Best TWAS P=1.21e-29 · Best GWAS P=5.47e-35 conditioned to 0.00134
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | FCHO2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 1.2e-01 | -5.2 | -7.0 | 3.3e-12 | 0.56 | 0.06 | 0.66 | FALSE |
2 | GTEx | Artery Aorta | FCHO2 | 0.07 | 0.04 | lasso | 2 | 0.03 | 5.2e-03 | -5.4 | -6.0 | 2.6e-09 | 0.48 | 0.17 | 0.35 | FALSE |
3 | GTEx | Artery Tibial | FCHO2 | 0.14 | 0.03 | enet | 59 | 0.02 | 5.9e-03 | -7.5 | -8.8 | 1.0e-18 | 0.49 | 0.28 | 0.40 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | FCHO2 | 0.28 | 0.15 | enet | 21 | 0.05 | 8.7e-03 | -5.1 | -6.6 | 3.9e-11 | 0.52 | 0.16 | 0.35 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | FCHO2 | 0.10 | 0.04 | lasso | 10 | 0.05 | 6.0e-05 | -5.4 | -5.8 | 7.3e-09 | 0.40 | 0.63 | 0.28 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | FCHO2 | 0.16 | -0.01 | enet | 24 | -0.01 | 7.5e-01 | -7.5 | -9.8 | 1.6e-22 | 0.54 | 0.05 | 0.43 | TRUE |
7 | GTEx | Esophagus Mucosa | FCHO2 | 0.15 | 0.07 | lasso | 2 | 0.09 | 1.1e-06 | -5.4 | 5.4 | 5.7e-08 | -0.42 | 0.98 | 0.00 | FALSE |
8 | GTEx | Nerve Tibial | FCHO2 | 0.10 | 0.08 | enet | 17 | 0.05 | 3.4e-04 | -5.2 | -5.8 | 7.3e-09 | 0.56 | 0.71 | 0.20 | FALSE |
9 | GTEx | Pancreas | FCHO2 | 0.11 | 0.04 | enet | 7 | 0.03 | 1.8e-02 | -7.7 | -8.4 | 4.3e-17 | 0.56 | 0.23 | 0.16 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | FCHO2 | 0.06 | 0.03 | enet | 20 | 0.03 | 2.6e-03 | -5.1 | -8.3 | 8.4e-17 | 0.56 | 0.25 | 0.21 | FALSE |
11 | GTEx | Testis | FCHO2 | 0.13 | 0.06 | lasso | 8 | 0.06 | 1.4e-03 | -11.6 | -11.3 | 1.2e-29 | 0.93 | 0.07 | 0.82 | TRUE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FCHO2 | 0.05 | 0.04 | blup | 84 | 0.04 | 1.9e-09 | -5.1 | -7.1 | 1.0e-12 | 0.46 | 1.00 | 0.00 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FCHO2 | 0.08 | 0.00 | blup | 84 | 0.03 | 1.0e-02 | -5.0 | -6.8 | 7.2e-12 | 0.50 | 0.04 | 0.18 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | FCHO2 | 0.05 | 0.03 | blup | 84 | 0.01 | 1.2e-02 | -5.4 | -5.8 | 6.4e-09 | 0.41 | 0.10 | 0.11 | FALSE |