Best TWAS P=1.68e-13 · Best GWAS P=7.34e-13 conditioned to 0.0946
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C2orf47 | 0.05 | 0.02 | blup | 361 | 0.02 | 4.3e-03 | 7.2 | -7.4 | 1.7e-13 | -0.86 | 0.01 | 0.99 | TRUE |
2 | GTEx | Cells Transformed fibroblasts | C2orf69 | 0.07 | 0.10 | enet | 17 | 0.10 | 2.7e-08 | 7.0 | 6.2 | 4.8e-10 | 0.92 | 0.01 | 0.99 | FALSE |
3 | GTEx | Spleen | KCTD18 | 0.26 | 0.03 | lasso | 4 | 0.04 | 3.8e-02 | 6.0 | 6.6 | 4.1e-11 | 0.85 | 0.10 | 0.43 | FALSE |
4 | GTEx | Testis | C2orf69 | 0.14 | 0.09 | enet | 17 | 0.10 | 2.7e-05 | 7.2 | 7.4 | 1.7e-13 | 0.93 | 0.02 | 0.98 | FALSE |
5 | GTEx | Whole Blood | C2orf47 | 0.04 | 0.05 | lasso | 2 | 0.03 | 3.6e-04 | 6.9 | 6.8 | 7.3e-12 | 0.99 | 0.02 | 0.97 | FALSE |
6 | METSIM | Adipose | C2orf69 | 0.04 | 0.03 | blup | 376 | 0.04 | 1.3e-06 | 5.4 | 6.2 | 6.3e-10 | 0.84 | 0.03 | 0.97 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf60 | 0.08 | 0.06 | enet | 11 | 0.06 | 1.4e-04 | 6.9 | -5.5 | 3.6e-08 | -0.91 | 0.01 | 0.94 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2orf69 | 0.02 | 0.00 | blup | 35 | 0.01 | 2.6e-02 | 3.7 | 5.8 | 8.8e-09 | 0.85 | 0.03 | 0.71 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C2orf60 | 0.06 | 0.02 | blup | 44 | 0.03 | 6.2e-04 | -2.3 | 5.4 | 7.3e-08 | 0.52 | 0.04 | 0.24 | FALSE |
10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2orf47 | 0.15 | 0.05 | blup | 39 | 0.05 | 7.6e-03 | 6.9 | -6.1 | 9.2e-10 | -0.93 | 0.00 | 0.97 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2orf60 | 0.15 | 0.05 | enet | 12 | 0.08 | 8.2e-04 | 6.9 | -5.5 | 3.3e-08 | -0.86 | 0.01 | 0.98 | FALSE |