Hub : Genes

RCHY1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1540 0.0360 1.6e-09 0.094 0.088 0.085 0.093 0.093 1.7e-11 7.8e-11 1.5e-10 2.3e-11 2.3e-11
2 GTEx Adipose Subcutaneous 0.1040 0.0390 1.8e-03 0.089 NA 0.069 NA 0.073 8.9e-08 NA 2.6e-06 NA 1.3e-06
3 GTEx Artery Tibial 0.0939 0.0373 2.4e-03 0.052 NA 0.100 NA 0.095 6.7e-05 NA 3.0e-08 NA 7.0e-08
4 GTEx Cells Transformed fibroblasts 0.2580 0.0590 5.1e-09 0.216 NA 0.224 NA 0.225 3.8e-16 NA 9.9e-17 NA 8.6e-17
5 GTEx Testis 0.2160 0.0710 2.8e-04 0.161 NA 0.147 NA 0.162 1.3e-07 NA 4.5e-07 NA 1.2e-07
6 ROSMAP Brain Pre-frontal Cortex 0.5590 0.0452 0.0e+00 0.355 0.428 0.487 0.424 0.489 1.2e-47 3.8e-60 1.9e-71 2.5e-59 9.3e-72
7 YFS Blood 0.1739 0.0300 0.0e+00 0.099 0.132 0.143 0.142 0.143 1.4e-30 7.6e-41 2.3e-44 3.0e-44 1.8e-44
8 TCGA Ovarian Serous Cystadenocarcinoma 0.0600 0.0380 4.4e-03 0.009 0.013 0.007 NA 0.003 7.3e-02 4.0e-02 1.1e-01 NA 1.8e-01
9 TCGA Stomach Adenocarcinoma 0.0590 0.0400 3.5e-03 0.006 0.019 0.002 NA 0.005 1.0e-01 1.4e-02 2.1e-01 NA 1.3e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 2.0 3.1 6.1 2.5 1.8 2.4 1.9 -0.9 -1.7 2.0 1.2 0.6
Bipolar Disorder or Schizophrenia 0.8 1.9 5.2 0.8 -0.0 1.8 0.1 -1.8 -2.3 1.2 1.5 1.0
Depressed Affect (Nagel 2018) 1.6 3.3 6.7 -1.8 -2.3 -1.6 -2.6 1.0 1.2 -1.7 -1.6 -2.0
Depression (Nagel 2018) 1.6 2.4 3.9 -1.4 -1.9 -1.4 -2.0 1.7 0.9 -1.7 -1.4 -1.5
Intelligence (Savage-Jansen 2018) 0.8 2.5 5.7 -2.0 -2.2 -1.8 -2.4 0.3 0.3 -2.2 0.2 -0.1
Neuroticism (Nagel 2018) 0.5 1.1 3.0 -0.4 -1.1 -0.8 -1.3 0.7 0.8 -0.9 -1.1 -1.7
Schizophrenia (2018) 0.7 1.4 2.6 -1.1 -1.5 0.4 -1.4 -1.6 -1.6 -0.1 1.0 0.8
Schizophrenia vs Biploar Disorder 0.9 1.2 3.6 -1.9 -1.7 -0.8 -1.6 -0.6 -0.3 -0.8 0.6 0.0
Worry (Nagel 2018) 0.1 0.3 1.2 0.5 -0.3 0.1 -0.0 0.6 0.2 -0.1 -0.5 -1.1
Alzheimer’s Disease (in mother) 0.5 0.5 1.2 1.1 0.9 1.0 0.5 0.1 -0.9 0.6 0.2 0.5
Alzheimer’s Disease (in father) 0.5 0.5 1.3 -0.2 1.1 0.6 1.1 -0.2 -0.3 0.5 1.1 0.5
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.4 0.6 0.6 0.4 0.5 -0.4 0.2 -0.0 -0.1
Crohns Disease (2017) 0.2 0.4 1.6 0.1 0.3 0.4 0.5 -0.8 -0.3 0.8 1.3 0.5
Irritable Bowel Disease (IBD) 0.6 1.4 3.9 -0.1 0.4 0.9 0.6 -2.0 -1.0 1.4 1.7 1.4
Ulcerative Colitis (UC) 1.3 2.4 5.9 0.1 0.7 1.5 0.9 -2.4 -1.5 1.9 1.6 1.8
Major Depression (MDD) 0.1 0.1 0.3 0.2 -0.5 -0.1 -0.4 0.2 -0.4 -0.4 0.6 -0.1
Reaction Time 0.4 0.7 3.3 0.5 0.4 0.6 0.4 -0.7 -0.9 0.5 1.8 0.9
Verbal and Numeric Reasoning (VNR) 1.0 2.3 5.0 -2.0 -2.2 -1.7 -2.2 -0.3 0.3 -1.9 0.1 -0.1
Breast Cancer 0.4 0.9 2.0 0.9 -0.1 -0.8 -0.1 1.4 1.1 -0.8 -1.0 -1.3
Ovarian Cancer 0.5 0.7 2.5 0.1 0.0 0.3 0.2 -1.6 -0.8 0.6 1.4 0.8
Prostate Cancer 0.7 1.0 2.1 0.8 0.9 0.8 0.7 -1.1 -0.8 0.9 1.4 1.3
Age at First Birth 1.8 2.6 6.9 0.8 0.6 2.5 0.4 -1.0 -2.6 1.7 1.2 1.9
Bipolar Disorder (2011) 0.3 0.3 0.6 0.0 -0.8 0.2 -0.6 0.5 -0.7 -0.6 -0.1 -0.5
Body Mass Index (BMI) (2010) 0.4 0.6 1.7 -1.0 -1.1 -0.5 -1.3 -0.7 0.1 -0.3 -0.4 -0.1
Coronary Artery Disease (CAD) 0.2 0.3 0.7 0.4 0.8 0.8 0.5 0.5 -0.3 0.4 0.2 -0.3
Crohns Disease (2012) 0.3 0.4 1.0 -0.6 -0.7 -1.0 -0.8 -0.4 0.4 -0.5 0.8 0.0
Mean Putamen Volume 0.5 0.6 1.9 0.2 0.3 0.8 -0.0 -0.6 -1.2 0.5 0.6 1.4
Fasting Glucose 1.5 1.8 6.1 0.6 0.6 -0.3 0.8 2.5 1.3 -0.8 -1.8 -1.8
HbA1C 0.3 0.3 1.0 -0.1 -1.0 0.2 -0.4 0.4 -0.2 -0.3 -0.3 -1.0
HDL Cholesterol 0.6 1.0 2.2 1.1 1.4 0.6 1.5 -0.6 -0.2 1.3 0.5 0.6
LDL Cholesterol 0.7 1.1 4.5 1.3 2.1 0.8 1.5 -0.1 0.0 0.9 0.3 0.4
Lupus 3.9 5.9 10.7 -1.4 -0.9 -2.5 -0.8 3.1 3.3 -2.4 -2.9 -3.0
Neuroticism (2016) 0.3 0.5 1.5 0.2 -0.6 0.5 -0.3 1.2 -0.2 -0.1 -0.7 -1.2
Primary Biliary Cirrhosis 0.3 0.4 1.6 0.6 -0.2 1.3 0.1 -0.1 -0.8 0.6 0.3 -0.4
Rheumatoid Arthritis 1.9 2.6 3.6 -1.9 -1.8 -1.8 -1.6 1.3 1.3 -1.7 -1.5 -1.4
Schizophrenia (2014) 0.7 1.5 4.3 -0.4 -1.2 1.1 -1.1 -1.7 -2.1 0.5 1.3 0.6
Triglycerides 0.3 0.4 1.6 -0.3 -0.1 -0.3 0.0 0.6 0.9 -0.3 -1.3 -1.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.4 0.1 -0.2 -0.6 -0.4 0.1 0.6 -0.2 -0.0 -0.4
Ulcerative Colitis 0.5 0.7 2.3 -1.5 -0.8 -0.3 -0.9 -1.3 -0.2 0.0 0.4 0.6
Blood Eosinophil Count 0.2 1.4 3.5 -1.7 -1.8 -1.0 -1.9 -0.6 0.3 -1.0 -0.1 -0.3
Blood Platelet Count 1.5 17.1 49.4 -5.6 -6.5 -3.1 -7.0 -3.2 -1.0 -2.8 1.2 1.3
Blood Red Count 0.2 1.8 4.9 1.1 0.7 0.4 0.9 2.2 1.2 -0.1 -2.0 -1.6
Blood White Count 0.3 2.5 8.8 -0.1 -0.3 0.8 -0.5 -3.0 -1.7 1.1 2.2 1.8
Heel T-Score 0.1 0.7 2.2 0.4 0.5 1.2 0.5 0.1 -1.5 0.6 0.8 0.9
BMI 0.3 1.7 4.4 -1.6 -2.0 -0.3 -2.1 -1.3 -0.8 -0.4 1.1 0.9
Height 0.1 2.2 5.4 -1.2 -2.3 -1.9 -2.3 -1.1 0.6 -1.5 0.1 0.5
Waist Hip Ratio (WHR) 0.5 2.1 4.4 1.6 2.1 1.6 1.8 -0.3 -0.9 1.9 -0.1 1.2
Systolic Blood Pressure 0.4 2.2 4.4 -0.8 -0.4 -1.5 -0.2 2.1 2.1 -1.4 -1.3 -2.1
Smoking Status 1.0 2.4 7.3 1.1 1.0 -1.2 1.0 1.5 2.7 -0.4 -1.8 -2.0
Allergy or Eczema 0.6 1.6 4.8 1.2 2.2 1.0 2.0 -0.5 -0.5 1.2 1.0 0.8
Cardiovascular Disease 0.1 0.2 0.8 -0.2 -0.4 -0.2 -0.0 0.5 0.5 -0.2 0.0 -0.9
Hypothyroidism (self reported) 1.7 4.0 6.2 -1.1 -1.6 -2.2 -1.4 2.3 2.2 -2.5 -1.8 -2.5
Respiratory disease 1.0 2.3 5.5 -0.6 -0.1 -1.3 0.2 2.3 2.1 -1.1 -1.5 -2.2
Type 2 Diabetes (T2D) (2018) 1.8 3.4 7.5 -1.3 -2.7 -1.4 -2.4 1.2 1.1 -1.7 -1.8 -2.2
Lung FEV1/FVC ratio 0.1 0.7 1.7 0.5 -0.9 -0.7 -0.9 -0.2 -0.4 -1.3 1.2 0.5
Lung FVC 0.3 1.5 4.2 -0.5 1.0 -0.8 0.9 2.0 1.6 -1.0 -1.3 -1.3
Neuroticism 0.6 1.5 3.2 -0.5 -1.6 -1.0 -1.5 0.9 0.7 -1.2 -1.1 -1.8
Chronotype (morning person) 0.7 1.7 3.1 1.5 1.0 1.4 1.4 -0.9 -1.2 1.4 1.8 0.7
Hair Pigment 0.0 0.8 3.7 1.9 1.2 0.5 1.2 0.6 0.3 0.5 0.1 -0.2
Tanning 0.1 1.7 2.0 1.4 1.4 1.4 1.3 -1.3 -1.3 1.4 1.1 1.3
Hand grip strength (left) 1.6 4.2 8.5 -2.9 -1.6 -2.9 -1.9 1.6 2.2 -2.4 -1.2 -0.6
Number of treatments/medications taken 2.0 3.6 6.5 -1.9 -1.0 -1.8 -1.1 2.5 2.2 -2.0 -2.1 -2.1
Average weekly spirits intake 2.5 3.1 5.0 -1.9 -1.4 -1.8 -1.5 1.4 2.1 -1.6 -2.2 -1.7
Sensitivity / hurt feelings 0.6 1.1 2.4 -0.6 -1.1 -1.0 -0.8 1.1 0.9 -1.2 -0.4 -1.5
Frequency of depressed mood in last 2 weeks 3.1 4.3 6.3 -1.9 -2.3 -1.8 -2.3 1.9 1.5 -2.1 -2.5 -2.3
Hearing difficulty/problems: Yes 0.5 0.7 1.4 0.7 1.0 0.6 1.0 -0.8 -0.6 0.8 1.2 0.4
Relative age of first facial hair 0.6 1.2 4.1 -0.6 -0.0 -0.1 -0.2 -2.0 -0.5 0.5 1.6 1.8
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.1 -0.0 1.0 -0.1 0.9 0.4 0.5 0.2 0.3 0.0
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.8 -1.3 -0.4 -0.6 -0.3 0.1 0.2 -0.5 0.1 0.0
Ever had hysterectomy (womb removed) 0.7 0.8 2.2 -0.3 0.3 -0.7 0.4 1.1 1.5 -0.6 -1.2 -0.9
Systolic blood pressure, automated reading 0.3 0.8 1.8 -1.3 -0.8 -1.2 -1.0 0.4 1.0 -1.0 -0.1 -0.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.4 -0.3 -0.5 -1.0 -0.3 0.8 1.3 -1.0 -0.0 -1.6
Angina 0.6 0.8 2.5 -0.3 -0.5 -0.9 -0.1 1.0 1.1 -1.0 -0.3 -1.6
Medication for hormone replacement therapy 0.5 0.6 1.3 -0.8 -0.6 -0.5 -0.3 0.8 0.8 -0.4 -1.1 -1.2
Vitamin and mineral supplements 1.0 1.3 2.6 0.6 1.1 0.8 0.9 -1.3 -0.8 1.4 1.6 1.5
Supplements: Zinc 1.3 1.4 3.2 1.8 1.2 1.7 1.2 0.7 -0.8 1.2 -0.9 -0.5
Medication: Co-codamol 3.5 4.0 7.6 -2.4 -2.8 -2.2 -2.6 0.6 1.5 -2.5 -0.3 -1.5
Medication: Metformin 0.5 0.7 2.0 -0.2 -1.4 -0.8 -1.1 0.4 0.5 -1.1 -0.2 -0.9
Diabetes (father) 0.7 0.8 1.9 0.7 -0.2 -0.4 -0.0 1.4 1.1 -0.6 -1.2 -1.4
Diabetes (mother) 0.1 0.1 0.6 0.8 -0.5 0.1 -0.3 -0.0 -0.2 -0.1 -0.1 -0.2
Severe depression (siblings) 0.3 0.3 1.1 0.5 -0.2 1.0 -0.3 0.3 -1.0 0.4 0.1 -0.3
Pack years adult smoking proportion 0.1 0.1 0.4 -0.0 -0.2 -0.0 -0.1 -0.6 0.2 0.4 -0.6 -0.3
Impedance of leg (right) 0.1 0.4 0.8 0.4 0.6 0.1 0.8 0.6 0.5 0.1 -0.9 -0.7
Leg fat-free mass (left) 0.5 2.4 7.1 -1.9 -2.5 -1.5 -2.7 -0.7 0.4 -1.3 -0.2 0.0
Trunk fat percentage 0.6 2.6 7.4 -2.1 -2.7 -1.1 -2.7 -1.0 -0.2 -1.2 0.0 0.3
Hand grip strength (right) 0.5 1.3 2.8 -1.5 -0.6 -1.7 -0.9 1.1 1.3 -1.5 -0.6 -0.1
Townsend deprivation index at recruitment 0.0 0.0 0.1 0.2 -0.1 0.1 -0.0 0.1 0.1 0.0 -0.3 -0.3
Current tobacco smoking 0.6 1.0 3.5 1.9 1.2 0.1 1.2 0.3 1.0 0.6 -1.0 -0.5
Average weekly fortified wine intake 0.2 0.3 1.2 -0.6 0.4 0.2 0.5 -0.3 -0.4 -0.0 1.1 0.1
Maternal smoking around birth 0.1 0.1 0.4 -0.3 -0.2 -0.6 -0.3 0.1 0.5 -0.5 -0.2 -0.0
Fed-up feelings 0.8 1.4 4.0 -0.6 -0.8 -0.7 -1.1 1.0 1.1 -0.7 -1.8 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 2.4 -1.3 -1.2 -1.1 -1.5 1.6 0.7 -1.3 -1.2 -1.2
Relative age voice broke 0.5 0.7 2.1 0.2 1.0 0.3 0.9 -0.7 -0.3 0.7 1.4 1.0
Taking other prescription medications 2.2 3.3 5.5 -1.9 -1.7 -2.3 -1.5 1.7 2.0 -2.3 -1.0 -1.7
Age when periods started (menarche) 1.4 3.5 8.3 0.8 0.7 1.1 0.9 -2.4 -2.2 1.1 2.8 2.9
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 7.1 -0.1 0.8 -0.2 0.9 2.7 1.4 -0.7 -1.7 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.9 0.4 0.3 0.8 0.3 -0.4 -1.0 0.8 0.7 0.9
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.6 0.8 1.2 0.9 1.3 -0.9 -0.6 1.2 1.0 1.0
Qualifications: CSEs or equivalent 1.1 1.5 3.9 -0.1 -0.7 -0.6 -0.5 2.0 1.2 -0.6 -1.9 -1.8
Serious illness, injury or assault to yourself 2.0 2.5 6.5 2.2 2.5 1.4 2.5 0.0 -0.2 1.4 0.9 0.1
High blood pressure 0.1 0.3 1.2 0.3 0.6 -0.1 0.6 0.5 0.4 -0.1 1.1 -0.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 4.6 1.6 2.1 0.6 2.1 -0.5 0.1 1.1 0.7 0.6
Multivitamins +/- minerals 0.1 0.1 0.2 -0.1 -0.3 0.3 -0.3 0.1 -0.4 -0.2 -0.5 -0.2
Stomach or abdominal pain in last month 2.2 2.8 5.0 -1.4 -2.2 -2.0 -2.0 1.0 1.3 -2.0 -0.8 -1.6
Supplements: Glucosamine 0.1 0.1 0.3 0.1 0.1 0.0 0.3 -0.3 -0.2 -0.1 0.6 0.4
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 3.3 1.4 1.8 1.4 1.5 -0.3 -0.6 1.5 0.7 0.9
Medication: Atenolol 0.3 0.4 1.1 -0.4 -0.9 0.1 -0.6 0.6 -0.1 -0.6 -0.3 -1.0
Medication: Levothyroxine sodium 1.4 2.3 4.6 -1.4 -1.4 -2.1 -1.4 0.8 1.8 -1.8 -1.3 -1.2
Sitting height 0.5 3.2 6.7 -2.1 -2.6 -1.8 -2.5 0.9 0.7 -2.1 -1.2 -0.9
Chronic bronchitis/emphysema (father) 0.6 0.7 2.1 1.0 1.5 0.1 1.4 -0.2 0.5 0.5 0.4 0.3
High blood pressure (mother) 1.2 1.7 4.7 0.7 0.4 -0.3 0.8 1.6 1.7 -0.4 -2.2 -2.0
Body mass index (BMI) 0.3 1.4 4.2 -1.0 -1.9 -0.1 -2.0 -1.1 -0.9 -0.4 0.8 0.7
Impedance of leg (left) 0.1 0.3 0.6 0.5 0.5 0.1 0.8 0.5 0.3 0.2 -0.7 -0.5
Leg predicted mass (left) 0.5 2.5 7.5 -2.0 -2.6 -1.5 -2.7 -0.7 0.3 -1.3 -0.3 0.0
Trunk fat mass 0.7 3.0 8.6 -2.2 -2.8 -1.2 -2.9 -1.2 -0.3 -1.2 0.2 0.6
Waist circumference 0.3 0.9 2.5 -1.0 -1.4 -0.1 -1.6 -1.1 -0.8 -0.2 0.6 0.9
Number of incorrect matches in round 1.6 2.6 5.3 2.3 2.1 2.0 2.1 -0.2 -0.9 2.0 0.6 0.1
Past tobacco smoking 0.8 1.5 3.8 -0.4 -0.5 0.9 -0.4 -1.6 -2.0 0.7 1.2 1.9
Alcohol usually taken with meals 0.3 0.4 1.2 0.4 0.9 -0.4 0.8 1.1 0.7 -0.4 -0.1 -0.3
Nervous feelings 0.3 0.6 1.1 0.9 0.8 0.9 0.9 0.3 0.0 0.8 -0.8 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.0 -0.1 -0.8 -0.2 -0.9 0.1 0.2 -0.0 -0.8 -1.0
Hearing difficulty/problems with background noise 0.3 0.4 1.1 0.5 0.8 -0.7 0.9 -0.0 0.6 -0.1 1.1 -0.1
Hair/balding pattern: Pattern 2 0.4 0.5 2.0 -0.5 -0.2 0.7 0.0 -0.5 -1.0 0.2 1.4 0.5
Had menopause 0.7 0.9 2.0 1.0 1.4 0.4 1.1 -0.5 -0.3 0.4 1.4 1.0
Had other major operations 0.9 1.1 2.9 -1.7 -0.7 -0.9 -1.1 1.2 0.6 -1.3 -0.8 -0.3
Forced vital capacity (FVC) 0.6 2.2 3.7 -1.9 -0.8 -1.7 -1.0 1.6 1.6 -1.5 -1.9 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 1.4 1.0 1.1 0.8 1.0 -0.5 -0.8 1.2 0.6 0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 0.1 0.4 -0.8 0.5 1.0 1.1 -0.6 -0.5 -0.8
Qualifications: None of the above 2.4 5.2 9.5 -2.5 -2.9 -2.3 -3.1 1.3 1.6 -2.4 -1.8 -2.0
Financial difficulties in last 2 years 0.3 0.3 0.7 0.8 0.8 0.8 0.8 0.1 0.0 0.7 -0.1 -0.4
Mouth/teeth dental problems 0.3 0.5 1.5 -0.5 -0.4 0.2 -0.4 -1.0 -1.1 0.1 0.6 1.2
Heart attack 0.8 1.0 2.4 -1.2 -1.6 -1.0 -1.2 -0.3 0.3 -1.2 0.7 -0.6
Allergy 0.6 1.3 4.4 -1.5 -2.0 -0.6 -2.1 -0.5 -0.5 -0.7 0.1 0.4
Pain all over the body in last month 0.5 0.6 1.3 1.1 0.3 0.9 0.8 -0.9 -0.8 0.6 0.6 0.2
Diabetes (self-reported) 2.0 3.0 6.1 -1.4 -2.5 -1.5 -2.4 1.1 1.2 -1.7 -1.6 -1.7
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 4.4 1.6 1.8 0.5 2.1 0.6 0.6 0.7 -0.2 -0.2
Medication: Ramipril 1.0 1.3 3.4 0.4 -0.3 1.2 -0.3 -1.2 -1.8 0.7 1.6 1.4
Medication: Simvastatin 0.8 1.2 2.2 -1.3 -0.5 -1.5 -0.8 1.3 1.3 -1.4 -0.6 -0.7
Fluid intelligence score 0.1 0.1 0.5 -0.3 -0.4 -0.3 -0.5 -0.2 -0.1 -0.7 0.3 -0.1
Illnesses of siblings 0.4 0.5 1.2 1.1 0.6 0.9 0.6 -0.5 -0.7 0.8 -0.3 0.6
Neuroticism score 1.0 2.1 5.3 -0.8 -1.7 -1.2 -1.4 1.4 1.0 -1.5 -1.2 -2.3
Weight 0.5 2.5 7.8 -1.9 -2.6 -1.1 -2.8 -1.2 -0.3 -1.1 0.5 0.7
Impedance of arm (right) 0.1 0.7 2.4 0.3 0.6 -0.5 0.8 0.6 1.2 0.0 -1.5 -0.8
Arm fat percentage (right) 0.3 1.4 4.6 -1.3 -2.1 -0.5 -2.1 -0.9 -0.5 -0.7 0.2 0.2
Trunk fat-free mass 0.2 1.0 3.0 -1.2 -1.5 -1.0 -1.7 -0.7 0.0 -0.8 0.5 0.5
Hip circumference 0.5 2.2 5.8 -1.8 -2.3 -0.9 -2.4 -1.5 -0.4 -1.0 0.7 0.8
Time employed in main current job 0.8 0.9 2.6 -1.3 -1.4 -0.9 -1.6 0.1 0.3 -1.0 0.1 -0.6
Alcohol intake versus 10 years previously 0.5 0.8 2.0 1.1 -0.2 0.9 -0.0 -1.4 -1.0 0.8 1.1 0.5
Father’s age at death 0.2 0.3 1.1 0.1 0.6 0.3 1.0 -0.2 -0.1 0.5 0.5 0.6
Worrier / anxious feelings 0.7 1.3 4.0 -0.4 0.0 -0.9 -0.0 2.0 1.3 -1.0 -1.4 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.9 -1.4 -1.7 -0.8 -1.5 -0.4 0.5 -0.6 -0.6 -1.2
Falls in the last year 0.4 0.5 1.5 0.9 1.2 0.5 1.1 0.6 0.1 0.4 0.3 -0.1
Hair/balding pattern: Pattern 3 0.5 0.8 3.1 -0.2 -1.2 -0.4 -0.9 0.0 0.6 -0.3 -1.8 -1.0
Number of live births 0.8 1.2 4.6 0.8 0.6 0.8 0.7 -1.0 -1.2 0.7 2.1 1.1
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 4.5 -1.8 -1.3 -2.1 -1.4 1.9 2.0 -2.0 -2.0 -1.6
Pulse rate 1.0 1.7 5.6 0.3 -0.2 1.7 -0.2 -1.1 -2.4 0.8 1.6 1.5
Happiness 0.6 0.7 1.9 1.1 0.2 1.4 0.5 -0.0 -1.4 0.4 0.9 0.1
Noisy workplace 4.0 4.9 7.5 -1.6 -1.3 -2.7 -1.2 2.7 2.7 -2.7 -1.9 -2.3
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.2 0.4 0.9 -0.2 0.9 1.1 0.6 -0.3 -0.5 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.2 0.8 1.1 0.9 1.1 0.1 -0.4 0.9 0.4 0.4
Mouth/teeth dental problems: Dentures 0.4 0.7 2.0 -0.7 -1.3 -0.6 -0.7 0.0 0.7 -0.9 -0.0 -1.4
Asthma 1.2 2.3 6.4 -0.9 -0.3 -1.1 0.1 2.5 1.8 -1.3 -1.4 -2.3
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.5 5.4 0.6 0.0 -0.5 -0.1 1.5 1.2 -0.6 -2.3 -1.7
Medication: Cholesterol lowering 1.1 1.7 3.1 -1.2 -0.6 -1.7 -0.9 1.8 1.6 -1.5 -0.7 -1.2
Depression (self-reported) 7.8 9.4 12.4 -2.7 -2.0 -3.4 -2.0 3.5 3.5 -3.2 -3.5 -3.2
Medication: Lansoprazole 1.4 1.6 3.5 -1.3 -1.9 -1.4 -1.4 0.7 0.7 -1.7 0.2 -1.2
Prospective memory result 0.4 0.4 1.3 0.3 -0.0 0.8 0.4 -1.1 -0.7 0.8 0.6 0.5
Lung cancer (father) 0.9 1.1 2.0 0.9 1.1 0.1 1.1 1.3 1.0 0.0 -1.4 -1.3
Illnesses of mother 0.4 0.6 1.5 -0.3 0.3 0.4 0.3 -1.0 -0.7 0.5 1.2 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.3 7.1 -2.1 -2.0 -2.7 -2.1 1.3 2.1 -2.4 -2.1 -1.6
Pulse wave Arterial Stiffness index 0.6 0.8 2.6 1.0 1.6 0.8 1.4 0.3 0.1 0.7 -0.1 -0.0
Impedance of arm (left) 0.1 0.6 2.7 -0.3 0.2 -0.5 0.3 0.6 1.1 -0.1 -1.6 -0.6
Arm fat mass (right) 0.5 2.2 7.1 -1.7 -2.6 -0.8 -2.7 -1.1 -0.5 -0.9 0.3 0.4
Trunk predicted mass 0.2 1.0 3.1 -1.2 -1.5 -1.0 -1.8 -0.7 0.0 -0.8 0.4 0.5
Standing height 0.3 3.2 7.2 -2.4 -1.9 -2.7 -2.1 0.2 1.8 -2.0 -0.8 -0.3
Length of working week for main job 0.8 0.9 1.7 -1.3 -1.0 -0.9 -1.0 0.7 0.9 -0.9 -0.8 -0.9
Exposure to tobacco smoke at home 1.5 1.7 4.4 0.3 0.5 -0.7 0.5 2.1 1.8 -0.6 -1.4 -2.0
Breastfed as a baby 1.7 2.1 6.2 2.5 1.7 1.6 1.6 -0.7 -1.0 1.5 0.3 0.8
Tense / ‘highly strung’ 0.5 0.8 2.3 0.1 -0.5 0.0 -0.1 1.4 0.4 -0.7 -1.3 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.4 -0.2 -0.4 -1.4 -0.3 1.7 1.4 -1.5 -0.7 -1.8
Hair/balding pattern: Pattern 4 0.5 1.3 3.6 -0.3 0.8 -1.5 0.3 1.5 1.9 -1.0 -1.0 -0.6
Birth weight of first child 0.4 0.7 2.1 1.3 1.2 0.4 1.4 0.4 0.3 0.2 -0.6 -0.5
Peak expiratory flow (PEF) 1.6 3.8 6.1 -1.4 -1.4 -1.8 -1.1 2.2 2.2 -2.0 -2.4 -2.5
Pulse wave reflection index 0.7 0.9 2.2 0.6 1.1 -0.2 0.9 1.0 1.2 0.2 -1.5 -0.8
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.2 1.0 -1.1 0.2 -0.7 -1.1 -0.3 -0.1 -0.2 -0.3
Loud music exposure frequency 1.3 1.5 4.4 -0.5 -0.9 -0.5 -0.5 2.1 1.0 -1.3 -1.5 -1.6
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.8 0.8 0.8 -0.3 1.0 1.5 1.4 -0.3 -1.7 -1.3
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.3 0.8 1.0 -0.1 0.6 1.3 1.1 0.5 -1.5 -0.5
Blood clot in the leg (DVT) 2.2 2.9 4.5 2.1 2.0 1.5 1.8 -1.5 -1.3 1.9 1.4 1.6
Medication: Paracetamol 0.8 1.4 3.3 0.1 -0.1 -1.2 -0.0 1.7 1.8 -1.1 -1.3 -1.4
Headache pain in last month 0.9 1.6 3.5 0.7 1.6 0.2 1.7 1.9 1.2 0.2 -1.5 -1.0
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.3 0.1 -0.2 0.3 0.0 -0.5 -0.2 0.1 -0.2 -0.0
Glaucoma (self-reported) 1.2 1.4 3.7 0.9 1.1 1.9 1.0 -0.5 -1.5 1.6 0.8 0.7
Gout (self-reported) 0.2 0.2 0.6 -0.3 0.3 0.7 -0.2 -0.3 -0.6 0.8 0.1 0.7
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 3.6 -1.2 -1.5 -1.9 -1.6 0.7 1.4 -1.8 -0.9 -1.1
Medication: Amlodipine 0.5 0.6 2.2 -0.6 -0.3 -1.2 -0.1 0.4 1.5 -0.8 -0.1 -0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.3 -1.1 -0.6 -0.6 -0.7 -0.5 0.1 -0.4 0.7 0.5
Birth weight 0.4 0.9 3.1 1.8 0.7 0.4 0.5 -0.7 -0.8 0.3 1.3 0.9
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.4 0.8 1.2 0.5 1.0 0.1 0.3 0.7 0.0 -0.3
High blood pressure (siblings) 0.1 0.2 1.0 -0.2 0.3 0.2 0.2 -0.3 -0.2 0.4 1.0 0.1
Forced vital capacity (FVC), Best measure 0.8 2.8 5.1 -2.1 -1.4 -2.3 -1.6 0.9 1.8 -1.8 -1.8 -1.0
Body fat percentage 0.5 2.0 5.8 -1.7 -2.4 -0.6 -2.4 -1.3 -0.7 -0.8 0.5 0.6
Leg fat percentage (right) 0.4 1.3 2.8 -0.9 -1.6 0.4 -1.7 -1.4 -1.3 -0.1 1.0 0.8
Arm fat-free mass (right) 0.4 2.0 6.0 -1.8 -2.2 -1.3 -2.4 -0.6 0.1 -1.2 0.2 0.2
Exposure to tobacco smoke outside home 0.6 0.8 1.9 1.4 1.2 0.4 1.2 1.0 0.6 0.1 -0.5 -1.0
Comparative body size at age 10 0.3 0.9 2.3 -1.4 -1.1 -1.1 -1.5 -0.2 0.2 -0.9 0.4 0.2
Number of full brothers 1.9 2.3 6.6 -1.5 -2.6 -1.8 -2.0 -0.5 0.7 -1.8 0.3 -0.9
Worry too long after embarrassment 0.7 1.2 2.3 -1.0 -1.1 -1.4 -0.9 0.7 1.0 -1.5 -0.3 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 3.1 4.1 5.9 -2.1 -1.7 -2.4 -1.6 2.0 2.0 -2.3 -1.6 -2.2
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 0.6 0.5 0.1 0.6 0.7 0.6 0.4 -0.6 -0.9
Number of children fathered 0.4 0.4 1.2 -0.1 0.2 1.0 0.2 -0.1 -1.1 0.5 1.0 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.5 -0.6 -0.7 -0.1 -0.2 -0.1 -0.1 -0.4 0.5 -0.6
Age at first live birth 0.4 0.8 1.5 0.8 0.7 1.1 0.6 -1.2 -0.9 1.1 0.7 0.7
Pulse wave peak to peak time 0.6 0.8 2.4 -1.0 -1.5 -0.9 -1.4 -0.5 -0.0 -0.7 0.2 0.1
Health satisfaction 0.8 1.0 2.7 -0.7 -1.6 -0.6 -1.4 0.4 0.6 -0.7 -0.8 -1.4
Shortness of breath walking on level ground 0.7 0.8 1.8 -0.8 -1.0 -1.3 -0.8 -0.1 1.3 -0.5 -0.2 -1.0
Qualifications: College or University degree 0.2 0.8 1.4 0.9 1.2 0.8 1.2 -0.8 -0.4 1.1 0.3 0.7
Eye problems/disorders: None of the above 0.0 0.1 0.2 0.3 -0.0 0.1 -0.0 -0.4 -0.3 0.1 -0.1 0.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 0.3 0.0 0.1 -0.2 -0.0 -0.1 0.5 -0.6 -0.2
Emphysema/chronic bronchitis 1.7 1.9 5.0 2.2 2.1 0.7 2.2 -0.1 0.0 0.9 0.9 0.7
Medication for pain relief, constipation, heartburn 1.4 2.5 6.1 -0.3 -0.5 0.7 -0.4 -2.4 -2.0 0.9 2.1 2.5
Neck or shoulder pain in last month 3.8 5.4 8.9 -2.4 -1.3 -2.9 -1.2 2.5 3.0 -2.4 -2.0 -2.5
Medication: Blood pressure 0.3 0.6 1.1 0.7 1.0 0.6 0.8 -0.1 -0.6 0.7 1.0 0.8
Angina (self-reported) 0.6 0.8 2.5 -0.5 -0.6 -0.9 -0.2 1.0 1.0 -1.1 -0.3 -1.6
Migraine (self-reported) 2.2 2.8 6.9 0.1 1.1 -1.1 0.9 2.6 2.5 -0.9 -2.2 -1.8
Medication: Ibuprofen 1.0 1.2 4.0 0.6 0.5 -0.1 0.5 1.6 1.0 -0.4 -2.0 -1.6
Medication: Allopurinol 0.5 0.7 2.0 -1.4 -0.7 -0.9 -1.4 -0.1 0.2 -0.5 -0.1 0.6
Medication: Omeprazole 0.4 0.5 1.1 0.4 1.1 0.3 0.9 1.0 0.6 0.3 -0.8 -0.6
Medication: Seretide 50 evohaler 2.1 2.4 7.0 2.1 2.5 1.0 2.6 -0.1 0.2 1.2 1.1 0.2
Mean time to correctly identify matches 0.3 0.6 2.3 -0.5 -0.9 -0.2 -0.8 -0.5 -0.7 -0.7 1.5 0.5
Heart disease (mother) 1.1 1.3 2.5 -1.6 -1.3 -0.7 -1.4 1.1 0.4 -1.0 -1.4 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.8 0.2 -0.2 -0.5 -0.3 0.2 0.6 -0.0 -0.9 -0.5
Whole body fat mass 0.6 2.4 7.4 -1.9 -2.7 -0.9 -2.7 -1.2 -0.5 -1.0 0.4 0.5
Leg fat mass (right) 0.5 1.8 5.0 -1.3 -2.2 -0.1 -2.2 -1.5 -1.1 -0.4 0.9 0.8
Arm predicted mass (right) 0.4 1.8 5.5 -1.7 -2.1 -1.2 -2.4 -0.7 0.0 -1.2 0.3 0.3
Pulse rate, automated reading 0.7 2.4 5.5 -0.3 -0.6 0.7 -0.8 -2.3 -2.0 0.7 2.1 2.4
Alcohol intake frequency. 0.5 1.3 2.1 -1.0 -1.4 -0.9 -1.4 1.0 0.8 -1.3 -1.0 -1.1
Comparative height size at age 10 0.2 1.4 3.0 -1.4 -0.7 -1.7 -0.8 0.3 1.6 -1.3 -1.1 -0.7
Number of full sisters 0.8 1.0 1.9 0.6 1.0 -0.2 1.1 1.1 1.3 -0.0 -1.4 -1.2
Suffer from ‘nerves’ 0.1 0.2 0.9 0.6 -0.5 0.3 -0.1 -0.2 -0.2 0.1 -0.4 -1.0
Overall health rating 1.0 2.2 5.4 -1.6 -2.3 -1.3 -2.0 0.6 0.9 -1.5 -0.6 -1.5
Chest pain or discomfort 0.2 0.3 1.1 0.1 -0.6 0.1 -0.3 -0.1 0.4 0.2 -1.0 -1.0
Had major operations 0.6 0.7 2.2 -0.8 -1.5 -0.7 -1.3 -0.6 -0.2 -0.6 0.6 0.2
Age at last live birth 3.4 5.0 8.6 1.7 1.3 2.2 1.3 -2.9 -2.5 2.2 2.8 2.5
Family relationship satisfaction 0.1 0.1 0.4 0.2 0.3 0.6 0.2 -0.0 -0.4 0.3 -0.6 -0.0
Leg pain on walking 0.8 1.0 1.7 -0.4 -0.9 -1.3 -1.1 0.6 1.3 -1.1 -0.7 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 0.7 1.3 0.2 1.3 -0.2 0.2 0.7 -0.0 0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.8 -0.3 -0.4 -0.7 -0.4 1.3 0.7 -0.7 -0.6 -0.7
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.4 -1.5 -1.8 -0.7 -1.5 -0.7 -0.3 -0.8 -0.4 0.2
Medication: Aspirin 0.6 0.8 1.6 -1.3 -0.5 -1.1 -0.7 0.8 1.2 -0.9 -0.2 -1.1
Supplements: Vitamin C 0.3 0.3 0.6 -0.0 -0.4 -0.5 -0.4 0.8 0.6 -0.7 -0.8 -0.7
Knee pain experienced in last month 1.9 2.9 5.6 -1.8 -0.9 -2.4 -0.9 1.9 2.1 -2.1 -0.9 -1.5
Hypertension (Self-reported) 0.1 0.3 1.3 0.5 0.7 -0.0 0.7 0.0 0.2 0.2 1.2 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 0.3 0.3 0.2 0.6 0.3 0.0 -0.0 0.1 0.0
Illnesses of father: Heart disease 0.3 0.5 0.9 -0.7 -0.6 -0.3 -0.8 0.8 0.1 -0.8 -1.0 -0.4
Illnesses of siblings: Diabetes 2.7 3.3 6.0 -1.0 -1.4 -1.8 -1.4 1.9 2.1 -1.7 -2.1 -2.5
Smoking status: Previous 1.1 1.6 3.4 -1.0 -0.5 -1.4 -0.5 1.4 1.9 -1.2 -1.0 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.2 -1.3 -0.7 -1.8 -1.0 0.9 1.8 -0.9 -1.1 -0.9
Whole body fat-free mass 0.3 2.0 5.9 -1.7 -2.2 -1.4 -2.4 -0.6 0.3 -1.2 0.0 0.2
Leg fat-free mass (right) 0.5 2.8 8.1 -2.1 -2.7 -1.7 -2.9 -0.5 0.5 -1.4 -0.4 -0.1
Arm fat percentage (left) 0.4 1.5 4.8 -1.5 -2.1 -0.5 -2.2 -0.9 -0.5 -0.7 0.1 0.3
Average weekly red wine intake 1.3 1.9 4.4 0.4 1.4 0.8 1.2 -1.4 -1.1 1.0 2.1 2.0
Handedness (chirality/laterality): Left-handed 1.5 1.8 5.7 2.4 1.1 1.6 1.4 -0.5 -1.3 1.3 1.0 0.6
Mood swings 0.7 1.3 2.7 -1.0 -1.2 -1.6 -1.4 0.7 1.1 -1.4 -0.6 -1.0
Loneliness, isolation 1.2 1.6 3.8 -1.2 -1.3 -0.5 -1.4 1.4 0.6 -0.9 -1.6 -1.9
Long-standing illness, disability or infirmity 0.1 0.2 0.4 -0.5 -0.6 -0.4 -0.6 0.0 0.5 -0.3 -0.4 -0.4
Ever had bowel cancer screening 0.3 0.3 1.1 0.5 1.0 -0.1 0.8 0.4 0.6 0.2 -0.2 0.4
Diabetes diagnosed by doctor 1.2 2.0 3.3 -0.9 -1.8 -1.5 -1.8 1.0 1.3 -1.5 -1.4 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.9 0.7 1.0 0.9 0.8 0.2 -0.6 0.7 0.7 -0.1
Friendships satisfaction 0.1 0.1 0.2 0.3 -0.1 -0.1 -0.4 -0.3 -0.3 -0.2 0.1 0.2
Qualifications: nursing, teaching 0.9 1.4 3.1 0.6 1.0 1.7 1.1 -0.9 -1.5 1.3 0.9 1.1
Commuting to job workplace: Walk 0.3 0.3 0.9 -0.2 0.9 -0.0 0.8 0.2 -0.1 0.1 1.0 0.4
Eye problems/disorders: Cataract 0.4 0.4 1.2 0.7 1.1 0.5 0.8 -0.4 -0.2 0.9 0.0 0.8
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.5 -0.1 0.1 -0.4 -0.1 0.7 0.6 -0.5 -0.4 -0.2
Medication for cholesterol 0.1 0.1 0.2 0.2 0.0 0.1 -0.2 -0.5 -0.4 0.1 0.2 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 2.4 0.4 0.6 0.3 0.6 -0.6 -0.4 0.3 1.5 0.3
Back pain experienced in last month 0.6 0.8 1.6 -0.8 -0.7 -0.8 -0.6 1.3 0.9 -0.8 -1.1 -1.0
Mineral and other dietary supplements 0.3 0.4 1.5 0.6 0.0 0.4 0.1 -1.2 -0.4 0.9 0.7 0.6
Breast cancer (self-reported) 0.1 0.2 0.6 0.6 0.4 0.5 0.8 0.1 -0.0 -0.0 -0.1 -0.2
Asthma (self-reported) 1.2 2.3 5.7 -1.2 -0.5 -1.1 -0.1 2.4 1.8 -1.4 -1.4 -2.3
Osteoporosis (self-reported) 0.8 1.0 3.0 0.1 1.7 0.5 1.7 0.5 -0.0 0.6 1.5 0.5
Osteoarthritis (self-reported) 0.8 1.0 1.5 -0.8 -1.0 -1.2 -1.0 0.9 1.2 -1.2 -0.6 -0.8
Medication: Aspirin 0.6 0.7 1.4 -1.2 -0.5 -1.1 -0.7 0.7 1.0 -1.0 0.2 -0.9
Medication: Gliclazide 1.7 1.9 3.1 -0.9 -0.9 -1.3 -0.9 1.8 1.6 -1.1 -1.7 -1.7
Illnesses of father: None of the above (group 1) 0.1 0.2 0.3 0.4 0.3 0.3 0.4 -0.3 -0.3 0.5 0.5 0.5
Smoking status: Current 0.8 1.3 4.6 2.1 1.4 0.2 1.4 0.4 1.0 0.7 -1.0 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.6 5.9 -2.4 -1.6 -2.4 -1.7 1.7 1.7 -2.3 -1.5 -1.2
Whole body water mass 0.3 1.7 5.2 -1.6 -2.1 -1.3 -2.3 -0.7 0.2 -1.1 0.2 0.3
Leg predicted mass (right) 0.5 2.6 7.9 -2.0 -2.6 -1.6 -2.8 -0.6 0.4 -1.3 -0.3 -0.0
Arm fat mass (left) 0.5 2.0 6.3 -1.6 -2.4 -0.8 -2.5 -1.1 -0.5 -0.9 0.3 0.5
Number of self-reported non-cancer illnesses 1.6 2.8 3.6 -1.7 -1.5 -1.7 -1.4 1.8 1.9 -1.8 -1.4 -1.7
Average weekly champagne plus white wine intake 0.8 1.1 2.0 -0.4 -0.7 -1.2 -0.6 1.2 1.2 -0.9 -1.2 -1.4
Miserableness 2.4 4.1 6.2 -1.7 -2.0 -1.7 -2.1 2.2 1.5 -2.0 -2.3 -2.5
Guilty feelings 0.2 0.3 0.7 -0.1 -0.5 -0.8 -0.5 0.5 0.4 -0.8 -0.7 -0.4
Wears glasses or contact lenses 0.4 0.4 1.2 -1.0 0.2 -1.1 0.1 -0.1 1.0 -0.7 -0.1 -0.2
Ever taken oral contraceptive pill 0.5 0.5 1.8 -0.6 -0.1 0.2 -0.0 -0.8 -1.1 0.2 1.3 1.0
Hearing aid user 0.2 0.3 0.7 0.1 0.8 -0.3 0.8 0.2 0.7 0.1 0.4 -0.2
Mother’s age at death 2.9 3.7 6.4 2.5 2.5 2.4 2.3 -0.5 -1.5 2.2 0.9 1.2
Financial situation satisfaction 0.6 0.7 1.6 -0.4 -0.8 -0.9 -0.6 0.9 0.8 -1.3 0.1 -1.2
Tinnitus: Yes, now most or all of the time 3.4 4.0 10.5 -0.6 -0.6 -0.9 -0.3 3.2 2.0 -1.4 -3.1 -2.9
Commuting to job workplace: Public transport 0.4 0.5 2.0 -0.1 -0.1 -0.8 0.1 -1.0 0.5 -0.4 1.4 0.4
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 -0.4 -0.0 0.7 -0.2 -0.2 -0.9 0.7 0.6 0.6
Medication: Blood pressure 0.2 0.3 1.1 0.4 0.1 0.6 0.4 -0.7 -0.5 0.4 1.1 0.3
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.4 -1.4 -1.2 -1.6 -1.1 0.3 1.0 -1.2 0.3 -0.6
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.2 -0.9 0.1 -0.3 -0.0 1.1 0.2 -0.7 -0.4 -0.2
High cholesterol (Self-reported) 0.8 1.4 2.6 -1.6 -1.0 -1.5 -1.0 1.0 1.3 -1.3 -0.6 -0.9
Medication: Bendroflumethiazide 0.1 0.1 0.7 0.2 0.4 -0.0 0.1 0.8 0.1 -0.2 -0.4 -0.1
Medication: Paracetamol 0.5 0.7 1.8 -0.2 -0.4 -1.0 -0.2 1.1 1.3 -0.9 -0.8 -1.1
Medication: Lisinopril 0.3 0.3 1.2 -0.1 0.0 0.4 0.1 -1.1 -0.5 0.8 0.6 0.7
Medication: Atorvastatin 0.6 0.7 2.1 -0.5 -0.2 -1.1 0.2 0.9 1.4 -0.9 -0.2 -1.1
Illnesses of father: High blood pressure 1.9 2.4 4.3 -0.9 -1.4 -1.6 -1.1 1.8 1.6 -1.7 -1.4 -2.1
Alcohol drinker status: Never 0.3 0.3 1.4 -0.0 0.5 0.3 0.7 1.2 0.3 -0.1 -0.4 -0.5
Ever smoked 1.3 2.3 5.2 1.0 1.0 -0.8 0.9 1.7 2.3 -0.4 -1.9 -2.3
Basal metabolic rate 0.4 2.3 6.9 -1.9 -2.4 -1.4 -2.6 -0.7 0.2 -1.3 0.1 0.2
Leg fat percentage (left) 0.4 1.3 2.9 -0.9 -1.6 0.3 -1.7 -1.4 -1.3 -0.0 1.1 0.8
Arm fat-free mass (left) 0.3 1.7 5.7 -1.4 -2.2 -1.2 -2.4 -0.6 0.0 -1.2 0.3 0.3
Number of operations (self-reported) 0.4 0.5 1.3 -0.7 -0.1 -0.9 -0.4 1.1 1.1 -0.7 -0.0 -0.5
Average weekly beer plus cider intake 0.4 0.5 2.1 -0.4 -0.4 -0.5 -0.7 0.6 0.6 -0.2 -1.4 -0.8
Irritability 0.1 0.2 0.5 0.7 0.5 0.7 0.3 0.0 -0.4 0.6 -0.5 -0.3
Risk taking 2.6 3.8 6.5 2.6 1.4 2.4 1.5 -1.4 -2.3 2.2 1.5 1.8
Ever had prostate specific antigen (PSA) test 2.5 2.8 4.6 0.9 1.3 1.9 0.9 -1.5 -2.1 1.6 2.1 2.1
Fractured/broken bones in last 5 years 0.8 1.0 3.3 0.2 0.0 -0.2 0.3 1.8 1.2 -0.6 -1.1 -1.7
Age started oral contraceptive pill 1.6 2.0 4.9 1.0 2.0 1.3 2.2 -1.0 -0.7 1.5 1.2 1.1
Diastolic blood pressure, automated reading 0.2 0.7 2.3 -0.9 -1.2 -0.4 -1.5 -1.0 -0.4 -0.1 0.2 0.6
Ever depressed for a whole week 0.9 1.1 3.0 1.0 0.7 -0.2 1.1 1.7 0.9 -0.6 -0.9 -1.6
Unable to work because of sickness or disability 0.4 0.5 1.1 -0.3 -0.8 -0.7 -0.7 0.3 0.8 -0.6 -0.5 -1.0
Commuting to job workplace: Cycle 1.0 1.2 1.9 1.2 1.4 1.4 1.1 -1.0 -0.9 1.4 0.4 0.8
Myopia 1.1 1.6 4.1 0.2 0.5 -0.4 0.8 2.0 1.4 -0.7 -1.7 -1.8
Vascular/heart problems diagnosed by doctor 0.1 0.3 1.7 -0.5 -0.4 0.1 -0.5 -0.2 -0.2 0.1 -1.3 0.1
Cholesterol lowering medication 0.2 0.4 0.8 -0.7 -0.4 -0.6 -0.1 0.6 0.9 -0.6 -0.4 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.9 0.2 1.0 0.5 0.8 0.7 0.1 0.5 -0.7 -0.0
Pain experienced in last month 0.3 0.5 1.4 0.0 -0.3 0.7 -0.6 -1.0 -1.2 0.4 0.5 0.9
Supplements: Calcium 0.2 0.2 0.6 0.4 0.6 0.4 0.3 -0.4 -0.4 0.5 0.8 0.5
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.3 0.3 0.0 0.2 0.2 0.2 -0.1 0.4 -0.5
Heart attack/myocardial infarction (self-reported) 0.7 1.0 2.2 -1.3 -1.5 -1.1 -1.2 -0.3 0.3 -1.2 0.7 -0.4
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 4.3 2.1 1.9 1.4 1.6 -1.5 -1.2 1.8 1.2 1.5
Heart disease (siblings) 0.8 0.9 2.9 -0.5 -0.9 0.3 -0.7 -1.7 -1.1 0.5 1.4 0.8
Alcohol drinker status: Previous 1.6 1.8 2.7 -0.9 -1.2 -1.3 -1.0 1.3 1.5 -1.4 -1.7 -1.6
Pack years of smoking 0.1 0.2 1.3 -0.1 -0.1 0.2 -0.0 -1.1 -0.3 0.6 -0.1 0.3
Impedance of whole body 0.1 0.7 2.4 -0.1 0.1 -0.7 0.3 0.9 1.2 -0.4 -1.6 -1.0
Leg fat mass (left) 0.5 2.0 5.3 -1.4 -2.2 -0.2 -2.3 -1.6 -1.2 -0.3 1.1 0.9
Arm predicted mass (left) 0.4 2.1 6.7 -1.6 -2.4 -1.4 -2.6 -0.5 0.2 -1.3 0.0 -0.0