[Hub]/) : Traits : Blood Platelet Count :

chr3:135,273,949-137,423,165

Best TWAS P=2.39e-19 · Best GWAS P=3.79e-18 conditioned to 0.0228

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NCK1 0.05 0.00 blup 357 0.01 1.2e-02 -7.3 5.2 1.9e-07 -0.75 0.28 0.61 FALSE
2 CommonMind Brain Pre-frontal Cortex PCCB 0.09 0.19 lasso 7 0.18 1.2e-21 7.0 6.9 4.9e-12 -0.55 0.66 0.34 FALSE
3 GTEx Adipose Subcutaneous PCCB 0.07 0.05 enet 4 0.02 6.6e-03 -7.0 6.8 7.5e-12 -0.37 0.19 0.53 FALSE
4 GTEx Adipose Subcutaneous RP11-85F14.5 0.07 0.08 lasso 13 0.07 3.3e-06 -7.4 7.3 2.1e-13 -0.86 0.56 0.44 FALSE
5 GTEx Adipose Visceral Omentum RP11-85F14.5 0.09 0.07 lasso 3 0.04 2.4e-03 -7.4 7.4 1.5e-13 -0.85 0.53 0.26 FALSE
6 GTEx Adrenal Gland PCCB 0.17 0.09 lasso 6 0.10 2.1e-04 6.8 7.7 1.3e-14 -0.70 0.09 0.81 FALSE
7 GTEx Artery Aorta PCCB 0.12 0.03 enet 11 0.09 2.0e-05 -6.0 7.3 2.5e-13 -0.49 0.36 0.48 FALSE
8 GTEx Artery Coronary RP11-85F14.5 0.15 0.01 lasso 4 0.00 2.3e-01 6.5 7.0 1.8e-12 -0.48 0.13 0.27 FALSE
9 GTEx Artery Tibial PCCB 0.05 0.02 lasso 5 0.02 1.7e-02 6.8 7.8 9.3e-15 -0.60 0.10 0.88 FALSE
10 GTEx Brain Caudate basal ganglia PCCB 0.11 0.01 enet 12 0.01 2.1e-01 7.1 6.2 5.9e-10 -0.49 0.04 0.52 FALSE
11 GTEx Brain Cerebellar Hemisphere RP11-731C17.2 0.16 0.02 enet 24 0.09 3.0e-03 -6.2 8.1 7.8e-16 -0.66 0.11 0.51 FALSE
12 GTEx Brain Cerebellum RP11-85F14.5 0.13 0.10 lasso 7 0.07 4.1e-03 -7.3 7.7 1.0e-14 -0.84 0.16 0.73 FALSE
13 GTEx Brain Cerebellum RP11-731C17.2 0.31 0.05 enet 39 0.12 2.3e-04 -7.3 5.5 3.8e-08 -0.62 0.13 0.67 FALSE
14 GTEx Brain Cortex RP11-731C17.2 0.11 0.08 lasso 3 0.09 1.6e-03 -7.2 7.3 3.7e-13 -0.81 0.15 0.38 FALSE
15 GTEx Brain Frontal Cortex BA9 PCCB 0.11 0.01 enet 9 0.01 1.7e-01 -7.0 8.2 2.3e-16 -0.48 0.06 0.55 FALSE
16 GTEx Brain Hippocampus RP11-731C17.2 0.19 0.06 enet 24 0.11 1.8e-03 -8.7 9.0 2.4e-19 -0.82 0.04 0.88 TRUE
17 GTEx Breast Mammary Tissue PCCB 0.08 0.05 lasso 3 0.03 1.3e-02 -7.0 7.3 2.5e-13 -0.41 0.15 0.52 FALSE
18 GTEx Cells EBV-transformed lymphocytes PCCB 0.11 0.10 lasso 3 0.11 2.3e-04 3.4 5.4 5.7e-08 -0.50 0.12 0.63 FALSE
19 GTEx Cells EBV-transformed lymphocytes RP11-85F14.5 0.23 0.14 lasso 19 0.12 8.4e-05 -7.4 7.4 1.2e-13 -0.86 0.24 0.71 FALSE
20 GTEx Cells Transformed fibroblasts PCCB 0.10 0.09 lasso 3 0.07 5.0e-06 7.3 7.5 7.1e-14 -0.60 0.14 0.86 FALSE
21 GTEx Cells Transformed fibroblasts RP11-85F14.5 0.10 0.08 enet 38 0.09 3.9e-07 -7.4 5.3 1.4e-07 -0.62 0.85 0.14 FALSE
22 GTEx Colon Transverse PCCB 0.07 0.06 lasso 3 0.04 7.7e-03 7.0 7.1 1.2e-12 -0.64 0.08 0.80 FALSE
23 GTEx Colon Transverse RP11-85F14.5 0.07 0.06 lasso 4 0.04 6.3e-03 -7.4 7.5 7.7e-14 -0.87 0.24 0.53 FALSE
24 GTEx Esophagus Mucosa PCCB 0.10 0.12 lasso 3 0.11 4.8e-08 6.9 6.3 2.9e-10 -0.50 0.36 0.64 FALSE
25 GTEx Esophagus Mucosa SLC35G2 0.13 0.10 lasso 10 0.09 1.3e-06 -7.3 -7.3 2.2e-13 0.86 0.58 0.41 FALSE
26 GTEx Esophagus Mucosa RP11-85F14.5 0.13 0.10 lasso 3 0.11 5.1e-08 -7.6 7.7 1.8e-14 -0.68 0.92 0.08 FALSE
27 GTEx Esophagus Muscularis RP11-85F14.5 0.13 0.09 lasso 4 0.06 8.9e-05 -7.4 6.8 1.0e-11 -0.84 0.40 0.58 FALSE
28 GTEx Heart Left Ventricle PCCB 0.08 0.05 enet 7 0.01 7.2e-02 6.8 7.2 4.4e-13 -0.52 0.16 0.79 FALSE
29 GTEx Lung PCCB 0.07 0.04 lasso 3 0.03 4.2e-03 7.0 6.8 1.0e-11 -0.54 0.14 0.66 FALSE
30 GTEx Lung RP11-85F14.5 0.07 0.05 lasso 19 0.05 8.8e-05 -7.6 8.3 1.3e-16 -0.77 0.42 0.56 FALSE
31 GTEx Muscle Skeletal PCCB 0.09 0.09 enet 13 0.11 1.2e-10 6.9 7.6 4.2e-14 -0.52 0.28 0.72 FALSE
32 GTEx Muscle Skeletal RP11-731C17.2 0.15 0.12 lasso 16 0.12 3.8e-12 -7.3 5.7 1.4e-08 -0.73 0.99 0.01 FALSE
33 GTEx Nerve Tibial PCCB 0.07 0.01 enet 14 0.01 6.2e-02 6.8 7.3 2.8e-13 -0.54 0.04 0.88 FALSE
34 GTEx Pancreas RP11-731C17.2 0.09 0.03 lasso 2 0.02 6.0e-02 -7.2 -8.1 5.2e-16 0.86 0.10 0.68 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic IL20RB 0.22 0.16 lasso 9 0.19 1.2e-10 -5.3 -5.2 1.6e-07 0.37 1.00 0.00 FALSE
36 GTEx Skin Sun Exposed Lower leg RP11-85F14.5 0.04 0.01 enet 9 0.03 2.8e-03 -7.4 6.5 8.2e-11 -0.76 0.20 0.56 FALSE
37 GTEx Stomach RP11-85F14.5 0.17 0.11 lasso 5 0.08 9.4e-05 -7.3 7.6 3.1e-14 -0.83 0.39 0.57 FALSE
38 GTEx Testis PCCB 0.26 0.22 lasso 10 0.22 4.7e-10 6.9 7.7 1.3e-14 -0.55 0.09 0.91 FALSE
39 GTEx Testis SLC35G2 0.17 0.19 lasso 10 0.18 1.5e-08 -7.4 -7.9 2.3e-15 0.84 0.18 0.82 FALSE
40 GTEx Thyroid PCCB 0.10 0.09 lasso 6 0.09 1.3e-07 7.5 8.4 2.9e-17 -0.58 0.03 0.97 FALSE
41 GTEx Thyroid RP11-85F14.5 0.07 0.00 lasso 7 0.01 4.7e-02 -7.6 5.6 1.9e-08 -0.39 0.12 0.18 FALSE
42 GTEx Thyroid RP11-731C17.2 0.06 0.03 enet 6 0.02 1.5e-02 7.9 -7.1 9.4e-13 0.85 0.08 0.83 FALSE
43 METSIM Adipose PCCB 0.07 0.06 lasso 12 0.06 4.1e-09 6.9 7.9 3.2e-15 -0.59 0.35 0.65 FALSE
44 ROSMAP Brain Pre-frontal Cortex PCCB 0.10 0.07 lasso 4 0.10 4.2e-13 6.8 7.9 2.8e-15 -0.53 0.41 0.59 FALSE
45 YFS Blood NCK1 0.01 0.02 enet 4 0.02 2.2e-06 -7.6 7.7 2.1e-14 -0.68 0.72 0.26 FALSE
46 YFS Blood PCCB 0.13 0.20 lasso 9 0.20 1.3e-64 6.8 7.1 1.7e-12 -0.55 0.73 0.27 FALSE
47 The Cancer Genome Atlas Bladder Urothelial Carcinoma PCCB 0.05 0.03 blup 53 0.03 1.2e-03 6.9 8.0 1.7e-15 -0.57 0.01 0.95 FALSE
48 The Cancer Genome Atlas Breast Invasive Carcinoma IL20RB 0.03 0.01 blup 67 0.02 6.3e-05 -7.4 5.6 2.4e-08 -0.79 0.11 0.84 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma MSL2 0.05 0.01 enet 6 0.01 1.5e-03 2.6 6.5 9.8e-11 -0.52 0.01 0.91 FALSE
50 The Cancer Genome Atlas Breast Invasive Carcinoma NCK1 0.01 0.00 blup 66 0.01 1.6e-02 -7.7 8.3 1.2e-16 -0.88 0.04 0.46 FALSE
51 The Cancer Genome Atlas Breast Invasive Carcinoma PCCB 0.05 0.02 enet 12 0.04 4.0e-09 6.5 6.9 6.0e-12 -0.52 0.13 0.87 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM22 0.03 0.01 enet 9 0.01 4.0e-03 -7.6 8.4 5.7e-17 -0.72 0.07 0.51 FALSE
53 The Cancer Genome Atlas Colon Adenocarcinoma PCCB 0.11 0.03 blup 54 0.04 2.3e-03 6.8 6.6 3.2e-11 -0.50 0.01 0.65 FALSE
54 The Cancer Genome Atlas Esophageal Carcinoma PCCB 0.15 0.03 blup 54 0.05 9.6e-03 6.8 6.0 2.4e-09 -0.43 0.02 0.38 FALSE
55 The Cancer Genome Atlas Glioblastoma Multiforme PCCB 0.10 0.03 blup 53 0.02 5.8e-02 6.8 6.9 6.0e-12 -0.46 0.02 0.51 FALSE
56 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MSL2 0.07 0.02 enet 6 0.03 1.7e-04 7.5 7.0 3.2e-12 -0.52 0.00 0.97 FALSE
57 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PCCB 0.12 0.05 enet 7 0.09 9.7e-11 7.6 6.4 1.4e-10 -0.39 0.00 1.00 FALSE
58 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NCK1 0.04 0.02 blup 66 0.01 1.0e-02 -7.4 -7.6 2.8e-14 0.92 0.01 0.98 FALSE
59 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PCCB 0.05 0.05 blup 54 0.05 3.5e-06 6.9 7.5 7.5e-14 -0.51 0.08 0.92 FALSE
60 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPP2R3A 0.05 0.02 enet 8 0.02 1.1e-03 7.6 5.7 1.3e-08 -0.48 0.00 0.96 FALSE
61 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PCCB 0.07 0.06 blup 53 0.06 2.1e-04 7.1 8.1 5.6e-16 -0.59 0.02 0.94 FALSE
62 The Cancer Genome Atlas Brain Lower Grade Glioma PCCB 0.06 0.05 lasso 2 0.03 1.2e-04 6.8 7.3 1.9e-13 -0.53 0.07 0.90 FALSE
63 The Cancer Genome Atlas Lung Adenocarcinoma PCCB 0.11 0.10 lasso 3 0.10 1.3e-11 6.8 6.9 6.8e-12 -0.53 0.17 0.83 FALSE
64 The Cancer Genome Atlas Lung Adenocarcinoma STAG1 0.02 0.02 enet 6 0.02 3.5e-03 6.5 6.9 6.0e-12 -0.53 0.10 0.46 FALSE
65 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MSL2 0.04 0.02 blup 35 0.01 1.9e-02 7.6 7.5 7.6e-14 -0.47 0.00 0.94 FALSE
66 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PCCB 0.13 0.10 lasso 4 0.10 2.4e-11 6.8 6.7 1.7e-11 -0.54 0.27 0.73 FALSE
67 The Cancer Genome Atlas Lung Squamous Cell Carcinoma STAG1 0.05 0.00 blup 151 0.01 2.9e-02 7.0 6.6 4.5e-11 -0.50 0.13 0.84 FALSE
68 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MSL2 0.09 0.01 blup 35 0.02 8.1e-03 -7.0 7.2 7.1e-13 -0.46 0.01 0.88 FALSE
69 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PCCB 0.12 0.07 enet 3 0.06 1.0e-04 7.6 8.1 6.6e-16 -0.58 0.00 0.99 FALSE
70 The Cancer Genome Atlas Pancreatic Adenocarcinoma PCCB 0.12 0.02 lasso 5 0.02 6.7e-02 6.5 6.0 1.6e-09 -0.53 0.02 0.43 FALSE
71 The Cancer Genome Atlas Soft Tissue Sarcoma PCCB 0.14 0.10 enet 6 0.10 1.0e-06 6.8 6.6 3.6e-11 -0.52 0.12 0.87 FALSE
72 The Cancer Genome Atlas Soft Tissue Sarcoma STAG1 0.06 0.06 lasso 1 0.04 2.0e-03 7.0 7.0 2.2e-12 -0.54 0.07 0.39 FALSE
73 The Cancer Genome Atlas Stomach Adenocarcinoma PCCB 0.07 0.04 lasso 1 0.02 1.1e-02 6.9 6.9 5.5e-12 -0.52 0.05 0.75 FALSE
74 The Cancer Genome Atlas Testicular Germ Cell Tumors PCCB 0.13 0.02 blup 53 0.02 4.4e-02 2.7 7.2 4.1e-13 -0.60 0.02 0.44 FALSE
75 The Cancer Genome Atlas Thyroid Carcinoma PCCB 0.06 0.03 enet 8 0.03 2.3e-04 6.5 7.1 1.0e-12 -0.54 0.03 0.95 FALSE