[Hub]/) : Traits : Blood Platelet Count : ← →

chr5:73,626,450-79,059,417

Best TWAS P=2.81e-69 · Best GWAS P=6.41e-233 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
79	YFS	Blood	F2R	0.08	0.07	bslmm	562	0.08	1.4e-23	-19.56	17.6	2.8e-69	-0.41	1.00	0.00	TRUE
35	GTEx	Heart Left Ventricle	F2R	0.14	0.02	lasso	6	0.03	1.4e-02	-18.15	-17.1	7.6e-66	0.42	0.19	0.07	TRUE
99	The Cancer Genome Atlas	Thyroid Carcinoma	SCAMP1	0.14	0.10	enet	14	0.10	1.6e-09	-13.67	14.8	3.0e-49	0.06	0.00	1.00	TRUE
57	GTEx	Thyroid	IQGAP2	0.27	0.04	enet	29	0.08	8.8e-07	8.96	-13.9	4.9e-44	0.21	0.74	0.02	TRUE
13	GTEx	Artery Tibial	SCAMP1	0.08	0.03	lasso	4	0.02	1.5e-02	-13.03	-11.1	8.0e-29	-0.05	0.43	0.07	TRUE
41	GTEx	Nerve Tibial	F2R	0.15	0.05	lasso	10	0.05	2.0e-04	8.42	-10.9	6.8e-28	0.31	0.79	0.04	TRUE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	F2RL1	0.02	0.01	blup	50	0.02	2.2e-03	-8.75	10.8	2.9e-27	-0.26	0.04	0.06	TRUE
96	The Cancer Genome Atlas	Thyroid Carcinoma	F2RL1	0.05	0.03	enet	7	0.03	2.7e-04	-10.34	10.6	2.6e-26	-0.27	0.06	0.13	TRUE
19	GTEx	Brain Hippocampus	ARSB	0.40	0.03	lasso	10	0.09	4.2e-03	-13.49	10.3	5.7e-25	0.04	0.04	0.61	TRUE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	CRHBP	0.19	0.07	enet	14	0.12	5.1e-12	-8.20	-9.8	1.1e-22	0.23	1.00	0.00	TRUE
69	NTR	Blood	F2RL2	0.04	0.02	bslmm	571	0.02	7.7e-08	8.99	-9.2	5.2e-20	0.01	1.00	0.00	TRUE
5	CommonMind	Brain Pre-frontal Cortex	POC5	0.17	0.16	lasso	5	0.15	5.2e-18	8.95	-9.0	2.1e-19	0.01	0.74	0.26	TRUE
33	GTEx	Esophagus Muscularis	F2R	0.13	0.11	lasso	4	0.08	1.6e-05	8.10	-8.7	3.9e-18	0.19	0.76	0.04	TRUE
91	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	F2R	0.10	0.02	enet	9	0.05	6.8e-03	12.10	8.5	2.4e-17	-0.08	0.06	0.04	TRUE
49	GTEx	Stomach	ARSB	0.19	0.01	lasso	7	0.04	6.6e-03	1.58	8.4	6.3e-17	0.06	0.11	0.26	TRUE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	F2RL1	0.05	0.05	lasso	3	0.05	2.4e-06	7.88	7.9	3.4e-15	-0.24	1.00	0.00	TRUE
63	METSIM	Adipose	AP3B1	0.07	0.01	blup	556	0.02	2.4e-04	-3.68	7.5	6.5e-14	-0.01	0.43	0.08	TRUE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TBCA	0.04	0.01	blup	86	0.02	1.8e-03	-5.35	7.3	3.9e-13	-0.05	0.16	0.14	TRUE
59	GTEx	Thyroid	CTD-2037K23.2	0.12	0.00	enet	17	0.00	3.2e-01	-13.57	7.1	1.3e-12	0.00	0.02	0.68	TRUE
64	METSIM	Adipose	CTD-2037K23.2	0.05	0.03	bslmm	431	0.04	1.3e-06	-12.41	7.1	1.6e-12	0.04	0.05	0.94	TRUE
47	GTEx	Spleen	CTD-2037K23.2	0.37	0.10	enet	15	0.19	1.1e-05	-13.57	6.7	2.4e-11	0.02	0.04	0.85	TRUE
8	CommonMind	Brain Pre-frontal Cortex	WDR41	0.23	0.14	bslmm	576	0.19	5.0e-23	-5.61	-6.6	3.1e-11	0.08	1.00	0.00	TRUE
26	GTEx	Cells Transformed fibroblasts	CTD-2037K23.2	0.11	0.00	enet	37	0.01	6.1e-02	0.58	6.6	4.2e-11	0.00	0.14	0.60	TRUE
85	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PDE8B	0.17	0.03	lasso	6	0.02	7.1e-04	5.35	6.6	5.4e-11	-0.04	0.15	0.25	TRUE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	AGGF1	0.07	0.04	lasso	3	0.03	3.5e-04	-6.82	-6.5	6.7e-11	0.14	0.00	1.00	TRUE
97	The Cancer Genome Atlas	Thyroid Carcinoma	F2RL2	0.11	0.13	enet	6	0.13	1.5e-12	5.91	6.5	7.2e-11	-0.13	1.00	0.00	TRUE
38	GTEx	Muscle Skeletal	WDR41	0.25	0.18	lasso	4	0.17	9.1e-17	-6.03	-6.2	5.4e-10	0.09	1.00	0.00	TRUE
34	GTEx	Heart Atrial Appendage	WDR41	0.28	-0.01	enet	35	0.02	4.7e-02	-5.61	-6.2	6.9e-10	0.10	0.52	0.02	TRUE
44	GTEx	Skin Sun Exposed Lower leg	WDR41	0.35	0.13	lasso	10	0.27	1.3e-22	-4.92	-6.2	7.1e-10	0.04	1.00	0.00	TRUE
31	GTEx	Esophagus Mucosa	CTD-2037K23.2	0.11	0.00	enet	24	0.03	2.5e-03	-13.51	5.6	1.7e-08	-0.01	0.04	0.55	TRUE
92	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	F2RL2	0.11	0.02	blup	112	0.03	2.6e-02	5.11	5.6	1.7e-08	-0.19	0.04	0.05	TRUE
51	GTEx	Testis	LHFPL2	0.18	-0.01	enet	21	0.10	2.1e-05	-5.58	-5.6	2.4e-08	-0.01	0.11	0.13	TRUE
28	GTEx	Esophagus Gastroesophageal Junction	WDR41	0.35	-0.01	enet	25	0.08	7.4e-04	-5.18	-5.5	5.1e-08	0.04	0.10	0.10	TRUE
18	GTEx	Brain Cerebellar Hemisphere	WDR41	0.41	0.31	lasso	2	0.30	1.4e-08	-5.61	-5.3	9.3e-08	0.05	0.79	0.01	TRUE
2	CommonMind	Brain Pre-frontal Cortex	DMGDH	0.13	0.13	bslmm	465	0.13	2.9e-15	3.88	5.3	1.1e-07	-0.05	1.00	0.00	TRUE
39	GTEx	Muscle Skeletal	F2R	0.18	0.19	enet	16	0.19	9.0e-19	8.42	-15.0	5.5e-51	0.38	1.00	0.00	FALSE
71	NTR	Blood	LHFPL2	0.01	0.00	blup	516	0.00	8.5e-03	-12.99	13.8	2.4e-43	0.04	0.04	0.94	FALSE
55	GTEx	Testis	CTD-2037K23.2	0.20	0.19	lasso	2	0.18	2.7e-08	-13.49	13.7	1.6e-42	0.08	0.01	0.99	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	LHFPL2	0.06	0.06	lasso	2	0.05	1.2e-05	-13.43	13.4	3.7e-41	0.07	0.01	0.98	FALSE
37	GTEx	Muscle Skeletal	LHFPL2	0.05	0.00	lasso	3	0.00	9.1e-01	-13.15	13.2	1.1e-39	0.03	0.06	0.33	FALSE
56	GTEx	Thyroid	LHFPL2	0.08	0.09	lasso	5	0.08	1.0e-06	-13.04	13.0	6.4e-39	0.07	0.68	0.30	FALSE
81	YFS	Blood	LHFPL2	0.06	0.02	enet	24	0.04	7.6e-12	-13.69	12.9	4.8e-38	0.06	0.00	1.00	FALSE
23	GTEx	Cells Transformed fibroblasts	SCAMP1	0.12	0.05	enet	12	0.03	1.2e-03	-12.70	-11.6	5.1e-31	-0.05	0.14	0.78	FALSE
3	CommonMind	Brain Pre-frontal Cortex	F2R	0.06	0.03	lasso	3	0.04	3.6e-05	12.10	11.2	5.4e-29	-0.18	0.77	0.02	FALSE
43	GTEx	Pituitary	F2R	0.36	0.16	lasso	13	0.10	2.0e-03	-10.57	-9.3	9.6e-21	0.21	0.10	0.06	FALSE
80	YFS	Blood	IQGAP2	0.29	0.29	enet	33	0.29	7.1e-95	8.96	-9.3	1.2e-20	0.05	1.00	0.00	FALSE
10	GTEx	Adipose Subcutaneous	F2R	0.16	0.14	enet	11	0.13	5.7e-11	8.10	-9.2	3.6e-20	0.24	1.00	0.00	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	POLK	0.03	0.01	lasso	7	0.02	3.9e-03	7.98	8.9	3.8e-19	-0.04	0.19	0.74	FALSE
70	NTR	Blood	IQGAP2	0.07	0.06	lasso	6	0.06	1.1e-17	8.70	-8.8	1.2e-18	0.03	1.00	0.00	FALSE
90	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGCR	0.04	0.02	enet	4	0.03	6.0e-03	8.16	8.1	5.3e-16	-0.05	0.02	0.66	FALSE
36	GTEx	Lung	F2R	0.39	0.40	lasso	2	0.41	7.7e-34	8.10	-8.1	5.5e-16	0.18	1.00	0.00	FALSE
27	GTEx	Colon Sigmoid	F2R	0.23	0.18	lasso	2	0.14	8.8e-06	8.10	-8.1	6.5e-16	0.18	0.40	0.10	FALSE
48	GTEx	Spleen	CTC-366B18.2	0.16	0.11	lasso	3	0.14	2.2e-04	6.14	8.0	1.5e-15	-0.03	0.19	0.32	FALSE
16	GTEx	Brain Cerebellar Hemisphere	POLK	0.27	0.20	lasso	6	0.16	8.3e-05	6.84	7.9	3.4e-15	0.00	0.19	0.54	FALSE
45	GTEx	Spleen	POLK	0.18	-0.01	lasso	16	0.03	5.1e-02	5.66	7.8	8.2e-15	-0.03	0.12	0.44	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	ANKDD1B	0.07	0.00	bslmm	382	0.03	7.0e-05	5.95	-7.5	4.2e-14	0.02	0.14	0.19	FALSE
4	CommonMind	Brain Pre-frontal Cortex	F2RL1	0.26	0.27	lasso	6	0.29	2.7e-35	7.43	7.4	1.1e-13	-0.25	1.00	0.00	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	F2RL1	0.16	0.16	lasso	9	0.17	4.2e-21	6.46	7.3	3.2e-13	-0.24	1.00	0.00	FALSE
60	GTEx	Thyroid	CTC-366B18.2	0.06	0.03	lasso	9	0.02	6.2e-03	7.32	7.3	3.6e-13	-0.01	0.29	0.21	FALSE
54	GTEx	Testis	F2R	0.30	0.20	lasso	3	0.16	1.9e-07	8.10	-7.2	5.3e-13	0.15	0.98	0.00	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	SCAMP1	0.08	0.03	enet	10	0.03	1.9e-04	-0.75	-7.2	7.7e-13	-0.02	0.91	0.05	FALSE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLK	0.03	0.01	blup	53	0.01	1.6e-02	5.19	-7.1	1.5e-12	0.02	0.30	0.45	FALSE
29	GTEx	Esophagus Mucosa	COL4A3BP	0.09	0.06	lasso	5	0.05	4.2e-04	5.70	-7.0	2.0e-12	0.05	0.79	0.05	FALSE
100	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	POC5	0.24	0.13	blup	70	0.14	1.2e-04	6.83	7.0	3.6e-12	-0.06	0.05	0.80	FALSE
66	METSIM	Adipose	POLK	0.05	0.01	enet	16	0.03	4.3e-05	9.49	6.9	6.9e-12	-0.02	0.03	0.97	FALSE
7	CommonMind	Brain Pre-frontal Cortex	TBCA	0.07	0.07	lasso	3	0.05	9.2e-07	-6.82	6.7	2.4e-11	-0.05	0.83	0.17	FALSE
89	The Cancer Genome Atlas	Brain Lower Grade Glioma	POC5	0.04	0.00	enet	7	0.03	2.1e-04	8.95	-6.7	2.6e-11	0.04	0.02	0.57	FALSE
46	GTEx	Spleen	POC5	0.42	0.37	lasso	4	0.34	1.3e-09	6.14	6.6	4.6e-11	-0.03	0.97	0.01	FALSE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	GCNT4	0.10	0.06	enet	6	0.05	8.7e-04	4.86	-6.6	4.7e-11	0.02	0.08	0.54	FALSE
14	GTEx	Artery Tibial	WDR41	0.22	0.11	lasso	5	0.07	3.3e-06	-4.92	-6.6	5.1e-11	0.05	0.98	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	POLK	0.06	0.04	lasso	3	0.04	1.0e-03	6.00	-6.6	5.2e-11	0.03	0.40	0.12	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	POC5	0.47	0.36	lasso	4	0.39	1.3e-13	6.14	6.5	7.3e-11	-0.03	1.00	0.00	FALSE
12	GTEx	Adrenal Gland	GCNT4	0.13	0.02	lasso	8	0.01	1.3e-01	5.60	6.5	8.5e-11	-0.03	0.07	0.82	FALSE
83	YFS	Blood	TBCA	0.24	0.25	enet	34	0.26	7.2e-84	-6.74	-6.4	1.8e-10	0.05	1.00	0.00	FALSE
20	GTEx	Brain Hypothalamus	CTC-366B18.4	0.26	0.12	lasso	8	0.07	9.0e-03	6.14	-6.3	2.8e-10	0.02	0.10	0.07	FALSE
53	GTEx	Testis	GCNT4	0.42	0.35	enet	62	0.37	3.8e-17	6.30	6.2	4.2e-10	-0.04	1.00	0.00	FALSE
9	GTEx	Adipose Subcutaneous	POC5	0.08	0.07	lasso	7	0.07	3.2e-06	6.14	6.2	5.2e-10	-0.03	0.96	0.00	FALSE
42	GTEx	Pancreas	POC5	0.32	0.23	lasso	3	0.21	3.5e-09	6.08	6.2	6.3e-10	-0.03	1.00	0.00	FALSE
82	YFS	Blood	SCAMP1	0.03	0.01	blup	488	0.02	1.1e-06	-13.49	6.1	8.2e-10	0.06	0.03	0.97	FALSE
25	GTEx	Cells Transformed fibroblasts	POC5	0.15	0.17	lasso	6	0.16	3.4e-12	6.08	6.1	1.2e-09	-0.02	1.00	0.00	FALSE
30	GTEx	Esophagus Mucosa	POC5	0.18	0.16	lasso	1	0.15	4.8e-10	6.08	6.1	1.2e-09	-0.02	1.00	0.00	FALSE
40	GTEx	Nerve Tibial	POC5	0.16	0.12	lasso	5	0.10	7.6e-08	6.02	6.1	1.2e-09	-0.03	0.99	0.00	FALSE
68	NTR	Blood	F2RL1	0.10	0.13	lasso	4	0.13	8.9e-41	7.88	6.1	1.2e-09	-0.22	1.00	0.00	FALSE
11	GTEx	Adipose Visceral Omentum	POC5	0.13	0.08	lasso	9	0.08	6.1e-05	6.08	6.0	1.5e-09	-0.03	0.87	0.01	FALSE
61	GTEx	Whole Blood	SCAMP1	0.06	0.00	enet	19	0.01	8.8e-02	5.32	-5.8	4.9e-09	-0.01	0.16	0.03	FALSE
52	GTEx	Testis	POC5	0.27	0.13	lasso	8	0.09	8.1e-05	6.49	-5.8	5.0e-09	0.03	0.70	0.05	FALSE
15	GTEx	Artery Tibial	GCNT4	0.08	0.07	lasso	2	0.04	3.9e-04	5.60	-5.7	1.5e-08	0.03	0.67	0.09	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANKRD31	0.10	0.13	lasso	9	0.13	3.9e-15	6.22	-5.7	1.6e-08	0.04	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	WDR41	0.25	0.04	lasso	4	0.06	1.2e-04	4.68	-5.6	2.1e-08	0.04	0.89	0.00	FALSE
17	GTEx	Brain Cerebellar Hemisphere	POC5	0.31	0.15	enet	18	0.30	1.6e-08	6.14	5.5	4.0e-08	-0.04	0.73	0.08	FALSE
65	METSIM	Adipose	POC5	0.11	0.09	enet	29	0.10	7.5e-15	6.02	5.5	4.0e-08	-0.02	1.00	0.00	FALSE
58	GTEx	Thyroid	POC5	0.26	0.23	enet	15	0.23	1.8e-17	6.02	5.4	5.2e-08	-0.04	1.00	0.00	FALSE
6	CommonMind	Brain Pre-frontal Cortex	SV2C	0.11	0.07	bslmm	660	0.07	4.0e-09	0.88	5.4	6.7e-08	-0.04	1.00	0.00	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	POC5	0.05	0.00	blup	384	0.02	8.6e-04	6.02	5.4	7.5e-08	-0.03	0.31	0.09	FALSE
50	GTEx	Stomach	POC5	0.10	0.06	enet	12	0.08	8.3e-05	6.00	5.3	9.5e-08	-0.02	0.56	0.02	FALSE
62	GTEx	Whole Blood	WDR41	0.09	0.00	enet	18	0.00	4.9e-01	5.35	-5.3	1.3e-07	0.10	0.10	0.07	FALSE
21	GTEx	Breast Mammary Tissue (Female)	POC5	0.10	0.06	lasso	3	0.05	1.8e-02	4.18	5.2	1.7e-07	0.00	0.06	0.06	FALSE
67	METSIM	Adipose	WDR41	0.19	0.08	enet	25	0.16	8.8e-24	-6.10	-5.2	1.8e-07	0.01	1.00	0.00	FALSE
78	YFS	Blood	AP3B1	0.25	0.22	lasso	9	0.23	2.6e-74	-4.43	5.2	1.8e-07	-0.03	1.00	0.00	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	WDR41	0.12	0.09	bslmm	614	0.09	2.8e-11	-5.09	-5.1	2.7e-07	0.04	1.00	0.00	FALSE