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chr4:99,094,892-101,562,813

Best TWAS P=4.08e-23 · Best GWAS P=2.15e-26 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADH5	0.11	0.08	lasso	7	0.09	2.6e-11	-5.33	-5.3	1.0e-07	0.40	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	DNAJB14	0.08	0.00	lasso	4	0.00	1.4e-01	-5.39	-5.7	1.3e-08	0.07	0.04	0.91	FALSE
3	GTEx	Adipose Subcutaneous	RP11-696N14.1	0.43	0.04	enet	72	0.18	1.6e-14	0.22	5.7	1.5e-08	-0.51	0.13	0.87	FALSE
4	GTEx	Artery Aorta	DNAJB14	0.24	0.01	lasso	13	0.09	8.1e-06	-6.29	-5.7	9.5e-09	0.02	0.03	0.97	FALSE
5	GTEx	Artery Tibial	EIF4E	0.17	0.02	enet	17	0.06	1.7e-05	-6.02	5.6	2.6e-08	-0.46	0.74	0.02	FALSE
6	GTEx	Brain Cerebellar Hemisphere	LAMTOR3	0.19	0.15	lasso	4	0.17	3.6e-05	-5.87	5.9	3.6e-09	-0.05	0.04	0.90	FALSE
7	GTEx	Brain Cerebellar Hemisphere	ADH5	0.74	0.08	lasso	29	0.24	5.6e-07	-8.97	-5.2	2.3e-07	0.63	0.08	0.87	FALSE
8	GTEx	Cells Transformed fibroblasts	DNAJB14	0.22	0.11	lasso	11	0.15	2.0e-11	-6.29	-6.5	6.1e-11	0.05	0.01	0.99	TRUE
9	GTEx	Cells Transformed fibroblasts	ADH5	0.08	0.07	lasso	3	0.03	1.5e-03	-5.38	-5.4	7.6e-08	0.38	0.89	0.04	FALSE
10	GTEx	Esophagus Mucosa	EIF4E	0.16	0.10	lasso	5	0.06	6.1e-05	-5.52	5.9	3.6e-09	-0.52	0.90	0.02	FALSE
11	GTEx	Liver	RP11-571L19.8	0.31	0.05	lasso	6	0.11	5.1e-04	0.22	-5.3	1.1e-07	0.47	0.14	0.40	FALSE
12	GTEx	Lung	RP11-696N14.1	0.28	0.13	lasso	9	0.24	2.0e-18	0.22	5.7	1.3e-08	-0.49	0.18	0.82	FALSE
13	GTEx	Skin Sun Exposed Lower leg	ADH5	0.10	0.10	lasso	2	0.09	6.8e-08	-5.42	-5.4	6.0e-08	0.39	0.97	0.02	FALSE
14	GTEx	Small Intestine Terminal Ileum	RP11-696N14.1	0.31	0.04	lasso	13	0.04	5.3e-02	-7.05	7.1	1.4e-12	-0.50	0.07	0.22	FALSE
15	GTEx	Thyroid	DNAJB14	0.07	0.01	lasso	7	0.00	3.4e-01	-5.69	-6.2	4.2e-10	0.06	0.04	0.83	FALSE
16	GTEx	Whole Blood	ADH5	0.12	0.07	lasso	3	0.05	2.3e-05	-5.42	-6.7	2.5e-11	0.54	0.95	0.03	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	ADH5	0.13	0.07	enet	27	0.08	1.6e-10	-5.33	-5.2	2.3e-07	0.42	1.00	0.00	FALSE
18	YFS	Blood	DAPP1	0.04	0.01	lasso	7	0.02	1.9e-08	-6.16	5.3	1.2e-07	-0.12	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	ADH4	0.17	0.13	lasso	1	0.10	1.4e-06	-9.44	-9.4	3.8e-21	0.80	0.35	0.62	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	MAPKSP1	0.06	0.09	lasso	1	0.08	3.9e-05	-6.16	6.2	7.4e-10	-0.09	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	EIF4E	0.04	0.03	lasso	2	0.03	3.1e-04	-6.06	6.2	5.6e-10	-0.56	0.01	0.98	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	ADH4	0.15	0.15	enet	12	0.14	6.9e-16	-9.44	-9.1	8.3e-20	0.81	0.89	0.11	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	ADH5	0.03	0.01	blup	94	0.02	5.1e-03	-5.33	-7.4	1.2e-13	0.70	0.05	0.32	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	EIF4E	0.03	0.03	lasso	3	0.03	3.3e-04	-5.90	6.1	1.2e-09	-0.54	0.01	0.98	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADH4	0.07	0.02	lasso	1	0.00	4.6e-01	-9.24	-9.2	2.5e-20	0.75	0.03	0.62	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADH5	0.12	0.07	lasso	3	0.07	1.5e-07	-7.20	-7.2	7.9e-13	0.75	0.53	0.47	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAPKSP1	0.03	0.03	lasso	2	0.03	5.4e-04	-5.98	6.0	2.7e-09	-0.09	0.01	0.96	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	ADH4	0.13	0.07	enet	4	0.05	9.0e-05	-9.44	-8.3	8.3e-17	0.75	0.09	0.64	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	EIF4E	0.06	0.03	blup	44	0.05	2.8e-05	-6.06	6.4	1.9e-10	-0.52	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ADH4	0.19	0.16	blup	92	0.20	3.3e-06	-10.48	-9.9	4.1e-23	0.97	0.06	0.94	TRUE