Best TWAS P=1.08e-36 · Best GWAS P=6.1e-45 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | DEXI | 0.17 | 0.02 | enet | 27 | 0.03 | 1.3e-02 | -12.6 | -9.1 | 7.7e-20 | 0.53 | 0.08 | 0.84 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP11-876N24.5 | 0.11 | 0.08 | lasso | 2 | 0.10 | 6.0e-06 | -11.5 | -10.6 | 3.5e-26 | 0.68 | 0.06 | 0.92 | TRUE |
3 | GTEx | Brain Putamen basal ganglia | RMI2 | 0.48 | 0.31 | lasso | 9 | 0.40 | 1.7e-10 | -2.9 | -6.4 | 1.5e-10 | 0.34 | 0.69 | 0.03 | FALSE |
4 | GTEx | Breast Mammary Tissue | DEXI | 0.12 | 0.07 | enet | 14 | 0.08 | 6.9e-05 | -10.5 | -10.3 | 6.9e-25 | 0.72 | 0.06 | 0.89 | TRUE |
5 | GTEx | Breast Mammary Tissue | RP11-876N24.5 | 0.15 | 0.11 | enet | 19 | 0.12 | 1.4e-06 | -10.5 | -12.5 | 9.5e-36 | 0.73 | 0.29 | 0.69 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | RMI2 | 0.32 | 0.15 | enet | 25 | 0.10 | 2.9e-03 | -2.9 | -5.2 | 1.5e-07 | 0.26 | 0.07 | 0.13 | FALSE |
7 | GTEx | Breast Mammary Tissue (Male) | DEXI | 0.18 | 0.04 | lasso | 3 | -0.01 | 4.9e-01 | -7.3 | -7.8 | 6.1e-15 | 0.63 | 0.03 | 0.64 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | RP11-876N24.5 | 0.16 | 0.24 | lasso | 2 | 0.21 | 1.5e-05 | -6.2 | -6.8 | 8.3e-12 | 0.36 | 0.07 | 0.22 | FALSE |
9 | GTEx | Breast Mammary Tissue (Female) | DEXI | 0.13 | 0.06 | lasso | 2 | 0.04 | 2.0e-02 | -11.8 | -11.8 | 5.8e-32 | 0.79 | 0.05 | 0.52 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | RP11-876N24.5 | 0.22 | 0.14 | enet | 11 | 0.13 | 1.0e-04 | -11.8 | -12.5 | 9.9e-36 | 0.77 | 0.14 | 0.75 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | DEXI | 0.12 | 0.05 | lasso | 5 | 0.08 | 9.6e-07 | -6.7 | -9.6 | 5.8e-22 | 0.72 | 0.18 | 0.82 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | RP11-876N24.4 | 0.12 | 0.04 | lasso | 5 | 0.08 | 2.1e-06 | -6.7 | -9.6 | 5.3e-22 | 0.73 | 0.18 | 0.82 | TRUE |
13 | GTEx | Esophagus Muscularis | RMI2 | 0.35 | 0.20 | enet | 71 | 0.23 | 7.4e-14 | -2.9 | -5.6 | 2.1e-08 | 0.10 | 1.00 | 0.00 | TRUE |
14 | GTEx | Nerve Tibial | DEXI | 0.11 | 0.05 | enet | 7 | 0.07 | 1.7e-05 | -10.5 | -12.7 | 1.1e-36 | 0.81 | 0.64 | 0.28 | TRUE |
15 | GTEx | Pancreas | DEXI | 0.13 | 0.06 | lasso | 4 | 0.07 | 5.7e-04 | -10.7 | -10.8 | 4.1e-27 | 0.67 | 0.18 | 0.68 | TRUE |
16 | GTEx | Pancreas | RP11-876N24.4 | 0.11 | 0.05 | lasso | 3 | 0.04 | 8.6e-03 | -10.7 | -10.7 | 6.2e-27 | 0.67 | 0.15 | 0.67 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | DEXI | 0.05 | 0.06 | lasso | 2 | 0.03 | 7.8e-04 | -10.7 | -10.4 | 1.6e-25 | 0.65 | 0.70 | 0.20 | FALSE |
18 | GTEx | Testis | CLEC16A | 0.15 | 0.00 | enet | 20 | 0.01 | 1.2e-01 | -10.3 | -11.5 | 2.1e-30 | 0.71 | 0.02 | 0.92 | FALSE |
19 | GTEx | Testis | DEXI | 0.21 | 0.11 | lasso | 3 | 0.08 | 2.1e-04 | -13.1 | -11.7 | 7.4e-32 | 0.68 | 0.29 | 0.32 | FALSE |
20 | GTEx | Testis | RP11-876N24.4 | 0.21 | 0.06 | lasso | 5 | 0.07 | 6.0e-04 | -13.1 | -12.5 | 1.2e-35 | 0.70 | 0.22 | 0.30 | FALSE |
21 | GTEx | Thyroid | DEXI | 0.08 | 0.00 | enet | 18 | 0.03 | 1.8e-03 | -10.7 | -9.2 | 5.1e-20 | 0.53 | 0.18 | 0.65 | FALSE |
22 | GTEx | Thyroid | RP11-876N24.4 | 0.06 | 0.00 | enet | 17 | 0.02 | 1.5e-02 | 3.3 | -7.6 | 3.3e-14 | 0.43 | 0.18 | 0.32 | TRUE |
23 | GTEx | Thyroid | RP11-396B14.2 | 0.12 | 0.01 | lasso | 6 | 0.01 | 4.0e-02 | -13.1 | 12.5 | 6.7e-36 | -0.80 | 0.01 | 0.96 | TRUE |
24 | ROSMAP | Brain Pre-frontal Cortex | DEXI | 0.12 | 0.12 | lasso | 6 | 0.13 | 5.9e-16 | -10.0 | -10.8 | 4.7e-27 | 0.70 | 1.00 | 0.00 | FALSE |
25 | YFS | Blood | CLEC16A | 0.08 | 0.01 | bslmm | 627 | 0.03 | 1.2e-09 | -0.2 | 6.6 | 5.1e-11 | -0.17 | 0.93 | 0.00 | TRUE |
26 | YFS | Blood | DEXI | 0.11 | 0.15 | enet | 29 | 0.16 | 2.6e-51 | -10.0 | -9.9 | 2.5e-23 | 0.66 | 1.00 | 0.00 | TRUE |
27 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DEXI | 0.04 | 0.02 | blup | 49 | 0.04 | 8.6e-08 | -11.5 | -10.7 | 1.1e-26 | 0.66 | 0.03 | 0.97 | TRUE |
28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DEXI | 0.05 | 0.02 | lasso | 4 | 0.03 | 1.7e-04 | -7.3 | -8.4 | 2.9e-17 | 0.64 | 0.02 | 0.84 | FALSE |
29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DEXI | 0.09 | 0.01 | blup | 49 | 0.07 | 8.8e-08 | 3.2 | -6.0 | 2.0e-09 | 0.54 | 0.02 | 0.87 | FALSE |
30 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | DEXI | 0.20 | 0.00 | blup | 49 | 0.06 | 1.3e-02 | 6.1 | -5.2 | 2.4e-07 | 0.42 | 0.01 | 0.10 | FALSE |
31 | The Cancer Genome Atlas | Thyroid Carcinoma | CLEC16A | 0.14 | 0.06 | lasso | 4 | 0.09 | 6.8e-09 | -10.5 | 7.4 | 1.6e-13 | -0.63 | 0.22 | 0.78 | FALSE |