[Hub]/) : Traits : Blood Platelet Count : ← →

chr3:120,799,666-129,284,415

Best TWAS P=4.77e-89 · Best GWAS P=9.45e-93 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EEFSEC	0.07	0.04	blup	496	0.04	1.2e-05	-6.60	6.2	5.5e-10	-0.03	0.97	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RPN1	0.11	0.12	lasso	2	0.12	1.0e-14	-6.18	6.2	7.7e-10	0.08	0.62	0.38	FALSE
3	GTEx	Adipose Subcutaneous	PLXNA1	0.11	0.13	lasso	5	0.14	3.5e-11	7.06	-7.5	6.7e-14	0.07	0.30	0.70	TRUE
4	GTEx	Adipose Subcutaneous	EEFSEC	0.07	0.03	enet	12	0.06	2.4e-05	-6.53	6.3	2.8e-10	-0.06	0.77	0.02	FALSE
5	GTEx	Adipose Visceral Omentum	PLXNA1	0.12	0.12	lasso	2	0.09	1.5e-05	6.83	-7.1	1.6e-12	0.03	0.48	0.36	FALSE
6	GTEx	Artery Aorta	RPN1	0.17	0.06	enet	27	0.07	9.7e-05	5.40	6.0	2.1e-09	0.02	0.23	0.67	FALSE
7	GTEx	Artery Coronary	RPN1	0.15	0.05	lasso	5	0.03	3.0e-02	5.49	5.8	8.1e-09	0.02	0.12	0.11	FALSE
8	GTEx	Artery Tibial	PDIA5	0.11	0.00	enet	36	0.03	2.4e-03	-3.14	6.3	2.8e-10	0.11	0.63	0.03	TRUE
9	GTEx	Artery Tibial	RPN1	0.12	0.07	lasso	4	0.05	1.3e-04	5.48	5.5	2.8e-08	0.01	0.94	0.02	FALSE
10	GTEx	Brain Cerebellar Hemisphere	SLC15A2	0.17	0.03	lasso	15	0.02	9.7e-02	6.82	7.0	3.3e-12	0.01	0.04	0.86	TRUE
11	GTEx	Brain Cerebellar Hemisphere	IQCB1	0.27	0.24	lasso	7	0.25	5.1e-07	5.57	5.3	1.0e-07	-0.04	0.36	0.10	FALSE
12	GTEx	Brain Cerebellum	SLC15A2	0.33	0.47	lasso	18	0.44	1.8e-14	6.85	6.8	9.2e-12	0.02	0.03	0.97	FALSE
13	GTEx	Brain Cortex	RPN1	0.30	0.14	lasso	5	0.15	7.0e-05	5.36	6.5	5.7e-11	0.04	0.07	0.62	FALSE
14	GTEx	Brain Frontal Cortex BA9	ZXDC	0.37	0.08	enet	20	0.18	1.3e-05	3.43	5.5	3.7e-08	0.07	0.19	0.41	FALSE
15	GTEx	Breast Mammary Tissue (Male)	ZXDC	0.04	0.01	lasso	8	0.01	1.4e-01	-4.44	5.6	2.1e-08	0.02	0.05	0.17	FALSE
16	GTEx	Cells Transformed fibroblasts	SEC61A1	0.13	0.18	lasso	2	0.17	1.0e-12	-5.82	-5.9	4.1e-09	-0.01	0.96	0.04	FALSE
17	GTEx	Cells Transformed fibroblasts	EEFSEC	0.08	0.08	lasso	2	0.06	2.4e-05	-6.43	6.4	1.3e-10	-0.05	0.76	0.01	FALSE
18	GTEx	Cells Transformed fibroblasts	EAF2	0.16	0.04	lasso	11	0.07	3.2e-06	6.14	6.9	3.8e-12	-0.07	0.49	0.30	TRUE
19	GTEx	Cells Transformed fibroblasts	CHCHD6	0.08	0.06	enet	12	0.04	3.4e-04	3.95	-5.5	3.2e-08	0.06	0.77	0.05	FALSE
20	GTEx	Cells Transformed fibroblasts	RUVBL1	0.07	0.04	lasso	3	0.02	2.5e-02	-6.95	-6.7	2.8e-11	0.00	0.90	0.01	FALSE
21	GTEx	Cells Transformed fibroblasts	RP11-797D24.4	0.10	0.05	lasso	4	0.03	1.3e-03	-6.19	-6.0	2.3e-09	-0.27	0.51	0.02	FALSE
22	GTEx	Colon Sigmoid	RP11-723O4.9	0.20	0.10	lasso	4	0.08	7.9e-04	4.42	5.9	3.6e-09	0.03	0.10	0.69	TRUE
23	GTEx	Esophagus Gastroesophageal Junction	RPN1	0.13	0.10	lasso	3	0.08	9.9e-04	5.42	5.5	3.5e-08	0.02	0.35	0.14	FALSE
24	GTEx	Esophagus Mucosa	TXNRD3	0.08	0.02	lasso	3	0.01	5.1e-02	-5.53	-6.0	2.6e-09	-0.02	0.20	0.06	FALSE
25	GTEx	Esophagus Muscularis	EEFSEC	0.07	0.08	lasso	5	0.07	4.4e-05	-6.53	6.6	4.6e-11	-0.04	0.71	0.03	FALSE
26	GTEx	Esophagus Muscularis	SLC15A2	0.12	0.01	enet	19	0.04	2.7e-03	5.85	6.8	1.2e-11	-0.06	0.05	0.89	FALSE
27	GTEx	Esophagus Muscularis	RPN1	0.19	0.11	lasso	6	0.10	7.3e-07	5.42	5.2	2.3e-07	0.02	0.80	0.16	FALSE
28	GTEx	Esophagus Muscularis	TXNRD3	0.17	0.05	lasso	4	0.04	1.7e-03	-5.50	-7.2	6.8e-13	-0.02	0.39	0.37	FALSE
29	GTEx	Heart Atrial Appendage	SLC15A2	0.23	0.25	lasso	14	0.24	2.3e-11	6.60	6.4	1.2e-10	0.02	0.03	0.97	FALSE
30	GTEx	Heart Left Ventricle	SLC15A2	0.16	0.19	lasso	6	0.20	8.6e-11	6.60	6.9	4.5e-12	0.01	0.04	0.96	FALSE
31	GTEx	Heart Left Ventricle	RP11-723O4.2	0.10	0.03	enet	11	0.09	1.6e-05	4.66	6.0	1.5e-09	0.01	0.26	0.14	FALSE
32	GTEx	Liver	EAF2	0.16	0.06	enet	32	0.07	5.4e-03	4.83	6.2	7.5e-10	0.02	0.07	0.51	FALSE
33	GTEx	Lung	UMPS	0.14	0.00	enet	28	0.02	1.6e-02	-5.57	5.6	2.2e-08	0.10	0.12	0.04	FALSE
34	GTEx	Lung	PLXNA1	0.10	0.06	lasso	6	0.06	3.6e-05	6.66	-8.2	3.2e-16	0.05	0.38	0.55	TRUE
35	GTEx	Lung	RPN1	0.08	0.06	lasso	4	0.04	2.6e-04	5.74	5.7	1.6e-08	0.03	0.36	0.36	FALSE
36	GTEx	Muscle Skeletal	EAF2	0.05	0.04	lasso	6	0.02	1.5e-03	6.14	5.9	2.8e-09	-0.01	0.08	0.66	FALSE
37	GTEx	Muscle Skeletal	KALRN	0.10	0.08	enet	16	0.06	9.9e-07	-5.60	-6.9	5.2e-12	-0.06	1.00	0.00	TRUE
38	GTEx	Nerve Tibial	PLXNA1	0.10	0.06	lasso	4	0.06	3.4e-05	5.95	-7.3	2.1e-13	0.04	0.41	0.57	FALSE
39	GTEx	Nerve Tibial	EEFSEC	0.07	0.06	lasso	2	0.06	4.5e-05	-6.58	6.5	5.9e-11	-0.04	0.96	0.00	FALSE
40	GTEx	Nerve Tibial	SLC15A2	0.08	0.10	lasso	8	0.07	8.0e-06	6.85	6.9	5.2e-12	0.03	0.03	0.97	FALSE
41	GTEx	Pancreas	KALRN	0.22	0.10	lasso	10	0.11	2.9e-05	3.87	-6.0	2.6e-09	-0.03	0.86	0.01	FALSE
42	GTEx	Pituitary	IQCB1	0.29	0.14	enet	19	0.24	1.1e-06	3.45	5.4	7.8e-08	-0.02	0.21	0.52	FALSE
43	GTEx	Skin Sun Exposed Lower leg	CHCHD6	0.10	0.00	enet	15	0.02	1.8e-02	4.25	-5.6	1.8e-08	0.03	0.22	0.17	FALSE
44	GTEx	Spleen	ZXDC	0.34	0.18	enet	5	0.15	9.9e-05	-5.63	5.5	4.2e-08	0.01	0.39	0.06	FALSE
45	GTEx	Spleen	SLC41A3	0.25	0.02	enet	10	0.11	1.1e-03	1.94	-6.0	2.1e-09	0.05	0.07	0.46	TRUE
46	GTEx	Spleen	CHCHD6	0.46	0.03	lasso	6	0.06	1.0e-02	5.12	-5.5	4.3e-08	0.03	0.07	0.06	FALSE
47	GTEx	Spleen	IQCB1	0.29	0.08	enet	18	0.12	6.9e-04	4.71	5.8	8.0e-09	-0.05	0.07	0.20	FALSE
48	GTEx	Testis	RPN1	0.30	0.15	enet	22	0.15	2.8e-07	5.42	8.1	4.0e-16	0.02	0.09	0.91	TRUE
49	GTEx	Testis	RUVBL1	0.31	0.30	lasso	12	0.30	1.2e-13	-6.46	-6.8	1.1e-11	0.01	1.00	0.00	FALSE
50	GTEx	Thyroid	SEC61A1	0.14	0.07	lasso	6	0.05	1.2e-04	-5.81	-5.8	6.6e-09	-0.02	0.88	0.05	FALSE
51	GTEx	Thyroid	RP11-71H17.7	0.18	0.05	lasso	3	0.10	2.5e-08	-4.47	-7.1	1.2e-12	0.01	0.67	0.01	TRUE
52	GTEx	Vagina	RP11-723O4.9	0.30	0.12	lasso	9	0.20	3.0e-05	4.38	5.3	1.3e-07	0.03	0.18	0.05	FALSE
53	GTEx	Whole Blood	ZXDC	0.08	0.01	lasso	6	0.02	1.2e-02	-7.08	7.3	3.4e-13	0.02	0.05	0.88	FALSE
54	METSIM	Adipose	CHST13	0.32	0.27	lasso	6	0.31	4.3e-47	-7.49	8.2	2.7e-16	0.01	0.01	0.99	FALSE
55	METSIM	Adipose	PLXNA1	0.13	0.14	lasso	9	0.14	3.7e-20	6.66	-6.7	2.4e-11	0.05	0.34	0.66	FALSE
56	NTR	Blood	CHST13	0.04	0.02	lasso	7	0.03	2.4e-09	-7.60	6.9	5.7e-12	0.02	0.01	0.99	FALSE
57	YFS	Blood	CHST13	0.59	0.68	enet	27	0.73	0.0e+00	-7.52	8.2	3.3e-16	0.01	0.01	0.99	FALSE
58	YFS	Blood	PDIA5	0.03	0.02	lasso	2	0.02	7.5e-08	20.43	20.0	4.8e-89	0.98	0.00	1.00	TRUE
59	YFS	Blood	RAB7A	0.03	0.00	blup	370	0.01	8.5e-06	-0.69	-8.6	9.8e-18	0.00	0.16	0.03	TRUE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHST13	0.09	0.12	lasso	7	0.14	6.1e-12	-7.31	7.8	6.4e-15	0.00	0.03	0.97	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEFSEC	0.04	0.02	blup	115	0.02	6.7e-03	-6.56	6.0	2.6e-09	0.01	0.05	0.78	FALSE
62	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC90246	0.11	0.08	blup	48	0.09	6.5e-08	5.78	-7.5	8.0e-14	0.00	0.00	1.00	TRUE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHST13	0.24	0.38	enet	10	0.44	5.0e-101	-7.49	8.2	3.6e-16	0.01	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHST13	0.17	0.23	enet	8	0.26	2.1e-13	-7.52	8.1	7.5e-16	0.01	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	CHST13	0.19	0.20	enet	11	0.20	1.7e-11	-7.49	7.5	7.5e-14	0.00	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	KALRN	0.11	0.03	lasso	5	0.02	2.5e-02	-5.86	6.3	2.2e-10	0.09	0.10	0.03	FALSE
67	The Cancer Genome Atlas	Esophageal Carcinoma	CHST13	0.10	0.09	lasso	2	0.09	8.9e-04	-5.29	5.9	4.2e-09	0.03	0.06	0.71	FALSE
68	The Cancer Genome Atlas	Glioblastoma Multiforme	CHST13	0.43	0.26	lasso	4	0.24	6.5e-08	-7.52	8.1	5.7e-16	0.01	0.01	0.99	TRUE
69	The Cancer Genome Atlas	Glioblastoma Multiforme	EEFSEC	0.09	0.07	lasso	10	0.05	1.7e-02	-6.41	7.2	4.7e-13	0.00	0.03	0.72	FALSE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHST13	0.15	0.19	blup	66	0.24	4.0e-26	-7.49	8.1	7.7e-16	0.00	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHST13	0.09	0.20	enet	11	0.21	2.5e-23	-7.30	7.8	4.6e-15	0.01	0.03	0.97	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHST13	0.21	0.17	lasso	3	0.16	1.8e-09	-7.49	7.8	8.0e-15	0.01	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHST13	0.23	0.33	lasso	6	0.32	5.5e-37	-7.52	7.8	9.4e-15	0.01	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	EAF2	0.05	0.01	blup	70	0.04	3.3e-05	6.60	6.2	4.3e-10	0.00	0.03	0.96	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEFSEC	0.07	0.05	blup	115	0.07	1.6e-08	-6.57	7.5	7.5e-14	-0.04	0.16	0.84	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	GOLGB1	0.06	0.01	blup	70	0.01	4.7e-02	-4.62	-5.4	6.0e-08	0.03	0.02	0.17	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPN1	0.06	0.04	lasso	4	0.04	1.7e-05	-6.46	7.8	7.2e-15	0.05	0.01	0.99	FALSE
78	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CHST13	0.10	0.06	blup	65	0.08	2.0e-04	-6.75	6.7	1.7e-11	-0.01	0.05	0.74	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	CHST13	0.25	0.36	lasso	5	0.41	3.5e-52	-7.60	8.0	1.8e-15	0.02	0.00	1.00	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	RUVBL1	0.02	0.02	lasso	3	0.02	1.5e-03	-4.77	-5.6	2.0e-08	-0.03	0.04	0.52	FALSE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CHST13	0.10	0.17	blup	66	0.21	1.8e-23	-7.20	8.1	6.7e-16	0.02	0.03	0.97	FALSE
82	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CHST13	0.25	0.21	lasso	6	0.26	1.2e-17	-7.31	8.0	1.1e-15	0.00	0.02	0.98	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CHST13	0.20	0.27	lasso	7	0.25	6.0e-11	-7.52	7.8	5.9e-15	0.01	0.01	0.99	FALSE
84	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CHST13	0.25	0.13	blup	65	0.20	2.7e-08	-7.16	6.9	4.0e-12	0.02	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TXNRD3IT1	0.07	-0.01	blup	86	0.00	2.9e-01	-3.87	-7.0	2.9e-12	0.00	0.02	0.48	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHST13	0.28	0.39	lasso	5	0.46	3.5e-53	-7.49	8.2	3.5e-16	0.01	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC90246	0.06	0.06	enet	8	0.05	1.1e-05	5.24	-6.1	8.4e-10	-0.01	0.00	1.00	FALSE
88	The Cancer Genome Atlas	Rectum Adenocarcinoma	CHST13	0.35	0.07	blup	66	0.07	1.1e-02	-7.30	5.9	3.0e-09	0.02	0.01	0.64	FALSE
89	The Cancer Genome Atlas	Soft Tissue Sarcoma	CHST13	0.23	0.16	blup	66	0.20	5.8e-12	-7.49	8.2	3.8e-16	0.01	0.01	0.99	TRUE
90	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CHST13	0.14	0.09	blup	64	0.09	1.8e-03	-7.31	8.4	4.4e-17	0.01	0.02	0.76	TRUE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHST13	0.12	0.15	blup	66	0.17	3.8e-12	-7.25	8.1	7.8e-16	0.01	0.02	0.98	FALSE
92	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CHST13	0.12	0.09	blup	66	0.09	5.6e-04	-7.30	7.2	5.4e-13	0.00	0.02	0.89	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	CHCHD6	0.03	0.00	blup	124	0.02	9.3e-03	3.78	-6.0	2.5e-09	0.07	0.06	0.52	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	CHST13	0.24	0.37	lasso	5	0.38	5.2e-39	-7.52	8.0	1.6e-15	0.01	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	EEFSEC	0.08	0.03	blup	116	0.04	1.8e-04	-6.41	7.8	8.9e-15	-0.04	0.14	0.84	TRUE
96	The Cancer Genome Atlas	Thyroid Carcinoma	SLC15A2	0.06	0.04	blup	73	0.05	8.0e-06	-3.97	-6.0	1.5e-09	0.03	0.11	0.87	FALSE