TWAS hub - TRANK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0280	1.7e-06	0.012	0.034	0.023	0.031	0.025	1.2e-02	5.1e-05	0.00071	9.7e-05	4.5e-04
2	GTEx	Artery Tibial	0.1009	0.0401	1.9e-03	-0.001	NA	0.020	NA	0.005	3.6e-01	NA	0.00990	NA	1.1e-01
3	METSIM	Adipose	0.0316	0.0144	1.8e-04	0.017	0.016	0.008	0.016	0.006	1.0e-03	1.3e-03	0.01900	1.4e-03	3.2e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.0510	0.0204	2.9e-04	0.049	0.014	0.021	0.017	0.024	5.9e-07	5.1e-03	0.00095	2.2e-03	4.1e-04
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0241	0.0135	3.2e-03	0.038	0.027	0.032	NA	0.036	3.8e-05	5.0e-04	0.00014	NA	5.4e-05
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0460	0.0250	2.7e-03	0.023	0.037	0.021	NA	0.025	1.6e-02	3.5e-03	0.02000	NA	1.4e-02
7	TCGA	Thyroid Carcinoma	0.0500	0.0280	7.1e-04	0.034	0.035	0.031	NA	0.028	2.8e-04	2.4e-04	0.00054	NA	9.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder or Schizophrenia	6.4	15.6	29.0	-2.6	0.8	4.0	-5.4	3.9	4.2	4.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.1	7.2	17.6	-4.2	-3.3	0.3	-1.3	-2.4	-2.7	-2.6
Schizophrenia (2018)	5.0	10.5	23.1	-1.0	1.5	2.9	-3.0	3.8	3.8	4.8
Schizophrenia (2014)	4.7	10.4	21.3	-1.0	0.3	3.0	-3.2	3.9	4.1	4.6
Bipolar Disorder (2018)	4.5	7.2	23.3	-2.8	-0.6	2.8	-4.8	1.6	2.0	2.1
Ever depressed for a whole week	4.5	5.5	12.5	2.0	1.4	1.3	1.1	3.0	3.5	2.9
Hypothyroidism/myxoedema (self-reported)	4.1	8.0	22.5	3.7	1.3	-4.7	4.0	0.2	-0.9	-1.0
Hypothyroidism (self reported)	3.7	8.5	21.3	4.0	1.9	-4.2	4.6	0.9	-0.0	-0.2
Other serious medical condition/disability diagnosed by doctor	3.6	4.7	13.3	0.3	-2.1	-3.6	0.1	-2.3	-2.5	-1.8
Medication: Levothyroxine sodium	3.1	5.2	13.0	3.5	0.7	-3.6	3.0	1.2	-0.0	-0.2
Bipolar Disorder (2011)	3.0	2.9	5.5	-1.0	1.1	0.9	-2.3	1.5	2.0	2.4
Ulcerative Colitis	2.7	3.9	8.8	-0.3	1.5	1.7	0.3	3.0	2.6	2.5
Had other major operations	2.7	3.3	11.1	2.4	0.1	-3.3	1.5	-0.8	-1.2	-1.5
Ever highly irritable/argumentative for 2 days	2.7	3.3	9.5	2.3	1.6	-0.6	3.1	1.9	1.1	0.9
Diabetes (mother)	2.6	3.4	11.1	1.9	1.1	-3.3	1.1	-0.7	-1.5	-1.8
Qualifications: CSEs or equivalent	2.6	3.4	6.9	-0.2	0.2	2.4	0.7	2.6	2.2	2.4
Heart disease (mother)	2.6	3.2	9.7	1.4	0.5	-2.5	3.1	-1.1	-1.1	-1.3
Medication: Gliclazide	2.6	2.9	8.6	2.0	0.6	-2.6	2.9	0.3	-0.5	-0.3
Maternal smoking around birth	2.5	3.6	8.1	2.4	2.8	0.3	1.9	1.8	1.8	1.3
Number of children fathered	2.5	2.9	6.9	0.5	-1.2	-1.9	0.2	-1.8	-2.1	-2.6
Falls in the last year	2.4	3.3	9.9	2.0	0.4	-2.2	3.1	-0.5	-1.3	-1.4
Had menopause	2.3	2.9	6.1	-0.6	-0.1	-1.8	-0.5	-2.5	-2.2	-2.3
Fluid intelligence score	2.3	4.8	9.8	-1.4	-0.6	-2.2	-1.2	-3.1	-2.8	-2.7
Trunk fat mass	2.2	9.3	18.4	4.2	3.7	-3.6	4.3	1.7	0.0	0.2
Suffer from ‘nerves’	2.2	3.5	6.0	0.4	1.5	2.2	-0.0	2.3	2.5	2.4
Trunk fat percentage	2.1	8.5	16.5	4.0	3.4	-3.7	4.1	1.4	-0.1	0.1
Overall health rating	2.1	4.4	10.4	3.2	1.5	-0.4	1.8	2.6	2.3	1.7
Mean Putamen Volume	2.0	2.3	8.1	2.9	-0.4	-1.0	1.6	1.4	1.3	0.6
Qualifications: None of the above	2.0	4.3	8.4	2.0	2.0	0.2	2.9	2.7	2.0	1.4
Birth weight of first child	2.0	3.6	7.3	1.3	1.5	0.9	-0.3	2.7	2.6	2.6
Qualifications: nursing, teaching	2.0	3.2	6.0	-0.5	-0.5	-1.3	-1.8	-2.4	-2.2	-2.4
Prospective memory result	1.9	2.3	6.8	1.0	-0.1	-2.6	1.6	-1.0	-1.2	-1.8
Long-standing illness, disability or infirmity	1.9	2.9	7.9	0.9	-0.1	-2.8	1.5	-1.6	-1.6	-2.2
Ulcerative Colitis (UC)	1.8	3.3	6.6	-1.0	0.3	2.6	-1.1	2.3	2.3	1.9
Verbal and Numeric Reasoning (VNR)	1.8	4.3	8.1	-1.1	-0.9	-2.2	-1.2	-2.8	-2.8	-2.4
Multivitamins +/- minerals	1.8	2.3	5.1	0.4	1.8	0.5	0.4	2.3	1.9	2.0
Number of full sisters	1.8	2.2	4.8	0.4	-1.4	-1.5	0.7	-1.4	-1.9	-2.2
Eye problems/disorders: Glaucoma	1.8	2.1	5.3	0.8	0.9	-2.3	1.3	-1.1	-1.8	-1.4
Number of operations (self-reported)	1.8	2.6	5.8	1.8	-0.7	-2.4	1.7	-1.1	-1.4	-1.6
Pulse wave reflection index	1.7	2.1	4.0	0.5	0.9	-1.9	-0.3	-1.8	-1.8	-2.0
Body fat percentage	1.7	6.7	13.1	3.4	3.1	-3.3	3.6	1.2	-0.4	-0.1
Whole body fat mass	1.7	7.2	14.6	3.6	3.3	-3.0	3.8	1.5	-0.2	0.0
Illnesses of father: None of the above (group 1)	1.7	2.1	4.7	0.6	1.0	0.5	-1.3	1.7	2.2	2.0
Wears glasses or contact lenses	1.7	1.9	4.6	1.7	2.2	-1.7	1.8	0.5	0.0	-0.1
Family relationship satisfaction	1.6	2.0	4.9	0.5	0.2	1.4	-0.1	2.2	1.8	1.9
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.0	-0.4	-1.7	2.2	-0.7	1.8	1.6	1.9
Intelligence (Savage-Jansen 2018)	1.5	4.7	9.4	-1.2	-1.5	-1.8	-2.0	-3.1	-2.7	-2.3
Arm fat mass (right)	1.5	6.0	12.0	3.3	2.9	-2.9	3.5	1.5	-0.1	0.2
High blood pressure (siblings)	1.5	2.1	5.1	2.3	-0.1	-2.2	2.1	0.0	-0.2	-0.6
Health satisfaction	1.5	1.9	3.9	2.0	1.7	-1.6	1.7	0.6	0.5	0.2
Eye problems/disorders: None of the above	1.5	1.7	2.8	0.6	-0.5	1.6	-1.3	1.7	1.6	1.4
Alzheimer’s Disease (in mother)	1.4	1.7	3.8	-1.7	-0.4	1.3	-2.0	1.1	0.4	1.3
HDL Cholesterol	1.4	2.3	6.6	-1.9	-2.6	1.2	-2.1	-0.6	-0.4	-0.2
Systolic blood pressure, automated reading	1.4	4.1	7.1	1.3	-0.1	-2.7	1.9	-2.2	-2.4	-2.4
Arm fat percentage (right)	1.4	5.5	10.2	3.2	2.8	-2.8	3.1	1.6	0.1	0.3
Hip circumference	1.4	6.0	13.6	3.3	2.9	-2.1	3.7	2.0	0.4	0.8
Age at first live birth	1.4	2.5	10.0	-2.0	-1.3	1.2	-3.2	-0.4	-0.2	-0.2
Medication: Ibuprofen	1.4	1.6	3.2	1.0	0.2	0.8	1.2	1.5	1.6	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	7.5	1.8	0.3	-0.7	2.7	0.5	0.3	0.1
Arm fat mass (left)	1.4	5.6	11.1	3.1	2.9	-2.6	3.3	1.6	-0.1	0.4
Breast Cancer	1.3	3.2	6.8	-2.1	-0.9	2.6	-1.4	1.1	1.8	1.9
Medication: Co-codamol	1.3	1.5	4.0	-0.1	-2.0	-1.6	0.5	-1.0	-1.2	-1.0
Weight	1.3	6.4	13.2	3.5	3.1	-2.7	3.6	1.7	-0.0	0.3
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	8.4	1.2	1.4	2.0	1.2	2.6	2.9	2.8
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	4.4	0.3	-0.3	1.2	0.5	1.9	1.4	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	6.9	0.2	1.8	2.3	0.6	2.4	2.6	2.6
Glaucoma (self-reported)	1.3	1.6	4.8	0.5	0.6	-2.2	1.0	-1.1	-1.4	-1.2
Leg pain on walking	1.3	1.6	6.9	1.5	0.2	-1.3	2.6	0.5	0.1	0.2
Arm fat percentage (left)	1.3	5.3	10.1	3.1	2.8	-2.6	3.2	1.6	0.0	0.5
Back pain experienced in last month	1.3	1.9	3.3	1.2	-1.7	0.7	1.8	1.4	1.4	1.1
Alcohol drinker status: Never	1.3	1.6	5.3	1.6	2.3	-1.1	0.6	-0.8	-0.7	-0.9
Average weekly beer plus cider intake	1.3	1.9	4.8	0.3	0.6	2.2	1.1	1.0	1.3	2.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.4	2.1	1.6	-1.1	1.3	0.3	0.9	0.1
Alzheimer’s Disease (including proxy)	1.2	1.8	5.9	-2.4	-0.7	1.8	-1.5	0.4	0.2	0.8
Systolic Blood Pressure	1.2	6.1	12.0	0.8	-0.7	-2.9	0.6	-3.5	-3.1	-3.4
Lung FVC	1.2	6.0	17.1	-1.5	-0.4	4.1	-0.8	2.3	2.8	3.0
Current tobacco smoking	1.2	1.9	7.0	2.6	0.7	-1.0	1.2	1.2	0.8	1.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.8	0.4	0.3	0.8	1.3	1.7	1.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	5.4	1.4	2.3	-0.2	1.6	1.9	1.7	1.2
Unable to work because of sickness or disability	1.2	1.6	4.0	2.0	-1.0	-1.5	1.4	1.1	0.7	0.6
Leg fat mass (left)	1.2	4.6	9.0	3.0	2.6	-2.4	3.0	1.3	-0.3	-0.0
Stomach or abdominal pain in last month	1.1	1.4	4.8	-0.8	0.3	2.2	-0.6	1.5	1.1	0.6
Chronic bronchitis/emphysema (father)	1.1	1.3	3.1	-0.4	0.7	-0.7	1.3	-1.3	-1.8	-1.3
Forced vital capacity (FVC)	1.1	4.1	7.9	0.3	1.3	2.5	0.7	2.4	2.6	2.8
Number of live births	1.1	1.6	10.3	0.2	0.5	0.3	3.2	0.4	-0.2	0.5
Leg fat mass (right)	1.1	4.2	8.5	2.6	2.9	-2.1	2.8	1.3	-0.3	-0.0
Knee pain experienced in last month	1.1	1.7	4.3	1.1	-0.7	-2.1	1.4	-1.3	-1.1	-1.0
Loneliness, isolation	1.1	1.5	3.5	0.3	1.9	0.5	1.1	1.7	1.2	1.0
Commuting to job workplace: Public transport	1.1	1.3	4.4	0.0	0.8	-1.1	0.1	-2.1	-1.0	-1.2
Schizophrenia vs Biploar Disorder	1.0	1.3	3.6	1.9	-0.6	-0.7	1.8	0.9	0.4	0.6
Coronary Artery Disease (CAD)	1.0	1.1	3.8	0.9	1.2	-1.2	1.9	0.1	-0.2	-0.5
Crohns Disease (2012)	1.0	1.6	4.8	0.2	0.7	-2.2	0.2	-1.1	-1.5	-1.5
Rheumatoid Arthritis	1.0	1.4	2.8	1.4	0.8	-0.5	1.7	1.5	0.9	0.9
Blood Platelet Count	1.0	11.1	27.2	0.2	0.6	2.8	0.7	5.2	4.6	4.5
Average weekly spirits intake	1.0	1.2	3.0	-1.7	0.3	1.6	-1.0	0.8	1.0	0.6
Hand grip strength (right)	1.0	2.8	4.8	1.6	1.6	2.2	0.9	1.9	1.7	1.6
Sitting height	1.0	7.2	12.1	3.0	2.7	-0.6	2.9	3.5	2.6	2.6
Waist circumference	1.0	3.6	6.9	2.4	2.2	-2.6	2.6	0.5	-0.7	-0.3
Noisy workplace	1.0	1.2	2.3	-0.2	-1.1	1.4	0.6	1.5	1.5	0.7
Peak expiratory flow (PEF)	1.0	2.3	4.4	0.9	2.1	1.1	0.9	1.7	2.0	1.5
Qualifications: College or University degree	1.0	3.3	15.8	-1.0	-1.1	-1.1	-4.0	-1.7	-0.9	-0.6
Neck or shoulder pain in last month	1.0	1.4	2.0	-0.8	-1.4	1.2	-1.1	-1.4	-1.1	-1.0
Illnesses of siblings: Diabetes	1.0	1.2	3.8	1.6	0.7	-2.0	1.2	0.4	-0.1	-0.3
Illnesses of father: High blood pressure	1.0	1.2	2.5	1.1	-1.4	-1.0	1.6	-0.7	-0.9	-0.7
Risk taking	1.0	1.4	4.2	-1.2	-0.6	1.4	-2.0	0.5	0.6	1.1
Alzheimer’s Disease (in father)	0.9	0.9	2.7	-1.6	-0.3	1.6	-0.8	0.0	0.7	0.4
Triglycerides	0.9	1.5	2.7	0.5	1.6	-1.5	-0.4	-0.9	-1.4	-1.5
Respiratory disease	0.9	1.9	4.7	-1.7	0.5	2.2	-1.8	1.0	1.0	0.4
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.6	0.6	0.4	-1.9	1.8	-1.1	-1.4	-1.1
Leg fat-free mass (left)	0.9	4.7	9.6	2.9	2.8	-2.0	3.1	1.6	0.5	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	6.0	0.9	-0.5	-1.0	2.4	-0.0	-0.7	-0.5
Relative age voice broke	0.9	1.4	3.4	1.0	1.1	0.4	0.2	1.4	1.8	1.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.9	-1.2	0.2	1.7	0.6	0.3	0.8	1.4
Leg predicted mass (left)	0.9	4.9	9.8	2.9	2.9	-2.0	3.1	1.6	0.5	0.8
Financial difficulties in last 2 years	0.9	1.2	2.3	1.2	1.1	-0.2	1.4	1.5	1.0	0.8
Illnesses of siblings	0.9	1.3	3.8	-1.3	0.3	1.7	-1.9	-0.1	0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.6	0.1	-0.6	-0.3	-0.6	1.3	1.1	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.4	1.5	0.4	-0.1	-0.2	1.8	1.2	1.6
Forced vital capacity (FVC), Best measure	0.9	3.4	6.4	-0.2	1.8	2.3	0.4	2.1	2.2	2.5
Comparative body size at age 10	0.9	2.5	7.8	-1.0	-1.7	2.0	-2.8	0.7	0.9	0.8
Leg fat-free mass (right)	0.9	4.6	9.3	3.0	2.4	-2.0	3.0	1.8	0.6	0.9
Commuting to job workplace: Walk	0.9	1.0	3.1	1.8	0.3	-1.5	0.7	-0.2	-0.4	-0.7
Leg predicted mass (right)	0.9	4.9	9.8	3.1	2.5	-2.1	3.1	1.7	0.6	0.9
Ever taken oral contraceptive pill	0.9	1.0	2.5	0.7	0.8	-0.0	0.9	1.6	1.2	1.1
Commuting to job workplace: Cycle	0.9	1.1	3.0	-0.6	-0.1	0.9	-1.0	0.9	1.4	1.7
Age at First Birth	0.8	1.2	2.2	-1.5	-1.1	1.3	-0.9	-1.1	-0.9	-0.9
Lupus	0.8	1.2	3.5	-0.2	-0.2	1.1	-0.1	1.6	1.2	1.9
Height	0.8	15.4	36.8	6.1	3.1	-5.1	5.8	1.3	0.2	-0.5
Time employed in main current job	0.8	0.9	1.7	-1.1	-0.5	0.7	-1.3	-1.1	-0.7	-0.9
Mouth/teeth dental problems: Dentures	0.8	1.3	2.9	1.7	0.4	-0.9	1.5	-1.1	-0.7	-1.2
Standing height	0.8	8.4	20.9	4.6	3.1	-3.4	3.6	1.6	0.9	0.5
Exposure to tobacco smoke at home	0.8	0.9	3.3	1.1	1.8	-0.7	0.7	-0.7	-0.1	0.2
Breastfed as a baby	0.8	1.0	5.1	0.0	0.3	0.6	-2.2	0.2	0.3	1.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.5	-1.7	-0.6	1.2	-1.9	-0.9	-0.4	-0.0
Comparative height size at age 10	0.8	4.7	14.2	3.8	1.8	-2.1	2.5	1.7	1.2	0.8
Medication: Aspirin	0.8	1.0	3.1	0.7	-1.3	-0.9	1.8	-0.5	-0.5	-0.6
Average weekly red wine intake	0.8	1.2	2.8	-0.8	-0.6	-0.2	-0.5	-1.3	-1.7	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	-0.0	-0.4	-0.8	0.2	-1.4	-1.4	-1.3
Osteoarthritis (self-reported)	0.8	1.0	2.8	-0.0	-0.9	-0.8	1.2	-1.7	-1.0	-0.7
Guilty feelings	0.8	1.2	2.9	-0.5	0.2	1.7	0.9	1.0	1.1	1.6
Basal metabolic rate	0.8	4.2	9.5	2.8	2.5	-2.0	3.1	1.2	0.2	0.3
Pain experienced in last month	0.8	1.3	4.6	-1.7	1.0	0.7	-2.1	-0.1	0.1	0.4
Irritable Bowel Disease (IBD)	0.7	1.6	3.9	-0.1	0.8	1.1	0.1	2.0	1.9	1.2
Relative age of first facial hair	0.7	1.5	2.8	0.7	0.3	-0.4	1.5	1.6	1.7	1.3
Vitamin and mineral supplements	0.7	1.0	2.2	-0.7	-1.2	0.5	-0.7	-1.5	-1.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.1	-0.3	1.3	1.3	-0.3	1.7	1.8	1.0
Mouth/teeth dental problems	0.7	1.1	2.6	-1.2	0.8	-1.2	-1.6	-0.9	-0.7	-0.5
Medication: Paracetamol	0.7	1.1	5.1	0.5	0.0	-1.3	2.3	-0.1	-0.6	-0.5
Medication: Amlodipine	0.7	0.9	2.8	1.7	0.7	-0.3	1.7	-0.3	0.4	-0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.2	1.0	-1.5	-0.5	1.5	0.3	0.1	-0.1
Eye problems/disorders: Cataract	0.7	0.8	1.7	-0.6	0.9	-0.3	0.1	-1.3	-1.0	-1.2
Asthma (self-reported)	0.7	1.4	3.1	-1.3	1.5	1.2	-1.8	0.9	0.6	0.6
Medication: Aspirin	0.7	0.9	3.7	0.9	-0.8	-1.0	1.9	-0.3	-0.3	-0.3
Smoking status: Current	0.7	1.1	4.5	2.1	0.2	-0.6	0.8	0.9	0.7	1.1
Medication: Atorvastatin	0.7	0.9	2.6	0.4	-0.5	-1.1	-0.0	-1.6	-0.9	-1.1
Leg fat percentage (left)	0.7	2.6	4.7	2.2	1.8	-2.1	2.1	0.6	-0.8	-0.6
Prostate Cancer	0.6	0.9	4.1	-0.6	-0.2	0.3	-2.0	-0.9	-0.1	-0.9
Lung FEV1/FVC ratio	0.6	3.2	7.7	2.8	2.5	-2.3	1.6	-0.2	-0.3	-0.5
Number of treatments/medications taken	0.6	1.0	3.1	0.9	0.2	-1.8	1.7	0.3	0.4	0.2
Sensitivity / hurt feelings	0.6	1.0	3.0	-0.8	-0.1	0.8	-0.2	1.0	1.3	1.7
Ever had hysterectomy (womb removed)	0.6	0.7	3.6	0.4	0.5	0.8	1.9	0.3	0.2	0.5
Severe depression (siblings)	0.6	0.7	2.2	-0.4	-0.2	0.6	-1.5	0.5	0.9	0.9
Heart attack	0.6	0.8	2.2	1.1	0.1	-0.1	1.5	1.0	0.9	0.5
Happiness	0.6	0.8	2.7	-0.6	0.2	0.7	-1.6	1.1	0.3	0.7
Asthma	0.6	1.1	3.6	-1.3	1.2	0.9	-1.9	0.6	0.3	0.3
Length of working week for main job	0.6	0.6	1.5	-0.4	-0.5	-1.2	0.2	-0.8	-1.0	-0.8
Tense / ‘highly strung’	0.6	1.0	2.8	-0.9	0.2	-0.6	-0.5	-1.7	-1.3	-0.8
Leg fat percentage (right)	0.6	2.3	5.5	1.7	2.4	-1.7	2.0	0.6	-0.7	-0.6
Exposure to tobacco smoke outside home	0.6	0.9	2.4	1.5	0.7	-0.2	0.7	0.7	1.1	0.9
Whole body fat-free mass	0.6	3.4	8.0	2.4	2.4	-1.8	2.8	1.0	0.2	0.3
Mood swings	0.6	1.1	2.1	-0.0	0.9	1.0	0.3	1.3	1.4	1.4
Osteoporosis (self-reported)	0.6	0.8	1.8	0.7	-0.2	-1.3	0.4	-0.4	-1.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.5	-2.3	0.2	1.9	0.1	-0.0	0.1	0.5
Whole body water mass	0.6	3.5	8.0	2.5	2.4	-1.8	2.8	1.1	0.3	0.4
Average weekly champagne plus white wine intake	0.6	0.8	3.0	-1.0	0.2	-0.1	-1.7	-1.2	-0.5	-0.4
Arm fat-free mass (left)	0.6	3.2	9.1	2.3	2.0	-1.9	3.0	0.8	-0.2	0.0
Fractured/broken bones in last 5 years	0.6	0.7	1.6	0.7	0.7	-1.3	0.9	-0.7	-0.7	-0.8
Cholesterol lowering medication	0.6	0.9	2.0	0.8	-0.5	0.4	0.8	1.1	1.0	1.4
Supplements: Calcium	0.6	0.7	2.0	-0.3	-0.5	0.6	0.2	1.4	0.8	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.4	1.0	0.5	-1.6	0.9	-0.5	-0.4	-0.4
Arm predicted mass (left)	0.6	3.1	8.2	2.3	2.0	-1.8	2.9	0.7	-0.2	-0.1
Depression (Nagel 2018)	0.5	0.8	1.7	-0.7	-1.1	-1.2	0.3	-0.3	-1.3	-0.9
Worry (Nagel 2018)	0.5	1.0	2.0	-0.2	-0.0	1.3	-0.7	1.3	1.2	1.4
Body Mass Index (BMI) (2010)	0.5	0.6	1.3	0.2	0.9	-0.5	0.8	1.0	0.5	1.2
Primary Biliary Cirrhosis	0.5	0.8	1.6	-1.0	-1.3	-0.6	-0.7	-0.7	-0.9	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.6	-0.6	0.5	-1.1	0.2	-0.3	-1.3	-0.8
BMI	0.5	2.7	7.6	1.6	1.9	-1.9	2.8	0.1	-1.0	-0.3
Chronotype (morning person)	0.5	1.2	2.1	0.6	1.4	-0.8	1.4	-0.9	-0.5	-1.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	-1.6	-0.8	0.6	-0.5	0.6	0.2	0.7
Angina	0.5	0.7	1.7	0.2	-1.2	1.3	0.2	0.2	0.8	0.9
Diabetes (father)	0.5	0.6	1.6	0.9	-1.0	-0.6	1.3	0.4	-0.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.4	-1.3	1.0	0.7	-0.4	-0.7	0.1
Medication: Atenolol	0.5	0.6	2.2	-1.5	-0.4	1.1	0.5	-0.4	0.2	-0.3
High blood pressure (mother)	0.5	0.8	2.0	1.4	0.1	-0.7	0.3	0.8	1.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.1	0.5	1.4	0.5	-0.5	1.4	1.5	1.1
Neuroticism score	0.5	0.9	1.9	-0.6	0.9	1.2	0.7	1.0	0.7	1.4
Trunk fat-free mass	0.5	2.7	6.8	2.1	2.3	-1.6	2.6	0.5	-0.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	4.4	-1.3	0.1	0.6	-2.1	-0.7	-0.1	0.3
Depression (self-reported)	0.5	0.6	1.9	-0.1	0.5	1.1	-0.0	1.4	0.7	0.7
Pulse wave Arterial Stiffness index	0.5	0.5	1.0	0.7	0.2	-1.0	0.0	-0.9	-0.9	-0.9
Trunk predicted mass	0.5	2.7	6.7	2.0	2.3	-1.5	2.6	0.6	0.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.4	1.1	0.2	-0.3	1.0	1.0	1.2
Shortness of breath walking on level ground	0.5	0.6	2.2	0.5	0.2	-1.5	0.0	-0.6	-1.1	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	4.7	-0.5	0.5	0.4	-2.2	-0.9	-0.2	-0.2
Angina (self-reported)	0.5	0.7	1.9	0.2	-1.2	1.4	0.5	0.3	0.8	0.8
Friendships satisfaction	0.5	0.6	1.6	-0.2	1.1	0.2	0.1	1.3	0.8	0.9
Medication: Bendroflumethiazide	0.5	0.8	2.4	-0.3	-0.6	-0.6	0.6	-1.6	-1.0	-1.1
Medication: Paracetamol	0.5	0.7	3.5	0.6	0.7	-0.9	1.9	-0.1	0.0	-0.2
Age started oral contraceptive pill	0.5	0.7	1.9	-1.1	1.4	-0.2	0.3	0.5	0.3	1.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.7	1.1	-0.1	-0.1	1.3	1.0	0.8	0.5
Ovarian Cancer	0.4	0.5	2.1	-0.8	0.7	0.3	-1.4	-0.3	-0.0	-0.1
Fasting Glucose	0.4	0.5	1.1	-0.2	-0.9	-0.6	-1.1	-0.5	-0.9	0.5
LDL Cholesterol	0.4	0.7	2.1	1.5	0.7	-0.7	0.2	0.9	0.8	0.3
Blood White Count	0.4	2.6	4.9	-1.6	-0.5	2.2	0.7	2.0	1.8	1.8
Heel T-Score	0.4	3.2	10.3	-2.2	1.6	1.7	-3.2	-1.1	-0.3	-0.6
Neuroticism	0.4	1.1	2.8	-1.2	0.4	1.4	0.6	0.7	0.5	1.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.6	-1.1	-0.0	0.2	-0.4	-0.6	-1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.7	-0.1	-0.5	-0.9	1.3	-0.1	-0.3	-0.1
Townsend deprivation index at recruitment	0.4	0.6	1.8	1.4	-0.2	0.0	0.5	0.4	1.1	0.7
Average weekly fortified wine intake	0.4	0.5	1.4	-0.4	-0.1	-0.9	-0.5	-0.7	-0.8	-1.2
Body mass index (BMI)	0.4	1.9	4.6	1.6	1.8	-1.3	2.1	1.1	-0.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.1	-1.5	0.3	0.7	-0.4	0.5	0.1	0.3
Impedance of arm (right)	0.4	1.6	5.1	2.3	1.1	-1.7	0.4	0.9	1.0	0.5
Father’s age at death	0.4	0.6	1.2	-1.1	0.4	-0.7	-1.1	-0.6	-0.6	-0.5
Worrier / anxious feelings	0.4	0.7	1.4	0.0	-1.2	0.9	-0.2	0.9	0.8	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-0.7	-0.1	0.7	0.2	1.1	1.1	0.8
Medication: Cholesterol lowering	0.4	0.6	1.2	0.3	0.8	-1.0	0.2	-1.1	-0.6	-0.7
Lung cancer (father)	0.4	0.5	1.1	-0.4	0.9	0.0	-0.2	-0.8	-1.1	-0.9
Loud music exposure frequency	0.4	0.4	1.2	0.5	-0.3	-0.7	1.1	0.3	0.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	-0.3	-1.0	1.1	-0.2	0.9	0.2	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.5	-0.9	1.3	0.3	0.4	0.4	-0.5
Birth weight	0.4	0.9	3.8	0.8	1.9	0.5	1.2	-0.0	-0.4	0.1
Arm fat-free mass (right)	0.4	2.1	7.0	1.5	1.7	-1.4	2.6	0.4	-0.4	-0.1
Emphysema/chronic bronchitis	0.4	0.4	1.2	-0.9	-0.2	-0.2	-0.5	0.5	0.6	1.1
Medication: Blood pressure	0.4	0.6	2.1	0.4	-0.4	-1.4	0.7	-1.0	0.0	-0.7
Medication: Omeprazole	0.4	0.5	1.3	-0.6	-1.1	0.5	-0.0	-0.6	-0.7	-0.8
Medication: Seretide 50 evohaler	0.4	0.5	1.4	0.1	0.4	0.9	-0.3	1.2	0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	0.2	0.9	0.8	0.6	0.7	1.1	0.3
Arm predicted mass (right)	0.4	2.2	6.4	1.5	2.1	-1.4	2.5	0.5	-0.4	0.0
Alcohol intake frequency.	0.4	0.8	3.2	1.0	0.9	0.1	1.8	0.9	0.4	-0.1
Had major operations	0.4	0.5	1.3	0.8	0.4	-0.9	1.1	-0.4	-0.5	-0.6
Supplements: Vitamin C	0.4	0.5	2.5	0.3	1.6	-0.4	-0.7	0.1	-0.1	-0.0
Illnesses of father: Heart disease	0.4	0.6	0.9	-0.9	-0.9	0.7	0.1	-0.6	-0.9	-0.8
Diabetes diagnosed by doctor	0.4	0.6	2.0	-0.1	-0.5	-1.4	0.7	-0.5	-1.0	-0.7
Mother’s age at death	0.4	0.5	1.2	-1.1	-0.3	-0.2	-1.0	-0.7	-0.7	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.1	0.5	1.0	-1.4	0.3	-0.5	0.0	-0.7
Myopia	0.4	0.6	1.9	1.0	-1.4	0.1	0.1	0.2	0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.5	0.2	-0.1	0.4	-1.0	-0.9	-0.9
Alcohol drinker status: Previous	0.4	0.5	1.6	0.5	0.7	-0.7	1.3	0.7	-0.0	-0.2
Pack years of smoking	0.4	0.6	1.4	0.4	1.2	0.6	1.2	0.1	0.0	-0.9
Reaction Time	0.3	0.5	0.9	-0.4	-0.5	0.9	-0.6	0.7	1.0	0.9
Blood Eosinophil Count	0.3	2.6	5.8	-1.1	2.4	2.0	-1.2	1.5	1.6	1.1
Waist Hip Ratio (WHR)	0.3	1.2	2.0	-0.6	0.6	-1.1	-1.4	-1.4	-1.0	-1.2
Smoking Status	0.3	0.7	1.8	1.4	0.7	-0.6	0.3	0.7	0.6	1.2
Cardiovascular Disease	0.3	0.9	1.9	-0.0	0.3	-0.7	1.4	-1.3	-1.0	-0.8
Hearing difficulty/problems: Yes	0.3	0.5	3.4	0.2	0.1	-0.1	1.8	0.0	0.0	-0.0
Supplements: Zinc	0.3	0.3	1.0	-1.0	-0.3	0.7	-0.5	0.4	0.0	-0.3
Pack years adult smoking proportion	0.3	0.5	1.5	0.8	0.9	0.3	1.2	0.4	0.2	-0.6
Fed-up feelings	0.3	0.6	1.7	-0.3	0.5	1.1	1.0	1.3	0.2	0.4
Age when periods started (menarche)	0.3	0.8	2.0	0.8	0.7	-1.0	1.4	-0.6	-0.7	-0.5
Supplements: Glucosamine	0.3	0.3	0.8	-0.9	-0.2	-0.1	0.2	0.5	0.6	0.9
Nervous feelings	0.3	0.5	0.8	0.5	0.8	0.9	0.2	0.8	0.7	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.5	0.7	1.1	0.4	0.6	0.4	1.0
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.3	-0.5	-0.3	0.8	-1.0	-0.7	-1.0
Medication: Ramipril	0.3	0.4	1.3	-0.1	-1.1	-1.1	-0.5	-0.5	-0.3	-0.3
Medication: Lansoprazole	0.3	0.3	1.2	-1.1	-0.4	0.3	-0.4	0.2	-0.5	-0.5
Illnesses of mother	0.3	0.4	1.1	-0.4	-0.3	1.1	-1.0	-0.3	-0.2	-0.2
Hair/balding pattern: Pattern 4	0.3	0.8	1.9	-0.5	-1.4	-0.3	-1.0	-1.4	-0.4	-0.6
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.3	0.4	-0.3	0.1	-0.9	-0.9	-1.0
Headache pain in last month	0.3	0.5	1.2	1.1	-1.0	-0.1	0.6	0.6	0.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.7	-0.2	0.3	1.3	-0.3	1.1	0.2	0.6
Gout (self-reported)	0.3	0.4	1.9	0.4	-0.2	-0.4	1.4	-0.3	-0.5	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.9	0.5	0.3	-0.2	1.4	0.3	0.3	-0.5
Worry too long after embarrassment	0.3	0.5	1.8	0.7	-0.3	-0.2	0.9	0.5	0.5	1.4
Pulse wave peak to peak time	0.3	0.4	0.6	-0.5	0.1	0.8	0.1	0.8	0.8	0.8
Age at last live birth	0.3	0.4	2.2	-0.4	0.2	0.5	-1.5	-0.2	-0.3	-0.4
Breast cancer (self-reported)	0.3	0.4	1.2	0.4	0.1	-1.1	-0.1	-0.5	-0.7	-0.8
Hearing aid user	0.3	0.4	1.6	0.3	-0.1	-0.4	1.2	-0.2	-0.2	-0.9
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	-1.0	0.5	1.0	-0.0	0.4	0.4	-0.0
Medication: Blood pressure	0.3	0.6	1.2	-1.0	-1.1	0.3	0.2	-0.8	-0.7	-0.9
Medication: Lisinopril	0.3	0.3	0.8	-0.5	0.8	0.8	0.1	0.1	0.9	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	-0.7	-1.0	0.5	-0.4	-0.1	-0.5	-0.4
Heart disease (siblings)	0.3	0.4	0.8	-0.1	0.1	-0.9	0.8	-0.6	-0.5	-0.6
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.6	0.8	0.3	0.9	0.9	0.1	0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.1	-0.6	0.4	0.7	0.1	1.0	0.6	0.8
Crohns Disease (2017)	0.2	0.4	1.2	0.6	0.6	-1.1	0.8	0.2	0.1	-0.4
Hand grip strength (left)	0.2	0.6	2.2	1.5	0.9	0.6	-0.0	0.5	0.5	0.2
Medication: Metformin	0.2	0.3	1.0	0.2	0.6	-1.0	0.7	0.0	-0.2	-0.3
Taking other prescription medications	0.2	0.3	1.2	-0.4	-0.6	-1.1	0.0	0.4	-0.5	0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.9	-0.9	0.1	0.0	0.2	0.4	0.0	0.5
High blood pressure	0.2	0.4	1.2	-0.6	-0.3	-0.2	1.1	-0.9	-0.5	-0.5
Number of incorrect matches in round	0.2	0.3	0.6	-0.3	0.8	-0.3	-0.7	-0.8	-0.3	0.2
Diabetes (self-reported)	0.2	0.4	1.1	-0.0	-0.2	-1.0	0.9	-0.3	-0.5	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	1.1	-0.8	-1.1	0.3	0.3	-0.5	0.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	2.2	0.2	-0.1	0.5	1.5	-0.1	-0.1	-0.4
Pulse rate	0.2	0.3	1.1	-0.5	-1.0	-0.3	0.3	-0.5	-0.5	-0.6
Impedance of arm (left)	0.2	1.1	3.5	1.9	0.7	-1.3	0.5	0.9	0.8	0.7
Number of full brothers	0.2	0.3	0.6	-0.1	-0.0	-0.5	-0.7	-0.5	-0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	-0.1	0.0	0.5	-0.9	-0.3	0.4	0.6
Migraine (self-reported)	0.2	0.3	1.0	-0.8	-0.2	1.0	-0.0	0.1	0.3	0.2
Medication: Allopurinol	0.2	0.3	1.1	-0.5	-0.3	1.0	0.4	0.2	-0.3	0.5
Pulse rate, automated reading	0.2	0.7	2.9	-0.0	-1.7	-0.4	0.4	-0.0	-1.0	-0.6
Chest pain or discomfort	0.2	0.2	0.7	-0.4	0.9	0.1	-0.8	0.1	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.3	-0.0	0.1	0.7	0.8	0.3	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.9	0.3	-0.4	-0.4	0.4	-0.0	-0.2	-1.0
Ever had bowel cancer screening	0.2	0.2	0.9	-0.2	0.1	0.3	0.1	-0.7	-0.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.0	-0.3	-0.2	1.0	-0.1	0.4	0.3	0.3
Medication for cholesterol	0.2	0.3	1.3	0.2	1.2	0.1	-0.9	0.0	0.3	0.2
Mineral and other dietary supplements	0.2	0.3	1.2	0.2	-0.8	1.1	-0.1	0.6	0.2	0.4
Number of self-reported non-cancer illnesses	0.2	0.4	2.4	0.1	-0.2	-1.5	0.1	0.1	-0.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.0	-0.6	0.5	0.8	0.1	0.2	0.5
High cholesterol (Self-reported)	0.2	0.4	1.3	0.5	-0.1	-0.9	0.1	-1.2	-0.6	-0.4
Ever smoked	0.2	0.3	1.2	-0.2	-0.1	0.4	-1.1	0.1	0.4	0.6
Irritability	0.2	0.4	1.3	-1.1	-0.3	0.3	0.2	-0.6	-0.8	-0.3
Diastolic blood pressure, automated reading	0.2	0.7	1.5	-1.0	-0.7	1.2	-1.0	0.6	0.2	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.4	0.6	1.2	-0.1	-1.0	0.6	0.3	0.0
Major Depression (MDD)	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.2	-0.2	-0.5	-0.1
HbA1C	0.1	0.1	0.3	0.1	0.2	-0.3	-0.2	0.0	-0.0	0.5
Neuroticism (2016)	0.1	0.2	0.4	-0.2	-0.4	0.6	-0.6	-0.0	0.1	0.5
Tanning	0.1	0.6	1.5	-1.0	1.2	1.2	-0.3	-0.1	0.1	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.3	0.2	0.2	-0.1	-0.0	-0.4	-0.6	-0.4
Impedance of leg (right)	0.1	0.3	0.7	-0.7	-0.3	0.6	-0.8	-0.6	0.1	-0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.3	-0.3	-0.6	-0.3	0.1	-0.1	0.1
Impedance of leg (left)	0.1	0.3	1.3	-0.1	-1.1	0.2	-0.7	-0.4	0.2	-0.5
Past tobacco smoking	0.1	0.1	0.4	0.0	-0.1	-0.1	0.2	-0.1	-0.4	-0.6
Alcohol usually taken with meals	0.1	0.2	0.6	0.3	0.6	-0.3	0.4	-0.8	-0.3	-0.2
Hair/balding pattern: Pattern 2	0.1	0.2	1.0	-0.1	-0.3	1.0	0.0	0.2	0.2	-0.0
Allergy	0.1	0.3	0.6	0.5	-0.8	-0.5	0.8	-0.7	-0.4	-0.3
Pain all over the body in last month	0.1	0.1	0.3	-0.1	0.2	-0.5	0.3	-0.1	0.2	-0.4
Medication: Simvastatin	0.1	0.1	0.2	-0.1	0.3	-0.3	0.3	-0.4	-0.4	0.1
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.2	0.3	0.0	-0.6	0.4	0.0	-0.2
Mean time to correctly identify matches	0.1	0.2	0.4	-0.5	0.1	0.5	-0.4	-0.0	0.6	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	0.4	0.6	-0.1	0.8	-0.0	-0.1	-0.1
Hypertension (Self-reported)	0.1	0.4	1.0	-0.6	-0.8	-0.1	1.0	-0.8	-0.3	-0.3
Smoking status: Previous	0.1	0.2	0.4	0.1	0.6	-0.0	0.4	0.2	0.5	0.6
Miserableness	0.1	0.2	1.0	-0.0	0.6	0.3	1.0	-0.1	-0.1	-0.1
Financial situation satisfaction	0.1	0.1	0.4	0.1	0.5	0.1	-0.0	0.5	0.1	0.6
Impedance of whole body	0.1	0.4	1.3	1.1	-0.1	-0.9	0.1	0.4	0.4	0.2
Blood Red Count	0.0	0.3	0.7	0.7	0.5	0.5	0.6	0.9	0.3	0.2
Allergy or Eczema	0.0	0.1	0.5	-0.1	0.2	0.7	-0.2	-0.1	-0.2	-0.4
Hair Pigment	0.0	0.2	0.5	-0.2	0.1	-0.0	0.4	-0.2	-0.7	-0.6
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.1	0.5	0.4	-0.4	0.2	0.1	-0.0

Hub : Genes

TRANK1

Models

Trait associations