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chr6:202,452-1,408,677

Best TWAS P=3.31e-193 · Best GWAS P=0 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EXOC2	0.24	0.11	lasso	15	0.22	8.8e-27	12.3	25.3	1.4e-141	-0.13	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	EXOC2	0.16	0.06	lasso	6	0.09	6.1e-08	9.9	13.6	2.2e-42	-0.07	0.96	0.00	TRUE
3	GTEx	Adipose Visceral Omentum	EXOC2	0.13	0.07	lasso	3	0.07	1.0e-04	12.6	12.9	5.1e-38	-0.04	0.82	0.02	TRUE
4	GTEx	Artery Aorta	EXOC2	0.33	0.10	lasso	10	0.09	1.3e-05	12.3	18.5	3.5e-76	-0.09	0.86	0.01	TRUE
5	GTEx	Artery Tibial	EXOC2	0.21	0.16	lasso	4	0.18	3.2e-14	9.9	12.7	4.3e-37	-0.09	1.00	0.00	FALSE
6	GTEx	Cells Transformed fibroblasts	EXOC2	0.23	0.16	lasso	4	0.16	4.0e-12	12.3	13.9	8.0e-44	-0.02	1.00	0.00	FALSE
7	GTEx	Colon Sigmoid	EXOC2	0.37	0.07	lasso	10	0.03	2.6e-02	12.3	12.3	1.4e-34	0.00	0.30	0.03	FALSE
8	GTEx	Colon Transverse	EXOC2	0.31	0.00	lasso	11	0.03	2.2e-02	10.8	10.3	5.5e-25	-0.05	0.34	0.03	TRUE
9	GTEx	Esophagus Mucosa	EXOC2	0.29	0.12	lasso	6	0.09	1.4e-06	13.6	16.9	9.4e-64	-0.08	0.98	0.00	FALSE
10	GTEx	Esophagus Muscularis	EXOC2	0.22	0.04	enet	9	0.09	4.2e-06	13.6	29.7	3.3e-193	-0.15	0.80	0.05	TRUE
11	GTEx	Heart Atrial Appendage	EXOC2	0.42	0.17	enet	51	0.20	2.1e-09	10.9	20.0	6.3e-89	-0.08	0.92	0.00	FALSE
12	GTEx	Heart Left Ventricle	EXOC2	0.33	0.12	enet	16	0.11	2.9e-06	10.7	21.9	1.6e-106	-0.12	0.93	0.01	TRUE
13	GTEx	Lung	EXOC2	0.15	0.07	lasso	4	0.08	1.8e-06	9.9	11.0	5.3e-28	-0.09	0.98	0.00	FALSE
14	GTEx	Muscle Skeletal	EXOC2	0.21	0.06	lasso	8	0.09	2.1e-09	12.3	14.7	3.9e-49	-0.06	1.00	0.00	TRUE
15	GTEx	Nerve Tibial	EXOC2	0.22	0.17	lasso	3	0.19	2.7e-13	13.6	15.5	6.0e-54	-0.08	1.00	0.00	FALSE
16	GTEx	Pituitary	EXOC2	0.41	0.15	enet	21	0.18	2.5e-05	10.8	6.4	1.2e-10	-0.03	0.45	0.05	TRUE
17	GTEx	Skin Sun Exposed Lower leg	EXOC2	0.10	0.01	enet	11	0.05	1.2e-04	13.3	19.8	4.1e-87	-0.11	0.56	0.02	FALSE
18	METSIM	Adipose	EXOC2	0.10	0.04	lasso	11	0.06	9.8e-10	12.3	21.8	2.0e-105	-0.08	1.00	0.00	FALSE
19	METSIM	Adipose	RP11-532F6.3	0.28	0.27	lasso	3	0.27	1.2e-40	9.3	-9.4	5.0e-21	-0.02	1.00	0.00	TRUE
20	NTR	Blood	EXOC2	0.03	0.00	bslmm	624	0.01	3.4e-04	18.6	16.9	8.5e-64	-0.06	0.50	0.01	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	EXOC2	0.07	0.02	lasso	5	0.05	1.8e-07	21.5	22.5	8.4e-112	-0.13	0.72	0.03	FALSE
22	YFS	Blood	EXOC2	0.05	0.02	lasso	5	0.02	9.7e-09	23.5	28.5	2.8e-179	-0.12	1.00	0.00	FALSE
23	YFS	Blood	IRF4	0.03	0.00	bslmm	417	0.00	2.2e-01	4.8	11.8	5.6e-32	-0.02	0.05	0.04	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EXOC2	0.11	0.00	blup	203	0.03	1.7e-03	11.7	24.7	2.1e-134	-0.19	0.06	0.18	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EXOC2	0.05	0.02	blup	204	0.03	3.9e-04	21.6	29.0	8.7e-185	-0.13	0.36	0.15	TRUE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	EXOC2	0.07	0.06	lasso	5	0.06	2.6e-07	21.5	21.9	4.3e-106	-0.07	0.91	0.01	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	EXOC2	0.10	0.01	blup	204	0.03	6.8e-05	21.6	16.0	2.2e-57	-0.04	0.18	0.03	TRUE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EXOC2	0.40	0.06	blup	204	0.14	3.8e-06	14.3	7.9	3.2e-15	0.02	0.21	0.04	TRUE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	EXOC2	0.14	0.02	blup	203	0.06	3.1e-07	12.3	21.3	4.5e-101	-0.14	0.69	0.02	FALSE