Best TWAS P=5.98e-11 · Best GWAS P=8.7e-11 conditioned to 0.173
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | POLI | 0.55 | 0.37 | lasso | 5 | 0.44 | 7.6e-40 | -6.4 | 5.4 | 5.5e-08 | -0.96 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | POLI | 0.36 | 0.34 | enet | 26 | 0.34 | 3.5e-18 | -6.4 | 5.3 | 1.2e-07 | -0.93 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | POLI | 0.26 | 0.23 | lasso | 6 | 0.23 | 5.4e-13 | -6.4 | 5.7 | 1.2e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Coronary | POLI | 0.54 | 0.18 | lasso | 30 | 0.13 | 4.1e-05 | -6.4 | 5.4 | 8.3e-08 | -0.89 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | POLI | 0.50 | 0.31 | lasso | 8 | 0.36 | 2.5e-29 | -6.4 | 6.0 | 2.4e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Brain Cerebellar Hemisphere | POLI | 0.48 | 0.38 | lasso | 7 | 0.34 | 1.3e-09 | -6.4 | 6.2 | 6.1e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Brain Cerebellum | POLI | 0.52 | 0.32 | lasso | 5 | 0.34 | 8.8e-11 | -6.4 | 5.9 | 3.9e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | POLI | 0.33 | 0.28 | lasso | 7 | 0.32 | 6.8e-17 | -6.4 | 5.6 | 2.4e-08 | -0.95 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Male) | POLI | 0.31 | 0.35 | lasso | 3 | 0.32 | 4.5e-08 | -6.4 | 6.4 | 2.0e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Cells EBV-transformed lymphocytes | POLI | 0.33 | 0.30 | lasso | 5 | 0.34 | 1.0e-11 | -6.4 | 5.9 | 2.7e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | POLI | 0.46 | 0.36 | enet | 18 | 0.36 | 9.9e-28 | -6.4 | 6.2 | 7.4e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Colon Transverse | POLI | 0.24 | 0.26 | lasso | 4 | 0.25 | 4.5e-12 | -6.4 | 6.1 | 1.2e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | POLI | 0.21 | 0.19 | lasso | 4 | 0.30 | 2.0e-11 | 3.3 | 5.3 | 1.2e-07 | -0.88 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Esophagus Mucosa | POLI | 0.42 | 0.26 | lasso | 5 | 0.29 | 1.2e-19 | -6.4 | 5.5 | 3.5e-08 | -0.96 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Esophagus Muscularis | POLI | 0.30 | 0.20 | lasso | 7 | 0.29 | 4.3e-18 | 3.2 | 5.1 | 3.0e-07 | -0.89 | 0.01 | 0.99 | FALSE |
| 16 | GTEx | Heart Atrial Appendage | POLI | 0.29 | 0.26 | enet | 12 | 0.28 | 3.8e-13 | -6.4 | 5.8 | 8.5e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Heart Left Ventricle | POLI | 0.12 | 0.09 | lasso | 10 | 0.10 | 6.7e-06 | -6.4 | 5.8 | 8.9e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Lung | POLI | 0.39 | 0.31 | lasso | 5 | 0.35 | 2.1e-27 | -6.5 | 6.0 | 1.4e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Muscle Skeletal | POLI | 0.30 | 0.13 | lasso | 12 | 0.13 | 1.2e-12 | -6.5 | 5.2 | 1.7e-07 | -0.94 | 0.00 | 1.00 | FALSE |
| 20 | GTEx | Spleen | POLI | 0.44 | 0.26 | lasso | 3 | 0.36 | 3.4e-10 | 3.2 | 5.3 | 1.3e-07 | -0.87 | 0.01 | 0.99 | FALSE |
| 21 | GTEx | Testis | POLI | 0.32 | 0.25 | lasso | 4 | 0.23 | 1.4e-10 | -6.4 | 6.2 | 7.3e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Thyroid | POLI | 0.47 | 0.37 | enet | 14 | 0.44 | 3.3e-36 | -6.4 | 5.7 | 1.4e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 23 | GTEx | Whole Blood | POLI | 0.05 | 0.04 | enet | 8 | 0.05 | 1.6e-05 | -6.4 | 5.9 | 4.0e-09 | -0.92 | 0.00 | 1.00 | FALSE |
| 24 | METSIM | Adipose | POLI | 0.23 | 0.27 | enet | 25 | 0.27 | 2.8e-40 | -6.4 | 5.8 | 5.9e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 25 | NTR | Blood | POLI | 0.09 | 0.05 | enet | 19 | 0.07 | 9.2e-22 | -6.4 | 5.3 | 1.1e-07 | -0.89 | 0.00 | 1.00 | FALSE |
| 26 | YFS | Blood | POLI | 0.05 | 0.05 | lasso | 3 | 0.05 | 1.1e-15 | -6.4 | 5.8 | 6.8e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 27 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | POLI | 0.18 | 0.12 | lasso | 3 | 0.11 | 8.2e-10 | -6.4 | 6.3 | 2.4e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POLI | 0.11 | 0.11 | lasso | 4 | 0.11 | 2.1e-22 | -6.5 | 6.3 | 3.5e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POLI | 0.16 | 0.13 | lasso | 3 | 0.13 | 2.0e-14 | -6.4 | 6.4 | 1.5e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | POLI | 0.18 | 0.16 | enet | 4 | 0.16 | 1.4e-17 | -6.4 | 6.2 | 5.0e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 31 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | POLI | 0.10 | 0.04 | blup | 43 | 0.05 | 8.4e-04 | -6.4 | 5.6 | 2.6e-08 | -0.93 | 0.00 | 0.98 | FALSE |
| 32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | POLI | 0.20 | 0.17 | lasso | 6 | 0.18 | 3.6e-20 | -6.5 | 5.8 | 7.6e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Lung Adenocarcinoma | POLI | 0.08 | 0.07 | blup | 43 | 0.08 | 7.1e-10 | -6.5 | 6.5 | 6.0e-11 | -0.90 | 0.00 | 1.00 | TRUE |
| 34 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | POLI | 0.11 | 0.07 | blup | 43 | 0.09 | 4.5e-10 | -6.4 | 5.7 | 1.3e-08 | -0.86 | 0.00 | 1.00 | FALSE |
| 35 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | POLI | 0.23 | 0.15 | lasso | 4 | 0.16 | 6.0e-11 | -6.4 | 6.2 | 4.2e-10 | -0.95 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POLI | 0.20 | 0.17 | lasso | 4 | 0.14 | 1.6e-06 | -6.4 | 6.5 | 9.7e-11 | -0.99 | 0.00 | 1.00 | FALSE |
| 37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLI | 0.16 | 0.17 | lasso | 7 | 0.17 | 3.5e-17 | -6.5 | 6.1 | 9.5e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Rectum Adenocarcinoma | POLI | 0.20 | 0.03 | blup | 43 | 0.05 | 3.3e-02 | -6.4 | 6.5 | 8.8e-11 | -0.79 | 0.00 | 0.60 | FALSE |
| 39 | The Cancer Genome Atlas | Soft Tissue Sarcoma | POLI | 0.10 | 0.07 | lasso | 2 | 0.06 | 2.7e-04 | -6.4 | 6.4 | 1.6e-10 | -1.00 | 0.00 | 0.98 | FALSE |
| 40 | The Cancer Genome Atlas | Stomach Adenocarcinoma | POLI | 0.13 | 0.11 | enet | 5 | 0.11 | 1.8e-08 | -6.4 | 6.2 | 5.9e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 41 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | POLI | 0.14 | 0.05 | lasso | 3 | 0.04 | 1.1e-02 | -6.4 | 6.1 | 9.1e-10 | -0.98 | 0.00 | 0.97 | FALSE |
| 42 | The Cancer Genome Atlas | Thyroid Carcinoma | POLI | 0.24 | 0.28 | lasso | 2 | 0.28 | 7.3e-27 | -6.5 | 6.4 | 1.3e-10 | -1.00 | 0.00 | 1.00 | FALSE |