Hub : Genes

SGEF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Glioblastoma Multiforme	0.1750	0.0770	0.00055	0.131	0.138	0.120	NA	0.127	8.9e-05	5.5e-05	1.8e-04	NA	1.1e-04
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0388	0.0220	0.00011	0.040	0.040	0.043	NA	0.041	2.3e-05	2.1e-05	1.1e-05	NA	1.7e-05
3	TCGA	Prostate Adenocarcinoma	0.0365	0.0199	0.00150	0.035	0.027	0.021	NA	0.023	1.4e-04	7.0e-04	2.8e-03	NA	1.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.7	4.0	0.4	-1.0	2.0
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.3	0.5	0.7
Depressed Affect (Nagel 2018)	1.2	2.6	3.5	-1.7	1.9	-1.2
Depression (Nagel 2018)	0.3	0.5	1.1	-1.1	0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.7	-0.7	-0.8	0.5
Neuroticism (Nagel 2018)	0.6	1.3	2.0	-1.4	1.3	-0.5
Schizophrenia (2018)	0.5	1.0	2.0	-0.7	1.4	-0.7
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.1	-0.2	-0.2
Worry (Nagel 2018)	0.3	0.6	1.0	-0.4	1.0	-0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.0	0.8	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.7	-0.0	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	-0.4	0.5	0.6
Crohns Disease (2017)	1.1	2.4	4.8	-1.4	2.2	-0.6
Irritable Bowel Disease (IBD)	0.8	1.8	2.9	-1.7	1.6	0.1
Ulcerative Colitis (UC)	0.5	0.9	1.7	-1.3	0.7	0.7
Major Depression (MDD)	0.1	0.1	0.1	0.4	0.1	0.3
Reaction Time	0.3	0.5	0.8	-0.8	0.9	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.9	-1.4	-0.2	-0.7
Breast Cancer	1.2	2.9	6.2	2.5	-1.2	1.1
Ovarian Cancer	0.8	1.0	2.7	0.6	-1.6	-0.1
Prostate Cancer	6.6	9.2	14.7	-3.8	1.8	-3.1
Age at First Birth	0.1	0.2	0.5	-0.2	0.1	0.7
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.3	0.1	0.8
Body Mass Index (BMI) (2010)	1.6	2.3	3.7	-1.1	1.9	-1.4
Coronary Artery Disease (CAD)	7.9	9.4	14.7	-3.1	3.8	-2.0
Crohns Disease (2012)	0.3	0.5	0.7	-0.6	0.9	0.6
Mean Putamen Volume	1.3	1.5	2.0	-1.4	1.1	-1.1
Fasting Glucose	1.3	1.5	2.7	0.8	-1.1	1.6
HbA1C	0.1	0.1	0.1	0.0	0.3	-0.3
HDL Cholesterol	1.0	1.7	4.8	0.5	-0.2	2.2
LDL Cholesterol	0.6	1.0	2.0	-1.4	0.2	-0.9
Lupus	1.6	2.4	6.9	-0.6	-0.0	-2.6
Neuroticism (2016)	0.3	0.4	1.1	-0.4	-0.2	-1.1
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.6	-0.3	0.6
Rheumatoid Arthritis	3.2	4.4	6.7	2.6	-2.0	1.6
Schizophrenia (2014)	0.1	0.3	0.6	-0.3	0.8	0.3
Triglycerides	0.1	0.2	0.2	-0.5	-0.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.0	-1.0	0.5	-0.9
Ulcerative Colitis	1.1	1.5	2.5	0.7	-1.3	1.6
Blood Eosinophil Count	0.5	3.7	5.6	-2.4	2.3	0.7
Blood Platelet Count	0.3	4.0	6.1	2.4	-2.5	0.5
Blood Red Count	0.1	0.9	2.0	0.4	-1.4	0.7
Blood White Count	0.1	0.6	1.4	-0.5	1.2	-0.4
Heel T-Score	1.1	9.0	18.1	-2.4	1.7	-4.2
BMI	5.0	29.3	58.2	-2.7	7.6	-4.7
Height	0.7	13.5	27.4	-2.7	5.2	-2.4
Waist Hip Ratio (WHR)	2.1	9.6	23.8	2.0	-4.9	1.1
Systolic Blood Pressure	6.2	31.3	40.4	5.5	-6.4	4.8
Smoking Status	1.3	3.2	8.4	0.5	1.0	-2.9
Allergy or Eczema	0.8	2.0	4.9	0.7	-0.8	2.2
Cardiovascular Disease	0.2	0.7	1.9	1.4	-0.3	-0.4
Hypothyroidism (self reported)	0.2	0.5	1.6	-0.1	-0.2	1.3
Respiratory disease	0.5	1.0	2.3	0.0	0.8	1.5
Type 2 Diabetes (T2D) (2018)	2.5	4.6	6.4	-2.3	1.6	-2.5
Lung FEV1/FVC ratio	6.7	33.9	42.1	-6.5	6.5	-4.2
Lung FVC	0.8	4.1	6.8	2.0	-1.2	2.6
Neuroticism	0.1	0.2	0.5	-0.7	0.5	-0.2
Chronotype (morning person)	0.7	1.6	4.6	-0.0	0.4	-2.1
Hair Pigment	0.7	20.9	29.1	4.8	-3.2	5.4
Tanning	0.9	10.9	13.8	-2.7	3.4	-3.7
Hand grip strength (left)	0.6	1.6	2.5	1.6	-1.2	0.8
Number of treatments/medications taken	0.6	1.0	2.2	0.1	0.9	-1.5
Average weekly spirits intake	0.8	1.0	1.5	-1.2	1.1	0.2
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.7	0.8	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.7	0.2	0.1
Hearing difficulty/problems: Yes	0.5	0.8	1.4	1.2	-1.0	-0.1
Relative age of first facial hair	0.7	1.5	2.5	0.1	-1.6	-1.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.3	0.3	2.3	-0.3
Ever used hormone-replacement therapy (HRT)	3.1	3.9	7.8	-1.6	1.1	-2.8
Ever had hysterectomy (womb removed)	0.6	0.6	1.4	-0.1	1.2	-0.7
Systolic blood pressure, automated reading	2.4	7.0	9.6	3.0	-3.1	1.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.1	-0.8	-0.1	-2.0
Angina	3.5	4.6	7.8	-1.3	2.1	-2.8
Medication for hormone replacement therapy	0.7	0.8	1.7	-1.3	-0.4	-0.6
Vitamin and mineral supplements	0.2	0.3	0.5	0.2	-0.7	0.5
Supplements: Zinc	0.3	0.3	0.4	0.7	0.4	0.6
Medication: Co-codamol	0.5	0.6	1.2	0.8	-1.1	0.3
Medication: Metformin	2.5	3.6	6.5	-1.7	1.2	-2.5
Diabetes (father)	0.1	0.1	0.2	0.4	0.2	0.3
Diabetes (mother)	1.7	2.2	3.4	-1.8	1.2	-1.3
Severe depression (siblings)	0.7	0.7	1.4	-0.4	0.8	-1.2
Pack years adult smoking proportion	0.1	0.1	0.4	-0.1	0.6	0.0
Impedance of leg (right)	0.7	3.5	10.2	-0.5	-3.2	0.3
Leg fat-free mass (left)	4.1	21.7	47.2	-2.0	6.9	-3.8
Trunk fat percentage	3.6	14.4	25.6	-2.1	5.1	-3.6
Hand grip strength (right)	0.4	1.0	1.9	1.4	-1.0	0.2
Townsend deprivation index at recruitment	0.5	0.7	1.2	0.2	0.9	-1.1
Current tobacco smoking	0.5	0.8	2.2	1.5	0.1	-0.3
Average weekly fortified wine intake	0.2	0.2	0.5	-0.2	-0.2	0.7
Maternal smoking around birth	0.4	0.5	1.0	-0.4	0.7	-1.0
Fed-up feelings	0.8	1.5	3.5	-0.9	1.9	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.2	-0.9	-0.2
Relative age voice broke	1.9	2.9	5.9	-1.5	-0.8	-2.4
Taking other prescription medications	1.0	1.5	3.0	-0.0	1.7	-1.2
Age when periods started (menarche)	0.2	0.5	0.7	0.9	-0.8	0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.2	1.0	1.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	7.5	-1.0	0.7	-2.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	-1.1	0.4	0.4
Qualifications: CSEs or equivalent	0.9	1.1	2.4	0.9	1.5	-0.5
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.2	0.3	-0.1
High blood pressure	0.3	0.9	2.2	1.5	-0.7	0.0
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.5	0.7	-0.9	1.9
Multivitamins +/- minerals	0.1	0.1	0.2	0.0	0.0	-0.5
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.5	0.1	-0.6
Supplements: Glucosamine	1.4	1.8	3.5	-0.7	1.2	-1.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	0.4	-0.8	-1.3
Medication: Atenolol	0.6	0.8	1.0	0.9	0.7	-1.0
Medication: Levothyroxine sodium	1.2	2.1	3.5	1.9	-0.9	1.4
Sitting height	0.5	3.6	9.2	-0.9	3.0	-1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.3	0.1	1.1	-0.3
High blood pressure (mother)	0.0	0.0	0.1	-0.1	0.3	-0.1
Body mass index (BMI)	3.0	12.6	24.0	-1.1	4.9	-3.6
Impedance of leg (left)	1.2	5.9	16.6	-0.0	-4.1	1.1
Leg predicted mass (left)	4.0	21.1	46.0	-2.0	6.8	-3.7
Trunk fat mass	4.9	21.2	37.8	-2.5	6.2	-4.4
Waist circumference	3.2	11.8	22.2	-1.5	4.7	-3.3
Number of incorrect matches in round	0.8	1.4	3.2	0.8	1.8	0.4
Past tobacco smoking	0.9	1.7	4.8	-0.6	-0.1	2.2
Alcohol usually taken with meals	2.7	4.4	6.6	-2.6	1.9	-1.7
Nervous feelings	0.5	0.9	1.8	-1.3	0.7	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.4	0.6	-0.1
Hearing difficulty/problems with background noise	2.9	4.6	8.5	1.8	-2.9	1.5
Hair/balding pattern: Pattern 2	3.9	4.9	10.1	-2.0	0.9	-3.2
Had menopause	0.2	0.2	0.5	0.7	-0.2	0.2
Had other major operations	0.1	0.1	0.2	0.3	-0.0	0.4
Forced vital capacity (FVC)	0.1	0.6	1.2	0.5	0.5	1.1
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.5	16.9	-2.1	2.1	-4.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	-0.3	0.6	-0.7
Qualifications: None of the above	0.3	0.6	1.4	0.5	-0.0	-1.2
Financial difficulties in last 2 years	1.5	2.0	3.3	-1.8	1.7	-0.1
Mouth/teeth dental problems	0.2	0.3	0.6	0.3	0.8	0.5
Heart attack	5.4	6.9	10.9	-0.9	3.3	-3.0
Allergy	0.3	0.7	2.1	-0.1	-0.4	-1.4
Pain all over the body in last month	1.0	1.0	2.0	1.0	1.4	-0.3
Diabetes (self-reported)	3.0	4.6	5.8	-1.9	2.2	-2.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.1	0.8	0.3
Medication: Ramipril	1.4	1.8	2.9	-1.7	0.4	-1.6
Medication: Simvastatin	1.7	2.4	5.4	-0.6	1.2	-2.3
Fluid intelligence score	0.3	0.7	1.8	-1.4	0.0	-0.6
Illnesses of siblings	1.9	2.7	3.6	0.9	-1.9	1.9
Neuroticism score	0.5	1.1	2.0	-1.0	1.4	-0.5
Weight	4.6	22.8	44.6	-2.1	6.7	-4.4
Impedance of arm (right)	0.3	1.3	2.2	-0.2	-1.3	1.5
Arm fat percentage (right)	2.7	10.6	21.7	-1.1	4.7	-3.0
Trunk fat-free mass	2.2	12.7	25.1	-1.4	5.0	-3.3
Hip circumference	5.9	25.4	54.2	-2.7	7.4	-3.9
Time employed in main current job	3.9	4.5	7.8	1.9	-1.5	2.8
Alcohol intake versus 10 years previously	2.0	2.9	5.2	-1.3	1.4	-2.3
Father’s age at death	1.5	1.9	3.2	1.8	-0.4	1.6
Worrier / anxious feelings	1.0	1.9	3.2	-0.6	1.8	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.3	0.3	0.9	-1.2
Falls in the last year	1.1	1.4	4.2	0.1	2.1	0.2
Hair/balding pattern: Pattern 3	6.3	9.4	17.2	3.1	-1.2	4.2
Number of live births	1.0	1.5	3.4	1.8	-1.0	0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.0	-1.2	2.0	0.2
Pulse rate	0.4	0.7	1.5	0.5	-1.2	0.6
Happiness	0.2	0.2	0.4	-0.7	-0.4	0.1
Noisy workplace	2.8	3.5	7.0	-1.3	2.6	-1.4
Qualifications: A levels/AS levels or equivalent	2.5	5.5	9.1	1.1	-3.0	2.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.7	0.7	-0.8	0.8
Mouth/teeth dental problems: Dentures	1.0	1.7	2.0	1.4	-1.1	1.4
Asthma	0.3	0.7	1.4	-0.2	0.8	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.0	1.4	-1.1	1.0
Medication: Cholesterol lowering	2.1	3.3	7.5	-1.0	1.2	-2.7
Depression (self-reported)	1.4	1.7	3.4	0.0	1.9	-1.3
Medication: Lansoprazole	4.0	4.5	8.8	-0.9	2.0	-3.0
Prospective memory result	0.6	0.7	1.4	-0.1	1.2	-0.9
Lung cancer (father)	1.4	1.7	4.4	2.1	-0.5	-0.6
Illnesses of mother	1.4	1.8	4.5	0.7	-2.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.5	-1.3	2.1	0.5
Pulse wave Arterial Stiffness index	5.2	6.0	10.8	1.6	-3.3	2.2
Impedance of arm (left)	0.2	1.0	2.0	-0.4	-0.9	1.4
Arm fat mass (right)	4.2	17.4	34.9	-1.8	5.9	-3.8
Trunk predicted mass	2.2	12.7	25.4	-1.4	5.0	-3.3
Standing height	1.0	10.1	19.4	-2.4	4.4	-2.2
Length of working week for main job	1.5	1.7	2.3	-1.3	1.0	-1.5
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.0	0.1	0.7
Breastfed as a baby	1.4	1.7	2.2	1.5	-1.5	0.9
Tense / ‘highly strung’	0.1	0.1	0.3	-0.1	-0.5	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	2.7	-1.5	1.7	-1.2
Hair/balding pattern: Pattern 4	1.5	3.7	7.0	1.0	-2.6	1.8
Birth weight of first child	0.0	0.1	0.1	-0.3	0.3	-0.0
Peak expiratory flow (PEF)	1.6	3.7	6.3	-2.2	2.5	-0.3
Pulse wave reflection index	2.2	2.7	3.3	1.3	-1.8	1.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.8	0.7	0.9	0.1
Loud music exposure frequency	1.1	1.2	1.9	1.4	0.2	1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.0	1.1	-1.0	1.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-1.4	-0.4	-0.5
Blood clot in the leg (DVT)	0.5	0.6	1.8	-0.1	0.3	-1.4
Medication: Paracetamol	1.5	2.5	4.0	1.9	0.2	2.0
Headache pain in last month	0.2	0.3	0.5	-0.4	-0.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.5	0.6	-0.3	1.6
Glaucoma (self-reported)	0.4	0.5	1.2	1.1	0.3	-0.5
Gout (self-reported)	3.0	4.1	4.5	-2.1	1.9	-2.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.5	0.6	-0.2	1.6
Medication: Amlodipine	0.1	0.1	0.4	0.6	-0.0	0.1
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.2	1.6	-1.0	1.8
Birth weight	0.2	0.4	0.8	0.9	-0.3	-0.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.5	-0.5	1.9	-0.1
High blood pressure (siblings)	0.3	0.5	1.1	1.1	-0.5	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.7	1.3	0.1	0.9	1.1
Body fat percentage	3.4	13.6	22.8	-1.9	4.8	-3.8
Leg fat percentage (right)	2.7	9.8	14.7	-1.4	3.6	-3.8
Arm fat-free mass (right)	3.5	17.9	30.9	-2.2	5.6	-4.2
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-0.0	1.2	-0.8
Comparative body size at age 10	0.7	1.8	3.4	0.4	1.9	-1.4
Number of full brothers	0.8	0.9	1.7	0.3	1.3	-1.0
Worry too long after embarrassment	0.2	0.3	0.6	-0.7	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.4	-0.7	2.1	0.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.3	0.8	-0.5
Number of children fathered	0.4	0.5	0.8	0.7	0.3	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.3	0.6	0.1
Age at first live birth	0.9	1.6	2.9	0.5	-1.3	1.7
Pulse wave peak to peak time	6.0	7.0	12.4	-1.8	3.5	-2.4
Health satisfaction	0.4	0.5	1.4	-0.2	1.2	0.3
Shortness of breath walking on level ground	0.0	0.1	0.1	-0.1	0.4	-0.1
Qualifications: College or University degree	0.8	2.4	3.8	-0.8	-1.7	2.0
Eye problems/disorders: None of the above	0.6	0.7	1.5	-0.5	-0.5	1.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	-0.1	0.0	-0.7
Emphysema/chronic bronchitis	0.6	0.7	1.8	1.4	-0.4	0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	2.5	-0.4	-1.6	0.3
Neck or shoulder pain in last month	1.0	1.4	2.3	0.1	1.5	-1.3
Medication: Blood pressure	0.2	0.4	0.9	-0.3	0.3	-0.9
Angina (self-reported)	3.6	4.7	7.9	-1.4	2.1	-2.8
Migraine (self-reported)	1.5	1.9	2.8	0.7	-1.5	1.7
Medication: Ibuprofen	1.0	1.2	1.5	1.0	-1.2	1.0
Medication: Allopurinol	3.4	4.5	5.4	-1.8	2.2	-2.3
Medication: Omeprazole	0.8	0.9	2.1	1.4	0.8	0.4
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.8	-0.0	0.6
Mean time to correctly identify matches	0.3	0.5	0.8	-0.7	0.9	-0.4
Heart disease (mother)	0.5	0.6	1.8	-0.3	0.3	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.9	-0.2	-1.4	-0.6
Whole body fat mass	5.1	21.2	38.2	-2.3	6.2	-4.5
Leg fat mass (right)	4.8	18.7	32.7	-1.9	5.7	-4.5
Arm predicted mass (right)	3.9	19.8	34.9	-2.3	5.9	-4.3
Pulse rate, automated reading	0.6	1.8	3.3	0.5	-1.8	1.3
Alcohol intake frequency.	0.2	0.4	0.5	0.7	0.5	0.7
Comparative height size at age 10	0.3	1.9	5.2	0.5	2.3	0.5
Number of full sisters	0.3	0.4	1.1	-0.3	0.2	-1.1
Suffer from ‘nerves’	0.2	0.3	0.3	0.4	0.5	0.6
Overall health rating	0.7	1.5	4.3	-0.1	2.1	-0.6
Chest pain or discomfort	0.1	0.2	0.3	-0.4	0.2	-0.5
Had major operations	0.3	0.4	0.5	0.6	-0.5	-0.7
Age at last live birth	0.7	1.0	1.5	0.3	-1.2	1.2
Family relationship satisfaction	0.1	0.2	0.3	0.3	0.6	-0.3
Leg pain on walking	3.1	3.9	5.3	-1.6	2.3	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	0.6	-0.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.3	1.1	-0.8	0.8
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	-0.4	-0.5
Medication: Aspirin	2.0	2.7	5.3	-0.7	1.5	-2.3
Supplements: Vitamin C	1.3	1.6	2.0	-1.2	1.1	-1.4
Knee pain experienced in last month	1.0	1.5	2.0	-1.2	1.4	-1.0
Hypertension (Self-reported)	0.4	1.0	2.4	1.5	-0.8	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.8	6.7	-0.3	2.2	-2.6
Illnesses of father: Heart disease	9.6	13.3	20.7	-4.5	2.9	-3.3
Illnesses of siblings: Diabetes	5.0	6.1	8.0	-1.6	2.8	-2.8
Smoking status: Previous	0.6	0.8	2.2	0.6	0.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	0.4	0.4	0.9
Whole body fat-free mass	3.0	17.2	35.6	-1.7	6.0	-3.6
Leg fat-free mass (right)	3.2	17.3	39.3	-1.6	6.3	-3.2
Arm fat percentage (left)	3.1	12.3	24.5	-1.3	5.0	-3.2
Average weekly red wine intake	0.5	0.8	1.8	-0.7	1.4	-0.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.0	0.5	-0.3	1.4
Mood swings	1.1	1.9	3.2	-0.3	1.6	-1.8
Loneliness, isolation	0.2	0.3	0.9	-0.9	0.1	0.4
Long-standing illness, disability or infirmity	0.7	1.1	2.6	-0.8	1.6	-0.5
Ever had bowel cancer screening	1.1	1.2	2.0	-1.0	0.9	-1.4
Diabetes diagnosed by doctor	3.7	6.1	8.3	-2.1	2.4	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.0	0.3	-1.4	0.8
Friendships satisfaction	1.1	1.4	2.7	1.6	-0.0	1.2
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.1	-0.2	0.9
Commuting to job workplace: Walk	0.3	0.3	0.7	-0.3	-0.8	-0.4
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.6	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.6	-1.4	1.1	-2.6
Medication for cholesterol	0.3	0.4	0.9	-0.2	-0.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-1.1	0.4	-0.8
Back pain experienced in last month	0.3	0.4	0.4	-0.6	0.6	-0.6
Mineral and other dietary supplements	0.8	1.1	2.3	0.5	-0.7	1.5
Breast cancer (self-reported)	0.6	0.7	0.9	0.6	-1.0	0.9
Asthma (self-reported)	0.4	0.7	1.6	-0.0	0.7	1.3
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.0	-0.2	0.6
Osteoarthritis (self-reported)	1.3	1.7	4.5	2.1	0.6	0.5
Medication: Aspirin	1.6	2.0	4.7	-0.4	1.1	-2.2
Medication: Gliclazide	1.8	2.0	3.5	-1.1	1.1	-1.9
Illnesses of father: None of the above (group 1)	3.1	3.9	5.8	2.4	-1.5	1.9
Smoking status: Current	0.4	0.6	0.9	1.0	0.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.7	-1.3	1.1	-0.1
Whole body water mass	3.0	17.2	35.0	-1.7	5.9	-3.7
Leg predicted mass (right)	3.2	17.1	39.1	-1.6	6.3	-3.1
Arm fat mass (left)	4.4	17.9	35.3	-1.8	5.9	-3.9
Number of self-reported non-cancer illnesses	2.4	4.1	6.9	-0.6	2.6	-2.3
Average weekly champagne plus white wine intake	2.0	2.8	4.4	-2.1	1.7	-0.9
Miserableness	2.2	3.8	4.5	-1.9	2.1	-1.8
Guilty feelings	0.3	0.5	1.1	-1.0	0.6	0.2
Wears glasses or contact lenses	0.4	0.5	1.1	-0.5	-0.2	-1.0
Ever taken oral contraceptive pill	0.6	0.6	1.9	-0.2	-1.4	-0.1
Hearing aid user	0.4	0.4	0.8	0.7	-0.9	0.1
Mother’s age at death	0.9	1.1	1.7	1.3	-0.9	1.0
Financial situation satisfaction	0.3	0.4	1.1	0.3	-0.0	1.1
Tinnitus: Yes, now most or all of the time	2.2	2.6	3.4	-1.8	1.8	-1.0
Commuting to job workplace: Public transport	0.9	1.1	2.8	-1.7	-0.1	-0.7
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	0.1	0.8	-1.0
Medication: Blood pressure	0.8	1.5	3.9	2.0	-0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.1	0.5	1.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.7	-0.7	0.2	-1.3
High cholesterol (Self-reported)	2.4	4.3	9.1	-1.3	1.5	-3.0
Medication: Bendroflumethiazide	0.8	1.1	1.7	1.3	-0.7	1.1
Medication: Paracetamol	1.0	1.6	2.9	1.7	0.5	1.2
Medication: Lisinopril	0.5	0.6	1.1	1.0	0.0	-0.8
Medication: Atorvastatin	5.5	6.8	9.1	-1.6	2.9	-3.0
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.6	-0.3	0.3
Alcohol drinker status: Never	1.2	1.5	3.4	0.9	0.3	1.9
Ever smoked	0.7	1.3	2.6	1.1	0.0	-1.6
Basal metabolic rate	3.6	19.7	40.4	-1.9	6.4	-3.9
Leg fat percentage (left)	2.0	7.2	11.3	-1.1	3.0	-3.4
Arm fat-free mass (left)	3.1	15.9	29.3	-1.8	5.4	-3.9
Number of operations (self-reported)	0.7	1.1	2.8	1.7	-0.6	-0.4
Average weekly beer plus cider intake	0.2	0.3	0.9	0.9	-0.2	-0.1
Irritability	0.3	0.4	1.0	-0.2	1.0	-0.6
Risk taking	0.3	0.5	1.4	0.1	1.2	0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	0.5	-0.2	-1.2
Fractured/broken bones in last 5 years	2.1	2.7	5.8	-1.4	2.4	-0.4
Age started oral contraceptive pill	0.2	0.3	0.5	-0.0	0.6	-0.7
Diastolic blood pressure, automated reading	3.5	10.8	15.4	3.5	-3.9	2.1
Ever depressed for a whole week	4.7	5.8	8.8	-1.9	2.2	-3.0
Unable to work because of sickness or disability	0.5	0.6	1.4	0.5	0.2	1.2
Commuting to job workplace: Cycle	0.3	0.4	0.5	0.4	0.7	0.7
Myopia	0.2	0.3	0.8	0.9	-0.3	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.3	-1.1	-0.2	0.9
Cholesterol lowering medication	4.8	7.1	10.1	-1.7	3.2	-2.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	3.7	0.2	1.9	-0.9
Pain experienced in last month	1.9	3.1	4.0	1.5	-2.0	1.8
Supplements: Calcium	0.2	0.2	0.5	0.0	0.3	-0.7
Basal cell carcinoma (self-reported)	2.4	2.9	4.7	1.2	-2.2	1.6
Heart attack/myocardial infarction (self-reported)	5.6	7.2	10.3	-1.0	3.2	-3.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	-0.3	0.5	-1.5
Heart disease (siblings)	1.6	1.9	4.3	-1.2	2.1	-0.3
Alcohol drinker status: Previous	0.4	0.5	1.3	1.1	0.4	0.2
Pack years of smoking	0.1	0.1	0.4	0.1	0.6	0.0
Impedance of whole body	0.6	2.9	6.5	-0.3	-2.5	1.5
Leg fat mass (left)	4.4	17.2	30.2	-1.7	5.5	-4.3
Arm predicted mass (left)	3.1	15.7	28.6	-1.7	5.3	-3.9