TWAS hub - C12orf29

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.189	0.0586	1.7e-04	0.103	NA	0.110	NA	0.108	4.0e-06	NA	1.9e-06	NA	2.4e-06
2	GTEx	Muscle Skeletal	0.236	0.0512	8.1e-12	0.095	NA	0.177	NA	0.154	1.5e-09	NA	4.2e-17	NA	6.4e-15
3	GTEx	Testis	0.188	0.0620	1.0e-03	-0.001	NA	0.003	NA	-0.002	3.7e-01	NA	2.4e-01	NA	4.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Atorvastatin	6.2	7.7	12.6	-3.5	-3.2	0.3
Supplements: Vitamin C	5.0	5.9	10.9	-3.3	-2.3	1.1
Schizophrenia (2018)	4.7	9.7	17.1	-3.5	-4.1	-0.3
Blood White Count	4.0	29.3	54.2	4.4	3.8	7.4
Eye problems/disorders: Diabetes related eye disease	3.6	4.0	6.7	-2.6	-2.0	1.1
Type 2 Diabetes (T2D) (2012)	3.4	4.0	6.3	-2.3	-2.5	0.5
Hair Pigment	3.3	95.1	158.8	-12.6	-8.9	6.8
Vitamin and mineral supplements	3.1	4.2	7.7	2.8	2.2	-0.2
Multivitamins +/- minerals	2.9	3.7	5.6	-2.4	-2.3	0.6
Diabetes (self-reported)	2.8	4.4	7.2	-2.3	-2.7	0.8
Average weekly spirits intake	2.7	3.4	5.9	2.4	1.9	-0.7
Pulse wave reflection index	2.7	3.3	5.0	2.2	1.6	1.6
Schizophrenia vs Biploar Disorder	2.6	3.5	5.3	-2.2	-2.3	0.4
Birth weight of first child	2.6	4.7	6.4	2.4	2.5	-1.4
Bipolar Disorder or Schizophrenia	2.3	5.5	9.8	-2.5	-3.1	-0.7
Body Mass Index (BMI) (2010)	2.3	3.1	4.7	2.2	2.1	-0.4
Mean Putamen Volume	2.3	2.6	3.6	-1.7	-1.9	1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	4.6	2.2	1.2	-1.1
Osteoarthritis (self-reported)	2.3	2.9	4.4	2.1	1.9	-0.9
Triglycerides	2.2	3.7	4.6	-2.1	-2.1	1.5
Blood Red Count	2.2	21.6	49.2	3.1	2.5	7.0
Number of live births	2.1	2.9	5.0	2.2	1.9	0.3
Shortness of breath walking on level ground	2.1	2.5	4.5	-1.7	-2.1	-0.5
Mineral and other dietary supplements	2.1	2.8	3.7	1.9	1.9	-1.1
Commuting to job workplace: Cycle	2.1	2.6	3.8	-1.9	-1.8	0.9
Schizophrenia (2014)	2.0	4.5	8.4	-2.2	-2.9	0.5
Supplements: Zinc	2.0	2.2	3.2	-1.8	-1.3	1.3
HbA1C	1.9	2.1	2.4	-1.6	-1.3	1.5
Maternal smoking around birth	1.9	2.7	4.1	-2.0	-2.0	-0.5
Exposure to tobacco smoke at home	1.9	2.2	3.0	1.2	1.4	1.7
Diabetes diagnosed by doctor	1.9	3.1	4.9	-2.0	-2.2	0.7
Illnesses of father: None of the above (group 1)	1.9	2.4	5.1	-1.2	-0.8	-2.3
Ever highly irritable/argumentative for 2 days	1.8	2.2	2.9	-1.5	-1.7	1.2
Medication: Aspirin	1.8	2.4	6.0	0.9	0.6	2.4
Depression (Nagel 2018)	1.7	2.5	3.1	-1.8	-1.8	-1.2
Taking other prescription medications	1.6	2.4	3.3	-1.8	-1.5	1.3
Breast cancer (self-reported)	1.6	1.9	3.6	1.9	1.3	-0.5
Angina	1.5	2.0	3.6	-1.9	-1.6	0.2
Stomach or abdominal pain in last month	1.5	1.8	2.8	-1.7	-1.7	0.2
Hair/balding pattern: Pattern 2	1.5	1.9	3.4	-1.8	-1.5	0.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	2.8	-1.5	-1.7	-0.1
Medication: Aspirin	1.4	1.8	5.2	0.3	0.2	2.3
Number of self-reported non-cancer illnesses	1.4	2.4	4.0	-1.5	-1.0	2.0
Type 2 Diabetes (T2D) (2018)	1.3	2.3	3.8	-1.7	-2.0	0.6
Medication: Metformin	1.3	1.9	3.1	-1.1	-1.8	-1.1
Townsend deprivation index at recruitment	1.3	1.8	5.3	-0.2	0.3	2.3
Lung cancer (father)	1.3	1.5	4.0	-0.2	-0.6	-2.0
Ever depressed for a whole week	1.3	1.6	2.9	-1.1	-0.8	1.7
Alcohol usually taken with meals	1.2	1.9	2.5	0.9	1.5	1.6
Medication: Simvastatin	1.2	1.8	2.4	1.3	1.5	1.2
Medication: Lansoprazole	1.2	1.4	3.8	-0.5	-0.0	2.0
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.3	1.5	1.5	-0.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	1.8	1.3	1.3	-0.9
Angina (self-reported)	1.2	1.6	2.9	-1.7	-1.4	-0.0
Major Depression (MDD)	1.1	1.3	1.9	-1.0	-1.0	-1.4
Allergy	1.1	2.5	3.0	-1.6	-1.7	-1.5
Gout (self-reported)	1.1	1.4	2.1	-1.4	-1.2	-0.9
Neuroticism (2016)	1.0	1.4	3.9	0.4	0.3	-2.0
Sensitivity / hurt feelings	1.0	1.7	2.4	1.6	1.3	0.9
Hayfever, allergic rhinitis or eczema	1.0	2.3	3.9	2.0	1.5	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.7	-0.9	-1.0	1.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	1.8	1.0	1.3	1.0
Pulse wave peak to peak time	1.0	1.1	1.6	-1.1	-0.7	-1.3
Emphysema/chronic bronchitis	1.0	1.1	1.3	1.0	1.1	1.0
Medication: Allopurinol	1.0	1.3	2.0	-1.1	-0.8	-1.4
Mean time to correctly identify matches	1.0	2.0	4.8	0.2	1.0	2.2
Overall health rating	1.0	2.1	3.0	-1.7	-0.9	1.6
Average weekly red wine intake	1.0	1.5	3.7	-1.9	-0.8	0.5
Medication: Gliclazide	1.0	1.1	2.5	-0.9	-1.6	0.1
Financial situation satisfaction	1.0	1.2	2.0	-1.4	-1.3	-0.1
Risk taking	1.0	1.5	2.7	-1.3	-1.7	-0.4
Cholesterol lowering medication	1.0	1.5	2.6	-0.8	-1.1	1.6
Diabetes (father)	0.9	1.1	1.8	1.4	0.9	0.7
Serious illness, injury or assault to yourself	0.9	1.1	1.9	-1.2	-1.4	-0.1
Mouth/teeth dental problems	0.9	1.4	2.8	-1.1	-1.7	-0.3
Mouth/teeth dental problems: Dentures	0.9	1.6	2.7	1.0	1.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.4	1.2	0.9	-1.1
Pulse wave Arterial Stiffness index	0.9	1.1	1.3	1.2	0.8	1.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.4	0.8	1.0	-1.2
Exposure to tobacco smoke outside home	0.9	1.2	1.6	-0.8	-1.2	1.3
Medication: Omeprazole	0.9	1.0	1.3	-1.2	-0.8	1.1
Chest pain or discomfort	0.9	1.3	3.7	-0.3	0.4	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.5	0.3	0.7	1.6
Medication for cholesterol	0.9	1.4	1.9	1.0	1.4	-1.1
Miserableness	0.9	1.6	3.4	1.9	1.0	-0.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.2	-1.1	-1.1	0.9
Unable to work because of sickness or disability	0.9	1.2	1.8	1.3	1.2	0.6
Irritable Bowel Disease (IBD)	0.8	1.8	2.2	1.5	1.4	-1.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.9	-0.3	-1.4	-1.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.6	1.3	0.7	-0.9
Medication: Levothyroxine sodium	0.8	1.4	2.2	-1.5	-1.1	-1.0
Medication: Ramipril	0.8	1.0	1.5	0.9	0.9	1.2
Length of working week for main job	0.8	0.9	1.6	-1.3	-1.0	0.1
Eye problems/disorders: None of the above	0.8	1.0	1.7	1.3	1.0	-0.3
Medication: Seretide 50 evohaler	0.8	1.0	2.1	0.5	0.7	1.4
Heart disease (mother)	0.8	1.0	1.4	-1.1	-1.2	0.5
Wears glasses or contact lenses	0.8	1.0	1.2	-1.0	-1.1	0.9
Medication: Blood pressure	0.8	1.6	3.6	-0.7	-0.8	1.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	-0.8	-0.6	1.3
Alzheimer’s Disease (in mother)	0.7	0.9	2.5	0.1	-0.2	1.6
Primary Biliary Cirrhosis	0.7	1.0	1.5	0.7	0.9	1.2
Neuroticism	0.7	1.6	3.4	0.7	1.0	-1.8
Hand grip strength (right)	0.7	2.0	6.0	0.1	-0.0	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.2	1.5	0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.3	1.0	1.1	0.8
Time employed in main current job	0.7	0.8	2.3	-0.2	0.1	-1.5
Prospective memory result	0.7	0.8	1.1	1.0	0.6	-1.0
Illnesses of mother	0.7	0.9	1.9	-1.4	-0.2	0.9
Headache pain in last month	0.7	1.1	1.3	-1.1	-1.1	0.9
Had major operations	0.7	0.9	1.3	1.1	1.1	0.3
Knee pain experienced in last month	0.7	1.2	3.1	-0.6	0.0	-1.8
Mother’s age at death	0.7	0.9	1.5	1.2	0.9	0.7
Illnesses of father: High blood pressure	0.7	0.9	1.8	0.8	0.3	1.4
Average weekly beer plus cider intake	0.7	1.1	1.2	-1.1	-1.1	-0.9
Pain experienced in last month	0.7	1.1	1.8	1.3	1.3	0.2
Depressed Affect (Nagel 2018)	0.6	1.2	2.0	0.8	0.9	-1.4
Reaction Time	0.6	1.1	2.8	0.3	0.6	1.7
Lupus	0.6	0.9	2.6	-0.0	0.2	1.6
Lung FEV1/FVC ratio	0.6	3.1	8.8	-0.3	-0.7	-3.0
Hearing difficulty/problems: Yes	0.6	0.9	1.6	-1.0	-0.1	1.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	0.9	-0.9	-1.0	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	-1.0	-0.9	0.1
Number of incorrect matches in round	0.6	1.0	2.2	0.7	0.6	1.5
Had other major operations	0.6	0.7	1.5	-0.7	-1.2	0.5
Breastfed as a baby	0.6	0.7	1.9	-0.4	0.2	1.4
Glaucoma (self-reported)	0.6	0.6	0.8	-0.8	-0.9	-0.7
High blood pressure (siblings)	0.6	0.8	1.8	-0.3	-0.7	-1.3
Number of full brothers	0.6	0.8	1.2	1.1	1.1	0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.0	1.0	1.0	-0.6
Loneliness, isolation	0.6	0.8	1.0	1.0	0.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.4	1.2	1.2	-0.4
Osteoporosis (self-reported)	0.6	0.8	1.4	-1.2	-0.8	-0.6
Commuting to job workplace: Public transport	0.6	0.7	1.3	-1.1	-0.6	0.8
Fractured/broken bones in last 5 years	0.6	0.7	1.2	-1.1	-0.7	0.8
Pack years of smoking	0.6	0.8	2.1	0.5	0.5	1.4
Neuroticism (Nagel 2018)	0.5	1.2	2.3	0.6	1.0	-1.5
Crohns Disease (2017)	0.5	1.0	1.4	1.2	1.2	-0.5
Ulcerative Colitis (UC)	0.5	1.0	2.1	0.7	0.7	-1.4
Bipolar Disorder (2011)	0.5	0.4	0.7	-0.8	-0.8	0.2
Fasting Glucose	0.5	0.5	1.1	-1.1	-0.7	-0.1
Allergy or Eczema	0.5	1.4	2.1	1.3	0.8	1.4
Relative age of first facial hair	0.5	1.1	1.3	-0.9	-1.1	-1.2
Systolic blood pressure, automated reading	0.5	1.5	2.2	-1.5	-1.5	0.0
Severe depression (siblings)	0.5	0.6	0.8	-0.7	-0.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	-0.8	-1.2	-0.3
High blood pressure (mother)	0.5	0.7	1.9	0.6	-0.2	-1.4
Hearing difficulty/problems with background noise	0.5	0.8	1.8	0.7	1.4	0.3
Forced vital capacity (FVC)	0.5	1.9	2.3	1.5	1.3	1.2
Pain all over the body in last month	0.5	0.5	1.2	0.4	1.1	0.4
Happiness	0.5	0.6	1.7	-0.3	-0.0	-1.3
Peak expiratory flow (PEF)	0.5	1.2	1.7	1.1	0.8	-1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.9	-0.8	-1.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.0	0.2	0.3	1.4
Qualifications: College or University degree	0.5	1.6	2.4	-1.2	-1.5	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	2.5	-0.6	-0.1	-1.6
Medication: Ibuprofen	0.5	0.5	1.0	0.6	0.5	-1.0
Arm predicted mass (right)	0.5	2.7	4.7	1.5	1.1	-2.2
Suffer from ‘nerves’	0.5	0.8	1.4	-0.8	-1.2	0.6
Smoking status: Previous	0.5	0.7	1.2	0.4	1.1	0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	-1.0	-0.6	0.7
Average weekly champagne plus white wine intake	0.5	0.6	1.7	0.1	0.4	-1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	-0.3	-0.5	1.2
High cholesterol (Self-reported)	0.5	0.9	1.1	0.7	1.1	1.1
Supplements: Calcium	0.5	0.6	1.2	-1.1	-0.6	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	-0.4	-0.8	-0.9
Heart disease (siblings)	0.5	0.7	1.3	0.8	1.1	0.2
Crohns Disease (2012)	0.4	0.7	1.1	1.0	1.0	-0.3
LDL Cholesterol	0.4	0.7	1.7	-0.5	-0.5	1.3
Rheumatoid Arthritis	0.4	0.5	1.4	0.3	0.2	1.2
Respiratory disease	0.4	1.0	1.6	0.9	1.2	0.7
Lung FVC	0.4	2.2	6.5	0.3	0.3	2.5
Supplements: Glucosamine	0.4	0.6	0.7	-0.6	-0.9	-0.8
Sitting height	0.4	3.2	5.0	2.2	2.1	-0.4
Neuroticism score	0.4	0.9	1.1	1.0	0.8	-1.0
Trunk fat-free mass	0.4	2.1	3.5	1.5	0.7	-1.9
Father’s age at death	0.4	0.5	0.8	0.9	0.6	-0.5
Hair/balding pattern: Pattern 3	0.4	0.7	1.0	0.9	1.0	0.5
Trunk predicted mass	0.4	2.1	3.2	1.5	0.8	-1.8
Standing height	0.4	4.4	6.4	2.5	2.0	-1.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.5	-0.9	-0.6	-1.2
Arm fat-free mass (right)	0.4	2.2	4.7	1.2	0.7	-2.2
Wheeze or whistling in the chest in last year	0.4	0.8	1.3	-0.9	-1.1	0.5
Age at first live birth	0.4	0.7	0.9	-0.7	-0.9	-0.8
Health satisfaction	0.4	0.5	1.0	-0.5	-0.6	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.5	0.3	1.1
Illnesses of father: Heart disease	0.4	0.5	1.1	0.6	0.2	1.1
Mood swings	0.4	0.7	1.7	1.3	0.6	-0.1
Asthma (self-reported)	0.4	0.8	1.0	0.8	1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	-1.4	-0.6	0.0
Medication: Lisinopril	0.4	0.5	1.3	0.3	0.4	1.1
Leg fat percentage (left)	0.4	1.5	1.8	-1.4	-1.2	-1.0
Arm fat-free mass (left)	0.4	2.1	3.8	1.4	0.8	-1.9
Irritability	0.4	0.7	1.8	0.0	0.7	-1.3
Age started oral contraceptive pill	0.4	0.5	1.6	0.1	0.2	1.3
Arm predicted mass (left)	0.4	2.1	3.8	1.4	0.7	-2.0
Worry (Nagel 2018)	0.3	0.6	1.7	-0.2	0.2	-1.3
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.5	0.1	-0.9
Ulcerative Colitis	0.3	0.4	1.1	0.0	-0.4	-1.1
Blood Eosinophil Count	0.3	2.2	6.5	0.4	0.2	2.5
Cardiovascular Disease	0.3	1.1	3.0	-0.5	-0.2	1.7
Tanning	0.3	4.2	7.3	-1.7	-1.5	-2.7
Number of treatments/medications taken	0.3	0.5	0.8	-0.6	-0.5	0.9
Medication: Co-codamol	0.3	0.3	0.3	0.5	0.6	0.5
Pack years adult smoking proportion	0.3	0.5	1.3	0.4	0.2	1.1
Age when periods started (menarche)	0.3	0.7	1.3	-1.2	-0.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	-0.1	-0.8	1.2
Past tobacco smoking	0.3	0.6	1.0	-0.1	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.0	0.2	-0.4	1.4
Worrier / anxious feelings	0.3	0.6	1.6	-0.5	-0.3	-1.3
Falls in the last year	0.3	0.5	0.6	-0.8	-0.7	-0.6
Asthma	0.3	0.6	0.8	0.7	0.9	0.7
Birth weight	0.3	0.6	1.4	-0.5	-1.2	-0.4
Body fat percentage	0.3	1.1	1.8	-0.9	-0.8	-1.3
Leg pain on walking	0.3	0.3	0.5	-0.6	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	-0.5	-0.9	-0.0
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.5	-0.9	0.2
Whole body fat-free mass	0.3	1.7	2.8	1.4	0.7	-1.7
Arm fat percentage (left)	0.3	1.3	1.3	-1.1	-1.1	-1.2
Friendships satisfaction	0.3	0.4	0.5	0.7	0.4	-0.7
Whole body water mass	0.3	1.9	3.3	1.4	0.6	-1.8
Arm fat mass (left)	0.3	1.1	1.9	-0.7	-0.9	-1.4
Guilty feelings	0.3	0.4	0.6	-0.1	-0.7	-0.8
Hearing aid user	0.3	0.3	0.7	0.4	0.9	0.3
Alcohol drinker status: Never	0.3	0.4	0.7	-0.3	-0.7	0.8
Ever smoked	0.3	0.5	0.8	0.0	0.9	0.8
Basal metabolic rate	0.3	1.6	3.3	1.1	0.4	-1.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.5	-0.5	0.8
Alcohol drinker status: Previous	0.3	0.4	0.6	-0.8	-0.6	-0.2
Leg fat mass (left)	0.3	1.0	1.9	-0.8	-0.8	-1.4
Bipolar Disorder (2018)	0.2	0.3	0.8	0.4	0.3	-0.9
Age at First Birth	0.2	0.3	0.6	0.3	0.3	-0.8
HDL Cholesterol	0.2	0.4	1.1	0.1	0.1	-1.1
Systolic Blood Pressure	0.2	1.2	2.5	-1.1	-1.6	0.0
Smoking Status	0.2	0.4	1.0	0.2	0.0	1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.2	-0.4	0.7
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.5	-0.5	-0.4
Diabetes (mother)	0.2	0.3	0.5	0.1	-0.5	-0.7
Leg fat-free mass (left)	0.2	0.8	1.7	0.9	0.2	-1.3
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	0.5	-0.1
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.2	0.0	-0.8
Body mass index (BMI)	0.2	1.0	1.2	-0.8	-1.1	-1.1
Leg predicted mass (left)	0.2	0.9	1.6	1.0	0.3	-1.3
Trunk fat mass	0.2	0.8	2.2	-0.3	-0.3	-1.5
Waist circumference	0.2	0.7	1.5	-0.4	-0.6	-1.2
Nervous feelings	0.2	0.3	0.7	0.5	0.8	0.3
Had menopause	0.2	0.2	0.4	-0.0	0.7	0.5
Qualifications: None of the above	0.2	0.3	0.5	-0.6	-0.4	-0.7
Financial difficulties in last 2 years	0.2	0.2	0.6	0.1	0.2	0.8
Heart attack	0.2	0.2	0.5	-0.3	-0.3	0.7
Illnesses of siblings	0.2	0.3	0.9	-0.2	0.2	0.9
Weight	0.2	1.1	3.2	0.3	-0.2	-1.8
Arm fat percentage (right)	0.2	0.9	1.0	-0.9	-1.0	-0.9
Hip circumference	0.2	0.8	1.9	-0.3	-0.6	-1.4
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.8	0.6	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.4	1.2	0.8	0.4
Pulse rate	0.2	0.3	0.5	-0.3	0.4	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.6	0.6	0.1	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.1	-0.7	0.2
Medication: Cholesterol lowering	0.2	0.2	0.5	0.3	0.7	0.3
Arm fat mass (right)	0.2	1.0	1.2	-0.8	-1.1	-1.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.4	-0.5	-0.4	-1.2
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.2	0.7	-0.5
Leg fat percentage (right)	0.2	0.9	1.3	-0.9	-0.8	-1.1
Worry too long after embarrassment	0.2	0.3	0.8	0.2	-0.0	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.6	-0.4	0.2
Migraine (self-reported)	0.2	0.2	0.6	0.8	0.1	0.3
Whole body fat mass	0.2	0.7	1.6	-0.5	-0.5	-1.3
Leg fat mass (right)	0.2	0.8	1.8	-0.6	-0.6	-1.4
Alcohol intake frequency.	0.2	0.6	1.4	0.0	-0.5	1.2
Family relationship satisfaction	0.2	0.3	0.8	-0.0	0.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	0.3	-0.2	-1.1
Leg fat-free mass (right)	0.2	0.8	1.7	0.8	0.2	-1.3
Long-standing illness, disability or infirmity	0.2	0.4	0.9	0.2	0.4	1.0
Commuting to job workplace: Walk	0.2	0.3	0.4	-0.7	-0.5	0.4
Eye problems/disorders: Cataract	0.2	0.3	0.7	-0.4	-0.8	-0.2
Ever taken oral contraceptive pill	0.2	0.3	0.6	0.2	0.4	0.8
Medication: Bendroflumethiazide	0.2	0.4	0.7	0.8	0.6	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.2	0.4	0.4	-0.4
Diastolic blood pressure, automated reading	0.2	0.7	1.1	-1.0	-1.0	-0.2
Myopia	0.2	0.2	0.6	-0.1	-0.8	0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.7	0.2	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	0.2	-0.6	-0.1
Ovarian Cancer	0.1	0.2	0.3	0.5	0.0	-0.5
Height	0.1	2.7	4.8	2.2	1.8	0.2
Waist Hip Ratio (WHR)	0.1	0.3	0.8	-0.2	-0.2	0.9
Hypothyroidism (self reported)	0.1	0.2	0.4	-0.6	-0.4	-0.3
Chronotype (morning person)	0.1	0.3	0.6	-0.8	-0.4	-0.4
Hand grip strength (left)	0.1	0.4	0.5	-0.7	-0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	-0.1	-0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.2	0.5	-0.3
Impedance of leg (right)	0.1	0.5	1.1	0.6	1.0	0.1
Trunk fat percentage	0.1	0.6	1.3	-0.5	-0.4	-1.1
Current tobacco smoking	0.1	0.1	0.3	0.5	-0.1	-0.3
Fed-up feelings	0.1	0.2	0.4	0.5	0.3	-0.6
Relative age voice broke	0.1	0.2	0.3	-0.6	-0.2	-0.4
High blood pressure	0.1	0.3	0.5	-0.7	-0.6	0.3
Medication: Atenolol	0.1	0.1	0.2	0.4	-0.2	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.3	0.2	0.2
Fluid intelligence score	0.1	0.1	0.3	0.6	-0.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	0.5	0.2	-0.5
Depression (self-reported)	0.1	0.1	0.3	0.1	0.1	-0.5
Loud music exposure frequency	0.1	0.1	0.3	0.5	0.4	0.0
Medication: Paracetamol	0.1	0.1	0.3	-0.2	-0.2	0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	0.6	0.7	0.8	0.6
Comparative body size at age 10	0.1	0.4	1.1	-0.3	-0.2	-1.0
Number of children fathered	0.1	0.1	0.1	0.1	0.2	0.3
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.2	-0.3	0.4
Medication: Blood pressure	0.1	0.2	0.4	0.3	0.6	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.1	0.1	-0.7
Pulse rate, automated reading	0.1	0.5	0.9	0.3	0.9	-0.6
Comparative height size at age 10	0.1	0.4	1.1	1.0	0.5	-0.0
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	0.3	0.0
Smoking status: Current	0.1	0.1	0.2	0.4	-0.2	-0.2
Leg predicted mass (right)	0.1	0.8	1.5	0.9	0.2	-1.2
Medication: Paracetamol	0.1	0.2	0.3	-0.5	-0.2	0.5
Number of operations (self-reported)	0.1	0.1	0.3	0.0	0.5	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.6	0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.2	0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	0.6	0.2	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.2	0.0	-0.2
Blood Platelet Count	0.0	0.4	0.8	0.9	0.5	-0.1
Heel T-Score	0.0	0.2	0.3	0.4	0.5	-0.5
BMI	0.0	0.1	0.3	-0.5	-0.3	-0.0
Impedance of leg (left)	0.0	0.2	0.4	0.2	0.7	0.0
Impedance of arm (right)	0.0	0.1	0.3	0.0	0.4	0.5
Noisy workplace	0.0	0.0	0.1	-0.1	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.0	0.2	0.1	-0.2
Impedance of arm (left)	0.0	0.1	0.1	-0.3	0.3	0.3
Tense / ‘highly strung’	0.0	0.1	0.1	0.2	0.1	0.4
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	-0.2	0.1	-0.1
Medication: Amlodipine	0.0	0.0	0.1	-0.2	0.0	-0.3
Number of full sisters	0.0	0.1	0.1	0.3	-0.1	0.2
Age at last live birth	0.0	0.1	0.2	0.1	-0.0	-0.4
Hypertension (Self-reported)	0.0	0.1	0.1	-0.3	-0.3	0.3
Qualifications: nursing, teaching	0.0	0.0	0.1	0.3	0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.1	0.2	-0.1
Back pain experienced in last month	0.0	0.0	0.1	0.2	-0.0	0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.1	0.3	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.3	-0.1	-0.1
Impedance of whole body	0.0	0.2	0.5	0.2	0.7	0.3

Hub : Genes

C12orf29

Models

Trait associations