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chr6:129,638,583-132,647,962

Best TWAS P=3.86e-12 · Best GWAS P=5.28e-19 conditioned to 0.00022

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	-5.8	-5.5	3.6e-08	0.05	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	-5.8	-5.8	7.6e-09	0.07	0.00	1.00	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	-5.8	-5.9	4.6e-09	0.08	0.00	1.00	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	-5.8	-6.0	1.4e-09	0.09	0.00	1.00	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	-5.8	-5.9	3.5e-09	0.06	0.01	0.97	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	-5.8	-6.0	1.5e-09	0.07	0.01	0.93	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	-4.4	-5.8	5.4e-09	0.09	0.01	0.98	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	-5.6	-6.0	1.5e-09	0.10	0.01	0.97	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	-5.8	-5.5	3.8e-08	0.08	0.01	0.95	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	-5.8	-6.1	1.2e-09	0.09	0.00	1.00	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	-5.8	-5.8	6.6e-09	0.07	0.00	0.99	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	-5.6	-6.1	9.6e-10	0.09	0.00	1.00	FALSE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	-5.8	-5.9	4.6e-09	0.07	0.00	1.00	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	-5.8	-5.7	1.2e-08	0.07	0.01	0.99	FALSE
15	GTEx	Nerve Tibial	AKAP7	0.26	0.14	lasso	6	0.14	4.3e-10	-4.8	-5.2	2.0e-07	0.26	1.00	0.00	FALSE
16	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	-5.8	-5.9	3.2e-09	0.08	0.00	1.00	FALSE
17	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	-5.8	-5.9	4.1e-09	0.07	0.00	1.00	FALSE
18	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	-4.4	-5.3	8.6e-08	0.09	0.01	0.99	FALSE
19	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	-5.8	-5.6	2.3e-08	0.07	0.00	0.98	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	-5.5	-6.1	8.2e-10	0.11	0.00	1.00	FALSE
21	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	-5.8	-5.8	4.8e-09	0.07	0.00	1.00	FALSE
22	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	-5.8	-6.0	1.8e-09	0.08	0.00	0.97	FALSE
23	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	-5.6	-6.0	2.3e-09	0.09	0.01	0.99	FALSE
24	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	-5.5	-5.9	3.2e-09	0.09	0.01	0.99	FALSE
25	GTEx	Stomach	MED23	0.14	0.04	lasso	3	0.06	7.9e-04	-6.2	-6.9	3.9e-12	0.63	0.02	0.71	TRUE
26	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	-5.8	-5.6	2.6e-08	0.07	0.00	1.00	FALSE
27	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	-5.8	-6.0	1.7e-09	0.09	0.00	1.00	FALSE
28	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	-4.6	-5.7	1.4e-08	0.07	0.01	0.99	FALSE
29	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	-5.8	-6.2	4.8e-10	0.09	0.00	1.00	TRUE
30	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	-5.8	-6.0	2.3e-09	0.09	0.00	0.99	FALSE
31	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	-5.6	-5.5	4.4e-08	0.14	0.01	0.99	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	AKAP7	0.07	0.05	lasso	4	0.05	7.5e-07	-5.5	-5.2	1.8e-07	0.25	0.99	0.00	TRUE