[Hub]/) : Traits : Hair Pigment : ← →

chr11:118,205,702-119,659,753

Best TWAS P=3.82e-12 · Best GWAS P=2.22e-10 conditioned to 0.208

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HMBS	0.22	0.14	lasso	3	0.16	1.1e-12	6.1	6.2	5.9e-10	0.97	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	HMBS	0.14	0.09	lasso	3	0.10	1.2e-05	5.4	5.5	3.8e-08	0.84	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-110I1.14	0.14	0.09	lasso	4	0.09	2.5e-05	6.1	-5.6	2.1e-08	-0.93	0.02	0.96	FALSE
4	GTEx	Adrenal Gland	HMBS	0.24	0.17	lasso	5	0.18	7.2e-07	6.2	6.3	2.1e-10	0.98	0.01	0.99	FALSE
5	GTEx	Artery Aorta	HMBS	0.24	0.14	enet	15	0.17	1.6e-09	6.2	6.0	1.5e-09	0.95	0.01	0.99	FALSE
6	GTEx	Artery Coronary	HMBS	0.27	0.19	lasso	4	0.17	2.3e-06	6.2	6.3	2.7e-10	0.97	0.01	0.99	FALSE
7	GTEx	Artery Tibial	HMBS	0.18	0.09	enet	28	0.09	3.1e-07	6.2	6.9	3.8e-12	0.81	0.01	0.99	TRUE
8	GTEx	Brain Caudate basal ganglia	VPS11	0.35	0.24	lasso	5	0.21	1.5e-06	6.2	-6.0	1.8e-09	-0.95	0.01	0.98	FALSE
9	GTEx	Brain Cerebellum	HMBS	0.21	0.15	lasso	3	0.15	3.3e-05	6.1	6.2	5.7e-10	0.98	0.01	0.97	FALSE
10	GTEx	Brain Cortex	VPS11	0.40	0.13	enet	16	0.10	9.1e-04	-4.1	-5.2	2.3e-07	-0.86	0.02	0.95	FALSE
11	GTEx	Brain Cortex	HMBS	0.22	0.12	lasso	1	0.11	6.5e-04	5.9	5.9	4.6e-09	0.97	0.02	0.88	FALSE
12	GTEx	Brain Hippocampus	VPS11	0.37	0.13	lasso	4	0.11	1.4e-03	6.1	-6.2	5.6e-10	-0.98	0.02	0.87	FALSE
13	GTEx	Brain Hypothalamus	HMBS	0.22	0.15	enet	12	0.14	4.2e-04	5.9	5.8	4.9e-09	0.85	0.02	0.91	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	VPS11	0.37	0.19	lasso	8	0.30	9.4e-09	6.1	-6.0	2.4e-09	-0.79	0.01	0.96	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	HMBS	0.34	0.14	enet	12	0.20	5.6e-06	6.1	6.2	5.4e-10	0.89	0.02	0.96	FALSE
16	GTEx	Breast Mammary Tissue	HMBS	0.20	0.08	lasso	8	0.08	6.0e-05	6.1	6.3	2.8e-10	0.96	0.02	0.98	FALSE
17	GTEx	Breast Mammary Tissue (Male)	HMBS	0.27	-0.01	enet	13	-0.01	5.7e-01	5.4	5.2	1.5e-07	0.63	0.03	0.31	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	HMBS	0.26	0.13	lasso	5	0.10	3.8e-04	6.3	6.4	1.8e-10	0.97	0.01	0.98	FALSE
19	GTEx	Cells Transformed fibroblasts	SLC37A4	0.09	0.02	enet	9	0.02	7.5e-03	6.2	6.0	1.7e-09	0.89	0.02	0.96	FALSE
20	GTEx	Cells Transformed fibroblasts	HMBS	0.31	0.25	lasso	7	0.25	1.0e-18	6.2	6.4	1.9e-10	0.95	0.01	0.99	FALSE
21	GTEx	Colon Transverse	HMBS	0.33	0.24	enet	21	0.25	1.9e-12	6.3	6.5	1.2e-10	0.97	0.01	0.99	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	HMBS	0.20	0.05	enet	42	0.15	5.5e-06	5.9	5.9	3.4e-09	0.69	0.02	0.92	FALSE
23	GTEx	Esophagus Mucosa	HMBS	0.26	0.18	lasso	5	0.18	3.9e-12	6.1	6.3	3.5e-10	0.97	0.02	0.98	FALSE
24	GTEx	Esophagus Muscularis	HMBS	0.30	0.27	enet	19	0.30	1.2e-18	6.2	6.2	7.2e-10	0.96	0.01	0.99	FALSE
25	GTEx	Heart Atrial Appendage	HMBS	0.17	0.08	lasso	9	0.03	2.5e-02	6.1	6.6	4.9e-11	0.91	0.01	0.98	FALSE
26	GTEx	Lung	HMBS	0.18	0.14	lasso	3	0.14	1.6e-10	6.1	6.2	5.7e-10	0.97	0.01	0.99	FALSE
27	GTEx	Muscle Skeletal	VPS11	0.35	0.35	lasso	5	0.38	6.4e-40	6.3	6.2	4.0e-10	0.94	0.01	0.99	FALSE
28	GTEx	Muscle Skeletal	HMBS	0.12	0.12	lasso	3	0.12	3.7e-12	6.2	6.2	6.9e-10	0.97	0.01	0.99	FALSE
29	GTEx	Muscle Skeletal	RP11-110I1.14	0.24	0.12	lasso	9	0.15	2.4e-14	6.1	-5.5	2.9e-08	-0.95	0.02	0.98	FALSE
30	GTEx	Nerve Tibial	HMBS	0.10	0.05	lasso	4	0.03	4.6e-03	6.2	6.8	1.1e-11	0.94	0.01	0.99	FALSE
31	GTEx	Pancreas	HMBS	0.25	0.21	enet	10	0.20	6.9e-09	6.2	6.6	4.3e-11	0.94	0.01	0.99	FALSE
32	GTEx	Pancreas	RP11-110I1.14	0.23	0.00	enet	15	0.03	2.5e-02	6.3	-6.5	1.1e-10	-0.91	0.01	0.92	FALSE
33	GTEx	Pituitary	VPS11	0.23	0.16	lasso	3	0.20	9.2e-06	6.3	-5.5	3.8e-08	-0.91	0.02	0.95	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	HMBS	0.24	0.18	lasso	6	0.18	4.5e-10	6.2	6.3	2.8e-10	0.96	0.01	0.99	FALSE
35	GTEx	Skin Sun Exposed Lower leg	HMBS	0.16	0.12	enet	22	0.12	2.1e-10	6.2	6.4	1.6e-10	0.84	0.01	0.99	FALSE
36	GTEx	Small Intestine Terminal Ileum	HMBS	0.49	0.27	enet	17	0.18	9.0e-05	6.3	6.4	1.5e-10	0.98	0.01	0.98	FALSE
37	GTEx	Stomach	HMBS	0.26	-0.01	enet	10	0.00	2.0e-01	2.0	6.2	5.0e-10	0.53	0.03	0.73	FALSE
38	GTEx	Thyroid	VPS11	0.19	0.12	lasso	6	0.09	1.7e-07	5.9	-6.0	2.6e-09	-0.97	0.02	0.98	FALSE
39	GTEx	Thyroid	HMBS	0.22	0.20	enet	10	0.22	2.2e-16	6.2	6.5	8.6e-11	0.97	0.01	0.99	FALSE
40	GTEx	Thyroid	RP11-110I1.14	0.16	0.13	lasso	3	0.12	9.0e-10	5.9	-6.0	2.4e-09	-0.98	0.02	0.98	FALSE
41	GTEx	Uterus	VPS11	0.20	0.18	enet	13	0.15	5.8e-04	6.1	-5.8	5.9e-09	-0.81	0.02	0.88	FALSE
42	GTEx	Vagina	HMBS	0.23	0.14	lasso	4	0.12	1.1e-03	6.1	6.0	1.8e-09	0.96	0.02	0.90	FALSE
43	METSIM	Adipose	HMBS	0.12	0.07	lasso	8	0.07	3.0e-10	6.1	6.2	5.6e-10	0.97	0.02	0.98	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	VPS11	0.25	0.17	lasso	5	0.18	5.0e-23	6.3	-5.9	4.5e-09	-0.95	0.00	1.00	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	HMBS	0.33	0.22	bslmm	259	0.24	5.1e-30	6.2	6.6	5.1e-11	0.94	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	HMBS	0.11	0.10	enet	4	0.09	1.3e-18	6.1	6.2	7.0e-10	0.96	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HMBS	0.17	0.06	blup	38	0.06	8.7e-04	6.2	5.6	2.3e-08	0.85	0.00	0.93	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	HMBS	0.28	0.14	lasso	2	0.13	8.6e-08	6.1	6.2	6.4e-10	0.97	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	SLC37A4	0.14	0.02	blup	11	0.04	3.0e-02	-3.0	5.1	2.7e-07	0.65	0.00	0.34	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HMBS	0.12	0.09	enet	5	0.10	5.2e-11	6.2	6.4	1.4e-10	0.96	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HMBS	0.15	0.13	blup	39	0.14	5.7e-16	6.3	6.1	1.1e-09	0.95	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HMBS	0.24	0.12	blup	38	0.13	4.5e-08	6.1	6.4	1.2e-10	0.83	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMBS	0.13	0.04	lasso	2	0.04	9.0e-06	6.1	6.3	2.4e-10	0.92	0.00	0.99	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS11	0.22	0.18	enet	7	0.21	1.2e-23	6.1	-5.7	1.5e-08	-0.92	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HMBS	0.17	0.08	blup	39	0.08	1.2e-04	6.2	5.4	6.5e-08	0.90	0.00	0.99	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	HMBS	0.25	0.20	lasso	5	0.19	7.3e-22	6.2	6.2	4.3e-10	0.95	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HMBS	0.05	0.03	lasso	8	0.02	2.1e-03	6.2	6.3	3.8e-10	0.95	0.00	0.93	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMBS	0.13	0.07	blup	38	0.07	2.4e-05	6.2	6.0	2.2e-09	0.94	0.00	0.99	FALSE
59	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HMBS	0.36	0.16	lasso	3	0.15	5.4e-07	6.2	6.4	1.3e-10	0.91	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HMBS	0.16	0.08	blup	38	0.10	1.1e-04	6.3	6.1	1.2e-09	0.85	0.00	0.98	FALSE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	VPS11	0.24	0.15	lasso	4	0.18	1.4e-07	6.2	-5.7	1.3e-08	-0.89	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	HMBS	0.30	0.18	blup	38	0.18	1.0e-18	6.1	5.9	4.4e-09	0.89	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	HMBS	0.13	0.08	lasso	2	0.08	1.5e-06	6.2	6.3	3.3e-10	0.93	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	HMBS	0.17	0.16	lasso	2	0.16	1.1e-15	6.1	6.2	4.5e-10	0.97	0.00	1.00	FALSE