Best TWAS P=1.02e-118 · Best GWAS P=1.55e-129 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DCT | 0.17 | 0.15 | lasso | 6 | 0.15 | 1.1e-17 | 23.1 | 22.5 | 2.6e-112 | 0.87 | 1.00 | 0.00 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | GPR180 | 0.21 | 0.12 | lasso | 5 | 0.16 | 9.8e-12 | 5.2 | 5.8 | 8.3e-09 | 0.33 | 1.00 | 0.00 | FALSE |
3 | GTEx | Esophagus Mucosa | GPR180 | 0.48 | 0.34 | enet | 23 | 0.42 | 6.1e-30 | -3.6 | 6.0 | 2.0e-09 | 0.34 | 1.00 | 0.00 | TRUE |
4 | GTEx | Lung | GPR180 | 0.40 | 0.31 | enet | 64 | 0.33 | 2.6e-26 | -3.6 | 5.8 | 5.3e-09 | 0.37 | 1.00 | 0.00 | FALSE |
5 | METSIM | Adipose | DCT | 0.17 | 0.15 | enet | 43 | 0.17 | 3.2e-24 | 23.1 | 22.1 | 2.6e-108 | 0.81 | 0.04 | 0.96 | TRUE |
6 | YFS | Blood | GPR180 | 0.28 | 0.26 | lasso | 3 | 0.31 | 1.3e-102 | 7.4 | 5.9 | 4.0e-09 | 0.33 | 1.00 | 0.00 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPR180 | 0.14 | 0.06 | blup | 63 | 0.08 | 5.9e-16 | -3.6 | 6.1 | 1.1e-09 | 0.32 | 1.00 | 0.00 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | GPR180 | 0.11 | 0.07 | blup | 63 | 0.07 | 9.8e-05 | -3.6 | 5.5 | 3.4e-08 | 0.33 | 0.53 | 0.07 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GPR180 | 0.12 | 0.06 | blup | 63 | 0.06 | 5.3e-07 | -3.7 | 6.5 | 6.6e-11 | 0.26 | 0.99 | 0.00 | TRUE |
10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | GPR180 | 0.09 | 0.06 | enet | 7 | 0.07 | 5.0e-04 | 5.7 | 5.6 | 2.1e-08 | 0.27 | 0.07 | 0.04 | TRUE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | GPR180 | 0.13 | 0.03 | blup | 63 | 0.06 | 4.0e-07 | -3.9 | 10.6 | 3.8e-26 | 0.48 | 0.95 | 0.03 | TRUE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | TGDS | 0.04 | 0.02 | blup | 52 | 0.03 | 2.9e-04 | -3.6 | 5.8 | 5.9e-09 | 0.12 | 0.25 | 0.05 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | DCT | 0.08 | 0.07 | lasso | 3 | 0.06 | 1.4e-06 | 23.1 | 23.2 | 1.0e-118 | 0.88 | 0.05 | 0.95 | TRUE |