TWAS hub - PLEKHO1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.063	0.037	0.0075	0.050	NA	0.009	NA	0.023	0.00053	NA	0.089	NA	0.0140
2	TCGA	Testicular Germ Cell Tumors	0.049	0.037	0.0077	0.077	0.042	0.036	NA	0.052	0.00110	0.013	0.020	NA	0.0066

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder or Schizophrenia	15.9	38.7	43.9	5.8	-6.6
Bipolar Disorder (2018)	12.4	19.6	22.4	4.1	-4.7
Lung FVC	12.2	62.1	66.5	7.6	-8.2
Bipolar Disorder (2011)	12.1	11.7	12.3	3.5	-3.3
Schizophrenia (2014)	11.7	25.9	28.5	4.8	-5.3
Schizophrenia (2018)	9.4	19.5	22.1	4.1	-4.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.2	17.4	19.0	4.0	-4.4
Stomach or abdominal pain in last month	8.0	10.0	13.0	3.6	-2.6
Depression (Nagel 2018)	7.2	10.9	11.9	3.1	-3.4
Frequency of depressed mood in last 2 weeks	6.6	9.2	10.8	3.3	-2.8
Ulcerative Colitis	6.4	9.3	10.4	3.2	-2.9
Osteoarthritis (self-reported)	6.2	8.0	8.1	-2.8	2.8
Supplements: Zinc	6.0	6.5	8.2	2.9	-2.2
Forced vital capacity (FVC)	5.5	21.0	22.2	4.7	-4.5
Forced expiratory volume in 1-second (FEV1)	5.3	17.8	19.1	4.0	-4.4
Forced expiratory volume in 1-second (FEV1), Best measure	4.9	15.6	18.3	3.6	-4.3
Commuting to job workplace: Cycle	4.9	5.9	6.1	-2.5	2.4
Forced vital capacity (FVC), Best measure	4.3	15.7	16.4	3.9	-4.0
Relative age of first facial hair	4.2	8.5	9.3	-2.8	3.1
Pack years adult smoking proportion	3.9	6.0	7.8	-2.8	2.1
Pack years of smoking	3.9	5.8	8.1	-2.9	1.9
Supplements: Vitamin C	3.8	4.5	5.3	1.9	-2.3
Breast cancer (self-reported)	3.8	4.5	4.6	-2.1	2.1
Relative age voice broke	3.7	5.7	5.8	-2.4	2.4
Prostate Cancer	3.3	4.6	4.9	-2.1	2.2
Medication for hormone replacement therapy	3.3	3.7	6.2	1.1	-2.5
Medication: Omeprazole	3.1	3.7	5.7	-2.4	1.3
Sensitivity / hurt feelings	2.9	5.0	7.5	2.7	-1.6
Medication: Seretide 50 evohaler	2.8	3.3	4.1	-1.6	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	4.5	1.5	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	5.0	1.9	-2.2
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	5.4	1.9	-2.3
Myopia	2.7	4.0	4.7	1.8	-2.2
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	4.4	-2.1	1.5
Medication: Levothyroxine sodium	2.6	4.3	4.4	2.1	-2.1
Migraine (self-reported)	2.6	3.2	3.9	1.6	-2.0
Reaction Time	2.4	4.5	8.8	0.5	-3.0
Lupus	2.4	3.7	4.2	2.0	-1.8
Number of incorrect matches in round	2.4	4.1	4.9	1.8	-2.2
Exposure to tobacco smoke outside home	2.4	3.3	3.9	-1.6	2.0
Heel T-Score	2.3	18.2	22.6	3.7	-4.8
Hearing difficulty/problems: Yes	2.3	3.5	3.6	-1.9	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	3.3	1.6	-1.8
Medication for cholesterol	2.3	3.5	4.3	-1.6	2.1
Mother’s age at death	2.3	2.9	3.4	1.5	-1.9
Allergy or Eczema	2.2	5.9	6.8	-2.6	2.2
Qualifications: A levels/AS levels or equivalent	2.2	4.9	9.5	-0.6	3.1
Hypothyroidism (self reported)	2.1	4.9	5.2	2.3	-2.1
Diabetes (mother)	2.1	2.6	3.4	1.8	-1.4
Supplements: Glucosamine	2.0	2.6	3.8	-1.1	2.0
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	2.6	-1.6	1.6
Neck or shoulder pain in last month	2.0	2.9	3.2	1.8	-1.6
Basal cell carcinoma (self-reported)	2.0	2.4	2.7	-1.4	1.6
Vitamin and mineral supplements	1.9	2.6	4.1	-2.0	1.0
Hearing aid user	1.9	2.1	2.4	-1.4	1.5
Neuroticism (Nagel 2018)	1.8	4.3	4.8	1.9	-2.2
Ulcerative Colitis (UC)	1.8	3.4	4.9	2.2	-1.4
Blood Platelet Count	1.8	20.3	26.9	5.2	-3.7
Illnesses of mother	1.8	2.2	3.3	-1.1	1.8
Shortness of breath walking on level ground	1.8	2.1	2.7	-1.6	1.2
Mean time to correctly identify matches	1.8	3.5	6.8	0.5	-2.6
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	3.4	1.8	-1.5
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	4.5	2.1	-1.4
Number of full sisters	1.7	2.1	3.5	-0.8	1.9
Family relationship satisfaction	1.7	2.1	2.9	1.7	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	2.9	-1.1	1.7
Worry (Nagel 2018)	1.6	3.4	5.0	1.4	-2.2
Alzheimer’s Disease (in father)	1.6	1.7	2.8	-0.8	1.7
Primary Biliary Cirrhosis	1.6	2.2	3.3	1.1	-1.8
Neuroticism	1.6	4.0	4.2	2.1	-1.9
Medication: Co-codamol	1.6	1.8	3.1	-1.8	0.7
Medication: Metformin	1.6	2.2	2.6	1.4	-1.6
Illnesses of siblings	1.6	2.3	2.7	-1.6	1.4
Leg fat percentage (right)	1.6	5.9	9.5	-3.1	1.5
Wears glasses or contact lenses	1.6	1.8	2.8	-1.7	0.9
Alcohol drinker status: Never	1.6	1.9	3.0	1.7	-0.9
Alcohol drinker status: Previous	1.6	1.8	2.0	1.3	-1.4
Impedance of leg (right)	1.5	7.4	13.7	-3.7	1.0
Average weekly fortified wine intake	1.5	1.7	2.9	0.7	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	2.7	1.2	-1.6
Impedance of leg (left)	1.5	7.1	13.5	-3.7	0.8
Depression (self-reported)	1.5	1.8	3.3	0.5	-1.8
Tense / ‘highly strung’	1.5	2.5	3.7	1.2	-1.9
Illnesses of father: None of the above (group 1)	1.5	1.8	2.5	1.1	-1.6
Ever taken oral contraceptive pill	1.5	1.6	1.7	-1.3	1.2
Leg fat percentage (left)	1.5	5.3	8.7	-2.9	1.4
Sitting height	1.4	9.9	12.9	-2.6	3.6
Pain all over the body in last month	1.4	1.5	2.5	-1.6	0.7
Worrier / anxious feelings	1.4	2.6	3.0	1.5	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.4	1.9	2.2	-1.2	1.5
Neuroticism (2016)	1.3	1.9	2.3	1.5	-1.2
Blood Red Count	1.3	12.8	14.9	-3.9	3.3
Blood White Count	1.3	9.8	11.4	-2.9	3.4
Happiness	1.3	1.6	2.2	1.5	-1.0
Length of working week for main job	1.3	1.4	2.7	-1.6	0.4
Body fat percentage	1.3	5.1	8.6	-2.9	1.2
Health satisfaction	1.3	1.7	3.1	1.8	-0.6
Illnesses of siblings: Diabetes	1.3	1.6	2.5	1.6	-0.9
Loneliness, isolation	1.3	1.9	2.7	1.6	-1.0
Ever depressed for a whole week	1.3	1.6	2.0	1.1	-1.4
Depressed Affect (Nagel 2018)	1.2	2.5	2.8	1.5	-1.7
Allergy	1.2	2.7	2.8	1.6	-1.7
Medication: Blood pressure	1.2	2.0	3.6	-1.9	0.7
Medication: Ibuprofen	1.2	1.4	1.6	-1.3	1.1
Asthma (self-reported)	1.2	2.4	2.9	-1.4	1.7
Intelligence (Savage-Jansen 2018)	1.1	3.4	5.2	-1.2	2.3
Hearing difficulty/problems with background noise	1.1	1.8	2.1	-1.2	1.5
Leg fat mass (right)	1.1	4.1	6.2	-2.5	1.4
Unable to work because of sickness or disability	1.1	1.4	2.0	0.9	-1.4
Pain experienced in last month	1.1	1.8	2.1	-1.5	1.2
Leg fat mass (left)	1.1	4.2	6.4	-2.5	1.4
Respiratory disease	1.0	2.2	2.9	-1.7	1.2
Diabetes (father)	1.0	1.3	1.3	1.1	-1.1
Trunk fat percentage	1.0	4.1	7.3	-2.7	1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.0	0.2	-1.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	2.5	-1.6	1.4
High blood pressure (mother)	1.0	1.4	1.6	1.1	-1.3
Neuroticism score	1.0	2.0	2.6	1.6	-1.2
Hip circumference	1.0	4.1	4.6	-2.1	1.9
Headache pain in last month	1.0	1.7	1.8	1.4	-1.2
Emphysema/chronic bronchitis	1.0	1.1	1.5	-1.2	0.9
Suffer from ‘nerves’	1.0	1.6	2.5	0.8	-1.6
Osteoporosis (self-reported)	1.0	1.3	1.6	1.3	-1.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.2	1.5	-0.4
Impedance of whole body	1.0	5.3	10.6	-3.2	0.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.6	-0.8	1.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.0	1.4	-0.2
Chronic bronchitis/emphysema (father)	0.9	1.0	1.9	-0.3	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	2.0	1.4	-1.4
Blood clot in the leg (DVT)	0.9	1.1	1.3	-1.0	1.1
Birth weight	0.9	1.9	3.0	-1.7	0.9
Knee pain experienced in last month	0.9	1.4	2.8	-0.1	1.7
Mood swings	0.9	1.6	1.6	1.3	-1.3
Guilty feelings	0.9	1.4	1.5	1.2	-1.1
Eye problems/disorders: Glaucoma	0.9	1.1	1.8	-0.6	1.3
Blood Eosinophil Count	0.8	6.1	6.7	-2.4	2.6
Townsend deprivation index at recruitment	0.8	1.1	1.1	-1.1	-1.0
Multivitamins +/- minerals	0.8	1.0	1.7	1.3	-0.6
Trunk fat mass	0.8	3.3	5.4	-2.3	1.1
Qualifications: None of the above	0.8	1.8	3.0	-0.8	-1.7
Medication: Simvastatin	0.8	1.1	2.2	-0.1	-1.5
Asthma	0.8	1.5	2.0	-1.0	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	1.7	1.3	-0.9
Birth weight of first child	0.8	1.5	1.8	1.1	-1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.3	1.2	-0.8
Glaucoma (self-reported)	0.8	0.9	1.7	-0.2	1.3
Miserableness	0.8	1.3	1.5	1.1	-1.2
Crohns Disease (2017)	0.7	1.5	2.7	-0.4	1.6
Ovarian Cancer	0.7	0.9	1.6	-0.6	1.2
Body Mass Index (BMI) (2010)	0.7	1.0	1.1	-0.9	1.0
Fasting Glucose	0.7	0.9	1.4	1.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.6	0.3	-1.3
Cardiovascular Disease	0.7	2.4	3.5	1.2	-1.9
Hair Pigment	0.7	19.5	20.1	-4.3	4.5
Serious illness, injury or assault to yourself	0.7	0.9	1.2	-1.1	0.7
Arm fat percentage (right)	0.7	2.6	4.7	-2.2	0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.0	-1.0	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.2	0.5	-1.1
Number of children fathered	0.7	0.8	1.5	-1.2	0.4
Whole body fat mass	0.7	2.8	4.5	-2.1	1.0
Alcohol intake frequency.	0.7	1.6	1.7	1.2	-1.3
Had major operations	0.7	0.9	1.6	1.3	0.3
Friendships satisfaction	0.7	0.9	1.7	1.3	-0.2
Eye problems/disorders: Cataract	0.7	0.9	1.6	1.3	-0.3
Medication: Blood pressure	0.7	1.3	1.7	1.3	-0.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.7	1.3	-0.3
Irritability	0.7	1.2	2.2	0.5	-1.5
Breast Cancer	0.6	1.4	2.7	1.6	-0.3
Age at First Birth	0.6	0.8	1.0	-1.0	0.8
HbA1C	0.6	0.7	1.3	0.4	-1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.2	-0.1	-1.1
Severe depression (siblings)	0.6	0.6	1.2	1.1	-0.0
Alcohol usually taken with meals	0.6	1.0	1.0	1.0	-1.0
Impedance of arm (right)	0.6	2.8	5.4	-2.3	-0.5
Number of live births	0.6	0.8	1.4	1.2	0.5
Medication: Amlodipine	0.6	0.8	0.9	-0.9	0.8
Overall health rating	0.6	1.2	1.5	1.0	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	1.2	-0.2
Arm fat percentage (left)	0.6	2.3	4.0	-2.0	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	0.9	-1.0	0.6
Medication: Lisinopril	0.6	0.8	1.4	0.5	-1.2
Supplements: Calcium	0.6	0.6	0.7	-0.8	0.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	-1.1	0.4
High blood pressure	0.5	1.5	2.0	1.0	-1.4
Waist circumference	0.5	1.8	2.0	-1.3	1.4
Fluid intelligence score	0.5	1.1	2.1	-0.1	1.5
Medication: Cholesterol lowering	0.5	0.8	1.6	-1.3	-0.1
Lung cancer (father)	0.5	0.6	1.2	-1.1	0.1
Impedance of arm (left)	0.5	2.5	4.9	-2.2	-0.1
Peak expiratory flow (PEF)	0.5	1.1	1.4	1.0	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.6	1.2	0.1
Number of full brothers	0.5	0.7	1.1	-0.4	-1.1
Medication: Aspirin	0.5	0.7	1.2	-0.5	1.1
Hypertension (Self-reported)	0.5	1.4	1.9	1.0	-1.4
Illnesses of father: Heart disease	0.5	0.7	1.0	-1.0	0.6
Average weekly red wine intake	0.5	0.8	1.5	0.0	1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.0	1.0	-0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.8	-0.9	0.4
Nervous feelings	0.4	0.8	1.4	0.4	-1.2
Weight	0.4	2.1	2.3	-1.4	1.5
Pulse wave Arterial Stiffness index	0.4	0.4	0.7	0.8	0.5
Arm fat mass (right)	0.4	1.5	2.3	-1.5	0.8
Standing height	0.4	3.8	4.7	-1.7	2.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.6	0.8	0.6
Comparative body size at age 10	0.4	1.1	2.1	1.4	-0.2
Worry too long after embarrassment	0.4	0.7	1.4	1.2	0.3
Pulse wave peak to peak time	0.4	0.4	0.8	-0.9	-0.3
Heart disease (mother)	0.4	0.5	0.7	0.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.5	-0.7	0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.9	0.5
Ever had bowel cancer screening	0.4	0.4	0.9	0.9	-0.2
Arm fat mass (left)	0.4	1.6	2.2	-1.5	0.9
Financial situation satisfaction	0.4	0.5	0.9	-0.1	1.0
Medication: Paracetamol	0.4	0.6	0.9	-0.9	0.5
Fractured/broken bones in last 5 years	0.4	0.6	0.7	-0.6	-0.9
Age started oral contraceptive pill	0.4	0.5	0.6	-0.6	0.8
Cholesterol lowering medication	0.4	0.6	0.9	1.0	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	-0.8	0.5
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	1.3	0.1
Crohns Disease (2012)	0.3	0.5	0.5	-0.7	0.7
Chronotype (morning person)	0.3	0.6	0.6	0.8	-0.8
Hand grip strength (left)	0.3	0.7	1.1	1.1	0.5
Average weekly spirits intake	0.3	0.3	0.5	-0.4	0.7
Fed-up feelings	0.3	0.5	0.6	0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	0.8	0.7	-0.9
Had menopause	0.3	0.4	0.6	0.8	-0.3
Mouth/teeth dental problems	0.3	0.5	0.9	-1.0	0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.5	-0.4	0.7
Father’s age at death	0.3	0.4	0.6	-0.6	0.7
Falls in the last year	0.3	0.4	0.8	-0.0	-0.9
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.9	-0.1
Medication: Lansoprazole	0.3	0.4	0.7	-0.2	-0.9
Hair/balding pattern: Pattern 4	0.3	0.7	0.7	-0.8	0.9
Pulse wave reflection index	0.3	0.4	0.7	0.3	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.8	0.9	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.4	0.5	0.7
Chest pain or discomfort	0.3	0.4	0.8	-0.9	0.3
Leg pain on walking	0.3	0.3	0.6	-0.2	0.8
Back pain experienced in last month	0.3	0.4	0.8	0.9	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.5	0.7	0.6
Illnesses of father: High blood pressure	0.3	0.3	0.7	-0.1	-0.8
Risk taking	0.3	0.4	0.4	0.7	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.1	-0.7	1.1
Major Depression (MDD)	0.2	0.3	0.6	0.1	-0.8
Rheumatoid Arthritis	0.2	0.3	0.6	-0.2	0.8
Triglycerides	0.2	0.4	0.6	0.7	-0.5
Height	0.2	4.0	6.6	-1.2	2.6
Waist Hip Ratio (WHR)	0.2	0.7	0.9	0.8	-0.9
Lung FEV1/FVC ratio	0.2	0.8	1.3	-0.5	-1.2
Hand grip strength (right)	0.2	0.5	0.9	-0.1	1.0
Qualifications: CSEs or equivalent	0.2	0.2	0.3	-0.5	0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	0.5	-0.5
Heart attack	0.2	0.3	0.3	0.5	-0.5
Time employed in main current job	0.2	0.2	0.4	-0.6	0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.1	-0.7
Noisy workplace	0.2	0.3	0.3	0.5	-0.5
Prospective memory result	0.2	0.2	0.2	0.4	-0.5
High blood pressure (siblings)	0.2	0.3	0.5	0.3	-0.7
Arm fat-free mass (right)	0.2	0.8	1.5	0.2	1.2
Age at first live birth	0.2	0.4	0.6	0.8	-0.5
Qualifications: College or University degree	0.2	0.6	0.9	1.0	0.6
Eye problems/disorders: None of the above	0.2	0.3	0.3	-0.4	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.4	0.5	-0.6
Medication: Allopurinol	0.2	0.3	0.4	-0.7	0.4
Arm predicted mass (right)	0.2	1.0	1.8	0.4	1.3
Comparative height size at age 10	0.2	1.2	1.3	-1.1	1.1
Long-standing illness, disability or infirmity	0.2	0.3	0.5	-0.3	0.7
Diabetes diagnosed by doctor	0.2	0.4	0.6	0.4	-0.7
Smoking status: Current	0.2	0.3	0.5	0.2	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	0.3	-0.7
Arm fat-free mass (left)	0.2	1.0	1.9	0.2	1.4
Number of operations (self-reported)	0.2	0.2	0.5	0.7	-0.0
Average weekly beer plus cider intake	0.2	0.3	0.6	0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.3	0.5	-0.6
Heart disease (siblings)	0.2	0.2	0.2	0.4	0.5
Arm predicted mass (left)	0.2	1.0	1.9	-0.1	1.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.3	0.6
Coronary Artery Disease (CAD)	0.1	0.2	0.3	-0.0	0.6
HDL Cholesterol	0.1	0.1	0.3	-0.1	0.5
LDL Cholesterol	0.1	0.1	0.1	-0.4	-0.2
Smoking Status	0.1	0.2	0.4	-0.4	-0.6
Tanning	0.1	0.9	1.8	-1.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	0.2	-0.5
Angina	0.1	0.1	0.2	-0.4	-0.3
Leg fat-free mass (left)	0.1	0.4	0.6	0.3	0.8
Taking other prescription medications	0.1	0.1	0.2	-0.4	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	0.6	0.1
Medication: Atenolol	0.1	0.1	0.2	-0.2	-0.4
Leg predicted mass (left)	0.1	0.4	0.6	0.3	0.8
Had other major operations	0.1	0.2	0.3	-0.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.3	0.3
Medication: Ramipril	0.1	0.2	0.3	0.3	-0.5
Trunk fat-free mass	0.1	0.7	1.0	0.6	1.0
Pulse rate	0.1	0.2	0.3	0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	0.3
Trunk predicted mass	0.1	0.7	1.0	0.6	1.0
Gout (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.2	-0.5
Angina (self-reported)	0.1	0.1	0.2	-0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	-0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	0.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.4	0.3	-0.6
Whole body fat-free mass	0.1	0.6	0.8	0.6	0.9
Leg fat-free mass (right)	0.1	0.5	0.6	0.6	0.8
Medication: Aspirin	0.1	0.1	0.2	-0.3	0.5
Whole body water mass	0.1	0.7	1.0	0.6	1.0
Leg predicted mass (right)	0.1	0.5	0.5	0.6	0.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.7	0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.2	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.4	-0.0
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.2	-0.6
Medication: Atorvastatin	0.1	0.2	0.2	-0.4	0.4
Ever smoked	0.1	0.1	0.2	0.5	-0.1
Basal metabolic rate	0.1	0.5	1.1	0.1	1.0
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.2	-0.7
Mean Putamen Volume	0.0	0.0	0.0	-0.1	0.0
BMI	0.0	0.0	0.1	0.1	0.3
Systolic Blood Pressure	0.0	0.0	0.0	-0.1	-0.2
Number of treatments/medications taken	0.0	0.0	0.1	-0.2	-0.1
Ever had hysterectomy (womb removed)	0.0	0.1	0.1	0.3	0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.4	-0.2
Current tobacco smoking	0.0	0.0	0.1	-0.2	-0.3
Maternal smoking around birth	0.0	0.0	0.1	-0.3	0.1
Age when periods started (menarche)	0.0	0.1	0.1	-0.3	0.3
Body mass index (BMI)	0.0	0.2	0.2	-0.5	0.4
Past tobacco smoking	0.0	0.0	0.1	0.1	-0.3
Financial difficulties in last 2 years	0.0	0.0	0.0	0.0	-0.1
Diabetes (self-reported)	0.0	0.1	0.1	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.0	-0.3
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.1	0.0
Breastfed as a baby	0.0	0.0	0.0	0.1	0.1
Loud music exposure frequency	0.0	0.0	0.0	0.1	-0.1
Medication: Paracetamol	0.0	0.0	0.1	0.3	-0.1
Pulse rate, automated reading	0.0	0.1	0.2	0.1	-0.4
Age at last live birth	0.0	0.0	0.1	0.3	0.0
Smoking status: Previous	0.0	0.0	0.0	-0.1	0.1
Qualifications: nursing, teaching	0.0	0.1	0.1	0.1	0.3
Commuting to job workplace: Walk	0.0	0.0	0.0	0.1	0.2
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	-0.3
Medication: Gliclazide	0.0	0.0	0.0	0.1	-0.2
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.3	0.1

Hub : Genes

PLEKHO1

Models

Trait associations