Hub : Genes

CD226

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0392	0.0146	5.7e-07	0.042	0.035	0.047	NA	0.044	4.8e-09	1.0e-07	5.3e-10	NA	2.3e-09
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0872	0.0314	1.4e-07	0.032	0.062	0.050	NA	0.018	1.5e-04	1.6e-07	2.7e-06	NA	3.5e-03
3	TCGA	Brain Lower Grade Glioma	0.0318	0.0163	5.3e-03	0.007	0.014	0.017	NA	0.012	5.2e-02	8.1e-03	4.3e-03	NA	1.5e-02
4	TCGA	Uterine Corpus Endometrial Carcinoma	0.3970	0.1180	8.2e-04	0.052	0.069	0.083	NA	0.077	1.4e-02	5.5e-03	2.6e-03	NA	3.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.0	2.1	1.5	1.3	-0.3	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.7	0.3	0.2	-0.6	-1.3
Depressed Affect (Nagel 2018)	1.1	2.3	4.6	-0.8	-2.1	-1.8	-0.7
Depression (Nagel 2018)	0.2	0.4	0.7	0.6	0.6	0.3	-0.8
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	-0.8	-0.1	0.2	0.9
Neuroticism (Nagel 2018)	1.4	3.4	5.5	-0.9	-2.3	-1.6	-2.2
Schizophrenia (2018)	0.5	1.0	2.2	-0.8	-0.9	-0.5	-1.5
Schizophrenia vs Biploar Disorder	2.5	3.3	4.8	1.2	2.0	2.2	1.7
Worry (Nagel 2018)	1.4	3.0	9.2	-0.5	-1.5	-0.5	-3.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.4	-0.1	0.1	-0.8
Alzheimer’s Disease (in father)	0.5	0.6	1.9	-0.2	0.1	1.4	0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.3	0.0	0.9	-0.5
Crohns Disease (2017)	1.9	4.2	7.0	-1.9	-2.6	-1.1	-2.2
Irritable Bowel Disease (IBD)	2.0	4.9	8.0	-2.4	-2.8	-2.1	-1.3
Ulcerative Colitis (UC)	1.5	2.8	4.4	-1.6	-2.0	-2.1	0.0
Major Depression (MDD)	1.4	1.7	4.1	-0.9	-2.0	-1.4	0.0
Reaction Time	0.9	1.7	4.9	-1.1	-0.5	-0.8	-2.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	0.1	0.4	0.6	0.6
Breast Cancer	1.2	3.0	6.3	-2.5	-1.6	-0.9	-1.5
Ovarian Cancer	0.4	0.5	1.3	-0.6	-0.4	0.4	-1.1
Prostate Cancer	0.1	0.1	0.3	-0.4	0.1	0.2	0.5
Age at First Birth	1.5	2.2	3.4	1.1	1.8	1.3	1.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.2	3.0	7.3	-1.1	-2.7	-1.6	-1.0
Coronary Artery Disease (CAD)	0.3	0.4	1.1	0.0	-0.2	-1.0	-0.7
Crohns Disease (2012)	1.1	1.8	3.4	-1.6	-1.8	-1.1	-0.5
Mean Putamen Volume	0.6	0.7	1.8	-0.9	-1.3	0.3	-0.1
Fasting Glucose	5.0	6.0	13.6	-1.2	-2.8	-3.7	-1.1
HbA1C	0.1	0.1	0.5	0.7	0.0	0.1	-0.3
HDL Cholesterol	0.4	0.7	1.0	1.0	0.7	1.0	0.5
LDL Cholesterol	0.4	0.6	1.4	-1.2	-0.8	0.2	0.4
Lupus	7.1	10.7	15.4	-3.9	-3.9	-2.8	-2.1
Neuroticism (2016)	0.2	0.3	0.4	-0.6	-0.3	0.6	0.5
Primary Biliary Cirrhosis	6.2	8.8	17.0	-3.2	-4.1	-2.5	-1.4
Rheumatoid Arthritis	2.5	3.5	5.9	-2.4	-2.3	-1.6	-0.3
Schizophrenia (2014)	0.2	0.5	0.8	0.8	0.9	0.3	-0.8
Triglycerides	1.7	2.8	4.6	-2.0	-2.2	-1.6	-0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.6	0.6	1.2	1.2	-0.8
Ulcerative Colitis	1.7	2.4	4.8	-1.1	-1.9	-2.2	-0.5
Blood Eosinophil Count	6.7	51.6	71.9	-7.8	-8.5	-6.6	-5.5
Blood Platelet Count	5.8	67.4	111.6	-10.6	-9.5	-8.0	-1.7
Blood Red Count	0.2	2.3	6.2	-0.9	-0.4	-1.4	-2.5
Blood White Count	3.9	28.7	43.6	-5.9	-6.6	-5.3	-2.8
Heel T-Score	0.1	0.9	1.7	1.3	0.0	0.5	1.2
BMI	0.1	0.5	0.9	0.7	-0.6	-0.9	-0.4
Height	0.3	6.6	10.0	3.2	2.9	1.8	2.1
Waist Hip Ratio (WHR)	0.1	0.2	0.8	0.1	-0.9	-0.3	-0.1
Systolic Blood Pressure	0.2	1.2	2.5	-0.3	-1.4	-1.6	-0.4
Smoking Status	0.1	0.2	0.6	-0.4	0.3	0.0	0.8
Allergy or Eczema	2.7	7.1	10.3	-3.0	-2.8	-3.2	-1.0
Cardiovascular Disease	0.8	2.6	4.1	-1.5	-2.0	-1.9	-0.7
Hypothyroidism (self reported)	8.2	18.8	32.3	-5.7	-4.8	-3.3	-3.0
Respiratory disease	2.9	6.5	8.9	-2.9	-3.0	-2.3	-1.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.5	-1.2	-0.3	0.0
Lung FEV1/FVC ratio	0.4	2.0	3.1	1.8	1.4	1.2	1.2
Lung FVC	0.1	0.3	0.9	-0.4	0.4	-0.0	1.0
Neuroticism	0.3	0.6	1.7	0.1	-0.9	0.0	-1.3
Chronotype (morning person)	0.3	0.7	2.0	0.0	1.4	0.8	0.4
Hair Pigment	0.0	1.0	2.0	-0.7	-1.0	-0.7	-1.4
Tanning	0.0	0.3	0.7	0.1	-0.7	0.1	-0.9
Hand grip strength (left)	0.1	0.2	0.5	0.0	-0.5	0.1	0.7
Number of treatments/medications taken	4.4	7.9	14.1	-3.8	-2.9	-2.4	-1.9
Average weekly spirits intake	1.4	1.7	3.4	-0.4	-1.9	-1.8	0.4
Sensitivity / hurt feelings	1.1	1.8	2.6	-1.6	-1.6	-0.4	-1.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.8	0.8	1.3	1.3	1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.0	-0.2	0.5	-0.9
Relative age of first facial hair	0.1	0.2	0.5	-0.7	0.1	0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.5	-0.0	1.0	1.6	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.2	0.1	-0.4	-0.7
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	-0.7	-0.5	-0.5	0.3
Systolic blood pressure, automated reading	0.6	1.6	3.4	-0.1	-1.8	-1.8	-0.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	0.5	0.5	1.3	-0.9
Angina	1.2	1.6	2.2	-1.5	-1.3	-0.6	-1.4
Medication for hormone replacement therapy	0.5	0.5	1.7	0.2	0.1	-1.3	0.6
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	-0.4	0.0	0.4
Supplements: Zinc	0.2	0.3	0.5	0.3	-0.4	-0.6	0.7
Medication: Co-codamol	0.6	0.7	1.1	0.7	1.0	1.0	0.6
Medication: Metformin	0.9	1.3	2.1	1.2	1.4	1.0	0.7
Diabetes (father)	0.8	1.0	3.2	-0.7	0.1	0.5	1.8
Diabetes (mother)	0.6	0.8	1.7	-0.4	-1.2	-1.3	-0.1
Severe depression (siblings)	0.8	0.8	3.0	-0.4	-0.4	-0.2	-1.7
Pack years adult smoking proportion	0.7	1.0	2.3	-0.0	-1.5	-1.2	-0.5
Impedance of leg (right)	0.0	0.1	0.3	-0.5	-0.0	0.3	0.2
Leg fat-free mass (left)	0.1	0.7	1.8	1.4	0.4	-0.8	-0.1
Trunk fat percentage	0.5	2.0	5.3	-0.3	-1.1	-2.3	-1.1
Hand grip strength (right)	0.2	0.4	1.1	0.5	-0.4	-0.5	1.1
Townsend deprivation index at recruitment	0.3	0.4	0.7	0.0	0.8	0.4	0.9
Current tobacco smoking	0.3	0.5	1.4	-0.7	-0.4	-0.4	1.2
Average weekly fortified wine intake	0.1	0.1	0.1	-0.2	0.4	0.4	0.2
Maternal smoking around birth	1.2	1.7	2.8	-1.4	-1.7	-1.4	-0.4
Fed-up feelings	0.2	0.4	0.9	0.6	0.3	0.9	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.1	0.7	0.9	1.0	-0.3
Relative age voice broke	1.1	1.7	2.3	-1.5	-1.1	-1.3	-1.3
Taking other prescription medications	3.1	4.8	10.5	-3.2	-1.8	-1.9	-1.4
Age when periods started (menarche)	0.4	1.0	2.8	0.2	0.3	1.0	-1.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	0.3	0.2	-0.2	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.5	1.2	0.5	1.2	0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	0.6	0.8	0.1	1.1
Qualifications: CSEs or equivalent	0.3	0.4	1.4	0.2	0.1	1.2	0.1
Serious illness, injury or assault to yourself	1.9	2.3	4.1	1.6	2.0	1.4	0.9
High blood pressure	0.1	0.3	0.4	-0.6	-0.6	-0.5	-0.5
Hayfever, allergic rhinitis or eczema	1.9	4.1	6.5	-2.1	-2.2	-2.5	-0.8
Multivitamins +/- minerals	0.1	0.2	0.4	0.4	0.7	-0.2	-0.1
Stomach or abdominal pain in last month	0.5	0.6	1.4	-0.4	-0.9	-0.2	1.2
Supplements: Glucosamine	0.2	0.3	0.8	-0.2	0.4	-0.9	0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	0.4	-0.3	-0.2	-1.4
Medication: Atenolol	0.2	0.2	0.5	-0.2	-0.4	-0.4	0.7
Medication: Levothyroxine sodium	11.1	18.9	20.2	-4.5	-4.5	-4.2	-4.2
Sitting height	0.9	6.3	14.1	3.8	2.6	0.7	2.0
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	-0.1	-1.6	-1.7	-0.5
High blood pressure (mother)	2.3	3.2	4.7	2.2	1.9	1.8	1.2
Body mass index (BMI)	0.2	1.0	2.2	-0.1	-1.1	-1.5	-0.7
Impedance of leg (left)	0.0	0.1	0.1	-0.2	0.4	0.3	0.1
Leg predicted mass (left)	0.1	0.6	1.6	1.3	0.3	-0.9	-0.1
Trunk fat mass	0.3	1.3	3.9	0.2	-0.8	-2.0	-0.8
Waist circumference	0.1	0.5	1.4	0.3	-0.7	-1.2	-0.4
Number of incorrect matches in round	0.2	0.3	0.5	-0.6	0.1	-0.7	-0.5
Past tobacco smoking	0.2	0.3	0.8	-0.5	-0.5	0.1	0.9
Alcohol usually taken with meals	1.4	2.3	6.4	-2.5	-1.5	-0.5	-0.4
Nervous feelings	0.4	0.8	1.7	-0.7	-1.0	0.2	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.2	1.0	1.1	1.5	-0.9
Hearing difficulty/problems with background noise	0.6	1.0	3.4	-0.6	-0.4	-0.2	-1.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.6	0.2	0.2	-0.2	1.3
Had menopause	2.4	3.1	6.2	-2.5	-1.2	-0.5	-2.1
Had other major operations	0.7	0.8	3.2	-0.1	-0.1	-1.8	-0.4
Forced vital capacity (FVC)	0.5	1.7	3.1	1.7	1.5	0.8	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.4	0.9	0.2	0.2	1.6
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	5.5	2.3	2.2	1.5	-0.5
Qualifications: None of the above	2.0	4.4	8.3	-2.7	-2.9	-1.2	-0.8
Financial difficulties in last 2 years	0.8	1.0	2.1	0.2	0.5	1.3	-1.5
Mouth/teeth dental problems	0.6	1.0	1.4	1.1	1.2	1.0	-0.5
Heart attack	0.3	0.4	1.0	-0.7	-0.3	-1.0	0.0
Allergy	2.5	5.7	7.8	2.6	2.7	2.8	1.0
Pain all over the body in last month	0.3	0.3	0.6	-0.5	-0.5	0.0	0.8
Diabetes (self-reported)	0.0	0.1	0.2	0.1	0.0	-0.1	0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.0	0.0	-0.5	0.2
Medication: Ramipril	0.1	0.2	0.4	0.1	0.5	0.6	0.3
Medication: Simvastatin	1.5	2.2	3.1	-1.7	-1.8	-1.4	-0.9
Fluid intelligence score	0.4	0.9	2.6	-0.1	0.5	1.6	0.9
Illnesses of siblings	0.2	0.2	0.3	-0.4	0.5	-0.6	0.4
Neuroticism score	0.8	1.6	4.1	-0.6	-1.4	-0.2	-2.0
Weight	0.1	0.7	1.6	1.0	-0.2	-1.2	-0.2
Impedance of arm (right)	0.1	0.4	1.1	-1.0	-0.2	-0.8	0.1
Arm fat percentage (right)	0.4	1.5	3.4	-0.5	-1.1	-1.8	-1.1
Trunk fat-free mass	0.2	1.2	3.5	1.9	0.8	0.2	0.8
Hip circumference	0.1	0.2	0.6	0.4	-0.2	-0.8	-0.2
Time employed in main current job	1.0	1.2	2.7	-0.3	-0.9	-1.1	-1.6
Alcohol intake versus 10 years previously	0.3	0.4	1.4	-0.1	0.3	-1.2	0.5
Father’s age at death	3.4	4.5	8.5	2.4	2.9	1.9	0.4
Worrier / anxious feelings	1.4	2.6	6.4	-0.8	-0.2	1.8	-2.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.3	-1.5	-1.5	-1.0	-0.1
Falls in the last year	0.2	0.3	0.4	-0.4	0.4	0.7	-0.6
Hair/balding pattern: Pattern 3	0.7	1.1	2.1	-0.0	0.9	1.4	-1.2
Number of live births	1.7	2.3	3.8	-1.9	-2.0	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	3.9	2.0	1.9	1.2	1.7
Pulse rate	0.4	0.6	1.2	-0.7	0.1	0.9	-1.1
Happiness	0.9	1.1	1.7	1.1	0.9	0.7	-1.3
Noisy workplace	1.3	1.6	3.2	1.3	1.8	0.8	0.9
Qualifications: A levels/AS levels or equivalent	2.6	5.7	8.6	2.3	2.7	2.9	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	0.1	0.2	-0.0
Mouth/teeth dental problems: Dentures	0.4	0.6	1.5	-1.2	-0.6	-0.7	-0.1
Asthma	2.5	4.9	8.0	-2.5	-2.8	-2.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.3	-1.2	-0.9	-0.8	0.4
Medication: Cholesterol lowering	2.8	4.4	9.3	-1.8	-3.1	-2.3	-0.1
Depression (self-reported)	0.1	0.1	0.5	-0.7	-0.1	0.3	0.1
Medication: Lansoprazole	0.1	0.1	0.3	-0.5	-0.1	-0.1	-0.1
Prospective memory result	1.0	1.2	2.1	1.4	1.0	1.1	0.8
Lung cancer (father)	2.8	3.3	4.2	1.3	2.0	2.0	1.8
Illnesses of mother	0.4	0.5	1.1	-0.3	-1.1	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.6	1.6	1.6	0.7	0.7
Pulse wave Arterial Stiffness index	0.8	0.9	3.2	0.3	-0.5	-0.4	-1.8
Impedance of arm (left)	0.1	0.5	0.8	-0.9	-0.1	-0.9	-0.4
Arm fat mass (right)	0.3	1.0	2.9	0.1	-0.9	-1.7	-0.7
Trunk predicted mass	0.2	1.2	3.4	1.8	0.8	0.2	0.8
Standing height	0.3	2.6	5.6	2.4	1.8	0.2	1.2
Length of working week for main job	0.4	0.5	0.9	1.0	-0.1	0.2	0.9
Exposure to tobacco smoke at home	0.5	0.6	1.4	0.4	0.8	1.2	-0.3
Breastfed as a baby	1.4	1.7	3.3	0.4	1.2	1.4	1.8
Tense / ‘highly strung’	0.7	1.2	3.1	-0.1	-1.8	-0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	0.1	0.3	0.9	-0.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.1	-0.6	-0.8	-0.2
Birth weight of first child	0.1	0.2	0.6	-0.2	0.1	-0.4	0.7
Peak expiratory flow (PEF)	1.2	2.7	4.8	2.2	1.7	1.3	1.2
Pulse wave reflection index	1.1	1.3	1.9	1.4	0.8	1.2	-1.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.4	-0.2	-0.4	-0.3
Loud music exposure frequency	1.0	1.1	2.9	0.5	1.7	0.9	0.5
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.6	1.3	1.6	1.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.1	-0.5	-0.0	0.5
Blood clot in the leg (DVT)	0.1	0.2	0.3	-0.4	-0.4	0.3	-0.6
Medication: Paracetamol	2.4	3.9	5.8	-2.0	-2.4	-1.6	-1.8
Headache pain in last month	0.7	1.2	2.3	-0.9	-0.9	-1.5	1.0
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	8.6	1.8	2.9	2.7	0.3
Glaucoma (self-reported)	1.6	1.8	2.3	-1.4	-1.2	-1.5	-1.3
Gout (self-reported)	0.5	0.6	1.5	-0.9	0.1	0.5	-1.2
Hypothyroidism/myxoedema (self-reported)	11.2	21.8	32.4	-5.7	-5.1	-3.6	-3.9
Medication: Amlodipine	0.2	0.3	0.5	-0.6	-0.7	-0.7	-0.2
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.8	-1.2	-1.7	-1.3	-0.5
Birth weight	0.1	0.3	0.6	0.8	-0.1	-0.4	0.6
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.6	-0.3	-0.6	-0.1	1.3
High blood pressure (siblings)	0.8	1.1	3.5	0.9	0.4	1.9	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	1.8	1.3	1.0	0.1	0.5
Body fat percentage	0.5	2.1	4.7	-0.7	-1.3	-2.2	-1.3
Leg fat percentage (right)	0.4	1.6	2.2	-0.9	-1.2	-1.5	-1.3
Arm fat-free mass (right)	0.2	1.1	3.5	1.9	0.7	-0.2	0.6
Exposure to tobacco smoke outside home	0.7	1.0	2.4	-1.6	-0.9	0.3	-0.8
Comparative body size at age 10	0.1	0.3	0.7	-0.4	-0.8	-0.2	-0.5
Number of full brothers	0.2	0.2	0.6	-0.3	-0.8	-0.2	-0.2
Worry too long after embarrassment	0.1	0.2	0.5	0.3	0.2	0.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.9	-0.4	0.0	1.4	-0.6
Wheeze or whistling in the chest in last year	2.3	4.1	6.2	-2.5	-2.1	-0.5	-2.3
Number of children fathered	3.6	4.1	8.2	-1.9	-2.9	0.1	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.1	0.4	0.9	-1.0
Age at first live birth	0.7	1.2	4.1	0.7	2.0	0.2	0.1
Pulse wave peak to peak time	0.7	0.9	2.9	-0.1	0.7	0.4	1.7
Health satisfaction	0.4	0.6	1.1	-0.6	-0.8	-0.5	-1.0
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.1	-0.7	-0.5	0.3
Qualifications: College or University degree	1.1	3.3	5.6	1.8	2.4	1.7	1.3
Eye problems/disorders: None of the above	0.5	0.6	1.6	0.5	0.5	1.3	0.3
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.8	-1.2	-1.7	-1.3	-1.1
Emphysema/chronic bronchitis	1.8	2.0	3.6	1.6	1.9	1.4	-0.1
Medication for pain relief, constipation, heartburn	2.7	4.6	6.7	2.5	2.6	2.0	1.3
Neck or shoulder pain in last month	1.7	2.5	4.6	-1.1	-1.9	-2.2	-0.8
Medication: Blood pressure	0.6	1.0	2.1	-0.5	-1.3	-1.5	0.0
Angina (self-reported)	0.6	0.8	1.5	-1.0	-0.8	-0.4	-1.2
Migraine (self-reported)	0.4	0.5	1.3	-0.8	-1.1	-0.4	0.2
Medication: Ibuprofen	0.2	0.2	0.6	-0.4	-0.2	-0.2	0.8
Medication: Allopurinol	0.3	0.4	0.8	-0.9	-0.6	-0.1	-0.6
Medication: Omeprazole	0.6	0.7	1.1	-0.6	1.1	0.6	1.0
Medication: Seretide 50 evohaler	2.1	2.4	4.8	-0.9	-1.5	-2.2	-1.3
Mean time to correctly identify matches	1.0	2.0	4.5	-1.8	-0.2	-0.6	-2.1
Heart disease (mother)	0.4	0.5	1.1	-1.0	0.9	-0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-1.1	-1.0	-0.1	-0.1
Whole body fat mass	0.3	1.3	3.6	0.0	-0.9	-1.9	-0.9
Leg fat mass (right)	0.1	0.6	1.3	0.3	-0.4	-1.1	-0.9
Arm predicted mass (right)	0.2	0.9	3.0	1.7	0.5	-0.3	0.5
Pulse rate, automated reading	0.4	1.3	3.6	-0.8	-0.7	0.5	-1.9
Alcohol intake frequency.	0.2	0.4	0.9	-0.7	0.0	-0.9	0.0
Comparative height size at age 10	0.1	0.5	1.8	0.3	-0.3	-1.4	0.0
Number of full sisters	0.2	0.2	0.4	0.3	0.4	0.3	-0.7
Suffer from ‘nerves’	1.3	2.1	5.3	-1.2	-1.1	0.7	-2.3
Overall health rating	0.7	1.6	3.1	-1.8	-1.1	-1.3	-0.6
Chest pain or discomfort	0.3	0.4	1.2	-0.7	-0.2	-0.1	-1.1
Had major operations	1.2	1.4	2.9	-1.7	-0.8	-1.2	-0.8
Age at last live birth	0.6	0.9	2.5	0.9	1.6	0.1	-0.2
Family relationship satisfaction	2.2	2.7	5.8	2.4	1.5	1.5	-0.5
Leg pain on walking	0.1	0.1	0.2	0.0	-0.4	-0.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	1.3	0.7	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	1.6	1.9	2.8	-0.9	-1.5	-1.2	-1.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.1	1.2	0.4	-0.2	1.8
Medication: Aspirin	2.4	3.2	5.9	-2.0	-2.4	-1.6	-0.5
Supplements: Vitamin C	0.1	0.1	0.4	-0.1	-0.1	0.6	0.2
Knee pain experienced in last month	0.1	0.2	0.4	-0.6	-0.4	-0.0	0.3
Hypertension (Self-reported)	0.2	0.7	1.1	-0.8	-1.1	-0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-1.0	-0.4	-0.6	0.6
Illnesses of father: Heart disease	0.0	0.1	0.1	0.2	-0.3	-0.3	0.0
Illnesses of siblings: Diabetes	0.9	1.1	2.9	-1.1	-1.7	-0.5	-0.1
Smoking status: Previous	0.3	0.4	1.0	0.7	0.5	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	0.8	1.1	0.7	0.5
Whole body fat-free mass	0.2	1.0	3.3	1.8	0.7	-0.2	0.5
Leg fat-free mass (right)	0.1	0.7	2.2	1.5	0.5	-0.7	-0.0
Arm fat percentage (left)	0.4	1.5	3.3	-0.5	-1.0	-1.8	-1.3
Average weekly red wine intake	0.3	0.4	1.3	-0.3	0.5	1.1	-0.3
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.1	1.5	0.7	1.0	1.8
Mood swings	1.3	2.4	4.8	-1.5	-2.2	-0.5	-1.5
Loneliness, isolation	0.1	0.1	0.3	0.4	-0.1	0.0	0.5
Long-standing illness, disability or infirmity	2.6	4.0	8.1	-2.9	-1.6	-1.3	-1.9
Ever had bowel cancer screening	0.6	0.7	2.6	-0.2	0.3	-0.2	1.6
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.1	-0.2	-0.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	0.5	-0.0	-0.1
Friendships satisfaction	0.3	0.4	1.3	1.1	-0.3	-0.0	-0.2
Qualifications: nursing, teaching	1.1	1.7	3.2	1.1	1.4	0.7	1.8
Commuting to job workplace: Walk	0.8	0.9	2.4	0.9	0.5	1.5	-0.3
Eye problems/disorders: Cataract	0.3	0.4	0.7	-0.5	-0.2	-0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	0.5	0.9	0.6	0.5
Medication for cholesterol	2.5	3.7	5.9	1.7	1.6	2.4	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.7	-1.9	-1.2	-1.2	-0.1
Back pain experienced in last month	0.6	0.8	3.0	-0.4	-0.1	-1.7	0.2
Mineral and other dietary supplements	1.6	2.1	4.6	2.1	1.2	1.5	0.6
Breast cancer (self-reported)	0.4	0.4	1.3	0.2	-0.0	1.1	-0.6
Asthma (self-reported)	2.5	5.0	8.7	-2.5	-2.9	-2.0	-1.0
Osteoporosis (self-reported)	0.5	0.7	1.5	-1.2	-0.3	-0.2	-1.1
Osteoarthritis (self-reported)	0.7	0.9	1.3	-1.1	-1.0	-1.1	0.1
Medication: Aspirin	2.2	2.9	4.7	-2.2	-2.1	-1.4	-0.5
Medication: Gliclazide	1.7	1.9	3.1	1.3	1.8	1.5	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.8	0.5	0.8	0.5
Smoking status: Current	0.4	0.6	2.0	-0.6	-0.0	-0.0	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	0.1	1.2	1.4	-0.0
Whole body water mass	0.1	0.8	2.7	1.6	0.5	-0.3	0.4
Leg predicted mass (right)	0.1	0.8	2.3	1.5	0.5	-0.7	-0.0
Arm fat mass (left)	0.3	1.1	3.0	0.2	-0.9	-1.7	-0.7
Number of self-reported non-cancer illnesses	2.8	4.8	9.3	-3.1	-2.3	-2.1	-0.8
Average weekly champagne plus white wine intake	1.5	2.0	4.5	1.0	1.0	1.2	-2.1
Miserableness	0.5	0.9	2.2	-0.0	-1.0	-1.5	0.6
Guilty feelings	0.4	0.6	1.8	0.6	-0.1	0.6	-1.3
Wears glasses or contact lenses	1.1	1.3	2.9	0.6	1.7	1.3	-0.1
Ever taken oral contraceptive pill	1.4	1.6	4.1	2.0	1.4	0.5	0.2
Hearing aid user	0.7	0.8	1.8	-0.8	-0.9	-1.3	-0.5
Mother’s age at death	0.8	1.0	2.9	0.6	0.6	1.7	-0.4
Financial situation satisfaction	1.2	1.5	3.3	1.8	1.2	1.2	0.3
Tinnitus: Yes, now most or all of the time	2.8	3.3	5.3	-1.3	-2.3	-1.6	-1.9
Commuting to job workplace: Public transport	0.1	0.2	0.5	0.0	0.0	0.4	-0.7
Eye problems/disorders: Glaucoma	2.0	2.4	3.7	-1.9	-1.6	-1.6	-0.9
Medication: Blood pressure	1.0	1.9	2.9	-1.0	-1.3	-1.4	-1.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.7	-0.4	-0.8	-0.7	-1.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.6	-0.2	-0.7	0.5
High cholesterol (Self-reported)	0.7	1.2	2.1	-1.3	-1.4	-0.9	-0.6
Medication: Bendroflumethiazide	0.3	0.5	1.4	-0.2	-0.4	-0.6	-1.2
Medication: Paracetamol	0.9	1.4	2.2	-0.8	-1.5	-1.2	-1.2
Medication: Lisinopril	1.4	1.9	3.5	-1.2	-1.6	-1.9	0.1
Medication: Atorvastatin	0.1	0.1	0.3	-0.5	0.3	-0.1	0.2
Illnesses of father: High blood pressure	0.0	0.1	0.2	0.2	0.4	-0.1	0.1
Alcohol drinker status: Never	0.2	0.3	0.6	-0.8	0.3	0.4	-0.5
Ever smoked	0.1	0.2	0.3	0.3	0.3	0.5	-0.5
Basal metabolic rate	0.1	0.8	2.6	1.6	0.4	-0.6	0.3
Leg fat percentage (left)	0.5	1.7	2.9	-0.9	-1.2	-1.7	-1.3
Arm fat-free mass (left)	0.1	0.7	2.3	1.5	0.1	-0.5	0.5
Number of operations (self-reported)	0.3	0.5	0.8	-0.9	-0.4	-0.8	-0.5
Average weekly beer plus cider intake	0.1	0.2	0.6	-0.1	-0.8	0.3	0.4
Irritability	0.7	1.2	1.8	-1.0	-1.4	-0.8	-1.1
Risk taking	0.2	0.2	0.6	0.5	0.4	0.8	-0.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.1	0.2	-0.1	0.1
Fractured/broken bones in last 5 years	0.6	0.7	1.4	1.0	0.4	0.5	-1.2
Age started oral contraceptive pill	1.3	1.7	5.2	-1.1	-0.2	-0.2	-2.3
Diastolic blood pressure, automated reading	0.3	1.1	2.1	0.7	-0.8	-1.5	-0.9
Ever depressed for a whole week	1.0	1.2	2.7	1.7	1.3	-0.0	-0.6
Unable to work because of sickness or disability	1.0	1.2	2.4	0.9	1.4	1.5	0.1
Commuting to job workplace: Cycle	1.8	2.2	3.4	1.6	1.3	1.2	1.9
Myopia	1.6	2.3	3.5	1.6	1.9	1.8	0.0
Vascular/heart problems diagnosed by doctor	0.6	1.5	1.7	1.3	1.3	1.3	1.0
Cholesterol lowering medication	1.7	2.4	4.6	-2.2	-0.9	-0.6	-2.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.0	-0.8	1.0	1.0	0.9
Pain experienced in last month	0.6	0.9	2.4	0.6	0.8	1.5	0.6
Supplements: Calcium	0.4	0.4	1.3	0.5	1.1	0.1	-0.3
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	0.9	1.3	0.8	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	-1.0	-0.5	-1.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.5	-0.3	0.2	-0.7
Heart disease (siblings)	0.3	0.3	0.6	-0.3	-0.8	-0.2	-0.7
Alcohol drinker status: Previous	0.7	0.8	1.4	1.2	0.8	0.9	0.6
Pack years of smoking	0.5	0.8	1.5	0.1	-1.2	-1.1	-0.6
Impedance of whole body	0.0	0.1	0.3	-0.6	-0.0	-0.3	-0.1
Leg fat mass (left)	0.2	0.8	2.1	0.2	-0.5	-1.4	-0.8
Arm predicted mass (left)	0.1	0.6	1.8	1.3	0.0	-0.5	0.4