Best TWAS P=6.55e-12 · Best GWAS P=5.56e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | MED20 | 0.11 | 0.05 | lasso | 4 | 0.08 | 9.4e-07 | 6.7 | -6.4 | 1.6e-10 | -0.80 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | USP49 | 0.13 | 0.02 | lasso | 4 | 0.02 | 2.4e-02 | 6.6 | 6.0 | 1.6e-09 | 0.93 | 0.01 | 0.96 | FALSE |
| 3 | GTEx | Liver | MED20 | 0.20 | 0.03 | enet | 54 | 0.08 | 3.4e-03 | -4.2 | -5.2 | 2.7e-07 | -0.59 | 0.03 | 0.86 | FALSE |
| 4 | GTEx | Lung | USP49 | 0.09 | 0.08 | lasso | 2 | 0.05 | 6.2e-05 | 6.6 | 6.4 | 1.3e-10 | 0.98 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Testis | MED20 | 0.13 | 0.03 | lasso | 6 | 0.00 | 2.0e-01 | 6.6 | -6.5 | 8.5e-11 | -0.98 | 0.02 | 0.88 | FALSE |
| 6 | METSIM | Adipose | MED20 | 0.13 | 0.11 | enet | 27 | 0.11 | 2.3e-16 | -4.4 | -5.7 | 1.2e-08 | -0.75 | 0.98 | 0.02 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | MED20 | 0.05 | 0.00 | blup | 50 | 0.04 | 2.8e-03 | -4.3 | -5.9 | 2.9e-09 | -0.84 | 0.02 | 0.76 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 7.3e-05 | 6.7 | -6.8 | 1.5e-11 | -0.97 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MED20 | 0.09 | 0.07 | lasso | 5 | 0.07 | 3.4e-04 | 6.6 | -6.9 | 6.6e-12 | -0.98 | 0.00 | 0.99 | TRUE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MED20 | 0.04 | 0.06 | enet | 6 | 0.05 | 2.6e-06 | -4.3 | -5.1 | 3.1e-07 | -0.66 | 0.45 | 0.52 | FALSE |
| 11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MED20 | 0.03 | 0.05 | lasso | 2 | 0.04 | 1.2e-03 | 6.7 | -6.7 | 1.5e-11 | -0.95 | 0.00 | 0.95 | FALSE |