Hub : Genes

SGEF

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Glioblastoma Multiforme 0.1750 0.0770 0.00055 0.131 0.138 0.120 NA 0.127 8.9e-05 5.5e-05 1.8e-04 NA 1.1e-04
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0388 0.0220 0.00011 0.040 0.040 0.043 NA 0.041 2.3e-05 2.1e-05 1.1e-05 NA 1.7e-05
3 TCGA Prostate Adenocarcinoma 0.0365 0.0199 0.00150 0.035 0.027 0.021 NA 0.023 1.4e-04 7.0e-04 2.8e-03 NA 1.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.1 1.7 4.0 0.4 -1.0 2.0
Bipolar Disorder or Schizophrenia 0.1 0.3 0.6 -0.3 0.5 0.7
Depressed Affect (Nagel 2018) 1.2 2.6 3.5 -1.7 1.9 -1.2
Depression (Nagel 2018) 0.3 0.5 1.1 -1.1 0.4 -0.2
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.7 -0.7 -0.8 0.5
Neuroticism (Nagel 2018) 0.6 1.3 2.0 -1.4 1.3 -0.5
Schizophrenia (2018) 0.5 1.0 2.0 -0.7 1.4 -0.7
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.1 -0.2 -0.2
Worry (Nagel 2018) 0.3 0.6 1.0 -0.4 1.0 -0.7
Alzheimer’s Disease (in mother) 0.2 0.2 0.6 0.0 0.8 0.4
Alzheimer’s Disease (in father) 0.2 0.2 0.5 -0.7 -0.0 0.2
Alzheimer’s Disease (including proxy) 0.2 0.3 0.4 -0.4 0.5 0.6
Crohns Disease (2017) 1.1 2.4 4.8 -1.4 2.2 -0.6
Irritable Bowel Disease (IBD) 0.8 1.8 2.9 -1.7 1.6 0.1
Ulcerative Colitis (UC) 0.5 0.9 1.7 -1.3 0.7 0.7
Major Depression (MDD) 0.1 0.1 0.1 0.4 0.1 0.3
Reaction Time 0.3 0.5 0.8 -0.8 0.9 0.2
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.9 -1.4 -0.2 -0.7
Breast Cancer 1.2 2.9 6.2 2.5 -1.2 1.1
Ovarian Cancer 0.8 1.0 2.7 0.6 -1.6 -0.1
Prostate Cancer 6.6 9.2 14.7 -3.8 1.8 -3.1
Age at First Birth 0.1 0.2 0.5 -0.2 0.1 0.7
Bipolar Disorder (2011) 0.2 0.2 0.6 -0.3 0.1 0.8
Body Mass Index (BMI) (2010) 1.6 2.3 3.7 -1.1 1.9 -1.4
Coronary Artery Disease (CAD) 7.9 9.4 14.7 -3.1 3.8 -2.0
Crohns Disease (2012) 0.3 0.5 0.7 -0.6 0.9 0.6
Mean Putamen Volume 1.3 1.5 2.0 -1.4 1.1 -1.1
Fasting Glucose 1.3 1.5 2.7 0.8 -1.1 1.6
HbA1C 0.1 0.1 0.1 0.0 0.3 -0.3
HDL Cholesterol 1.0 1.7 4.8 0.5 -0.2 2.2
LDL Cholesterol 0.6 1.0 2.0 -1.4 0.2 -0.9
Lupus 1.6 2.4 6.9 -0.6 -0.0 -2.6
Neuroticism (2016) 0.3 0.4 1.1 -0.4 -0.2 -1.1
Primary Biliary Cirrhosis 0.2 0.3 0.4 -0.6 -0.3 0.6
Rheumatoid Arthritis 3.2 4.4 6.7 2.6 -2.0 1.6
Schizophrenia (2014) 0.1 0.3 0.6 -0.3 0.8 0.3
Triglycerides 0.1 0.2 0.2 -0.5 -0.4 -0.4
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.0 -1.0 0.5 -0.9
Ulcerative Colitis 1.1 1.5 2.5 0.7 -1.3 1.6
Blood Eosinophil Count 0.5 3.7 5.6 -2.4 2.3 0.7
Blood Platelet Count 0.3 4.0 6.1 2.4 -2.5 0.5
Blood Red Count 0.1 0.9 2.0 0.4 -1.4 0.7
Blood White Count 0.1 0.6 1.4 -0.5 1.2 -0.4
Heel T-Score 1.1 9.0 18.1 -2.4 1.7 -4.2
BMI 5.0 29.3 58.2 -2.7 7.6 -4.7
Height 0.7 13.5 27.4 -2.7 5.2 -2.4
Waist Hip Ratio (WHR) 2.1 9.6 23.8 2.0 -4.9 1.1
Systolic Blood Pressure 6.2 31.3 40.4 5.5 -6.4 4.8
Smoking Status 1.3 3.2 8.4 0.5 1.0 -2.9
Allergy or Eczema 0.8 2.0 4.9 0.7 -0.8 2.2
Cardiovascular Disease 0.2 0.7 1.9 1.4 -0.3 -0.4
Hypothyroidism (self reported) 0.2 0.5 1.6 -0.1 -0.2 1.3
Respiratory disease 0.5 1.0 2.3 0.0 0.8 1.5
Type 2 Diabetes (T2D) (2018) 2.5 4.6 6.4 -2.3 1.6 -2.5
Lung FEV1/FVC ratio 6.7 33.9 42.1 -6.5 6.5 -4.2
Lung FVC 0.8 4.1 6.8 2.0 -1.2 2.6
Neuroticism 0.1 0.2 0.5 -0.7 0.5 -0.2
Chronotype (morning person) 0.7 1.6 4.6 -0.0 0.4 -2.1
Hair Pigment 0.7 20.9 29.1 4.8 -3.2 5.4
Tanning 0.9 10.9 13.8 -2.7 3.4 -3.7
Hand grip strength (left) 0.6 1.6 2.5 1.6 -1.2 0.8
Number of treatments/medications taken 0.6 1.0 2.2 0.1 0.9 -1.5
Average weekly spirits intake 0.8 1.0 1.5 -1.2 1.1 0.2
Sensitivity / hurt feelings 0.2 0.4 0.7 -0.7 0.8 0.2
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 -0.7 0.2 0.1
Hearing difficulty/problems: Yes 0.5 0.8 1.4 1.2 -1.0 -0.1
Relative age of first facial hair 0.7 1.5 2.5 0.1 -1.6 -1.4
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 5.3 0.3 2.3 -0.3
Ever used hormone-replacement therapy (HRT) 3.1 3.9 7.8 -1.6 1.1 -2.8
Ever had hysterectomy (womb removed) 0.6 0.6 1.4 -0.1 1.2 -0.7
Systolic blood pressure, automated reading 2.4 7.0 9.6 3.0 -3.1 1.6
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 4.1 -0.8 -0.1 -2.0
Angina 3.5 4.6 7.8 -1.3 2.1 -2.8
Medication for hormone replacement therapy 0.7 0.8 1.7 -1.3 -0.4 -0.6
Vitamin and mineral supplements 0.2 0.3 0.5 0.2 -0.7 0.5
Supplements: Zinc 0.3 0.3 0.4 0.7 0.4 0.6
Medication: Co-codamol 0.5 0.6 1.2 0.8 -1.1 0.3
Medication: Metformin 2.5 3.6 6.5 -1.7 1.2 -2.5
Diabetes (father) 0.1 0.1 0.2 0.4 0.2 0.3
Diabetes (mother) 1.7 2.2 3.4 -1.8 1.2 -1.3
Severe depression (siblings) 0.7 0.7 1.4 -0.4 0.8 -1.2
Pack years adult smoking proportion 0.1 0.1 0.4 -0.1 0.6 0.0
Impedance of leg (right) 0.7 3.5 10.2 -0.5 -3.2 0.3
Leg fat-free mass (left) 4.1 21.7 47.2 -2.0 6.9 -3.8
Trunk fat percentage 3.6 14.4 25.6 -2.1 5.1 -3.6
Hand grip strength (right) 0.4 1.0 1.9 1.4 -1.0 0.2
Townsend deprivation index at recruitment 0.5 0.7 1.2 0.2 0.9 -1.1
Current tobacco smoking 0.5 0.8 2.2 1.5 0.1 -0.3
Average weekly fortified wine intake 0.2 0.2 0.5 -0.2 -0.2 0.7
Maternal smoking around birth 0.4 0.5 1.0 -0.4 0.7 -1.0
Fed-up feelings 0.8 1.5 3.5 -0.9 1.9 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 0.2 -0.9 -0.2
Relative age voice broke 1.9 2.9 5.9 -1.5 -0.8 -2.4
Taking other prescription medications 1.0 1.5 3.0 -0.0 1.7 -1.2
Age when periods started (menarche) 0.2 0.5 0.7 0.9 -0.8 0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.2 1.0 1.1 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 7.5 -1.0 0.7 -2.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.1 -1.1 0.4 0.4
Qualifications: CSEs or equivalent 0.9 1.1 2.4 0.9 1.5 -0.5
Serious illness, injury or assault to yourself 0.0 0.0 0.1 0.2 0.3 -0.1
High blood pressure 0.3 0.9 2.2 1.5 -0.7 0.0
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.5 0.7 -0.9 1.9
Multivitamins +/- minerals 0.1 0.1 0.2 0.0 0.0 -0.5
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.5 0.1 -0.6
Supplements: Glucosamine 1.4 1.8 3.5 -0.7 1.2 -1.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.7 0.4 -0.8 -1.3
Medication: Atenolol 0.6 0.8 1.0 0.9 0.7 -1.0
Medication: Levothyroxine sodium 1.2 2.1 3.5 1.9 -0.9 1.4
Sitting height 0.5 3.6 9.2 -0.9 3.0 -1.0
Chronic bronchitis/emphysema (father) 0.4 0.5 1.3 0.1 1.1 -0.3
High blood pressure (mother) 0.0 0.0 0.1 -0.1 0.3 -0.1
Body mass index (BMI) 3.0 12.6 24.0 -1.1 4.9 -3.6
Impedance of leg (left) 1.2 5.9 16.6 -0.0 -4.1 1.1
Leg predicted mass (left) 4.0 21.1 46.0 -2.0 6.8 -3.7
Trunk fat mass 4.9 21.2 37.8 -2.5 6.2 -4.4
Waist circumference 3.2 11.8 22.2 -1.5 4.7 -3.3
Number of incorrect matches in round 0.8 1.4 3.2 0.8 1.8 0.4
Past tobacco smoking 0.9 1.7 4.8 -0.6 -0.1 2.2
Alcohol usually taken with meals 2.7 4.4 6.6 -2.6 1.9 -1.7
Nervous feelings 0.5 0.9 1.8 -1.3 0.7 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 -0.4 0.6 -0.1
Hearing difficulty/problems with background noise 2.9 4.6 8.5 1.8 -2.9 1.5
Hair/balding pattern: Pattern 2 3.9 4.9 10.1 -2.0 0.9 -3.2
Had menopause 0.2 0.2 0.5 0.7 -0.2 0.2
Had other major operations 0.1 0.1 0.2 0.3 -0.0 0.4
Forced vital capacity (FVC) 0.1 0.6 1.2 0.5 0.5 1.1
Heel bone mineral density (BMD) T-score, automated (right) 3.7 8.5 16.9 -2.1 2.1 -4.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.5 -0.3 0.6 -0.7
Qualifications: None of the above 0.3 0.6 1.4 0.5 -0.0 -1.2
Financial difficulties in last 2 years 1.5 2.0 3.3 -1.8 1.7 -0.1
Mouth/teeth dental problems 0.2 0.3 0.6 0.3 0.8 0.5
Heart attack 5.4 6.9 10.9 -0.9 3.3 -3.0
Allergy 0.3 0.7 2.1 -0.1 -0.4 -1.4
Pain all over the body in last month 1.0 1.0 2.0 1.0 1.4 -0.3
Diabetes (self-reported) 3.0 4.6 5.8 -1.9 2.2 -2.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.6 -0.1 0.8 0.3
Medication: Ramipril 1.4 1.8 2.9 -1.7 0.4 -1.6
Medication: Simvastatin 1.7 2.4 5.4 -0.6 1.2 -2.3
Fluid intelligence score 0.3 0.7 1.8 -1.4 0.0 -0.6
Illnesses of siblings 1.9 2.7 3.6 0.9 -1.9 1.9
Neuroticism score 0.5 1.1 2.0 -1.0 1.4 -0.5
Weight 4.6 22.8 44.6 -2.1 6.7 -4.4
Impedance of arm (right) 0.3 1.3 2.2 -0.2 -1.3 1.5
Arm fat percentage (right) 2.7 10.6 21.7 -1.1 4.7 -3.0
Trunk fat-free mass 2.2 12.7 25.1 -1.4 5.0 -3.3
Hip circumference 5.9 25.4 54.2 -2.7 7.4 -3.9
Time employed in main current job 3.9 4.5 7.8 1.9 -1.5 2.8
Alcohol intake versus 10 years previously 2.0 2.9 5.2 -1.3 1.4 -2.3
Father’s age at death 1.5 1.9 3.2 1.8 -0.4 1.6
Worrier / anxious feelings 1.0 1.9 3.2 -0.6 1.8 -1.4
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 1.3 0.3 0.9 -1.2
Falls in the last year 1.1 1.4 4.2 0.1 2.1 0.2
Hair/balding pattern: Pattern 3 6.3 9.4 17.2 3.1 -1.2 4.2
Number of live births 1.0 1.5 3.4 1.8 -1.0 0.2
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 4.0 -1.2 2.0 0.2
Pulse rate 0.4 0.7 1.5 0.5 -1.2 0.6
Happiness 0.2 0.2 0.4 -0.7 -0.4 0.1
Noisy workplace 2.8 3.5 7.0 -1.3 2.6 -1.4
Qualifications: A levels/AS levels or equivalent 2.5 5.5 9.1 1.1 -3.0 2.4
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 0.7 0.7 -0.8 0.8
Mouth/teeth dental problems: Dentures 1.0 1.7 2.0 1.4 -1.1 1.4
Asthma 0.3 0.7 1.4 -0.2 0.8 1.2
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.0 1.4 -1.1 1.0
Medication: Cholesterol lowering 2.1 3.3 7.5 -1.0 1.2 -2.7
Depression (self-reported) 1.4 1.7 3.4 0.0 1.9 -1.3
Medication: Lansoprazole 4.0 4.5 8.8 -0.9 2.0 -3.0
Prospective memory result 0.6 0.7 1.4 -0.1 1.2 -0.9
Lung cancer (father) 1.4 1.7 4.4 2.1 -0.5 -0.6
Illnesses of mother 1.4 1.8 4.5 0.7 -2.1 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 4.5 -1.3 2.1 0.5
Pulse wave Arterial Stiffness index 5.2 6.0 10.8 1.6 -3.3 2.2
Impedance of arm (left) 0.2 1.0 2.0 -0.4 -0.9 1.4
Arm fat mass (right) 4.2 17.4 34.9 -1.8 5.9 -3.8
Trunk predicted mass 2.2 12.7 25.4 -1.4 5.0 -3.3
Standing height 1.0 10.1 19.4 -2.4 4.4 -2.2
Length of working week for main job 1.5 1.7 2.3 -1.3 1.0 -1.5
Exposure to tobacco smoke at home 0.2 0.2 0.6 -0.0 0.1 0.7
Breastfed as a baby 1.4 1.7 2.2 1.5 -1.5 0.9
Tense / ‘highly strung’ 0.1 0.1 0.3 -0.1 -0.5 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 2.7 -1.5 1.7 -1.2
Hair/balding pattern: Pattern 4 1.5 3.7 7.0 1.0 -2.6 1.8
Birth weight of first child 0.0 0.1 0.1 -0.3 0.3 -0.0
Peak expiratory flow (PEF) 1.6 3.7 6.3 -2.2 2.5 -0.3
Pulse wave reflection index 2.2 2.7 3.3 1.3 -1.8 1.8
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.8 0.7 0.9 0.1
Loud music exposure frequency 1.1 1.2 1.9 1.4 0.2 1.3
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.0 1.1 -1.0 1.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 -1.4 -0.4 -0.5
Blood clot in the leg (DVT) 0.5 0.6 1.8 -0.1 0.3 -1.4
Medication: Paracetamol 1.5 2.5 4.0 1.9 0.2 2.0
Headache pain in last month 0.2 0.3 0.5 -0.4 -0.5 0.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.5 0.6 -0.3 1.6
Glaucoma (self-reported) 0.4 0.5 1.2 1.1 0.3 -0.5
Gout (self-reported) 3.0 4.1 4.5 -2.1 1.9 -2.0
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.5 0.6 -0.2 1.6
Medication: Amlodipine 0.1 0.1 0.4 0.6 -0.0 0.1
Medication: Ventolin 100micrograms inhaler 1.7 2.2 3.2 1.6 -1.0 1.8
Birth weight 0.2 0.4 0.8 0.9 -0.3 -0.6
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.5 -0.5 1.9 -0.1
High blood pressure (siblings) 0.3 0.5 1.1 1.1 -0.5 -0.2
Forced vital capacity (FVC), Best measure 0.2 0.7 1.3 0.1 0.9 1.1
Body fat percentage 3.4 13.6 22.8 -1.9 4.8 -3.8
Leg fat percentage (right) 2.7 9.8 14.7 -1.4 3.6 -3.8
Arm fat-free mass (right) 3.5 17.9 30.9 -2.2 5.6 -4.2
Exposure to tobacco smoke outside home 0.5 0.7 1.4 -0.0 1.2 -0.8
Comparative body size at age 10 0.7 1.8 3.4 0.4 1.9 -1.4
Number of full brothers 0.8 0.9 1.7 0.3 1.3 -1.0
Worry too long after embarrassment 0.2 0.3 0.6 -0.7 -0.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 4.4 -0.7 2.1 0.2
Wheeze or whistling in the chest in last year 0.2 0.3 0.7 0.3 0.8 -0.5
Number of children fathered 0.4 0.5 0.8 0.7 0.3 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 -0.3 0.6 0.1
Age at first live birth 0.9 1.6 2.9 0.5 -1.3 1.7
Pulse wave peak to peak time 6.0 7.0 12.4 -1.8 3.5 -2.4
Health satisfaction 0.4 0.5 1.4 -0.2 1.2 0.3
Shortness of breath walking on level ground 0.0 0.1 0.1 -0.1 0.4 -0.1
Qualifications: College or University degree 0.8 2.4 3.8 -0.8 -1.7 2.0
Eye problems/disorders: None of the above 0.6 0.7 1.5 -0.5 -0.5 1.2
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.5 -0.1 0.0 -0.7
Emphysema/chronic bronchitis 0.6 0.7 1.8 1.4 -0.4 0.2
Medication for pain relief, constipation, heartburn 0.5 0.9 2.5 -0.4 -1.6 0.3
Neck or shoulder pain in last month 1.0 1.4 2.3 0.1 1.5 -1.3
Medication: Blood pressure 0.2 0.4 0.9 -0.3 0.3 -0.9
Angina (self-reported) 3.6 4.7 7.9 -1.4 2.1 -2.8
Migraine (self-reported) 1.5 1.9 2.8 0.7 -1.5 1.7
Medication: Ibuprofen 1.0 1.2 1.5 1.0 -1.2 1.0
Medication: Allopurinol 3.4 4.5 5.4 -1.8 2.2 -2.3
Medication: Omeprazole 0.8 0.9 2.1 1.4 0.8 0.4
Medication: Seretide 50 evohaler 0.3 0.3 0.6 0.8 -0.0 0.6
Mean time to correctly identify matches 0.3 0.5 0.8 -0.7 0.9 -0.4
Heart disease (mother) 0.5 0.6 1.8 -0.3 0.3 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 1.9 -0.2 -1.4 -0.6
Whole body fat mass 5.1 21.2 38.2 -2.3 6.2 -4.5
Leg fat mass (right) 4.8 18.7 32.7 -1.9 5.7 -4.5
Arm predicted mass (right) 3.9 19.8 34.9 -2.3 5.9 -4.3
Pulse rate, automated reading 0.6 1.8 3.3 0.5 -1.8 1.3
Alcohol intake frequency. 0.2 0.4 0.5 0.7 0.5 0.7
Comparative height size at age 10 0.3 1.9 5.2 0.5 2.3 0.5
Number of full sisters 0.3 0.4 1.1 -0.3 0.2 -1.1
Suffer from ‘nerves’ 0.2 0.3 0.3 0.4 0.5 0.6
Overall health rating 0.7 1.5 4.3 -0.1 2.1 -0.6
Chest pain or discomfort 0.1 0.2 0.3 -0.4 0.2 -0.5
Had major operations 0.3 0.4 0.5 0.6 -0.5 -0.7
Age at last live birth 0.7 1.0 1.5 0.3 -1.2 1.2
Family relationship satisfaction 0.1 0.2 0.3 0.3 0.6 -0.3
Leg pain on walking 3.1 3.9 5.3 -1.6 2.3 -2.0
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.6 0.6 -0.1 -0.8
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.3 1.1 -0.8 0.8
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.2 -0.4 -0.5
Medication: Aspirin 2.0 2.7 5.3 -0.7 1.5 -2.3
Supplements: Vitamin C 1.3 1.6 2.0 -1.2 1.1 -1.4
Knee pain experienced in last month 1.0 1.5 2.0 -1.2 1.4 -1.0
Hypertension (Self-reported) 0.4 1.0 2.4 1.5 -0.8 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.3 3.8 6.7 -0.3 2.2 -2.6
Illnesses of father: Heart disease 9.6 13.3 20.7 -4.5 2.9 -3.3
Illnesses of siblings: Diabetes 5.0 6.1 8.0 -1.6 2.8 -2.8
Smoking status: Previous 0.6 0.8 2.2 0.6 0.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.7 0.4 0.4 0.9
Whole body fat-free mass 3.0 17.2 35.6 -1.7 6.0 -3.6
Leg fat-free mass (right) 3.2 17.3 39.3 -1.6 6.3 -3.2
Arm fat percentage (left) 3.1 12.3 24.5 -1.3 5.0 -3.2
Average weekly red wine intake 0.5 0.8 1.8 -0.7 1.4 -0.2
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.0 0.5 -0.3 1.4
Mood swings 1.1 1.9 3.2 -0.3 1.6 -1.8
Loneliness, isolation 0.2 0.3 0.9 -0.9 0.1 0.4
Long-standing illness, disability or infirmity 0.7 1.1 2.6 -0.8 1.6 -0.5
Ever had bowel cancer screening 1.1 1.2 2.0 -1.0 0.9 -1.4
Diabetes diagnosed by doctor 3.7 6.1 8.3 -2.1 2.4 -2.9
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.0 0.3 -1.4 0.8
Friendships satisfaction 1.1 1.4 2.7 1.6 -0.0 1.2
Qualifications: nursing, teaching 0.2 0.3 0.9 -0.1 -0.2 0.9
Commuting to job workplace: Walk 0.3 0.3 0.7 -0.3 -0.8 -0.4
Eye problems/disorders: Cataract 0.1 0.2 0.4 0.6 -0.1 -0.3
Mouth/teeth dental problems: Mouth ulcers 2.1 3.3 6.6 -1.4 1.1 -2.6
Medication for cholesterol 0.3 0.4 0.9 -0.2 -0.6 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.3 -1.1 0.4 -0.8
Back pain experienced in last month 0.3 0.4 0.4 -0.6 0.6 -0.6
Mineral and other dietary supplements 0.8 1.1 2.3 0.5 -0.7 1.5
Breast cancer (self-reported) 0.6 0.7 0.9 0.6 -1.0 0.9
Asthma (self-reported) 0.4 0.7 1.6 -0.0 0.7 1.3
Osteoporosis (self-reported) 0.1 0.1 0.4 -0.0 -0.2 0.6
Osteoarthritis (self-reported) 1.3 1.7 4.5 2.1 0.6 0.5
Medication: Aspirin 1.6 2.0 4.7 -0.4 1.1 -2.2
Medication: Gliclazide 1.8 2.0 3.5 -1.1 1.1 -1.9
Illnesses of father: None of the above (group 1) 3.1 3.9 5.8 2.4 -1.5 1.9
Smoking status: Current 0.4 0.6 0.9 1.0 0.0 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.7 -1.3 1.1 -0.1
Whole body water mass 3.0 17.2 35.0 -1.7 5.9 -3.7
Leg predicted mass (right) 3.2 17.1 39.1 -1.6 6.3 -3.1
Arm fat mass (left) 4.4 17.9 35.3 -1.8 5.9 -3.9
Number of self-reported non-cancer illnesses 2.4 4.1 6.9 -0.6 2.6 -2.3
Average weekly champagne plus white wine intake 2.0 2.8 4.4 -2.1 1.7 -0.9
Miserableness 2.2 3.8 4.5 -1.9 2.1 -1.8
Guilty feelings 0.3 0.5 1.1 -1.0 0.6 0.2
Wears glasses or contact lenses 0.4 0.5 1.1 -0.5 -0.2 -1.0
Ever taken oral contraceptive pill 0.6 0.6 1.9 -0.2 -1.4 -0.1
Hearing aid user 0.4 0.4 0.8 0.7 -0.9 0.1
Mother’s age at death 0.9 1.1 1.7 1.3 -0.9 1.0
Financial situation satisfaction 0.3 0.4 1.1 0.3 -0.0 1.1
Tinnitus: Yes, now most or all of the time 2.2 2.6 3.4 -1.8 1.8 -1.0
Commuting to job workplace: Public transport 0.9 1.1 2.8 -1.7 -0.1 -0.7
Eye problems/disorders: Glaucoma 0.5 0.6 1.0 0.1 0.8 -1.0
Medication: Blood pressure 0.8 1.5 3.9 2.0 -0.2 0.7
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.1 0.5 1.5 -1.0
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.7 -0.7 0.2 -1.3
High cholesterol (Self-reported) 2.4 4.3 9.1 -1.3 1.5 -3.0
Medication: Bendroflumethiazide 0.8 1.1 1.7 1.3 -0.7 1.1
Medication: Paracetamol 1.0 1.6 2.9 1.7 0.5 1.2
Medication: Lisinopril 0.5 0.6 1.1 1.0 0.0 -0.8
Medication: Atorvastatin 5.5 6.8 9.1 -1.6 2.9 -3.0
Illnesses of father: High blood pressure 0.1 0.2 0.3 0.6 -0.3 0.3
Alcohol drinker status: Never 1.2 1.5 3.4 0.9 0.3 1.9
Ever smoked 0.7 1.3 2.6 1.1 0.0 -1.6
Basal metabolic rate 3.6 19.7 40.4 -1.9 6.4 -3.9
Leg fat percentage (left) 2.0 7.2 11.3 -1.1 3.0 -3.4
Arm fat-free mass (left) 3.1 15.9 29.3 -1.8 5.4 -3.9
Number of operations (self-reported) 0.7 1.1 2.8 1.7 -0.6 -0.4
Average weekly beer plus cider intake 0.2 0.3 0.9 0.9 -0.2 -0.1
Irritability 0.3 0.4 1.0 -0.2 1.0 -0.6
Risk taking 0.3 0.5 1.4 0.1 1.2 0.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 0.5 -0.2 -1.2
Fractured/broken bones in last 5 years 2.1 2.7 5.8 -1.4 2.4 -0.4
Age started oral contraceptive pill 0.2 0.3 0.5 -0.0 0.6 -0.7
Diastolic blood pressure, automated reading 3.5 10.8 15.4 3.5 -3.9 2.1
Ever depressed for a whole week 4.7 5.8 8.8 -1.9 2.2 -3.0
Unable to work because of sickness or disability 0.5 0.6 1.4 0.5 0.2 1.2
Commuting to job workplace: Cycle 0.3 0.4 0.5 0.4 0.7 0.7
Myopia 0.2 0.3 0.8 0.9 -0.3 0.2
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.3 -1.1 -0.2 0.9
Cholesterol lowering medication 4.8 7.1 10.1 -1.7 3.2 -2.9
Medication: Omeprazole (e.g. Zanprol) 1.3 1.5 3.7 0.2 1.9 -0.9
Pain experienced in last month 1.9 3.1 4.0 1.5 -2.0 1.8
Supplements: Calcium 0.2 0.2 0.5 0.0 0.3 -0.7
Basal cell carcinoma (self-reported) 2.4 2.9 4.7 1.2 -2.2 1.6
Heart attack/myocardial infarction (self-reported) 5.6 7.2 10.3 -1.0 3.2 -3.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.3 -0.3 0.5 -1.5
Heart disease (siblings) 1.6 1.9 4.3 -1.2 2.1 -0.3
Alcohol drinker status: Previous 0.4 0.5 1.3 1.1 0.4 0.2
Pack years of smoking 0.1 0.1 0.4 0.1 0.6 0.0
Impedance of whole body 0.6 2.9 6.5 -0.3 -2.5 1.5
Leg fat mass (left) 4.4 17.2 30.2 -1.7 5.5 -4.3
Arm predicted mass (left) 3.1 15.7 28.6 -1.7 5.3 -3.9