[Hub]/) : Traits : Allergy or Eczema :

chr15:89,921,477-92,225,560

Best TWAS P=3.06e-27 · Best GWAS P=8.71e-22 conditioned to 0.308

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex IQGAP1 0.19 0.21 lasso 5 0.20 1.7e-24 -8.89 -8.6 7.0e-18 0.94 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex SEMA4B 0.12 0.01 bslmm 422 0.04 1.6e-05 -1.75 5.2 2.5e-07 -0.51 0.10 0.68 FALSE
3 GTEx Adipose Subcutaneous ZNF774 0.10 0.01 lasso 6 0.02 1.3e-02 -5.25 -5.5 4.6e-08 0.58 0.34 0.50 FALSE
4 GTEx Artery Aorta IQGAP1 0.44 0.51 enet 27 0.51 5.3e-32 -5.40 -6.3 2.5e-10 0.69 1.00 0.00 FALSE
5 GTEx Artery Aorta ZNF774 0.22 0.24 enet 16 0.23 7.6e-13 -7.28 -7.8 6.2e-15 0.78 0.90 0.10 FALSE
6 GTEx Artery Coronary IQGAP1 0.33 0.42 enet 19 0.44 2.6e-16 -5.40 -5.7 1.2e-08 0.61 1.00 0.00 FALSE
7 GTEx Cells Transformed fibroblasts IQGAP1 0.13 0.06 enet 19 0.11 9.2e-09 -3.77 -9.0 2.7e-19 0.55 0.39 0.43 FALSE
8 GTEx Colon Sigmoid IQGAP1 0.18 0.16 lasso 7 0.15 6.6e-06 -5.54 -5.5 3.3e-08 0.63 0.76 0.19 FALSE
9 GTEx Colon Transverse IQGAP1 0.23 0.15 lasso 2 0.10 1.4e-05 -5.40 -5.6 2.4e-08 0.63 0.72 0.20 FALSE
10 GTEx Colon Transverse ZNF774 0.24 0.09 lasso 4 0.08 1.5e-04 -4.60 -5.6 1.9e-08 0.36 0.45 0.15 FALSE
11 GTEx Esophagus Gastroesophageal Junction IQGAP1 0.11 0.15 lasso 3 0.14 7.9e-06 -5.54 -5.6 2.7e-08 0.64 0.56 0.24 FALSE
12 GTEx Esophagus Gastroesophageal Junction ZNF774 0.16 0.16 lasso 2 0.11 7.8e-05 -7.84 -8.0 1.3e-15 0.75 0.36 0.26 FALSE
13 GTEx Esophagus Mucosa IQGAP1 0.26 0.19 enet 39 0.21 2.3e-14 -9.36 -8.4 3.4e-17 0.73 0.02 0.98 FALSE
14 GTEx Esophagus Mucosa CRTC3 0.08 0.07 enet 7 0.04 6.1e-04 -7.74 7.9 2.0e-15 -0.81 0.26 0.69 FALSE
15 GTEx Esophagus Muscularis IQGAP1 0.24 0.14 enet 18 0.14 5.7e-09 -5.40 -6.7 2.8e-11 0.69 0.35 0.65 FALSE
16 GTEx Esophagus Muscularis ZNF774 0.18 0.19 lasso 5 0.18 4.1e-11 -7.14 7.4 1.1e-13 -0.74 1.00 0.00 FALSE
17 GTEx Lung ZNF774 0.06 0.09 enet 6 0.03 1.5e-03 -7.84 -6.2 5.0e-10 0.57 0.79 0.03 FALSE
18 GTEx Nerve Tibial PRC1 0.11 0.00 lasso 2 0.00 7.8e-01 -6.83 -5.8 6.0e-09 0.53 0.09 0.05 FALSE
19 GTEx Ovary IQGAP1 0.43 0.53 lasso 3 0.53 2.3e-15 -5.40 -5.5 4.5e-08 0.64 0.96 0.04 FALSE
20 GTEx Pituitary IQGAP1 0.60 0.45 enet 26 0.52 3.7e-15 -5.40 -6.5 1.0e-10 0.67 0.94 0.06 FALSE
21 GTEx Skin Sun Exposed Lower leg CRTC3 0.10 0.08 lasso 3 0.05 7.5e-05 -8.01 7.3 2.7e-13 -0.73 0.51 0.47 FALSE
22 GTEx Skin Sun Exposed Lower leg FES 0.09 0.04 lasso 5 0.04 1.4e-04 -3.41 5.2 2.0e-07 -0.13 0.14 0.42 TRUE
23 GTEx Small Intestine Terminal Ileum IQGAP1 0.27 0.26 lasso 4 0.20 2.7e-05 -5.40 -5.4 6.7e-08 0.64 0.12 0.65 FALSE
24 GTEx Stomach IQGAP1 0.21 0.14 enet 17 0.18 8.3e-09 -9.36 -8.1 6.2e-16 0.86 0.03 0.97 FALSE
25 GTEx Testis IQGAP1 0.25 0.37 lasso 4 0.36 1.2e-16 -5.54 -5.4 6.9e-08 0.63 1.00 0.00 FALSE
26 GTEx Testis ZNF774 0.13 0.09 lasso 4 0.08 1.5e-04 -9.36 9.3 2.2e-20 -0.99 0.01 0.99 FALSE
27 GTEx Thyroid ZNF774 0.09 0.06 enet 9 0.05 6.0e-05 -7.28 -6.8 9.6e-12 0.65 0.36 0.07 FALSE
28 GTEx Thyroid RP11-617F23.1 0.11 0.01 lasso 4 0.04 1.0e-03 -6.83 -6.4 1.6e-10 0.53 0.24 0.24 FALSE
29 GTEx Uterus IQGAP1 0.29 0.16 lasso 5 0.13 1.3e-03 -5.40 -5.5 5.0e-08 0.64 0.08 0.72 FALSE
30 GTEx Vagina IQGAP1 0.32 0.11 lasso 6 0.17 1.3e-04 -9.36 -8.4 6.1e-17 0.85 0.02 0.93 FALSE
31 METSIM Adipose IQGAP1 0.11 0.08 enet 32 0.12 3.9e-17 -8.07 -10.0 1.7e-23 0.86 0.08 0.92 FALSE
32 METSIM Adipose MAN2A2 0.04 0.00 blup 494 0.01 3.4e-03 0.61 -5.2 1.8e-07 0.33 0.14 0.15 FALSE
33 NTR Blood IQGAP1 0.03 0.04 enet 10 0.04 1.5e-12 -8.02 -8.1 4.1e-16 0.70 1.00 0.00 FALSE
34 YFS Blood CRTC3 0.02 0.01 blup 503 0.01 4.2e-05 -8.08 7.6 3.0e-14 -0.75 0.46 0.53 FALSE
35 YFS Blood IQGAP1 0.18 0.17 enet 46 0.20 5.8e-65 -9.59 -10.3 6.8e-25 0.91 0.00 1.00 FALSE
36 The Cancer Genome Atlas Bladder Urothelial Carcinoma IQGAP1 0.04 0.03 lasso 4 0.02 6.5e-03 -8.02 -6.7 2.0e-11 0.62 0.12 0.13 FALSE
37 The Cancer Genome Atlas Breast Invasive Carcinoma IQGAP1 0.03 0.02 blup 94 0.02 6.5e-05 -9.50 -9.6 5.0e-22 0.92 0.01 0.99 FALSE
38 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma IQGAP1 0.15 0.09 lasso 4 0.12 1.9e-06 -8.05 -8.6 7.4e-18 0.81 0.12 0.86 FALSE
39 The Cancer Genome Atlas Glioblastoma Multiforme IQGAP1 0.10 -0.01 blup 95 0.02 1.0e-01 -5.25 -5.8 7.7e-09 0.64 0.08 0.22 FALSE
40 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IQGAP1 0.15 0.05 enet 10 0.08 2.5e-09 -8.89 -9.3 1.0e-20 0.88 0.01 0.99 FALSE
41 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IQGAP1 0.07 0.06 blup 94 0.07 9.5e-09 -8.04 -7.1 1.3e-12 0.70 0.96 0.04 FALSE
42 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ZNF774 0.04 0.00 enet 7 0.01 5.1e-02 -7.84 -6.0 1.6e-09 0.75 0.01 0.78 TRUE
43 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma IQGAP1 0.06 0.05 blup 94 0.04 2.6e-03 -5.04 -6.9 5.7e-12 0.71 0.12 0.56 FALSE
44 The Cancer Genome Atlas Brain Lower Grade Glioma CRTC3 0.03 0.01 blup 78 0.01 4.2e-02 -4.58 6.1 8.1e-10 -0.44 0.05 0.04 FALSE
45 The Cancer Genome Atlas Brain Lower Grade Glioma IQGAP1 0.05 0.04 enet 12 0.03 1.1e-04 -5.23 -7.5 5.8e-14 0.54 0.51 0.28 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF774 0.06 0.06 lasso 3 0.04 1.2e-05 -7.84 8.0 1.6e-15 -0.77 0.07 0.92 FALSE
47 The Cancer Genome Atlas Lung Adenocarcinoma IQGAP1 0.06 0.04 blup 94 0.03 5.8e-05 -7.40 -7.2 5.0e-13 0.63 0.82 0.10 FALSE
48 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IQGAP1 0.02 0.02 blup 94 0.02 6.2e-03 -9.45 -9.1 7.3e-20 0.92 0.01 0.88 FALSE
49 The Cancer Genome Atlas Pancreatic Adenocarcinoma IQGAP1 0.40 0.06 enet 13 0.07 9.0e-04 -7.14 -6.4 1.6e-10 0.49 0.21 0.24 FALSE
50 The Cancer Genome Atlas Prostate Adenocarcinoma IQGAP1 0.11 0.03 enet 8 0.06 1.4e-06 -8.89 -10.8 3.1e-27 0.83 0.01 0.98 TRUE
51 The Cancer Genome Atlas Stomach Adenocarcinoma IQGAP1 0.12 0.07 lasso 4 0.07 1.4e-05 -8.07 -7.7 1.8e-14 0.77 0.48 0.49 FALSE
52 The Cancer Genome Atlas Testicular Germ Cell Tumors IQGAP1 0.14 0.07 lasso 2 0.08 8.5e-04 -3.59 -5.2 2.0e-07 0.41 0.10 0.26 FALSE
53 The Cancer Genome Atlas Thyroid Carcinoma IQGAP1 0.06 0.04 blup 95 0.08 3.0e-08 -9.36 -8.4 3.8e-17 0.85 0.04 0.96 FALSE