Best TWAS P=6.77e-12 · Best GWAS P=2.67e-12 conditioned to 0.118
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PCNX | 0.17 | 0.21 | lasso | 3 | 0.22 | 1.9e-17 | -4.5 | 5.5 | 4.8e-08 | -0.74 | 0.26 | 0.74 | FALSE |
2 | GTEx | Adipose Visceral Omentum | PCNX | 0.09 | 0.04 | lasso | 2 | 0.03 | 9.9e-03 | -6.8 | 6.8 | 8.2e-12 | -0.85 | 0.03 | 0.91 | FALSE |
3 | GTEx | Artery Aorta | PCNX | 0.26 | 0.32 | enet | 32 | 0.29 | 3.7e-16 | -4.5 | 5.5 | 4.4e-08 | -0.72 | 0.55 | 0.45 | FALSE |
4 | GTEx | Artery Tibial | PCNX | 0.21 | 0.32 | lasso | 5 | 0.31 | 6.7e-25 | -4.5 | 5.2 | 2.6e-07 | -0.75 | 0.91 | 0.09 | FALSE |
5 | GTEx | Brain Putamen basal ganglia | PCNX | 0.22 | 0.12 | lasso | 7 | 0.13 | 6.8e-04 | -6.8 | 6.3 | 2.1e-10 | -0.86 | 0.02 | 0.92 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | PCNX | 0.11 | 0.11 | lasso | 3 | 0.07 | 1.3e-02 | -6.5 | 6.4 | 1.6e-10 | -0.80 | 0.04 | 0.54 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | PCNX | 0.14 | 0.06 | enet | 28 | 0.10 | 1.2e-07 | -4.7 | 5.7 | 1.4e-08 | -0.65 | 0.09 | 0.91 | FALSE |
8 | GTEx | Esophagus Mucosa | PCNX | 0.20 | 0.18 | enet | 18 | 0.20 | 2.4e-13 | -6.5 | 6.4 | 1.8e-10 | -0.82 | 0.03 | 0.97 | FALSE |
9 | GTEx | Pituitary | PCNX | 0.39 | 0.35 | lasso | 3 | 0.34 | 2.6e-09 | -6.5 | 6.3 | 2.6e-10 | -0.88 | 0.02 | 0.98 | FALSE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | PCNX | 0.18 | 0.18 | lasso | 4 | 0.19 | 1.7e-10 | -4.5 | 5.9 | 3.2e-09 | -0.79 | 0.04 | 0.96 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | PCNX | 0.23 | 0.29 | enet | 30 | 0.29 | 2.1e-24 | -4.5 | 5.6 | 2.8e-08 | -0.73 | 0.82 | 0.18 | FALSE |
12 | GTEx | Testis | PCNX | 0.14 | 0.09 | enet | 12 | 0.07 | 3.2e-04 | -4.7 | 5.7 | 1.3e-08 | -0.77 | 0.04 | 0.94 | FALSE |
13 | GTEx | Thyroid | PCNX | 0.27 | 0.29 | enet | 36 | 0.27 | 4.8e-21 | -4.5 | 5.9 | 3.8e-09 | -0.74 | 0.92 | 0.08 | FALSE |
14 | METSIM | Adipose | PCNX | 0.13 | 0.11 | blup | 440 | 0.11 | 2.5e-16 | -4.8 | 5.4 | 8.3e-08 | -0.69 | 0.83 | 0.17 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCNX | 0.05 | 0.04 | blup | 92 | 0.04 | 4.2e-09 | -6.8 | 5.3 | 1.3e-07 | -0.70 | 0.02 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PCNX | 0.08 | 0.01 | blup | 91 | 0.02 | 6.2e-03 | -6.9 | 5.9 | 4.4e-09 | -0.87 | 0.02 | 0.94 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCNX | 0.03 | 0.02 | blup | 92 | 0.03 | 4.9e-04 | -6.9 | 6.7 | 1.8e-11 | -0.90 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PCNX | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.4e-04 | -6.5 | 6.9 | 6.8e-12 | -0.95 | 0.01 | 0.98 | TRUE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PCNX | 0.06 | 0.06 | blup | 91 | 0.07 | 7.1e-08 | -4.6 | 5.3 | 1.2e-07 | -0.66 | 0.13 | 0.87 | FALSE |
20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PCNX | 0.17 | 0.09 | blup | 92 | 0.11 | 1.5e-04 | -6.5 | 6.5 | 8.5e-11 | -0.81 | 0.01 | 0.87 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | PCNX | 0.08 | 0.06 | blup | 91 | 0.08 | 8.8e-08 | -6.9 | 5.9 | 3.1e-09 | -0.71 | 0.04 | 0.96 | FALSE |