TWAS
hub
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Blood Platelet Count
:
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chr18:66,371,289-68,204,223
Best TWAS P=2.4e-26 · Best GWAS P=4.14e-26 conditioned to 1
66.5M
67M
67.5M
68M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
NTR
Blood
DOK6
0.18
0.18
lasso
5
0.18
3.2e-56
10.4
10.6
2.4e-26
0.96
0.01
0.99
TRUE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
CD226
0.04
0.04
enet
7
0.05
5.3e-10
10.5
-10.6
4.4e-26
-0.93
0.00
1.00
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
CD226
0.09
0.03
blup
76
0.06
1.7e-07
10.5
-9.5
1.3e-21
-0.81
0.00
1.00
FALSE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
CD226
0.03
0.01
enet
7
0.02
4.3e-03
2.3
-8.0
1.2e-15
-0.51
0.02
0.60
FALSE