Best TWAS P=3.78e-11 · Best GWAS P=1.31e-14 conditioned to 7.21e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAIM | 0.14 | 0.20 | lasso | 12 | 0.21 | 3.2e-25 | -4.7 | 5.3 | 9.7e-08 | 0.70 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | FAIM | 0.10 | 0.10 | enet | 11 | 0.07 | 7.4e-03 | -5.4 | 5.4 | 5.4e-08 | 0.67 | 0.15 | 0.29 | FALSE |
| 3 | GTEx | Brain Hypothalamus | FAIM | 0.22 | 0.00 | enet | 26 | 0.05 | 2.3e-02 | -7.3 | 6.4 | 1.9e-10 | 0.72 | 0.04 | 0.55 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PIK3CB | 0.11 | 0.06 | enet | 21 | 0.04 | 4.0e-04 | -7.4 | 6.0 | 1.4e-09 | 0.57 | 0.05 | 0.94 | FALSE |
| 5 | GTEx | Esophagus Mucosa | FAIM | 0.09 | 0.07 | enet | 9 | 0.06 | 1.1e-04 | -4.7 | 5.5 | 4.5e-08 | 0.73 | 0.21 | 0.78 | FALSE |
| 6 | GTEx | Pancreas | FAIM | 0.13 | 0.13 | enet | 15 | 0.10 | 4.3e-05 | -5.4 | 5.4 | 6.5e-08 | 0.69 | 0.85 | 0.11 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | FAIM | 0.06 | 0.02 | lasso | 6 | 0.01 | 7.5e-02 | -7.3 | 6.6 | 3.8e-11 | 0.84 | 0.10 | 0.87 | TRUE |
| 8 | METSIM | Adipose | PIK3CB | 0.05 | 0.04 | bslmm | 347 | 0.04 | 2.4e-06 | -7.3 | 6.2 | 4.0e-10 | 0.79 | 0.05 | 0.95 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FAIM | 0.03 | 0.02 | blup | 42 | 0.03 | 4.0e-04 | -5.5 | 5.7 | 1.4e-08 | 0.69 | 0.08 | 0.36 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FAIM | 0.03 | 0.02 | blup | 41 | 0.03 | 3.9e-03 | 7.0 | 6.4 | 1.6e-10 | 0.81 | 0.03 | 0.61 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | FAIM | 0.03 | 0.01 | blup | 41 | 0.03 | 7.1e-04 | -6.1 | 6.5 | 1.1e-10 | 0.80 | 0.03 | 0.83 | FALSE |