Best TWAS P=1.54e-08 · Best GWAS P=1.82e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GSK3B | 0.15 | 0.09 | lasso | 5 | 0.07 | 1.4e-06 | -5.5 | -5.7 | 1.5e-08 | 0.96 | 0.02 | 0.98 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | GSK3B | 0.06 | 0.07 | lasso | 3 | 0.05 | 2.2e-04 | -5.6 | -5.6 | 1.9e-08 | 1.00 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | GSK3B | 0.09 | 0.11 | lasso | 8 | 0.09 | 1.7e-05 | -5.6 | -5.5 | 3.5e-08 | 0.99 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | GSK3B | 0.05 | -0.01 | lasso | 11 | 0.00 | 2.8e-01 | -5.5 | -5.5 | 3.8e-08 | 0.98 | 0.04 | 0.47 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GSK3B | 0.04 | 0.05 | lasso | 3 | 0.04 | 2.4e-05 | -5.5 | -5.3 | 1.1e-07 | 0.98 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | GSK3B | 0.19 | 0.12 | lasso | 5 | 0.10 | 2.0e-07 | -5.3 | -5.3 | 1.3e-07 | 0.99 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | GSK3B | 0.07 | 0.07 | blup | 145 | 0.05 | 9.5e-06 | -5.4 | -5.2 | 2.0e-07 | 0.93 | 0.03 | 0.97 | FALSE |