Best TWAS P=1.83e-24 · Best GWAS P=7.92e-23 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | POGZ | 0.27 | 0.16 | enet | 23 | 0.21 | 5.3e-06 | -3.830 | -5.1 | 2.8e-07 | -0.02 | 0.64 | 0.03 | TRUE |
2 | GTEx | Colon Sigmoid | S100A11 | 0.18 | 0.13 | lasso | 3 | 0.14 | 1.1e-05 | 6.045 | 6.4 | 1.5e-10 | -0.08 | 0.22 | 0.04 | TRUE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LINGO4 | 0.15 | 0.03 | lasso | 4 | 0.05 | 8.9e-10 | 6.999 | 6.6 | 4.5e-11 | 0.02 | 0.96 | 0.00 | TRUE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | LINGO4 | 0.29 | 0.07 | enet | 15 | 0.07 | 8.3e-05 | 6.999 | 10.2 | 1.8e-24 | -0.28 | 0.06 | 0.12 | TRUE |
5 | The Cancer Genome Atlas | Glioblastoma Multiforme | TDRKH | 0.24 | 0.05 | blup | 49 | 0.05 | 1.0e-02 | 0.169 | 5.2 | 2.6e-07 | -0.46 | 0.01 | 0.36 | TRUE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LINGO4 | 0.24 | 0.07 | lasso | 4 | 0.11 | 1.7e-12 | 6.999 | 6.3 | 2.9e-10 | 0.03 | 0.98 | 0.00 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LINGO4 | 0.24 | 0.00 | enet | 10 | 0.09 | 9.5e-06 | 0.072 | 6.8 | 1.2e-11 | -0.08 | 0.02 | 0.04 | TRUE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SMCP | 0.26 | 0.05 | enet | 13 | 0.09 | 1.4e-10 | 0.932 | 6.2 | 4.7e-10 | -0.04 | 0.07 | 0.88 | TRUE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | LINGO4 | 0.20 | 0.07 | lasso | 4 | 0.07 | 3.7e-08 | 6.999 | 6.2 | 7.8e-10 | 0.00 | 1.00 | 0.00 | TRUE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LINGO4 | 0.32 | 0.09 | lasso | 8 | 0.13 | 3.3e-06 | 6.999 | 8.4 | 5.4e-17 | -0.21 | 0.07 | 0.28 | TRUE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LINGO4 | 0.53 | 0.20 | lasso | 4 | 0.23 | 1.1e-23 | 6.999 | 6.1 | 1.1e-09 | 0.04 | 1.00 | 0.00 | TRUE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | LINGO4 | 0.43 | 0.15 | lasso | 7 | 0.20 | 2.3e-19 | 6.999 | 6.3 | 3.0e-10 | 0.04 | 1.00 | 0.00 | FALSE |