Best TWAS P=4.37e-10 · Best GWAS P=8.56e-09 conditioned to 0.297
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Breast Mammary Tissue | DHX36 | 0.15 | 0.07 | enet | 14 | 0.05 | 9.4e-04 | 5.7 | 5.2 | 2.3e-07 | 0.91 | 0.03 | 0.97 | FALSE |
2 | GTEx | Colon Transverse | DHX36 | 0.13 | 0.12 | lasso | 2 | 0.11 | 4.7e-06 | 5.4 | 6.2 | 4.4e-10 | 0.83 | 0.04 | 0.96 | TRUE |
3 | GTEx | Esophagus Gastroesophageal Junction | DHX36 | 0.19 | 0.16 | lasso | 7 | 0.12 | 6.1e-05 | 5.6 | 5.7 | 9.3e-09 | 0.98 | 0.02 | 0.97 | FALSE |
4 | GTEx | Esophagus Muscularis | DHX36 | 0.14 | 0.15 | lasso | 2 | 0.13 | 2.2e-08 | 5.3 | 5.3 | 8.9e-08 | 0.87 | 0.05 | 0.95 | FALSE |
5 | GTEx | Nerve Tibial | DHX36 | 0.10 | 0.11 | lasso | 2 | 0.10 | 1.3e-07 | 5.3 | 5.3 | 9.1e-08 | 0.87 | 0.05 | 0.95 | FALSE |
6 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | 5.5 | 5.3 | 1.2e-07 | 0.75 | 0.04 | 0.95 | FALSE |
7 | METSIM | Adipose | DHX36 | 0.08 | 0.05 | blup | 358 | 0.05 | 3.5e-08 | 5.7 | 5.1 | 2.8e-07 | 0.87 | 0.02 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DHX36 | 0.07 | 0.07 | blup | 50 | 0.07 | 1.1e-13 | 5.3 | 5.1 | 3.1e-07 | 0.85 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DHX36 | 0.09 | 0.10 | lasso | 1 | 0.09 | 4.8e-06 | 5.4 | 5.4 | 8.4e-08 | 0.87 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SGEF | 0.04 | 0.03 | blup | 74 | 0.03 | 6.9e-04 | 3.7 | 5.4 | 7.1e-08 | 0.81 | 0.02 | 0.72 | FALSE |