Best TWAS P=1.53e-135 · Best GWAS P=0 conditioned to 0
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC728084 | 0.10 | 0.04 | enet | 31 | 0.06 | 5.7e-08 | -2.5 | 8.2 | 2.3e-16 | 0.11 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | POC1B | 0.12 | 0.08 | lasso | 9 | 0.09 | 1.7e-07 | -10.1 | 11.1 | 9.8e-29 | 0.12 | 0.98 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | CEP290 | 0.12 | 0.01 | enet | 4 | 0.04 | 2.1e-04 | -2.3 | -12.8 | 9.8e-38 | -0.10 | 0.62 | 0.01 | TRUE |
| 4 | GTEx | Adrenal Gland | KITLG | 0.27 | -0.01 | enet | 22 | 0.06 | 2.7e-03 | -15.1 | -24.8 | 1.5e-135 | -0.03 | 0.04 | 0.09 | TRUE |
| 5 | GTEx | Adrenal Gland | RP11-981P6.1 | 0.33 | 0.29 | lasso | 3 | 0.19 | 2.2e-07 | -10.1 | -13.7 | 6.4e-43 | -0.12 | 0.99 | 0.00 | FALSE |
| 6 | GTEx | Artery Aorta | POC1B | 0.12 | 0.07 | lasso | 5 | 0.04 | 3.9e-03 | -10.1 | 6.9 | 4.0e-12 | 0.09 | 0.25 | 0.04 | FALSE |
| 7 | GTEx | Artery Tibial | ATP2B1 | 0.08 | 0.01 | enet | 10 | 0.03 | 3.5e-03 | -7.0 | -11.8 | 4.6e-32 | -0.09 | 0.26 | 0.03 | TRUE |
| 8 | GTEx | Artery Tibial | POC1B | 0.13 | 0.06 | enet | 29 | 0.06 | 1.7e-05 | -9.8 | 14.3 | 3.1e-46 | 0.22 | 0.69 | 0.02 | TRUE |
| 9 | GTEx | Artery Tibial | CEP290 | 0.16 | 0.06 | lasso | 6 | 0.07 | 7.7e-06 | -15.3 | -9.0 | 2.8e-19 | -0.04 | 0.91 | 0.00 | TRUE |
| 10 | GTEx | Artery Tibial | RP11-981P6.1 | 0.07 | 0.06 | lasso | 1 | 0.03 | 1.3e-03 | -9.9 | -9.9 | 4.8e-23 | -0.10 | 0.61 | 0.01 | FALSE |
| 11 | GTEx | Brain Cerebellum | RP11-981P6.1 | 0.47 | 0.27 | enet | 41 | 0.21 | 7.1e-07 | -3.3 | -5.5 | 3.5e-08 | 0.00 | 0.88 | 0.01 | FALSE |
| 12 | GTEx | Colon Sigmoid | RP11-981P6.1 | 0.19 | 0.12 | lasso | 4 | 0.11 | 9.7e-05 | -10.1 | -8.5 | 1.5e-17 | -0.08 | 0.33 | 0.03 | TRUE |
| 13 | GTEx | Colon Transverse | RP11-981P6.1 | 0.14 | 0.05 | enet | 26 | 0.05 | 1.9e-03 | -10.1 | -8.7 | 2.6e-18 | -0.13 | 0.38 | 0.09 | FALSE |
| 14 | GTEx | Esophagus Muscularis | RP11-981P6.1 | 0.18 | 0.10 | lasso | 3 | 0.06 | 2.9e-04 | -10.1 | -9.6 | 1.1e-21 | -0.10 | 0.92 | 0.00 | FALSE |
| 15 | GTEx | Heart Left Ventricle | C12orf29 | 0.19 | 0.10 | enet | 10 | 0.11 | 1.9e-06 | -13.6 | -12.6 | 3.8e-36 | -0.11 | 0.99 | 0.00 | TRUE |
| 16 | GTEx | Lung | RP11-981P6.1 | 0.08 | 0.01 | lasso | 3 | 0.01 | 3.9e-02 | -10.1 | -7.4 | 1.7e-13 | -0.06 | 0.33 | 0.04 | FALSE |
| 17 | GTEx | Muscle Skeletal | C12orf29 | 0.24 | 0.09 | enet | 48 | 0.18 | 4.2e-17 | -12.8 | -8.9 | 4.1e-19 | -0.06 | 1.00 | 0.00 | TRUE |
| 18 | GTEx | Nerve Tibial | POC1B | 0.30 | 0.18 | lasso | 6 | 0.22 | 1.0e-15 | 13.6 | 14.7 | 6.9e-49 | 0.11 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Prostate | POC1B | 0.25 | 0.00 | enet | 37 | 0.01 | 1.6e-01 | -4.1 | 12.5 | 7.2e-36 | 0.22 | 0.05 | 0.18 | FALSE |
| 20 | GTEx | Skin Sun Exposed Lower leg | TMTC3 | 0.13 | 0.04 | lasso | 4 | 0.09 | 7.9e-08 | -16.5 | 14.1 | 4.0e-45 | 0.03 | 0.99 | 0.00 | TRUE |
| 21 | GTEx | Spleen | RP11-981P6.1 | 0.28 | 0.18 | lasso | 13 | 0.14 | 2.1e-04 | -9.9 | -10.1 | 6.9e-24 | -0.10 | 0.42 | 0.04 | FALSE |
| 22 | GTEx | Testis | C12orf29 | 0.19 | 0.00 | enet | 24 | 0.00 | 2.4e-01 | 19.2 | 6.8 | 8.5e-12 | 0.21 | 0.05 | 0.04 | TRUE |
| 23 | GTEx | Thyroid | RP11-981P6.1 | 0.24 | 0.25 | lasso | 5 | 0.26 | 3.9e-20 | -10.1 | -10.1 | 5.6e-24 | -0.10 | 1.00 | 0.00 | FALSE |
| 24 | METSIM | Adipose | POC1B | 0.07 | 0.03 | bslmm | 381 | 0.03 | 5.2e-05 | -10.1 | 17.4 | 1.2e-67 | 0.17 | 0.91 | 0.02 | TRUE |
| 25 | YFS | Blood | DUSP6 | 0.08 | 0.07 | lasso | 4 | 0.07 | 2.6e-22 | -8.7 | -9.0 | 2.6e-19 | -0.17 | 1.00 | 0.00 | TRUE |
| 26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GALNT4 | 0.05 | 0.05 | lasso | 2 | 0.04 | 8.7e-06 | 13.5 | 13.4 | 1.2e-40 | 0.09 | 0.00 | 1.00 | FALSE |