Best TWAS P=8.94e-34 · Best GWAS P=2.76e-55 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NAALAD2 | 0.18 | 0.13 | enet | 13 | 0.16 | 1.3e-19 | -12.4 | 11.6 | 3.1e-31 | -0.26 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adrenal Gland | NAALAD2 | 0.26 | 0.19 | lasso | 8 | 0.19 | 1.8e-07 | -11.6 | -12.1 | 8.9e-34 | 0.16 | 0.09 | 0.89 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | NAALAD2 | 0.28 | 0.18 | lasso | 6 | 0.23 | 1.7e-17 | -11.5 | -10.0 | 1.6e-23 | 0.12 | 0.97 | 0.03 | FALSE |
| 4 | GTEx | Esophagus Mucosa | NAALAD2 | 0.17 | 0.10 | enet | 17 | 0.09 | 1.3e-06 | -11.6 | -8.1 | 5.7e-16 | 0.15 | 0.83 | 0.14 | FALSE |
| 5 | GTEx | Esophagus Muscularis | NAALAD2 | 0.33 | 0.06 | lasso | 6 | 0.07 | 6.7e-05 | -11.6 | -7.1 | 1.1e-12 | 0.09 | 0.35 | 0.47 | TRUE |
| 6 | GTEx | Heart Atrial Appendage | NAALAD2 | 0.17 | 0.10 | enet | 10 | 0.09 | 1.1e-04 | -11.6 | -11.4 | 5.7e-30 | 0.19 | 0.15 | 0.68 | FALSE |
| 7 | GTEx | Lung | NAALAD2 | 0.29 | 0.12 | enet | 28 | 0.13 | 2.1e-10 | -11.6 | -8.4 | 4.8e-17 | 0.17 | 0.93 | 0.07 | TRUE |
| 8 | GTEx | Pituitary | NAALAD2 | 0.46 | 0.30 | lasso | 5 | 0.26 | 2.7e-07 | -11.6 | -11.7 | 1.6e-31 | 0.18 | 0.06 | 0.93 | FALSE |
| 9 | GTEx | Testis | NAALAD2 | 0.11 | 0.03 | lasso | 5 | 0.01 | 1.1e-01 | -11.6 | -12.0 | 2.8e-33 | 0.15 | 0.04 | 0.82 | TRUE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | NAALAD2 | 0.26 | 0.10 | bslmm | 280 | 0.19 | 2.2e-23 | -6.5 | 9.2 | 3.6e-20 | -0.26 | 1.00 | 0.00 | TRUE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NAALAD2 | 0.11 | 0.01 | blup | 58 | 0.02 | 4.4e-03 | -1.1 | -8.5 | 1.7e-17 | 0.06 | 0.02 | 0.06 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NAALAD2 | 0.04 | 0.02 | lasso | 5 | 0.03 | 1.1e-06 | -6.3 | -7.1 | 1.0e-12 | -0.01 | 0.43 | 0.09 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NAALAD2 | 0.15 | 0.10 | blup | 58 | 0.09 | 1.3e-10 | -6.3 | -8.3 | 9.4e-17 | 0.03 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NAALAD2 | 0.03 | 0.02 | lasso | 3 | 0.01 | 3.0e-02 | -11.6 | -11.5 | 1.9e-30 | 0.18 | 0.04 | 0.15 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NAALAD2 | 0.06 | 0.06 | blup | 58 | 0.07 | 9.4e-08 | -7.6 | -10.5 | 6.1e-26 | 0.12 | 0.33 | 0.67 | FALSE |
| 16 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NAALAD2 | 0.16 | 0.04 | lasso | 6 | 0.11 | 6.0e-04 | -1.4 | -5.3 | 9.6e-08 | 0.11 | 0.02 | 0.08 | TRUE |