	1.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.5	1.2	-1.3	0.3	1.9
Medication: Amlodipine	0.8	1.2	2.5	0.8	-1.0	1.6	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.6	-0.8	0.3	0.5	0.6
Birth weight	0.3	0.6	1.3	-0.7	-0.5	0.6	1.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.8	0.2	-0.5	-2.0	0.0
High blood pressure (siblings)	2.2	3.1	5.6	2.4	-2.0	0.2	1.6
Forced vital capacity (FVC), Best measure	0.2	0.8	2.0	-0.2	1.1	0.1	-1.4
Body fat percentage	0.6	2.2	4.1	0.6	-2.0	0.7	2.0
Leg fat percentage (right)	0.4	1.5	3.1	0.3	-1.6	0.2	1.8
Arm fat-free mass (right)	0.3	1.6	4.1	-1.2	0.8	2.0	-0.1
Exposure to tobacco smoke outside home	1.3	1.7	4.6	-0.6	1.3	0.4	-2.2
Comparative body size at age 10	0.1	0.3	1.1	-1.0	-0.2	0.3	0.3
Number of full brothers	0.2	0.3	1.1	0.1	0.1	-0.2	-1.0
Worry too long after embarrassment	0.3	0.5	1.3	1.2	-0.2	-0.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.6	-0.0	-0.4	-1.6	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.5	-0.6	-0.9	0.5
Number of children fathered	0.1	0.2	0.5	0.0	-0.3	0.7	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	3.5	1.5	-1.7	-1.9	1.0
Age at first live birth	1.5	2.7	3.3	-1.8	1.3	1.6	-1.8
Pulse wave peak to peak time	0.4	0.5	1.0	0.4	0.9	-1.0	-0.0
Health satisfaction	0.4	0.5	1.0	0.4	-0.7	0.7	1.0
Shortness of breath walking on level ground	0.5	0.5	1.2	0.3	0.2	1.1	0.9
Qualifications: College or University degree	0.2	0.6	1.6	-0.3	0.3	-1.3	0.7
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.8	-0.1	-0.6	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.9	-0.3	0.3	1.4	0.1
Emphysema/chronic bronchitis	1.7	1.9	3.9	-1.5	1.2	0.0	-2.0
Medication for pain relief, constipation, heartburn	0.1	0.3	0.8	0.0	-0.4	0.2	-0.9
Neck or shoulder pain in last month	0.3	0.5	0.9	0.5	-0.8	-0.9	0.0
Medication: Blood pressure	0.4	0.7	1.9	0.8	-0.3	1.4	0.3
Angina (self-reported)	1.4	1.8	2.6	-1.6	1.4	-0.8	-1.4
Migraine (self-reported)	0.6	0.7	1.8	0.8	-0.6	0.4	1.3
Medication: Ibuprofen	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.2
Medication: Allopurinol	2.3	3.1	4.9	2.2	-2.2	1.1	1.2
Medication: Omeprazole	0.1	0.1	0.2	0.4	0.0	0.4	-0.4
Medication: Seretide 50 evohaler	1.3	1.5	2.2	-1.5	1.5	-0.8	-0.9
Mean time to correctly identify matches	2.4	4.5	6.7	2.5	-2.6	-1.4	1.7
Heart disease (mother)	0.4	0.5	1.4	-0.0	-0.4	-1.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	1.2	-0.7	1.0	0.1
Whole body fat mass	0.3	1.4	1.9	0.1	-1.4	1.4	1.3
Leg fat mass (right)	0.4	1.4	2.6	0.2	-1.4	1.1	1.6
Arm predicted mass (right)	0.4	1.8	4.0	-1.5	0.9	2.0	-0.3
Pulse rate, automated reading	0.3	1.1	4.0	-0.3	-0.4	2.0	0.3
Alcohol intake frequency.	0.6	1.3	3.4	-0.2	0.8	1.1	-1.8
Comparative height size at age 10	0.2	1.3	3.7	-0.5	0.2	1.9	-1.1
Number of full sisters	0.7	0.9	1.5	1.2	-1.0	-0.5	0.9
Suffer from ‘nerves’	0.5	0.7	2.1	1.5	-0.7	-0.1	0.5
Overall health rating	1.3	2.8	4.6	2.2	-1.9	0.6	1.6
Chest pain or discomfort	0.6	0.9	2.2	-0.1	0.8	0.8	-1.5
Had major operations	1.4	1.7	2.0	1.2	-1.3	-1.4	1.3
Age at last live birth	0.5	0.7	1.7	-1.0	0.2	1.3	-0.0
Family relationship satisfaction	0.1	0.2	0.3	0.5	0.5	0.4	-0.1
Leg pain on walking	0.4	0.5	0.9	0.1	-0.4	-0.9	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.6	-0.4	0.2	1.6	-0.0
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.5	-1.9	1.2	-1.9	-0.9
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.0	0.1	0.1	-0.2
Medication: Aspirin	0.4	0.6	1.5	-0.3	0.8	-1.2	-0.0
Supplements: Vitamin C	0.7	0.8	1.7	1.1	-0.1	1.3	0.5
Knee pain experienced in last month	1.2	1.8	2.7	0.4	-1.6	-1.6	1.4
Hypertension (Self-reported)	0.2	0.5	0.7	0.3	-0.8	0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	0.8	0.3	0.4	-0.4
Illnesses of father: Heart disease	0.5	0.7	1.4	-0.5	0.6	-1.2	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.5	0.6	-0.4	1.2	-0.1
Smoking status: Previous	1.6	2.5	4.7	1.6	-1.6	-0.3	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.4	-1.1	0.3	1.2	-1.2
Whole body fat-free mass	0.3	1.7	5.4	-0.9	0.7	2.3	-0.4
Leg fat-free mass (right)	0.3	1.6	5.9	-0.5	0.4	2.4	-0.3
Arm fat percentage (left)	0.5	1.8	3.5	1.0	-1.9	0.4	1.6
Average weekly red wine intake	1.6	2.4	8.2	-1.2	0.1	2.9	-0.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.6	-1.9	0.1	-1.4	0.2
Mood swings	0.3	0.5	1.9	-0.1	1.4	-0.2	-0.4
Loneliness, isolation	0.1	0.2	0.5	0.7	0.2	-0.3	0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.4	0.4	-0.6	0.3	0.2
Ever had bowel cancer screening	0.2	0.2	0.6	0.8	-0.1	0.3	0.1
Diabetes diagnosed by doctor	1.0	1.7	3.5	0.9	-1.6	0.0	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.3	1.5	-1.1	-0.3	-0.0
Friendships satisfaction	0.1	0.1	0.3	0.3	-0.4	-0.1	0.6
Qualifications: nursing, teaching	0.5	0.7	2.7	-0.0	-0.3	-1.6	0.1
Commuting to job workplace: Walk	0.5	0.6	1.7	-0.3	0.4	0.6	-1.3
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.5	0.4	0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	1.0	-0.4	-0.4	0.0
Medication for cholesterol	0.1	0.1	0.4	0.6	-0.2	-0.4	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	1.1	0.1	0.9	-0.2
Back pain experienced in last month	0.3	0.4	1.2	-0.2	0.1	-0.5	1.1
Mineral and other dietary supplements	0.1	0.2	0.7	-0.8	-0.2	0.1	-0.1
Breast cancer (self-reported)	0.2	0.3	0.7	0.5	-0.2	-0.8	-0.1
Asthma (self-reported)	0.2	0.4	0.8	-0.9	0.7	0.4	0.5
Osteoporosis (self-reported)	0.1	0.2	0.3	0.3	-0.6	0.1	0.5
Osteoarthritis (self-reported)	0.6	0.8	2.1	-0.4	1.4	0.9	-0.4
Medication: Aspirin	0.7	0.9	2.8	0.0	0.8	-1.7	0.0
Medication: Gliclazide	0.4	0.5	1.1	-0.4	-0.7	1.1	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-0.5	1.0	1.0	0.2
Smoking status: Current	0.5	0.9	2.2	1.0	-1.5	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	2.3	-0.9	1.5	-0.5	-1.1
Whole body water mass	0.3	1.7	5.3	-1.0	0.8	2.3	-0.4
Leg predicted mass (right)	0.3	1.6	5.6	-0.6	0.4	2.4	-0.4
Arm fat mass (left)	0.3	1.1	1.8	0.4	-1.4	1.0	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.5	-0.1	0.5	1.6	-1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-0.5	0.6	0.3	-1.2
Miserableness	0.3	0.5	1.4	1.2	-0.1	-0.5	0.4
Guilty feelings	0.7	1.0	1.8	1.4	-0.8	-0.8	0.9
Wears glasses or contact lenses	0.7	0.8	1.3	0.0	-1.1	-1.1	0.9
Ever taken oral contraceptive pill	0.5	0.5	1.0	1.0	0.2	1.0	0.3
Hearing aid user	0.3	0.4	0.8	0.4	0.6	-0.4	-0.9
Mother’s age at death	0.4	0.5	1.5	0.3	0.2	1.2	-0.7
Financial situation satisfaction	0.1	0.2	0.3	0.5	-0.5	0.1	0.4
Tinnitus: Yes, now most or all of the time	3.0	3.5	7.2	-1.4	2.1	0.8	-2.7
Commuting to job workplace: Public transport	0.6	0.8	1.2	1.1	-0.8	0.8	0.8
Eye problems/disorders: Glaucoma	1.0	1.1	1.7	-1.3	1.0	-0.2	-1.3
Medication: Blood pressure	0.2	0.3	1.1	-1.0	0.4	-0.4	-0.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	0.3	0.3	-0.4	-1.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	0.8	0.3	0.3	-0.3
High cholesterol (Self-reported)	0.2	0.3	0.8	0.5	-0.1	0.9	0.4
Medication: Bendroflumethiazide	0.1	0.2	0.5	0.1	-0.5	0.7	-0.0
Medication: Paracetamol	1.0	1.5	3.1	1.2	-1.0	-0.7	1.8
Medication: Lisinopril	0.1	0.1	0.3	0.0	0.3	-0.6	0.2
Medication: Atorvastatin	0.3	0.4	0.7	0.8	-0.9	-0.0	0.5
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.5	0.8	-0.4	-0.8
Alcohol drinker status: Never	0.2	0.2	0.7	-0.5	0.8	-0.2	-0.1
Ever smoked	0.7	1.2	2.7	0.5	-1.3	0.6	1.6
Basal metabolic rate	0.3	1.4	4.8	-0.8	0.4	2.2	-0.2
Leg fat percentage (left)	0.4	1.4	3.1	0.2	-1.6	0.3	1.8
Arm fat-free mass (left)	0.3	1.4	4.0	-1.1	0.5	2.0	-0.2
Number of operations (self-reported)	0.2	0.3	0.6	0.1	0.6	-0.7	-0.6
Average weekly beer plus cider intake	1.5	2.2	3.8	1.8	-2.0	-0.3	1.3
Irritability	0.2	0.4	0.5	0.7	0.6	0.7	-0.6
Risk taking	0.8	1.1	1.7	1.3	-0.8	1.1	1.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.4	0.2	0.1	-0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.5	-0.1	0.3	-0.2	0.7
Age started oral contraceptive pill	1.6	2.0	4.0	-2.0	1.6	-0.7	-0.9
Diastolic blood pressure, automated reading	1.6	5.0	6.2	2.1	-2.5	1.9	2.4
Ever depressed for a whole week	0.5	0.6	1.4	1.2	-0.3	0.4	0.8
Unable to work because of sickness or disability	2.8	3.6	6.0	2.4	-1.8	-0.2	2.3
Commuting to job workplace: Cycle	2.7	3.3	7.0	2.6	0.1	-2.4	-0.5
Myopia	0.4	0.6	1.3	1.1	-0.7	0.0	0.9
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.2	0.6	-0.8	-0.0
Cholesterol lowering medication	0.3	0.4	0.8	-0.9	0.2	0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.1	0.1	-0.1	-0.6
Pain experienced in last month	0.4	0.6	1.4	0.0	0.9	1.2	-0.5
Supplements: Calcium	2.9	3.2	5.2	2.2	-2.3	0.4	1.6
Basal cell carcinoma (self-reported)	2.0	2.4	5.8	-1.2	2.4	-1.4	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.2	0.9	0.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.1	-0.1	-0.7	-1.0
Heart disease (siblings)	0.9	1.1	1.7	1.2	-1.1	-1.3	0.5
Alcohol drinker status: Previous	1.1	1.3	4.0	0.8	-0.4	2.0	-0.5
Pack years of smoking	0.1	0.2	0.3	-0.4	-0.6	-0.4	-0.4
Impedance of whole body	0.1	0.7	2.0	0.5	-1.4	-0.8	0.4
Leg fat mass (left)	0.3	1.3	2.2	0.1	-1.3	1.1	1.5
Arm predicted mass (left)	0.3	1.5	4.6	-1.1	0.6	2.1	-0.1