Best TWAS P=3.06e-27 · Best GWAS P=8.71e-22 conditioned to 0.308
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IQGAP1 | 0.19 | 0.21 | lasso | 5 | 0.20 | 1.7e-24 | -8.89 | -8.6 | 7.0e-18 | 0.94 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SEMA4B | 0.12 | 0.01 | bslmm | 422 | 0.04 | 1.6e-05 | -1.75 | 5.2 | 2.5e-07 | -0.51 | 0.10 | 0.68 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | ZNF774 | 0.10 | 0.01 | lasso | 6 | 0.02 | 1.3e-02 | -5.25 | -5.5 | 4.6e-08 | 0.58 | 0.34 | 0.50 | FALSE |
| 4 | GTEx | Artery Aorta | IQGAP1 | 0.44 | 0.51 | enet | 27 | 0.51 | 5.3e-32 | -5.40 | -6.3 | 2.5e-10 | 0.69 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Aorta | ZNF774 | 0.22 | 0.24 | enet | 16 | 0.23 | 7.6e-13 | -7.28 | -7.8 | 6.2e-15 | 0.78 | 0.90 | 0.10 | FALSE |
| 6 | GTEx | Artery Coronary | IQGAP1 | 0.33 | 0.42 | enet | 19 | 0.44 | 2.6e-16 | -5.40 | -5.7 | 1.2e-08 | 0.61 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | IQGAP1 | 0.13 | 0.06 | enet | 19 | 0.11 | 9.2e-09 | -3.77 | -9.0 | 2.7e-19 | 0.55 | 0.39 | 0.43 | FALSE |
| 8 | GTEx | Colon Sigmoid | IQGAP1 | 0.18 | 0.16 | lasso | 7 | 0.15 | 6.6e-06 | -5.54 | -5.5 | 3.3e-08 | 0.63 | 0.76 | 0.19 | FALSE |
| 9 | GTEx | Colon Transverse | IQGAP1 | 0.23 | 0.15 | lasso | 2 | 0.10 | 1.4e-05 | -5.40 | -5.6 | 2.4e-08 | 0.63 | 0.72 | 0.20 | FALSE |
| 10 | GTEx | Colon Transverse | ZNF774 | 0.24 | 0.09 | lasso | 4 | 0.08 | 1.5e-04 | -4.60 | -5.6 | 1.9e-08 | 0.36 | 0.45 | 0.15 | FALSE |
| 11 | GTEx | Esophagus Gastroesophageal Junction | IQGAP1 | 0.11 | 0.15 | lasso | 3 | 0.14 | 7.9e-06 | -5.54 | -5.6 | 2.7e-08 | 0.64 | 0.56 | 0.24 | FALSE |
| 12 | GTEx | Esophagus Gastroesophageal Junction | ZNF774 | 0.16 | 0.16 | lasso | 2 | 0.11 | 7.8e-05 | -7.84 | -8.0 | 1.3e-15 | 0.75 | 0.36 | 0.26 | FALSE |
| 13 | GTEx | Esophagus Mucosa | IQGAP1 | 0.26 | 0.19 | enet | 39 | 0.21 | 2.3e-14 | -9.36 | -8.4 | 3.4e-17 | 0.73 | 0.02 | 0.98 | FALSE |
| 14 | GTEx | Esophagus Mucosa | CRTC3 | 0.08 | 0.07 | enet | 7 | 0.04 | 6.1e-04 | -7.74 | 7.9 | 2.0e-15 | -0.81 | 0.26 | 0.69 | FALSE |
| 15 | GTEx | Esophagus Muscularis | IQGAP1 | 0.24 | 0.14 | enet | 18 | 0.14 | 5.7e-09 | -5.40 | -6.7 | 2.8e-11 | 0.69 | 0.35 | 0.65 | FALSE |
| 16 | GTEx | Esophagus Muscularis | ZNF774 | 0.18 | 0.19 | lasso | 5 | 0.18 | 4.1e-11 | -7.14 | 7.4 | 1.1e-13 | -0.74 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Lung | ZNF774 | 0.06 | 0.09 | enet | 6 | 0.03 | 1.5e-03 | -7.84 | -6.2 | 5.0e-10 | 0.57 | 0.79 | 0.03 | FALSE |
| 18 | GTEx | Nerve Tibial | PRC1 | 0.11 | 0.00 | lasso | 2 | 0.00 | 7.8e-01 | -6.83 | -5.8 | 6.0e-09 | 0.53 | 0.09 | 0.05 | FALSE |
| 19 | GTEx | Ovary | IQGAP1 | 0.43 | 0.53 | lasso | 3 | 0.53 | 2.3e-15 | -5.40 | -5.5 | 4.5e-08 | 0.64 | 0.96 | 0.04 | FALSE |
| 20 | GTEx | Pituitary | IQGAP1 | 0.60 | 0.45 | enet | 26 | 0.52 | 3.7e-15 | -5.40 | -6.5 | 1.0e-10 | 0.67 | 0.94 | 0.06 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | CRTC3 | 0.10 | 0.08 | lasso | 3 | 0.05 | 7.5e-05 | -8.01 | 7.3 | 2.7e-13 | -0.73 | 0.51 | 0.47 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | FES | 0.09 | 0.04 | lasso | 5 | 0.04 | 1.4e-04 | -3.41 | 5.2 | 2.0e-07 | -0.13 | 0.14 | 0.42 | TRUE |
| 23 | GTEx | Small Intestine Terminal Ileum | IQGAP1 | 0.27 | 0.26 | lasso | 4 | 0.20 | 2.7e-05 | -5.40 | -5.4 | 6.7e-08 | 0.64 | 0.12 | 0.65 | FALSE |
| 24 | GTEx | Stomach | IQGAP1 | 0.21 | 0.14 | enet | 17 | 0.18 | 8.3e-09 | -9.36 | -8.1 | 6.2e-16 | 0.86 | 0.03 | 0.97 | FALSE |
| 25 | GTEx | Testis | IQGAP1 | 0.25 | 0.37 | lasso | 4 | 0.36 | 1.2e-16 | -5.54 | -5.4 | 6.9e-08 | 0.63 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Testis | ZNF774 | 0.13 | 0.09 | lasso | 4 | 0.08 | 1.5e-04 | -9.36 | 9.3 | 2.2e-20 | -0.99 | 0.01 | 0.99 | FALSE |
| 27 | GTEx | Thyroid | ZNF774 | 0.09 | 0.06 | enet | 9 | 0.05 | 6.0e-05 | -7.28 | -6.8 | 9.6e-12 | 0.65 | 0.36 | 0.07 | FALSE |
| 28 | GTEx | Thyroid | RP11-617F23.1 | 0.11 | 0.01 | lasso | 4 | 0.04 | 1.0e-03 | -6.83 | -6.4 | 1.6e-10 | 0.53 | 0.24 | 0.24 | FALSE |
| 29 | GTEx | Uterus | IQGAP1 | 0.29 | 0.16 | lasso | 5 | 0.13 | 1.3e-03 | -5.40 | -5.5 | 5.0e-08 | 0.64 | 0.08 | 0.72 | FALSE |
| 30 | GTEx | Vagina | IQGAP1 | 0.32 | 0.11 | lasso | 6 | 0.17 | 1.3e-04 | -9.36 | -8.4 | 6.1e-17 | 0.85 | 0.02 | 0.93 | FALSE |
| 31 | METSIM | Adipose | IQGAP1 | 0.11 | 0.08 | enet | 32 | 0.12 | 3.9e-17 | -8.07 | -10.0 | 1.7e-23 | 0.86 | 0.08 | 0.92 | FALSE |
| 32 | METSIM | Adipose | MAN2A2 | 0.04 | 0.00 | blup | 494 | 0.01 | 3.4e-03 | 0.61 | -5.2 | 1.8e-07 | 0.33 | 0.14 | 0.15 | FALSE |
| 33 | NTR | Blood | IQGAP1 | 0.03 | 0.04 | enet | 10 | 0.04 | 1.5e-12 | -8.02 | -8.1 | 4.1e-16 | 0.70 | 1.00 | 0.00 | FALSE |
| 34 | YFS | Blood | CRTC3 | 0.02 | 0.01 | blup | 503 | 0.01 | 4.2e-05 | -8.08 | 7.6 | 3.0e-14 | -0.75 | 0.46 | 0.53 | FALSE |
| 35 | YFS | Blood | IQGAP1 | 0.18 | 0.17 | enet | 46 | 0.20 | 5.8e-65 | -9.59 | -10.3 | 6.8e-25 | 0.91 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IQGAP1 | 0.04 | 0.03 | lasso | 4 | 0.02 | 6.5e-03 | -8.02 | -6.7 | 2.0e-11 | 0.62 | 0.12 | 0.13 | FALSE |
| 37 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQGAP1 | 0.03 | 0.02 | blup | 94 | 0.02 | 6.5e-05 | -9.50 | -9.6 | 5.0e-22 | 0.92 | 0.01 | 0.99 | FALSE |
| 38 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IQGAP1 | 0.15 | 0.09 | lasso | 4 | 0.12 | 1.9e-06 | -8.05 | -8.6 | 7.4e-18 | 0.81 | 0.12 | 0.86 | FALSE |
| 39 | The Cancer Genome Atlas | Glioblastoma Multiforme | IQGAP1 | 0.10 | -0.01 | blup | 95 | 0.02 | 1.0e-01 | -5.25 | -5.8 | 7.7e-09 | 0.64 | 0.08 | 0.22 | FALSE |
| 40 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IQGAP1 | 0.15 | 0.05 | enet | 10 | 0.08 | 2.5e-09 | -8.89 | -9.3 | 1.0e-20 | 0.88 | 0.01 | 0.99 | FALSE |
| 41 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IQGAP1 | 0.07 | 0.06 | blup | 94 | 0.07 | 9.5e-09 | -8.04 | -7.1 | 1.3e-12 | 0.70 | 0.96 | 0.04 | FALSE |
| 42 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF774 | 0.04 | 0.00 | enet | 7 | 0.01 | 5.1e-02 | -7.84 | -6.0 | 1.6e-09 | 0.75 | 0.01 | 0.78 | TRUE |
| 43 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IQGAP1 | 0.06 | 0.05 | blup | 94 | 0.04 | 2.6e-03 | -5.04 | -6.9 | 5.7e-12 | 0.71 | 0.12 | 0.56 | FALSE |
| 44 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CRTC3 | 0.03 | 0.01 | blup | 78 | 0.01 | 4.2e-02 | -4.58 | 6.1 | 8.1e-10 | -0.44 | 0.05 | 0.04 | FALSE |
| 45 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IQGAP1 | 0.05 | 0.04 | enet | 12 | 0.03 | 1.1e-04 | -5.23 | -7.5 | 5.8e-14 | 0.54 | 0.51 | 0.28 | FALSE |
| 46 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF774 | 0.06 | 0.06 | lasso | 3 | 0.04 | 1.2e-05 | -7.84 | 8.0 | 1.6e-15 | -0.77 | 0.07 | 0.92 | FALSE |
| 47 | The Cancer Genome Atlas | Lung Adenocarcinoma | IQGAP1 | 0.06 | 0.04 | blup | 94 | 0.03 | 5.8e-05 | -7.40 | -7.2 | 5.0e-13 | 0.63 | 0.82 | 0.10 | FALSE |
| 48 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQGAP1 | 0.02 | 0.02 | blup | 94 | 0.02 | 6.2e-03 | -9.45 | -9.1 | 7.3e-20 | 0.92 | 0.01 | 0.88 | FALSE |
| 49 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IQGAP1 | 0.40 | 0.06 | enet | 13 | 0.07 | 9.0e-04 | -7.14 | -6.4 | 1.6e-10 | 0.49 | 0.21 | 0.24 | FALSE |
| 50 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IQGAP1 | 0.11 | 0.03 | enet | 8 | 0.06 | 1.4e-06 | -8.89 | -10.8 | 3.1e-27 | 0.83 | 0.01 | 0.98 | TRUE |
| 51 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IQGAP1 | 0.12 | 0.07 | lasso | 4 | 0.07 | 1.4e-05 | -8.07 | -7.7 | 1.8e-14 | 0.77 | 0.48 | 0.49 | FALSE |
| 52 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IQGAP1 | 0.14 | 0.07 | lasso | 2 | 0.08 | 8.5e-04 | -3.59 | -5.2 | 2.0e-07 | 0.41 | 0.10 | 0.26 | FALSE |
| 53 | The Cancer Genome Atlas | Thyroid Carcinoma | IQGAP1 | 0.06 | 0.04 | blup | 95 | 0.08 | 3.0e-08 | -9.36 | -8.4 | 3.8e-17 | 0.85 | 0.04 | 0.96 | FALSE |