TWAS
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Models
Genes
Traits
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Traits
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Bipolar Disorder or Schizophrenia
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chr2:207,747,657-209,182,548
Best TWAS P=1.21e-07 · Best GWAS P=1.8e-07 conditioned to 1
207.8M
208M
208.2M
208.4M
208.6M
208.8M
209M
209.2M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
METTL21A
0.10
0.11
enet
10
0.12
3.7e-15
5.2
-5.3
1.2e-07
-0.96
0.02
0.98
TRUE
3
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
CREB1
0.08
0.02
lasso
3
0.03
9.1e-05
5.0
5.3
1.3e-07
0.88
0.04
0.95
FALSE
1
CommonMind
Brain Pre-frontal Cortex
METTL21A
0.18
0.20
lasso
7
0.21
2.0e-25
5.1
-5.2
2.0e-07
-0.97
0.03
0.97
FALSE