TWAS
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Usage
Models
Genes
Traits
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Traits
:
Blood Platelet Count
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chr4:75,706,212-77,132,557
Best TWAS P=2.05e-12 · Best GWAS P=4.23e-14 conditioned to 1.28e-07
75.8M
76M
76.2M
76.4M
76.6M
76.8M
77M
77.2M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Cells Transformed fibroblasts
RCHY1
0.26
0.22
lasso
4
0.22
8.6e-17
-7.0
-7.0
2.0e-12
-0.38
0.23
0.77
TRUE
2
GTEx
Adipose Subcutaneous
RCHY1
0.10
0.09
lasso
5
0.07
1.3e-06
-6.7
-6.5
9.6e-11
-0.33
0.30
0.70
FALSE
1
CommonMind
Brain Pre-frontal Cortex
RCHY1
0.15
0.09
bslmm
441
0.09
2.3e-11
-6.9
-5.6
2.6e-08
-0.22
0.31
0.69
FALSE