Best TWAS P=1.11e-13 · Best GWAS P=1.05e-18 conditioned to 7.65e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | LRRFIP2 | 0.08 | 0.08 | lasso | 5 | 0.08 | 1.0e-06 | 4.3 | 6.1 | 9.2e-10 | -0.51 | 0.92 | 0.07 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | LRRFIP2 | 0.16 | -0.01 | enet | 19 | 0.01 | 2.1e-01 | 8.1 | 7.4 | 1.1e-13 | -0.31 | 0.07 | 0.28 | TRUE |
| 3 | GTEx | Colon Sigmoid | LRRFIP2 | 0.13 | 0.00 | lasso | 5 | 0.00 | 2.1e-01 | 3.9 | 5.6 | 2.4e-08 | -0.42 | 0.19 | 0.15 | FALSE |
| 4 | GTEx | Muscle Skeletal | LRRFIP2 | 0.11 | 0.10 | enet | 15 | 0.13 | 1.1e-12 | 4.1 | 5.3 | 9.1e-08 | -0.44 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Prostate | LRRFIP2 | 0.15 | -0.01 | enet | 20 | 0.00 | 3.5e-01 | 4.1 | 5.9 | 2.9e-09 | -0.44 | 0.12 | 0.09 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | TRANK1 | 0.05 | 0.05 | lasso | 4 | 0.02 | 4.1e-04 | -6.5 | -5.4 | 7.2e-08 | 0.64 | 0.36 | 0.53 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | AC011816.1 | 0.08 | 0.06 | enet | 13 | 0.08 | 3.5e-10 | -3.0 | 6.2 | 4.9e-10 | -0.25 | 0.91 | 0.09 | FALSE |