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chr3:135,273,949-137,423,165

Best TWAS P=2.39e-19 · Best GWAS P=3.79e-18 conditioned to 0.0228

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	GTEx	Brain Hippocampus	RP11-731C17.2	0.19	0.06	enet	24	0.11	1.8e-03	-8.7	9.0	2.4e-19	-0.82	0.04	0.88	TRUE
40	GTEx	Thyroid	PCCB	0.10	0.09	lasso	6	0.09	1.3e-07	7.5	8.4	2.9e-17	-0.58	0.03	0.97	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM22	0.03	0.01	enet	9	0.01	4.0e-03	-7.6	8.4	5.7e-17	-0.72	0.07	0.51	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	NCK1	0.01	0.00	blup	66	0.01	1.6e-02	-7.7	8.3	1.2e-16	-0.88	0.04	0.46	FALSE
30	GTEx	Lung	RP11-85F14.5	0.07	0.05	lasso	19	0.05	8.8e-05	-7.6	8.3	1.3e-16	-0.77	0.42	0.56	FALSE
15	GTEx	Brain Frontal Cortex BA9	PCCB	0.11	0.01	enet	9	0.01	1.7e-01	-7.0	8.2	2.3e-16	-0.48	0.06	0.55	FALSE
34	GTEx	Pancreas	RP11-731C17.2	0.09	0.03	lasso	2	0.02	6.0e-02	-7.2	-8.1	5.2e-16	0.86	0.10	0.68	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PCCB	0.07	0.06	blup	53	0.06	2.1e-04	7.1	8.1	5.6e-16	-0.59	0.02	0.94	FALSE
69	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PCCB	0.12	0.07	enet	3	0.06	1.0e-04	7.6	8.1	6.6e-16	-0.58	0.00	0.99	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-731C17.2	0.16	0.02	enet	24	0.09	3.0e-03	-6.2	8.1	7.8e-16	-0.66	0.11	0.51	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PCCB	0.05	0.03	blup	53	0.03	1.2e-03	6.9	8.0	1.7e-15	-0.57	0.01	0.95	FALSE
39	GTEx	Testis	SLC35G2	0.17	0.19	lasso	10	0.18	1.5e-08	-7.4	-7.9	2.3e-15	0.84	0.18	0.82	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	PCCB	0.10	0.07	lasso	4	0.10	4.2e-13	6.8	7.9	2.8e-15	-0.53	0.41	0.59	FALSE
43	METSIM	Adipose	PCCB	0.07	0.06	lasso	12	0.06	4.1e-09	6.9	7.9	3.2e-15	-0.59	0.35	0.65	FALSE
9	GTEx	Artery Tibial	PCCB	0.05	0.02	lasso	5	0.02	1.7e-02	6.8	7.8	9.3e-15	-0.60	0.10	0.88	FALSE
12	GTEx	Brain Cerebellum	RP11-85F14.5	0.13	0.10	lasso	7	0.07	4.1e-03	-7.3	7.7	1.0e-14	-0.84	0.16	0.73	FALSE
6	GTEx	Adrenal Gland	PCCB	0.17	0.09	lasso	6	0.10	2.1e-04	6.8	7.7	1.3e-14	-0.70	0.09	0.81	FALSE
38	GTEx	Testis	PCCB	0.26	0.22	lasso	10	0.22	4.7e-10	6.9	7.7	1.3e-14	-0.55	0.09	0.91	FALSE
26	GTEx	Esophagus Mucosa	RP11-85F14.5	0.13	0.10	lasso	3	0.11	5.1e-08	-7.6	7.7	1.8e-14	-0.68	0.92	0.08	FALSE
45	YFS	Blood	NCK1	0.01	0.02	enet	4	0.02	2.2e-06	-7.6	7.7	2.1e-14	-0.68	0.72	0.26	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NCK1	0.04	0.02	blup	66	0.01	1.0e-02	-7.4	-7.6	2.8e-14	0.92	0.01	0.98	FALSE
37	GTEx	Stomach	RP11-85F14.5	0.17	0.11	lasso	5	0.08	9.4e-05	-7.3	7.6	3.1e-14	-0.83	0.39	0.57	FALSE
31	GTEx	Muscle Skeletal	PCCB	0.09	0.09	enet	13	0.11	1.2e-10	6.9	7.6	4.2e-14	-0.52	0.28	0.72	FALSE
20	GTEx	Cells Transformed fibroblasts	PCCB	0.10	0.09	lasso	3	0.07	5.0e-06	7.3	7.5	7.1e-14	-0.60	0.14	0.86	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PCCB	0.05	0.05	blup	54	0.05	3.5e-06	6.9	7.5	7.5e-14	-0.51	0.08	0.92	FALSE
65	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MSL2	0.04	0.02	blup	35	0.01	1.9e-02	7.6	7.5	7.6e-14	-0.47	0.00	0.94	FALSE
23	GTEx	Colon Transverse	RP11-85F14.5	0.07	0.06	lasso	4	0.04	6.3e-03	-7.4	7.5	7.7e-14	-0.87	0.24	0.53	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RP11-85F14.5	0.23	0.14	lasso	19	0.12	8.4e-05	-7.4	7.4	1.2e-13	-0.86	0.24	0.71	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-85F14.5	0.09	0.07	lasso	3	0.04	2.4e-03	-7.4	7.4	1.5e-13	-0.85	0.53	0.26	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	PCCB	0.06	0.05	lasso	2	0.03	1.2e-04	6.8	7.3	1.9e-13	-0.53	0.07	0.90	FALSE
4	GTEx	Adipose Subcutaneous	RP11-85F14.5	0.07	0.08	lasso	13	0.07	3.3e-06	-7.4	7.3	2.1e-13	-0.86	0.56	0.44	FALSE
25	GTEx	Esophagus Mucosa	SLC35G2	0.13	0.10	lasso	10	0.09	1.3e-06	-7.3	-7.3	2.2e-13	0.86	0.58	0.41	FALSE
7	GTEx	Artery Aorta	PCCB	0.12	0.03	enet	11	0.09	2.0e-05	-6.0	7.3	2.5e-13	-0.49	0.36	0.48	FALSE
17	GTEx	Breast Mammary Tissue	PCCB	0.08	0.05	lasso	3	0.03	1.3e-02	-7.0	7.3	2.5e-13	-0.41	0.15	0.52	FALSE
33	GTEx	Nerve Tibial	PCCB	0.07	0.01	enet	14	0.01	6.2e-02	6.8	7.3	2.8e-13	-0.54	0.04	0.88	FALSE
14	GTEx	Brain Cortex	RP11-731C17.2	0.11	0.08	lasso	3	0.09	1.6e-03	-7.2	7.3	3.7e-13	-0.81	0.15	0.38	FALSE
74	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PCCB	0.13	0.02	blup	53	0.02	4.4e-02	2.7	7.2	4.1e-13	-0.60	0.02	0.44	FALSE
28	GTEx	Heart Left Ventricle	PCCB	0.08	0.05	enet	7	0.01	7.2e-02	6.8	7.2	4.4e-13	-0.52	0.16	0.79	FALSE
68	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MSL2	0.09	0.01	blup	35	0.02	8.1e-03	-7.0	7.2	7.1e-13	-0.46	0.01	0.88	FALSE
42	GTEx	Thyroid	RP11-731C17.2	0.06	0.03	enet	6	0.02	1.5e-02	7.9	-7.1	9.4e-13	0.85	0.08	0.83	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	PCCB	0.06	0.03	enet	8	0.03	2.3e-04	6.5	7.1	1.0e-12	-0.54	0.03	0.95	FALSE
22	GTEx	Colon Transverse	PCCB	0.07	0.06	lasso	3	0.04	7.7e-03	7.0	7.1	1.2e-12	-0.64	0.08	0.80	FALSE
46	YFS	Blood	PCCB	0.13	0.20	lasso	9	0.20	1.3e-64	6.8	7.1	1.7e-12	-0.55	0.73	0.27	FALSE
8	GTEx	Artery Coronary	RP11-85F14.5	0.15	0.01	lasso	4	0.00	2.3e-01	6.5	7.0	1.8e-12	-0.48	0.13	0.27	FALSE
72	The Cancer Genome Atlas	Soft Tissue Sarcoma	STAG1	0.06	0.06	lasso	1	0.04	2.0e-03	7.0	7.0	2.2e-12	-0.54	0.07	0.39	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MSL2	0.07	0.02	enet	6	0.03	1.7e-04	7.5	7.0	3.2e-12	-0.52	0.00	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PCCB	0.09	0.19	lasso	7	0.18	1.2e-21	7.0	6.9	4.9e-12	-0.55	0.66	0.34	FALSE
73	The Cancer Genome Atlas	Stomach Adenocarcinoma	PCCB	0.07	0.04	lasso	1	0.02	1.1e-02	6.9	6.9	5.5e-12	-0.52	0.05	0.75	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	PCCB	0.05	0.02	enet	12	0.04	4.0e-09	6.5	6.9	6.0e-12	-0.52	0.13	0.87	FALSE
55	The Cancer Genome Atlas	Glioblastoma Multiforme	PCCB	0.10	0.03	blup	53	0.02	5.8e-02	6.8	6.9	6.0e-12	-0.46	0.02	0.51	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	STAG1	0.02	0.02	enet	6	0.02	3.5e-03	6.5	6.9	6.0e-12	-0.53	0.10	0.46	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	PCCB	0.11	0.10	lasso	3	0.10	1.3e-11	6.8	6.9	6.8e-12	-0.53	0.17	0.83	FALSE
3	GTEx	Adipose Subcutaneous	PCCB	0.07	0.05	enet	4	0.02	6.6e-03	-7.0	6.8	7.5e-12	-0.37	0.19	0.53	FALSE
27	GTEx	Esophagus Muscularis	RP11-85F14.5	0.13	0.09	lasso	4	0.06	8.9e-05	-7.4	6.8	1.0e-11	-0.84	0.40	0.58	FALSE
29	GTEx	Lung	PCCB	0.07	0.04	lasso	3	0.03	4.2e-03	7.0	6.8	1.0e-11	-0.54	0.14	0.66	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PCCB	0.13	0.10	lasso	4	0.10	2.4e-11	6.8	6.7	1.7e-11	-0.54	0.27	0.73	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	PCCB	0.11	0.03	blup	54	0.04	2.3e-03	6.8	6.6	3.2e-11	-0.50	0.01	0.65	FALSE
71	The Cancer Genome Atlas	Soft Tissue Sarcoma	PCCB	0.14	0.10	enet	6	0.10	1.0e-06	6.8	6.6	3.6e-11	-0.52	0.12	0.87	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STAG1	0.05	0.00	blup	151	0.01	2.9e-02	7.0	6.6	4.5e-11	-0.50	0.13	0.84	FALSE
36	GTEx	Skin Sun Exposed Lower leg	RP11-85F14.5	0.04	0.01	enet	9	0.03	2.8e-03	-7.4	6.5	8.2e-11	-0.76	0.20	0.56	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	MSL2	0.05	0.01	enet	6	0.01	1.5e-03	2.6	6.5	9.8e-11	-0.52	0.01	0.91	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PCCB	0.12	0.05	enet	7	0.09	9.7e-11	7.6	6.4	1.4e-10	-0.39	0.00	1.00	FALSE
24	GTEx	Esophagus Mucosa	PCCB	0.10	0.12	lasso	3	0.11	4.8e-08	6.9	6.3	2.9e-10	-0.50	0.36	0.64	FALSE
10	GTEx	Brain Caudate basal ganglia	PCCB	0.11	0.01	enet	12	0.01	2.1e-01	7.1	6.2	5.9e-10	-0.49	0.04	0.52	FALSE
70	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PCCB	0.12	0.02	lasso	5	0.02	6.7e-02	6.5	6.0	1.6e-09	-0.53	0.02	0.43	FALSE
54	The Cancer Genome Atlas	Esophageal Carcinoma	PCCB	0.15	0.03	blup	54	0.05	9.6e-03	6.8	6.0	2.4e-09	-0.43	0.02	0.38	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP2R3A	0.05	0.02	enet	8	0.02	1.1e-03	7.6	5.7	1.3e-08	-0.48	0.00	0.96	FALSE
32	GTEx	Muscle Skeletal	RP11-731C17.2	0.15	0.12	lasso	16	0.12	3.8e-12	-7.3	5.7	1.4e-08	-0.73	0.99	0.01	FALSE
41	GTEx	Thyroid	RP11-85F14.5	0.07	0.00	lasso	7	0.01	4.7e-02	-7.6	5.6	1.9e-08	-0.39	0.12	0.18	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL20RB	0.03	0.01	blup	67	0.02	6.3e-05	-7.4	5.6	2.4e-08	-0.79	0.11	0.84	FALSE
13	GTEx	Brain Cerebellum	RP11-731C17.2	0.31	0.05	enet	39	0.12	2.3e-04	-7.3	5.5	3.8e-08	-0.62	0.13	0.67	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	PCCB	0.11	0.10	lasso	3	0.11	2.3e-04	3.4	5.4	5.7e-08	-0.50	0.12	0.63	FALSE
21	GTEx	Cells Transformed fibroblasts	RP11-85F14.5	0.10	0.08	enet	38	0.09	3.9e-07	-7.4	5.3	1.4e-07	-0.62	0.85	0.14	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	IL20RB	0.22	0.16	lasso	9	0.19	1.2e-10	-5.3	-5.2	1.6e-07	0.37	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NCK1	0.05	0.00	blup	357	0.01	1.2e-02	-7.3	5.2	1.9e-07	-0.75	0.28	0.61	FALSE