Best TWAS P=3.5e-11 · Best GWAS P=1.02e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | HIST2H2BF | 0.07 | 0.05 | lasso | 5 | 0.05 | 8.9e-05 | -5.6 | -6.0 | 2.7e-09 | 0.86 | 0.12 | 0.82 | FALSE |
2 | GTEx | Colon Transverse | CTSS | 0.10 | 0.15 | lasso | 4 | 0.16 | 2.7e-08 | -5.1 | 5.3 | 9.4e-08 | -0.43 | 0.09 | 0.87 | FALSE |
3 | GTEx | Esophagus Mucosa | MRPS21 | 0.09 | 0.06 | lasso | 2 | 0.05 | 3.0e-04 | -5.4 | -5.2 | 1.8e-07 | 0.61 | 0.35 | 0.16 | FALSE |
4 | GTEx | Esophagus Muscularis | PLEKHO1 | 0.06 | 0.05 | lasso | 4 | 0.02 | 1.4e-02 | -6.0 | 5.8 | 7.1e-09 | -0.83 | 0.05 | 0.48 | FALSE |
5 | GTEx | Esophagus Muscularis | RPRD2 | 0.09 | 0.07 | lasso | 4 | 0.06 | 1.8e-04 | -5.0 | -5.3 | 1.2e-07 | 0.69 | 0.52 | 0.13 | FALSE |
6 | GTEx | Esophagus Muscularis | RP11-196G18.22 | 0.18 | 0.02 | enet | 9 | 0.01 | 1.2e-01 | -5.8 | 5.7 | 1.5e-08 | -0.73 | 0.05 | 0.12 | FALSE |
7 | GTEx | Testis | RPRD2 | 0.33 | 0.13 | lasso | 7 | 0.19 | 9.1e-09 | 2.8 | -5.2 | 2.0e-07 | 0.59 | 0.68 | 0.28 | FALSE |
8 | NTR | Blood | ANP32E | 0.01 | 0.01 | enet | 6 | 0.00 | 1.3e-02 | -6.7 | -5.6 | 2.2e-08 | 0.89 | 0.02 | 0.95 | FALSE |
9 | YFS | Blood | RPRD2 | 0.14 | 0.20 | lasso | 8 | 0.20 | 1.2e-63 | -5.5 | -5.6 | 1.7e-08 | 0.65 | 0.98 | 0.02 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPRD2 | 0.05 | 0.02 | enet | 5 | 0.02 | 1.6e-03 | -5.5 | -6.1 | 1.3e-09 | 0.66 | 0.00 | 0.88 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PLEKHO1 | 0.05 | 0.08 | lasso | 1 | 0.05 | 6.6e-03 | -6.6 | -6.6 | 3.5e-11 | 0.96 | 0.00 | 0.64 | TRUE |