TWAS
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Usage
Models
Genes
Traits
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Traits
:
Blood Platelet Count
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chr4:94,527,983-95,955,095
Best TWAS P=1.71e-07 · Best GWAS P=1.74e-08 conditioned to 0.0344
94.6M
94.8M
95M
95.2M
95.4M
95.6M
95.8M
96M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
HPGDS
0.06
0.05
lasso
4
0.04
1.8e-06
-5.2
5.2
1.7e-07
-0.91
0.03
0.97
TRUE
2
The Cancer Genome Atlas
Prostate Adenocarcinoma
HPGDS
0.07
0.08
blup
54
0.10
2.8e-10
-5.5
5.2
1.7e-07
-0.96
0.02
0.98
FALSE